MG(18:0/0:0/0:0) (BioDeep_00000018497)

   

human metabolite Endogenous blood metabolite LipidSearch


代谢物信息卡片


1,2,3-Propanetriol, homopolymer, isooctadecanoate

化学式: C21H42O4 (358.30829320000004)
中文名称: 单硬脂酸甘油酯(单甘酯), 单硬脂酸甘油酯, 硬脂酸甘油酯, 甘油硬脂酸酯
谱图信息: 最多检出来源 Homo sapiens(blood) 0.9%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(CO)O
InChI: InChI=1S/C21H42O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h20,22-23H,2-19H2,1H3

描述信息

MG(18:0/0:0/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups: 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1/3-isomers are not distinguished from each other and are termed alpha-monoacylglycerols, while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well. MG(18:0/0:0/0:0), in particular, consists of one chain of stearic acid at the C-1 position. MG(18:0/0:0/0:0 is used as a food additive (EAFUS: Everything Added to Food in the United States).
MG(18:0/0:0/0:0) belongs to the family of monoradyglycerols, which are glycerolipids lipids containing a common glycerol backbone to which at one fatty acyl group is attached. Their general formula is [R1]OCC(CO[R2])O[R3]. MG(18:0/0:0/0:0) is made up of one octadecanoyl(R1).

同义名列表

76 个代谢物同义名

1,2,3-Propanetriol, homopolymer, isooctadecanoate; Octadecanoic acid, ester with 1,2,3-propanetriol; Octadecanoic acid, 2,3-dihydroxypropyl ester; Octadecanoic acid 2,3-dihydroxypropyl ester; Octadecanoic acid-2,3-dihydroxypropyl ester; (2S)-2,3-Dihydroxypropyl octadecanoic acid; 1,2,3-Propanetriol 1-octadecanoyl ester; (2S)-2,3-Dihydroxypropyl octadecanoate; (±)-2,3-Dihydroxypropyl octadecanoate; 1,2,3-Propanetriol monooctadecanoate; 2,3-Dihydroxypropyl octadecanoate; Stearic acid alpha -monoglyceride; (2R)-2,3-Dihydroxypropyl stearate; (1)-2,3-Dihydroxypropyl stearate; Stearic acid alpha-monoglyceride; sn-1-Octadecanoyl-monoglyceride; 1-Monooctadecanoyl-rac-glycerol; 3-Stearoyloxy-1,2-propanediol; Stearic acid 1-monoglyceride; (S)-(+)-1-O-Stearoylglycerol; 2,3-Dihydroxypropyl stearate; 1-O-Octadecanoyl-sn-glycerol; Stearic acid α-monoglyceride; Glycerol alpha -monostearate; Glycerol 1-octadecanoic acid; 1-octadecanoyl-rac-glycerol; Glycerol alpha-monostearate; 1-monostearoyl-rac-glycerol; 1-Monooctadecanoylglycerol; 1-Octadecanoyl-sn-glycerol; Glyceryl monostearic acid; Glycerol 1-octadecanoate; Glyceryl 1-octadecanoate; 1-O-Octadecanoylglycerol; Glyceryl-1-monostearate; 1-Stearoyl-rac-glycerol; Glycerol alpha -sterate; Glycerol α-monostearate; Glycerin 1-monostearate; Glyceryl 1-monostearate; Glycerol 1-monostearate; 1-Monostearoylglycerol; 1-Octadecanoylglycerol; alpha-Monoacylglycerol; 1-Stearoyl-sn-glycerol; Glyceryl monostearate; Glycerol monostearate; 1-O-Stearoylglycerol; 1-Stearoyl-glycerol; Glycerol 1-stearate; 1-Monoacylglyceride; Glycerin 1-stearate; 1-Glyceryl stearate; a-Monoacylglycerol; 1-stearoylglycerol; 1-Monoacylglycerol; GLYCERYL STEARATE; MG (18:0/0:0/0:0); GLYCEROL STEARATE; (S)-1-Monostearin; alpha-Monostearin; Stearoylglycerol; MG(18:0/0:0/0:0); 1-mono-Stearin; MAG(18:0/0:0); α-Monostearin; 1-Monostearin; a-Monostearin; MG(18:0/0:0); MAG(18:0); Dermagine; FEMA 2527; MG(18:0); Cefatin; 1-GMS; GMS



