3-Butylidene-4,5-dihydrophthalide (BioDeep_00000185072)

   

human metabolite blood metabolite natural product


代谢物信息卡片


3-butylidene-1,3,4,5-tetrahydro-2-benzofuran-1-one

  化学式: C12H14O2 (190.0994)
中文名称:
  谱图信息: 最多检出来源 Homo sapiens(blood) 43.07%

分子结构信息

SMILES: CCCC=C1OC(=O)C2=C1CCC=C2
InChI: InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7-8H,2-4,6H2,1H3


描述信息

同义名列表

6 个代谢物同义名

3-butylidene-1,3,4,5-tetrahydro-2-benzofuran-1-one; 3-butylidene-4,5-dihydro-2-benzofuran-1-one; 3-butylidene-4,5-dihydrophthalide; ligustilide, (E)-isomer; ligustilide, (Z)-isomer; Ligustilide



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sujuan Guo, Guofeng Wang, Zhengxiong Yang. Ligustilide alleviates the insulin resistance, lipid accumulation, and pathological injury with elevated phosphorylated AMPK level in rats with diabetes mellitus. Journal of receptor and signal transduction research. 2021 Feb; 41(1):85-92. doi: 10.1080/10799893.2020.1789877. [PMID: 32643505]
  • Qinhui Wang, Tao Yan, Wei Jiang, Na Hu, Song Zhang, Peng Yang, Wenjuan Zhang, Lei Shi, Linna Liu. Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction. Biomedical chromatography : BMC. 2019 Oct; 33(10):e4625. doi: 10.1002/bmc.4625. [PMID: 31222844]
  • Feipeng Duan, Wenjuan Xu, Jie Liu, Zhixin Jia, Kuikui Chen, Yijun Chen, Mingxia Wang, Kaiyue Ma, Jiaojiao Dong, Lianming Chen, Hongbin Xiao. Preparing the key metabolite of Z-ligustilide in vivo by a specific electrochemical reaction. Journal of separation science. 2018 Jul; 41(13):2799-2807. doi: 10.1002/jssc.201800164. [PMID: 29663726]
  • Qin Zheng, Yu Tang, Peng-Yi Hu, Dan Liu, Delin Zhang, Pengfei Yue, Yuanyuan Guo, Ming Yang. The influence and mechanism of ligustilide, senkyunolide I, and senkyunolide A on echinacoside transport through MDCK-MDR1 cells as blood-brain barrier in vitro model. Phytotherapy research : PTR. 2018 Mar; 32(3):426-435. doi: 10.1002/ptr.5985. [PMID: 29193364]
  • Peng-Yi Hu, Dan Liu, Qin Zheng, Qing Wu, Yu Tang, Ming Yang. Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model. Molecules (Basel, Switzerland). 2016 Mar; 21(3):300. doi: 10.3390/molecules21030300. [PMID: 26950101]
  • Xu Liu, Xiuzhong Li, Songgang Ji, Xiaobo Cui, Mingchun Li. Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 40(3-4):770-780. doi: 10.1159/000453137. [PMID: 27915331]
  • Tingting Chen, Xiting Zhu, Qi Chen, Ming Ge, Xueping Jia, Xiang Wang, Cunwang Ge. Interaction between Z-ligustilide from Radix Angelica sinensis and human serum albumin. Food chemistry. 2015 Nov; 186(?):292-7. doi: 10.1016/j.foodchem.2014.11.041. [PMID: 25976824]
  • Valérian Bunel, Marie-Hélène Antoine, Joëlle Nortier, Pierre Duez, Caroline Stévigny. Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2015 Apr; 29(3):458-67. doi: 10.1016/j.tiv.2014.12.017. [PMID: 25561245]
  • Yapeng Lu, Siyuan Liu, Yu Zhao, Li Zhu, Shuqin Yu. Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability. Acta pharmaceutica (Zagreb, Croatia). 2014 Jun; 64(2):211-22. doi: 10.2478/acph-2014-0012. [PMID: 24914721]
  • Mingfei Zeng, Jing Zhang, Yifang Yang, Yan Jin, Wei Xiao, Zhenzhong Wang, Gang Ding, Renjie Yan. An automated dual-gradient liquid chromatography-MS/MS method for the simultaneous determination of ferulic acid, ligustrazine and ligustilide in rat plasma and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88(?):354-63. doi: 10.1016/j.jpba.2013.08.038. [PMID: 24140450]
