XIPAMIDE (BioDeep_00000185039)

   

human metabolite blood metabolite


代谢物信息卡片


4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulphamoylbenzene-1-carboximidic acid

化学式: C15H15ClN2O4S (354.04410200000007)
中文名称: 希伯胺
谱图信息: 最多检出来源 Homo sapiens(blood) 94.12%

分子结构信息

SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N
InChI: InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)

描述信息

C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic
D045283 - Natriuretic Agents > D004232 - Diuretics

同义名列表

8 个代谢物同义名

4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulphamoylbenzene-1-carboximidic acid; 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzene-1-carboximidic acid; 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulphamoylbenzene-1-carboximidate; 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzene-1-carboximidate; 4-chloro-N-(2,6-Dimethylphenyl)-2-hydroxy-5-sulphamoylbenzamide; BE-1293xipamide; XIPAMIDE; aquaphor



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • M M Tolba, F Belal. Two liquid chromatographic approaches for the simultaneous determination of xipamide and its degradation product (2,6-xylidine) using time-programmed fluorescence detection. Luminescence : the journal of biological and chemical luminescence. 2017 Jun; 32(4):491-501. doi: 10.1002/bio.3203. [PMID: 27562288]
  • Ahmed S Al-Kady. Selective and sensitive spectrophotometric method for the determination of trace amounts of zirconium in environmental and biological samples using 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Nov; 97(?):284-9. doi: 10.1016/j.saa.2012.06.019. [PMID: 22771563]
  • Hadir M Maher, Rasha M Youssef, Eman I El-Kimary, Ekram M Hassan, Magda A Barary. Bioavailability study of triamterene and xipamide using urinary pharmacokinetic data following single oral dose of each drug or their combination. Journal of pharmaceutical and biomedical analysis. 2012 Mar; 61(?):78-85. doi: 10.1016/j.jpba.2011.11.032. [PMID: 22197154]
  • Jochen Beyer, Anabelle Bierl, Frank T Peters, Hans H Maurer. Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation. Therapeutic drug monitoring. 2005 Aug; 27(4):509-20. doi: 10.1097/01.ftd.0000160719.96445.91. [PMID: 16044110]
  • U Merkel, S Lindner, R Vollandt, H Sperschneider, A Balogh. Trough levels of mycophenolic acid and its glucuronidated metabolite in renal transplant recipients. International journal of clinical pharmacology and therapeutics. 2005 Aug; 43(8):379-88. doi: 10.5414/cpp43379. [PMID: 16119513]
  • Heinrich Knauf, Ernst Mutschler. [Mechanism of action of xipamide and its classification as a 'low ceiling diuretic'. Pharmacodynamic-pharmacokinetic studies in healthy volunteers and in kidney and liver patients]. Arzneimittel-Forschung. 2005; 55(1):1-14. doi: 10.1055/s-0031-1296819. [PMID: 15727159]
  • Yunje Kim, Kyungjin Han, Ki-Jung Paeng. Determination of Xipamide metabolite in human urine by high-performance liquid chromatography/diode-array detection, high-performance liquid chromatography/electrospray ionization mass spectrometry and gas chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM. 2004; 18(20):2505-12. doi: 10.1002/rcm.1636. [PMID: 15384135]
  • NULL. [Thiazide analogs. Also can be used in renal failure]. MMW Fortschritte der Medizin. 2003 Aug; 145(33-34):57. doi: NULL. [PMID: 14526580]
  • Anton Sandhofer, Chris Kähler, Doris Heininger, Romuald Bellmann, Christian J Wiedermann, Michael Joannidis. Severe electrolyte disturbances and renal failure in elderly patients with combined diuretic therapy including xipamid. Wiener klinische Wochenschrift. 2002 Nov; 114(21-22):938-42. doi: NULL. [PMID: 12528327]