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

172 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(172)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Juan Huang, Xuan Feng, Qingding Wang, Dongchen Liu, Shuo Zhang, Lanling Chu. Fabrication and characterization of dihydromyricetin-loaded microcapsules stabilized by glyceryl monostearate and whey protein-xanthan gum. International journal of biological macromolecules. 2024 Jan; 254(Pt 3):128039. doi: 10.1016/j.ijbiomac.2023.128039. [PMID: 37956807]
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  • Alok Pratap Singh, Satish Kumar Sharma, Praveen Kumar Gaur, Dinesh Kumar Gupta. Fabrication of Mupirocin-Loaded Nanostructured Lipid Carrier and Its In Vitro Characterization. Assay and drug development technologies. 2021 May; 19(4):216-225. doi: 10.1089/adt.2020.1070. [PMID: 33781090]
  • Dongkun Tu, Yujia Ou, Yixin Zheng, Yi Zhang, Baodong Zheng, Hongliang Zeng. Effects of freeze-thaw treatment and pullulanase debranching on the structural properties and digestibility of lotus seed starch-glycerin monostearin complexes. International journal of biological macromolecules. 2021 Apr; 177(?):447-454. doi: 10.1016/j.ijbiomac.2021.02.168. [PMID: 33636260]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Anne Trivino, Ashwini Gumireddy, Harsh Chauhan. Drug-Lipid-Surfactant Miscibility for the Development of Solid Lipid Nanoparticles. AAPS PharmSciTech. 2019 Jan; 20(2):46. doi: 10.1208/s12249-018-1229-3. [PMID: 30617602]
  • Vaishali M Gambhire, Makarand S Gambhire, Nisharani S Ranpise. Solid Lipid Nanoparticles of Dronedarone Hydrochloride for Oral Delivery: Optimization, In Vivo Pharmacokinetics and Uptake Studies. Pharmaceutical nanotechnology. 2019; 7(5):375-388. doi: 10.2174/2211738507666190802140607. [PMID: 31376827]
  • Qiuyu Wei, Qiuxuan Yang, Qilong Wang, Congyong Sun, Yuan Zhu, Ya Niu, Jiangnan Yu, Ximing Xu. Formulation, Characterization, and Pharmacokinetic Studies of 6-Gingerol-Loaded Nanostructured Lipid Carriers. AAPS PharmSciTech. 2018 Nov; 19(8):3661-3669. doi: 10.1208/s12249-018-1165-2. [PMID: 30324361]
  • Ting-Wei Zhu, Hao-Tian Weng, Xia Zhang, Hong Wu, Bing Li. Mechanistic insight into the relationship between triacylglycerol and crystallization of lipase-catalyzed interesterified blend of palm stearin and vegetable oil. Food chemistry. 2018 Sep; 260(?):306-316. doi: 10.1016/j.foodchem.2018.03.147. [PMID: 29699674]
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  • Claudia Oellig, Klara Brändle, Wolfgang Schwack. Characterization of E 471 food emulsifiers by high-performance thin-layer chromatography-fluorescence detection. Journal of chromatography. A. 2018 Jul; 1558(?):69-76. doi: 10.1016/j.chroma.2018.05.010. [PMID: 29752044]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Bingyan Chen, Xiangze Jia, Song Miao, Shaoxiao Zeng, Zebin Guo, Yi Zhang, Baodong Zheng. Slowly digestible properties of lotus seed starch-glycerine monostearin complexes formed by high pressure homogenization. Food chemistry. 2018 Jun; 252(?):115-125. doi: 10.1016/j.foodchem.2018.01.054. [PMID: 29478521]