  • Xiao Yun Zhang, Hua Qiao, Yan Bin Shi. HPLC method with fluorescence detection for the determination of ligustilide in rat plasma and its pharmacokinetics. Pharmaceutical biology. 2014 Jan; 52(1):21-30. doi: 10.3109/13880209.2013.805790. [PMID: 24044763]
  • Pei Liu, Zhenhao Li, Dawei Qian, Wei Li, Er-Xin Shang, Jin-Ao Duan. Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Jun; 929(?):63-9. doi: 10.1016/j.jchromb.2013.04.022. [PMID: 23665892]
  • Sayid Mahdi Mirghazanfari, Leila Hosseinzadeh, Yalda Shokoohinia, Majid Aslany, Mohammad Kamali-Nejad. Acute and subchronic toxicological evaluation of Echinophora platyloba DC (Apiaceae) total extract in Wistar rats. Clinics (Sao Paulo, Brazil). 2012; 67(5):497-502. doi: 10.6061/clinics/2012(05)15. [PMID: 22666795]
  • Meng Shao, Kai Qu, Ke Liu, Yuqin Zhang, Ling Zhang, Zeqin Lian, Tingting Chen, Junfeng Liu, Aili Wu, Yue Tang, Haibo Zhu. Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits. Planta medica. 2011 May; 77(8):809-16. doi: 10.1055/s-0030-1250573. [PMID: 21104607]
  • Mohammed Rabbani, Seyed Ebrahim Sajjadi, Masoud Sadeghi. Chemical composition of the essential oil from kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice. Clinics (Sao Paulo, Brazil). 2011; 66(5):843-8. doi: 10.1590/s1807-59322011000500022. [PMID: 21789390]
  • Wen-Wan Chao, Yong-Han Hong, Miaw-Ling Chen, Bi-Fong Lin. Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation. Journal of ethnopharmacology. 2010 May; 129(2):244-9. doi: 10.1016/j.jep.2010.03.022. [PMID: 20371279]
  • Chunguang Ding, Yuxin Sheng, Yinghao Zhang, Jinlan Zhang, Guanhua Du. Identification and comparison of metabolites after oral administration of essential oil of Ligusticum chuanxiong or its major constituent ligustilide in rats. Planta medica. 2008 Nov; 74(14):1684-92. doi: 10.1055/s-0028-1088309. [PMID: 18951338]
  • Ling Dong, Chunhui Deng, Ben Wang, Xizhong Shen. Fast determination of Z-ligustilide in plasma by gas chromatography/mass spectrometry following headspace single-drop microextraction. Journal of separation science. 2007 Jun; 30(9):1318-25. doi: 10.1002/jssc.200600379. [PMID: 17623474]
  • Yunfeng Shi, Langchong He, Sicen Wang. Determination of ligustilide in rat blood and tissues by capillary gas chromatography/mass spectrometry. Biomedical chromatography : BMC. 2006 Oct; 20(10):993-8. doi: 10.1002/bmc.614. [PMID: 16583458]
  • Ya-Li Wang, Yi-Zeng Liang, Ben-Mei Chen, Yong-Kang He, Bo-Yan Li, Qian-Nan Hu. LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. Analytical and bioanalytical chemistry. 2005 Sep; 383(2):247-54. doi: 10.1007/s00216-005-0008-7. [PMID: 16132135]
  • Mi-Hyun Ka, Eun Hye Choi, Hang-Sook Chun, Kwang-Geun Lee. Antioxidative activity of volatile extracts isolated from Angelica tenuissimae roots, peppermint leaves, pine needles, and sweet flag leaves. Journal of agricultural and food chemistry. 2005 May; 53(10):4124-9. doi: 10.1021/jf047932x. [PMID: 15884849]
  • S Kobayashi, Y Mimura, T Naitoh, I Kimura, M Kimura. Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells. Japanese journal of pharmacology. 1993 Nov; 63(3):353-9. doi: 10.1254/jjp.63.353. [PMID: 8107327]