ZINTEROL (BioDeep_00000185123)

   

human metabolite blood metabolite


代谢物信息卡片


N-(2-hydroxy-5-{1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl}phenyl)methanesulfonamide

化学式: C19H26N2O4S (378.16131960000007)
中文名称: 净特罗
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC(C)(CC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)NS(=O)(=O)C)O
InChI: InChI=1S/C19H26N2O4S/c1-19(2,12-14-7-5-4-6-8-14)20-13-18(23)15-9-10-17(22)16(11-15)21-26(3,24)25/h4-11,18,20-23H,12-13H2,1-3H3

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists

同义名列表

4 个代谢物同义名

N-(2-hydroxy-5-{1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl}phenyl)methanesulfonamide; Zinterol hydrochloride; Zinterol, (+-)-isomer; Zinterol



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Matías Regiart, Luis A Escudero, Pedro Aranda, Noelia A Martinez, Franco A Bertolino, Julio Raba. Copper nanoparticles applied to the preconcentration and electrochemical determination of β-adrenergic agonist: an efficient tool for the control of meat production. Talanta. 2015 Apr; 135(?):138-44. doi: 10.1016/j.talanta.2014.12.026. [PMID: 25640137]
  • Tuan M Tran, Jackie Friedman, Eyad Qunaibi, Faiza Baameur, Robert H Moore, Richard B Clark. Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies. Molecular pharmacology. 2004 Jan; 65(1):196-206. doi: 10.1124/mol.65.1.196. [PMID: 14722251]
  • Trevor W R Lee, Hilary P Grocott, Debra Schwinn, Eric Jacobsohn. High spinal anesthesia for cardiac surgery: effects on beta-adrenergic receptor function, stress response, and hemodynamics. Anesthesiology. 2003 Feb; 98(2):499-510. doi: 10.1097/00000542-200302000-00032. [PMID: 12552211]
  • R P Xiao, E D Tomhave, D J Wang, X Ji, M O Boluyt, H Cheng, E G Lakatta, W J Koch. Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. The Journal of clinical investigation. 1998 Mar; 101(6):1273-82. doi: 10.1172/jci1335. [PMID: 9502768]
  • C C Felder, M M Piccio, A M McKelvey, K T Nakamura, J E Robillard, P A Jose. Ontogeny of renal beta adrenoceptors in the sheep. Pediatric nephrology (Berlin, Germany). 1990 Nov; 4(6):635-9. doi: 10.1007/bf00858641. [PMID: 1982416]
  • M A McElligott, L Y Chaung, A Barreto. Effects of a beta-adrenergic agonist on protein turnover in muscle cells in culture. Biochemical pharmacology. 1989 Jul; 38(13):2199-205. doi: 10.1016/0006-2952(89)90077-4. [PMID: 2567597]
  • P Mauriège, G De Pergola, M Berlan, M Lafontan. Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta 1-antagonists. Journal of lipid research. 1988 May; 29(5):587-601. doi: 10.1016/s0022-2275(20)38502-3. [PMID: 2900871]
  • D P Healy, P A Münzel, P A Insel. Localization of beta 1- and beta 2-adrenergic receptors in rat kidney by autoradiography. Circulation research. 1985 Aug; 57(2):278-84. doi: 10.1161/01.res.57.2.278. [PMID: 2990758]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]
  • G Mechkov, D Dimov, Iu Iordanova. [Proceedings: Serum gamma-glutamyl tranapeptidase activity after the induction and inhibition of liver microsomal enzymes in nonconjugated hyperbilirubinemia]. Vutreshni bolesti. 1976; 15(1):93-5. doi: NULL. [PMID: 4927]
  • P Hernuss, E Müller Tyl, H Salzer, H Sinzinger, L Wicke, T Prey, L Reisinger. [Pollen diet as an adjuvans of radiotherapy in gynecologic carcinomas]. Strahlentherapie. 1975 Nov; 150(5):500-6. doi: NULL. [PMID: 2995]
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