Zaldaride (BioDeep_00000185082)

   

human metabolite blood metabolite


代谢物信息卡片


1-[1-({7-methyl-8-oxa-2-azatricyclo[8.4.0.0²,⁶]tetradeca-1(14),3,5,10,12-pentaen-7-yl}methyl)piperidin-4-yl]-1H-1,3-benzodiazol-2-ol

化学式: C26H28N4O2 (428.2212148)
中文名称: 1,3-二氢-1-[1-[(4-甲基-4H,6H-吡咯并[1,2-a][4,1]苯并氮杂-4-基)甲基]-4-哌啶]-2H-苯并咪唑-2-酮
谱图信息: 最多检出来源 Homo sapiens(blood) 35.56%

分子结构信息

SMILES: CC1(C2=CC=CN2C3=CC=CC=C3CO1)CN4CCC(CC4)N5C6=CC=CC=C6NC5=O
InChI: InChI=1S/C26H28N4O2/c1-26(24-11-6-14-29(24)22-9-4-2-7-19(22)17-32-26)18-28-15-12-20(13-16-28)30-23-10-5-3-8-21(23)27-25(30)31/h2-11,14,20H,12-13,15-18H2,1H3,(H,27,31)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C266 - Antidiarrheal Agent
D005765 - Gastrointestinal Agents > D000930 - Antidiarrheals

同义名列表

8 个代谢物同义名

1-[1-({7-methyl-8-oxa-2-azatricyclo[8.4.0.0²,⁶]tetradeca-1(14),3,5,10,12-pentaen-7-yl}methyl)piperidin-4-yl]-1H-1,3-benzodiazol-2-ol; 1-[1-({7-methyl-8-oxa-2-azatricyclo[8.4.0.0²,⁶]tetradeca-1(14),3,5,10,12-pentaen-7-yl}methyl)piperidin-4-yl]-1,3-benzodiazol-2-ol; 1,3-Dihydro-1-(1-((4-methyl-4H,6H-pyrrolo(1,2a)(4,1)-benzoxazepin-4-yl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; CGS 9343b Maleate; Zaldaride maleate; Zaldaride; CGS 9343b; CGS-9343b



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J H Lin, B Rydqvist. Inhibition of mechanotransducer currents in crayfish sensory neuron by CGS 9343B, a calmodulin antagonist. European journal of pharmacology. 2000 May; 397(1):11-7. doi: 10.1016/s0014-2999(00)00256-9. [PMID: 10844093]
  • N Aikawa, K Horikoshi, H Maeda, H Kobayashi, K Ohmori. Comparison of the antidiarrheal effects of zaldaride maleate and its optical isomers in rats. Biological & pharmaceutical bulletin. 2000 Apr; 23(4):402-5. doi: 10.1248/bpb.23.402. [PMID: 10784416]
  • N Aikawa, K Ohmori. Effect of zaldaride maleate, an antidiarrheal compound, on fecal pellet output induced by hyperpropulsion in gastrointestine of rats. Japanese journal of pharmacology. 2000 Apr; 82(4):350-2. doi: 10.1254/jjp.82.350. [PMID: 10875756]
  • N Aikawa, H Kobayashi, K Ohmori. Gender differences in the antidiarrheal effect of zaldaride maleate in rats. Biological & pharmaceutical bulletin. 2000 Jan; 23(1):33-6. doi: 10.1248/bpb.23.33. [PMID: 10706407]
  • N Aikawa, K Horikoshi, H Maeda, H Kobayashi, K Ohmori. Antidiarrheal effects of zaldaride maleate after oral, intravenous and subcutaneous administration to rats. Japanese journal of pharmacology. 1999 Dec; 81(4):397-400. doi: 10.1254/jjp.81.397. [PMID: 10669047]
  • P C Okhuysen, H L DuPont, C D Ericsson, S Marani, F G Martinez-Sandoval, M A Olesen, G P Ravelli. Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo-controlled trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 1995 Aug; 21(2):341-4. doi: 10.1093/clinids/21.2.341. [PMID: 8562742]
  • M Brandsch, V Ganapathy, F H Leibach. H(+)-peptide cotransport in Madin-Darby canine kidney cells: expression and calmodulin-dependent regulation. The American journal of physiology. 1995 Mar; 268(3 Pt 2):F391-7. doi: 10.1152/ajprenal.1995.268.3.f391. [PMID: 7900838]
  • L D Jayanthi, S Ramamoorthy, V B Mahesh, F H Leibach, V Ganapathy. Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. The Journal of biological chemistry. 1994 May; 269(20):14424-9. doi: 10.1016/s0021-9258(17)36640-1. [PMID: 8182048]
  • D Chollet, M Salanon. Determination of Zy 17617B in plasma by solid-phase extraction and liquid chromatography with automated pre-column exchange. Journal of chromatography. 1992 Feb; 593(1-2):73-8. doi: 10.1016/0021-9673(92)80269-z. [PMID: 1639914]
  • H Safayhi, M I Anazodo, H P Ammon. Calmodulin- and Ca2(+)-insensitive fatty acid methyltransferase from RINm5F cells. Inhibition by trifluoperazine and W7. The International journal of biochemistry. 1991; 23(7-8):769-72. doi: 10.1016/0020-711x(91)90051-n. [PMID: 1907579]
  • J E Shook, T F Burks, J W Wasley, J A Norman. Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. The Journal of pharmacology and experimental therapeutics. 1989 Oct; 251(1):247-52. doi: NULL. [PMID: 2795459]