  • Madiha Maboos, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Iqbal Nasiri, Tazeen Hussain, Hafiza Fouzia Ahmed, Wajiha Iffat. Effect of lipid and cellulose based matrix former on the release of highly soluble drug from extruded/spheronized, sintered and compacted pellets. Lipids in health and disease. 2018 Jun; 17(1):136. doi: 10.1186/s12944-018-0783-8. [PMID: 29885655]
  • Huaixiang Tian, Zhuoyan Lu, Danfeng Li, Jing Hu. Preparation and characterization of citral-loaded solid lipid nanoparticles. Food chemistry. 2018 May; 248(?):78-85. doi: 10.1016/j.foodchem.2017.11.091. [PMID: 29329873]
  • Himanshu Bhatt, Sri Vishnu Kiran Rompicharla, Neeraja Komanduri, Shah Aashma, Sateja Paradkar, Balaram Ghosh, Swati Biswas. Development of Curcumin-Loaded Solid Lipid Nanoparticles Utilizing Glyceryl Monostearate as Single Lipid Using QbD Approach: Characterization and Evaluation of Anticancer Activity Against Human Breast Cancer Cell Line. Current drug delivery. 2018; 15(9):1271-1283. doi: 10.2174/1567201815666180503120113. [PMID: 29732970]
  • Hemantkumar A Ranpise, Kishor N Gujar, Dyandevi Mathure, Pooja P Satpute, Rajendra Awasthi, Kamal Dua, Jyotsana R Madan. Skin Targeting of Oxiconazole Nitrate Loaded Nanostructured Lipid- Carrier Gel for Fungal Infections. Pharmaceutical nanotechnology. 2018; 6(3):192-200. doi: 10.2174/2211738506666180913125918. [PMID: 30210010]
  • Muhammad Hanif, Hafeez Ullah Khan, Samina Afzal, Asif Mahmood, Safirah Maheen, Khurram Afzal, Nabila Iqbal, Mehwish Andleeb, Nazar Abbas. Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology. Acta pharmaceutica (Zagreb, Croatia). 2017 Dec; 67(4):441-461. doi: 10.1515/acph-2017-0034. [PMID: 29337670]
  • Magdalena Münster, Corinna Schoch, Carsten Schmidt, Jörg Breitkreutz. Multiparticulate system combining taste masking and immediate release properties for the aversive compound praziquantel. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017 Nov; 109(?):446-454. doi: 10.1016/j.ejps.2017.08.034. [PMID: 28887230]
  • Bingyan Chen, Shaoxiao Zeng, Hongliang Zeng, Zebin Guo, Yi Zhang, Baodong Zheng. Properties of lotus seed starch-glycerin monostearin complexes formed by high pressure homogenization. Food chemistry. 2017 Jul; 226(?):119-127. doi: 10.1016/j.foodchem.2017.01.018. [PMID: 28254001]
  • Emil Joseph, Satish Reddi, Vibhu Rinwa, Garima Balwani, Ranendra Saha. Design and in vivo evaluation of solid lipid nanoparticulate systems of Olanzapine for acute phase schizophrenia treatment: Investigations on antipsychotic potential and adverse effects. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017 Jun; 104(?):315-325. doi: 10.1016/j.ejps.2017.03.050. [PMID: 28408348]
  • Eleonora Truzzi, Chiara Bongio, Francesca Sacchetti, Eleonora Maretti, Monica Montanari, Valentina Iannuccelli, Elena Vismara, Eliana Leo. Self-Assembled Lipid Nanoparticles for Oral Delivery of Heparin-Coated Iron Oxide Nanoparticles for Theranostic Purposes. Molecules (Basel, Switzerland). 2017 Jun; 22(6):. doi: 10.3390/molecules22060963. [PMID: 28598368]
  • Faaiza Qazi, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Muhammad Iqbal Nasiri, Kamran Ahmed, Mansoor Ahmad. Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent-Meclizine HCl. Lipids in health and disease. 2017 Apr; 16(1):75. doi: 10.1186/s12944-017-0466-x. [PMID: 28403892]
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