  • H Knauf, E Mutschler. Liver cirrhosis with ascites: pathogenesis of resistance to diuretics and long-term efficacy and safety of torasemide. Cardiology. 1994; 84 Suppl 2(?):87-98. doi: 10.1159/000176461. [PMID: 7954550]
  • S Youssef, L Osman, M S Sabbour. Serum lipoprotein profile under different antihypertensive therapy. International journal of clinical pharmacology research. 1992; 12(3):109-16. doi: NULL. [PMID: 1473876]
  • P Lijnen, R Fagard, J Staessen, A Amery. Hormonal effects of the diuretic xipamide in healthy men. Cardiovascular drugs and therapy. 1991 Aug; 5(4):741-6. doi: 10.1007/bf03029749. [PMID: 1832291]
  • H Knauf, W Gerok, E Mutschler, J Schölmerich, H Spahn, H Wietholtz. Xipamide disposition in liver cirrhosis. Clinical pharmacology and therapeutics. 1990 Dec; 48(6):628-32. doi: 10.1038/clpt.1990.206. [PMID: 2249374]
  • S Bodenan, M Paillet, M O Christen. Rapid determination of xipamide in human plasma and urine by high-performance liquid chromatography. Journal of chromatography. 1990 Nov; 533(?):275-81. doi: 10.1016/s0378-4347(00)82214-8. [PMID: 2081776]
  • H Knauf, E Wenk, J Schölmerich, K J Goerg, W Gerok, H G Leser, E Mutschler. Prediction of diuretic mobilization of cirrhotic ascites by pretreatment fractional sodium excretion. Klinische Wochenschrift. 1990 Jun; 68(11):545-51. doi: 10.1007/bf01667146. [PMID: 2198378]
  • C W Owens, B Tomlinson, J B Liu, B R Graham, C Gillham, C C Smith, D J Betteridge, B N Prichard. A log-dose-response study of xipamide and its effect on metabolic parameters. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. 1989 Dec; 7(6):S320-1. doi: 10.1097/00004872-198900076-00156. [PMID: 2632732]
  • P Lijnen, P Hespel, R Fagard, J Staessen, W Goossens, W Lissens, A Amery. Plasma atrial natriuretic peptide and the renin-aldosterone system during long-term administration of the diuretic xipamide in man. European journal of clinical pharmacology. 1989; 36(2):111-7. doi: 10.1007/bf00609181. [PMID: 2524386]
  • D Dadgar, M Kelly. High-performance liquid chromatographic determination of xipamide in human plasma. The Analyst. 1988 Feb; 113(2):229-31. doi: 10.1039/an9881300229. [PMID: 3377168]
  • R Ansuini, S Gaggi, A Barone, F Pupita. [Comparative evaluation of the effects of xipamide, indapamide and hydrochlorothiazide on water-electrolyte balance]. La Clinica terapeutica. 1988 Jan; 124(2):117-24. doi: NULL. [PMID: 2973922]
  • B N Prichard, R N Brogden. Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1985 Oct; 30(4):313-32. doi: 10.2165/00003495-198530040-00002. [PMID: 3905333]
  • S Dean, M J Kendall, S Potter, M H Thompson, D A Jackson. Nadolol in combination with indapamide and xipamide in resistant hypertensives. European journal of clinical pharmacology. 1985; 28(1):29-33. doi: 10.1007/bf00635704. [PMID: 3987783]
  • S Kumar, P Pandhi, P L Wahi, P L Sharma. A randomized double-blind clinical trial of xipamid and hydrochlorothiazide in essential hypertension. International journal of clinical pharmacology, therapy, and toxicology. 1984 Oct; 22(10):549-51. doi: NULL. [PMID: 6392119]
  • H Knauf, E Mutschler. Pharmacodynamics and pharmacokinetics of xipamide in patients with normal and impaired kidney function. European journal of clinical pharmacology. 1984; 26(4):513-20. doi: 10.1007/bf00542150. [PMID: 6734710]
  • A J Reyes, W P Leary. The magnesiuric effects of several single doses of xipamide in healthy adults. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1984; 17(3-4):285-91. doi: NULL. [PMID: 6529613]
  • A Brochez, M Castro, A Odegaard, J Thomis. Once daily administration of low-dose xipamide: a long-term study in mild to moderate hypertension. International journal of clinical pharmacology, therapy, and toxicology. 1983 Aug; 21(8):394-8. doi: NULL. [PMID: 6354942]
