Zaragozic acid A (BioDeep_00000185088)
human metabolite blood metabolite
代谢物信息卡片
化学式: C35H46O14 (690.2887416)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 98.55%
分子结构信息
SMILES: C=C(CC[C@]12O[C@H](C(=O)O)[C@@](O)(C(=O)O)[C@](C(=O)O)(O1)[C@H](OC(=O)/C=C/[C@@H](C)C[C@@H](C)CC)[C@H]2O)[C@@H](OC(C)=O)[C@H](C)Cc1ccccc1
InChI: InChI=1S/C35H46O14/c1-7-19(2)17-20(3)13-14-25(37)47-28-27(38)33(48-29(30(39)40)34(45,31(41)42)35(28,49-33)32(43)44)16-15-21(4)26(46-23(6)36)22(5)18-24-11-9-8-10-12-24/h8-14,19-20,22,26-29,38,45H,4,7,15-18H2,1-3,5-6H3,(H,39,40)(H,41,42)(H,43,44)
描述信息
同义名列表
4 个代谢物同义名
1-[4-(acetyloxy)-5-benzyl-3-methylidenehexyl]-6-[(4,6-dimethyloct-2-enoyl)oxy]-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid; 1-[4-(Acetyloxy)-5-benzyl-3-methylidenehexyl]-6-[(4,6-dimethyloct-2-enoyl)oxy]-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylate; Zaragozic acid A; zaragozic acid
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kent Sakai, Nobuhiro Koyama, Takashi Fukuda, Yukiko Mori, Hiroyasu Onaka, Hiroshi Tomoda. Search method for inhibitors of Staphyloxanthin production by methicillin-resistant Staphylococcus aureus.
Biological & pharmaceutical bulletin.
2012; 35(1):48-53. doi:
10.1248/bpb.35.48. [PMID: 22223336] - Tsuyoshi Goto, Hiroyuki Nagai, Kahori Egawa, Young-Il Kim, Sota Kato, Aki Taimatsu, Tomoya Sakamoto, Shogo Ebisu, Takahiro Hohsaka, Hiroh Miyagawa, Shigeru Murakami, Nobuyuki Takahashi, Teruo Kawada. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.
The Biochemical journal.
2011 Aug; 438(1):111-9. doi:
10.1042/bj20101939. [PMID: 21605082] - Anna Linetti, Alessandra Fratangeli, Elena Taverna, Pamela Valnegri, Maura Francolini, Valentina Cappello, Michela Matteoli, Maria Passafaro, Patrizia Rosa. Cholesterol reduction impairs exocytosis of synaptic vesicles.
Journal of cell science.
2010 Feb; 123(Pt 4):595-605. doi:
10.1242/jcs.060681. [PMID: 20103534] - Elzbieta Kojro, Petra Füger, Claudia Prinzen, Anna Maria Kanarek, Dorothea Rat, Kristina Endres, Falk Fahrenholz, Rolf Postina. Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis.
Journal of Alzheimer's disease : JAD.
2010; 20(4):1215-31. doi:
10.3233/jad-2010-091621. [PMID: 20413873] - Mohini Bedi, Melissa Niesen, Dayami Lopez. Inhibition of squalene synthase upregulates PCSK9 expression in rat liver.
Archives of biochemistry and biophysics.
2008 Feb; 470(2):116-9. doi:
10.1016/j.abb.2007.11.011. [PMID: 18054775] - Katsue Daicho, Hironori Maruyama, Asuka Suzuki, Masaru Ueno, Masahiro Uritani, Takashi Ushimaru. The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast.
Biochimica et biophysica acta.
2007 Jul; 1768(7):1681-90. doi:
10.1016/j.bbamem.2007.03.022. [PMID: 17531951] - Koen Brusselmans, Leen Timmermans, Tine Van de Sande, Paul P Van Veldhoven, Guimin Guan, Ishaiahu Shechter, Frank Claessens, Guido Verhoeven, Johannes V Swinnen. Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.
The Journal of biological chemistry.
2007 Jun; 282(26):18777-85. doi:
10.1074/jbc.m611763200. [PMID: 17483544] - Shingo Suzuki, Kazuyuki Kiyosue, Shunsuke Hazama, Akihiko Ogura, Megumi Kashihara, Tomoko Hara, Hisatsugu Koshimizu, Masami Kojima. Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007 Jun; 27(24):6417-27. doi:
10.1523/jneurosci.0690-07.2007. [PMID: 17567802] - Carlos Fernández, Miguel Martín, Diego Gómez-Coronado, Miguel A Lasunción. Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression.
Journal of lipid research.
2005 May; 46(5):920-9. doi:
10.1194/jlr.m400407-jlr200. [PMID: 15687348] - Timothy E Johnson, Xiaohua Zhang, Kimberly B Bleicher, Gary Dysart, Amy F Loughlin, William H Schaefer, Diane R Umbenhauer. Statins induce apoptosis in rat and human myotube cultures by inhibiting protein geranylgeranylation but not ubiquinone.
Toxicology and applied pharmacology.
2004 Nov; 200(3):237-50. doi:
10.1016/j.taap.2004.04.010. [PMID: 15504460] - J D Loike, D Y Shabtai, R Neuhut, S Malitzky, E Lu, J Husemann, I J Goldberg, S C Silverstein. Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol.
Arteriosclerosis, thrombosis, and vascular biology.
2004 Nov; 24(11):2051-6. doi:
10.1161/01.atv.0000143858.15909.29. [PMID: 15345508] - A Berger, D Rein, E Kratky, I Monnard, H Hajjaj, I Meirim, C Piguet-Welsch, J Hauser, K Mace, P Niederberger. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.
Lipids in health and disease.
2004 Feb; 3(?):2. doi:
10.1186/1476-511x-3-2. [PMID: 14969592]