Vitacoxib (BioDeep_00000184972)
human metabolite blood metabolite
Metabolite Card
Formula: C16H14ClN3O2S (347.0495)
Chinese Names:
Spectrum Hits:
Top Source Homo sapiens(blood) 100%
Molecular Structure
SMILES: CC1=CC=C(C=C1)C1=C(Cl)N=CN1C1=NC=C(C=C1)S(C)(=O)=O
InChI: InChI=1S/C16H14ClN3O2S/c1-11-3-5-12(6-4-11)15-16(17)19-10-20(15)14-8-7-13(9-18-14)23(2,21)22/h3-10H,1-2H3
Description
Synonyms
5 synonym names
2-[4-Chloro-5-(4-methylphenyl)-1H-imidazol-1-yl]-5-methanesulphonylpyridine; 2-[4-chloro-5-(4-methylphenyl)-1H-imidazol-1-yl]-5-methanesulfonylpyridine; 2-[4-chloro-5-(4-methylphenyl)imidazol-1-yl]-5-methanesulfonylpyridine; 2-(4-Chloro-5-p-tolyl-1H-imidazol-1-yl)-5-(methylsulfonyl)pyridine; Vitacoxib
Cross Reference
Classification Terms
Related Pathways
Reactome(0)
BioCyc(0)
PlantCyc(0)
Biological Process
0 related biological process reactions.
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 organism taxonomy source information
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
Literature Reference
- Jianzhong Wang, Jicheng Qiu, Hongzhi Xiao, Xiaohui Gong, Pan Sun, Jing Li, Suxia Zhang, Xingyuan Cao. Pharmacokinetics of three formulations of vitacoxib in horses.
Journal of veterinary pharmacology and therapeutics.
2020 Jul; 43(4):364-368. doi:
10.1111/jvp.12852. [PMID: 32162352] - Jianzhong Wang, Benjamin K Schneider, Pan Sun, Xiaohui Gong, Jicheng Qiu, Jing Li, Yeon-Jung Seo, Jonathan P Mochel, Xingyuan Cao. Nonlinear mixed-effects pharmacokinetic modeling of the novel COX-2 selective inhibitor vitacoxib in dogs.
Journal of veterinary pharmacology and therapeutics.
2019 Sep; 42(5):530-540. doi:
10.1111/jvp.12802. [PMID: 31369157] - Jianzhong Wang, Xiaohui Gong, Jiao Xue, Suxia Zhang, Jing Li, Xingyuan Cao. Pharmacokinetics of the novel COX-2 selective inhibitor vitacoxib in cats: The effects of feeding and dose.
Journal of veterinary pharmacology and therapeutics.
2019 May; 42(3):294-299. doi:
10.1111/jvp.12751. [PMID: 30737806] - Jianzhong Wang, Jiao Xue, Lu Zhang, Suxia Zhang, Jing Li, Xingyuan Cao. Pharmacokinetics of vitacoxib in rabbits after intravenous and oral administration.
Journal of veterinary pharmacology and therapeutics.
2019 May; 42(3):368-371. doi:
10.1111/jvp.12745. [PMID: 30761557] - Jianzhong Wang, Jiao Xue, Jingyuan Kong, Jing Li, Suxia Zhang, Xingyuan Cao. Evaluation of pharmacokinetic properties of vitacoxib in fasted and fed horses.
Journal of veterinary pharmacology and therapeutics.
2018 Dec; 41(6):843-847. doi:
10.1111/jvp.12703. [PMID: 30076623] - Jianzhong Wang, Tingting Zhao, Shusheng Tang, Suxia Zhang, Pengyyue Lv, Jing Li, Xingyuan Cao. Safety assessment of vitacoxib: 180-day chronic oral toxicity studies.
Regulatory toxicology and pharmacology : RTP.
2018 Jun; 95(?):244-249. doi:
10.1016/j.yrtph.2018.03.024. [PMID: 29601910] - Jianzhong Wang, Tingting Zhao, Jingyuan Kong, Haoyuan Peng, Pengyue Lv, Jing Li, Xingyuan Cao, Suxia Zhang. Determination of vitacoxib, a novel COX-2 inhibitor, in equine plasma using UPLC-MS/MS detection: Development and validation of new methodology.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Sep; 1061-1062(?):270-274. doi:
10.1016/j.jchromb.2017.07.024. [PMID: 28759842] - Jianzhong Wang, Feifei Sun, Shusheng Tang, Suxia Zhang, Pengyue Lv, Jing Li, Xingyuan Cao. Safety assessment of vitacoxib: Acute and 90-day sub-chronic oral toxicity studies.
Regulatory toxicology and pharmacology : RTP.
2017 Jun; 86(?):49-58. doi:
10.1016/j.yrtph.2017.02.020. [PMID: 28238853]