  • B Armah, R Dies, N Heinz. [Saluretic and diuretic effects of xipamide-triamterene combinations in varying dose ratios in rats]. Arzneimittel-Forschung. 1983; 33(1):131-5. doi: NULL. [PMID: 6681965]
  • R C Hanson, J B White, A W Gomoll. Acute and chronic diuretic-induced alterations in urinary sodium and calcium excretion in the conscious rat. Mineral and electrolyte metabolism. 1982 Dec; 8(6):314-24. doi: NULL. [PMID: 7167137]
  • G A MacGregor, R A Banks, N D Markandu, J Roulston. Xipamide and cyclopenthiazide in essential hypertension--comparative effects on blood pressure and plasma potassium. British journal of clinical pharmacology. 1982 Jun; 13(6):859-63. doi: 10.1111/j.1365-2125.1982.tb01879.x. [PMID: 7046777]
  • J Mihindukulasuriya, H A Lee. Effect of xipamide in oedema of renal disease with varying degrees of renal insufficiency: a comparative trial with frusemide. Current medical research and opinion. 1982; 8(3):208-14. doi: 10.1185/03007998209112386. [PMID: 6751705]
  • W Diembeck, R Dies, N Heinz. [Pharmacokinetics of xipamide and triamterene in healthy probands]. Arzneimittel-Forschung. 1982; 32(11):1482-5. doi: NULL. [PMID: 6891256]
  • R Pasquel, P W Tribble, A Simon. Hypotensive effects of xipamide in essential hypertension. Crossover comparison with hydrochlorothiazide. Journal of clinical pharmacology. 1981 Jul; 21(7):316-22. doi: 10.1002/j.1552-4604.1981.tb01773.x. [PMID: 7021608]
  • A J Reyes. [Pharmacologic bases of cardiovascular therapy with diuretics]. Archivos del Instituto de Cardiologia de Mexico. 1981 May; 51(3):291-303. doi: NULL. [PMID: 7283541]
  • D Bonaduce, N Ferrara, M Petretta, V Canonico, E Romango, F Rengo. Comparison of the antihypertensive activities of xipamide and chlorthalidone: a double-blind, randomized, crossover trial. Current medical research and opinion. 1981; 7(4):247-52. doi: 10.1185/03007998109114270. [PMID: 7014105]
  • M Sobel, E Mutschler. [Fluorimetric determination of xipamide in biological materials using a new fluorescence reagent]. Journal of chromatography. 1980 Jul; 183(1):124-30. doi: NULL. [PMID: 7400259]
  • M Castro. Xipamide ('Diurexan') in essential hypertension: a 24-month study. Current medical research and opinion. 1980; 6(6):416-22. doi: 10.1185/03007998009109461. [PMID: 7363642]
  • H Knauf, W Haase, E Mutschler. [Dose-response relationship of xipamide in healthy subjects]. Arzneimittel-Forschung. 1980; 30(9):1599-607. doi: NULL. [PMID: 7006620]
  • C H Gold, M Viljoen. Site of renal action of xipamide. Clinical pharmacology and therapeutics. 1979 May; 25(5 Pt 1):522-7. doi: 10.1002/cpt1979255part1522. [PMID: 436356]
  • J W Strandhoy, A W Gomoll. Clearance and micropuncture studies of the diuretic xipamide in dogs. European journal of pharmacology. 1979 Feb; 54(1-2):173-6. doi: 10.1016/0014-2999(79)90420-5. [PMID: 421739]
  • A M Ehrly, H Landgraft, K Saeger-Lorenz, M Wodniok. [Rheology of the blood during treatment of hypertension with xipamide (author's transl)]. Deutsche medizinische Wochenschrift (1946). 1979 Feb; 104(6):218-22. doi: 10.1055/s-0028-1103873. [PMID: 421671]
  • V H Heimsoth. Studies covering combined treatments with xipamide. Results of a long-term antihypertensive treatment. International journal of clinical pharmacology and biopharmacy. 1977 Jun; 15(6):260-6. doi: ". [PMID: 881278]
  • V H Heimsoth, C Graffe-Achelis. [Lipid metabolism disorders caused by saluretics]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin. 1977 Apr; 83(?):1722-5. doi: ". [PMID: 611919]
  • F W Hempelmann, P Dieker. [Studies on xipamide (4-chlor-5-sulfamoyl-2',6'-salicyloxylidide). Part II. Pharmacokinetics in man]. Arzneimittel-Forschung. 1977; 27(11):2143-51. doi: NULL. [PMID: 580018]