VERALIPRIDE (BioDeep_00000184926)

   

human metabolite blood metabolite


代谢物信息卡片


2,3-Dimethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-5-sulphamoylbenzene-1-carboximidic acid

化学式: C17H25N3O5S (383.15148400000004)
中文名称: 维拉普利特-d6
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=CC(=C1OC)C(=O)NCC2CCCN2CC=C)S(=O)(=O)N
InChI: InChI=1S/C17H25N3O5S/c1-4-7-20-8-5-6-12(20)11-19-17(21)14-9-13(26(18,22)23)10-15(24-2)16(14)25-3/h4,9-10,12H,1,5-8,11H2,2-3H3,(H,19,21)(H2,18,22,23)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AL - Benzamides
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
Veralipride is a D2 receptor antagonist. It is an alternative antidopaminergic treatment for menopausal symptoms.

同义名列表

13 个代谢物同义名

2,3-Dimethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-5-sulphamoylbenzene-1-carboximidic acid; 2,3-dimethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-5-sulfamoylbenzene-1-carboximidic acid; 2,3-Dimethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-5-sulphamoylbenzene-1-carboximidate; 2,3-Dimethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-5-sulfamoylbenzene-1-carboximidate; 2,3-Dimethoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-5-sulphamoylbenzamide; N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide; Veralipride monohydrochloride; VERALIPRIDE; Veraligral; Menofel; Agreal; (±)-Veralipride; LIR166



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Keith R Godfrey, Philip A Arundel, Zimeng Dong, Robert Bryant. Modelling the Double Peak Phenomenon in pharmacokinetics. Computer methods and programs in biomedicine. 2011 Nov; 104(2):62-9. doi: 10.1016/j.cmpb.2010.03.007. [PMID: 20381191]
  • N Carretti, P Florio, F M Reis, S Comai, A Bertazzo, F Petraglia. Reduction of serum serotonin precursors after veralipride treatment for postmenopausal hot flushes. Climacteric : the journal of the International Menopause Society. 2010 Apr; 13(2):141-6. doi: 10.3109/13697130903219208. [PMID: 20082603]
  • G Morgante, M Farina, A Cianci, A La Marca, F Petraglia, V De Leo. Veralipride administered in combination with raloxifene decreases hot flushes and improves bone density in early postmenopausal women. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2004 Apr; 18(4):194-8. doi: 10.1080/09513590410001692474. [PMID: 15293890]
  • Lorraine A Fitzpatrick. Alternatives to estrogen. The Medical clinics of North America. 2003 Sep; 87(5):1091-113, x. doi: 10.1016/s0025-7125(03)00116-0. [PMID: 14621333]
  • Hilke Winterhoff, Barbara Spengler, Volker Christoffel, Veronika Butterweck, Anke Löhning. Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity. Maturitas. 2003 Mar; 44 Suppl 1(?):S51-8. doi: 10.1016/s0378-5122(02)00348-1. [PMID: 12609559]
  • P Vercellini, P Sacerdote, L Trespidi, B Manfredi, A E Panerai, P G Crosignani. Veralipride for hot flushes induced by a gonadotropin-releasing hormone agonist: a controlled study. Fertility and sterility. 1994 Nov; 62(5):938-42. doi: NULL. [PMID: 7926138]
  • Y Plusquellec, G Houin. Pharmacokinetic compartmental model with n sites of absorption along the gastrointestinal tract. Arzneimittel-Forschung. 1994 May; 44(5):679-82. doi: NULL. [PMID: 8024648]
  • P Fioretti, A Cagnacci, A M Paoletti, M Gambacciani, R Soldani, G A Mauro, A Spinetti, G B Melis. Effects of the antidopaminergic drug veralipride on LH and PRL secretion in postmenopausal women. Journal of endocrinological investigation. 1989 May; 12(5):295-301. doi: 10.1007/bf03349989. [PMID: 2549113]
  • G B Melis, M Gambacciani, A Cagnacci, A M Paoletti, V Mais, P Fioretti. Effects of the dopamine antagonist veralipride on hot flushes and luteinizing hormone secretion in postmenopausal women. Obstetrics and gynecology. 1988 Nov; 72(5):688-92. doi: NULL. [PMID: 3140150]
  • K Verbeke, M Dhont, D Vandekerckhove. Clinical and hormonal effects of long-term veralipride treatment in post-menopausal women. Maturitas. 1988 Oct; 10(3):225-30. doi: 10.1016/0378-5122(88)90025-4. [PMID: 3185294]
  • G B Melis, A Cagnacci, M Gambacciani, A M Paoletti, L Moggi, P Fioretti. Restoration of luteinizing hormone response to naloxone in postmenopausal women by chronic administration of the antidopaminergic drug veralipride. The Journal of clinical endocrinology and metabolism. 1988 May; 66(5):964-7. doi: 10.1210/jcem-66-5-964. [PMID: 2834413]
  • Y Plusquellec, G Campistron, S Staveris, J Barre, L Jung, J P Tillement, G Houin. A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: a double-site model for drug absorption. Journal of pharmacokinetics and biopharmaceutics. 1987 Jun; 15(3):225-39. doi: 10.1007/bf01066319. [PMID: 3668801]
  • S Staveris, L Jung, G Jamet, J C Koffel. Quantitative analysis of veralipride in plasma and urine by gas chromatography-mass spectrometry and gas chromatography with flame-ionization detection. Journal of chromatography. 1985 Feb; 338(1):79-88. doi: 10.1016/0378-4347(85)80072-4. [PMID: 4019658]
  • L De Cecco, P L Venturini, M P Alibrandi, A L Grondona, S Morano, L Penna, G Campanella, N Ragni. [Effect of veralipride on LH, FSH, and PRL levels and on the climacteric syndrome]. Revue francaise de gynecologie et d'obstetrique. 1985 Feb; 80(3):152-5. doi: NULL. [PMID: 3922034]
  • N Pasetto, E Piccione, L Baschieri. [Veralipride in the treatment of hot flushes in the menopause]. Revue francaise de gynecologie et d'obstetrique. 1985 Feb; 80(3):163-5. doi: NULL. [PMID: 3922035]
  • J Brient-Clabaux. [Agreal: its acceptibility. Review of the literature]. Revue francaise de gynecologie et d'obstetrique. 1985 Feb; 80(3):167-70. doi: NULL. [PMID: 3922036]
  • S Staveris, G Houin, J P Tillement, G Jamet, M Schneider, L Jung, J C Koffel. Primary dose-dependent pharmacokinetic study of veralipride. Journal of pharmaceutical sciences. 1985 Jan; 74(1):94-6. doi: 10.1002/jps.2600740126. [PMID: 3981429]
  • F Laffargue, J L Viala, G Durand. [Veralipride and menopause]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1983 Sep; 59(29-30):2127-30. doi: ". [PMID: 6312585]
  • B Humbert. [Iatrogenic menopause: a case report (author's transl)]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1981 Jun; 57(21-24):1115-6. doi: NULL. [PMID: 6267710]
  • C Quereux, H Ezes, G Deltour, J Decaux, P Dorangeon, P Wahl. [A new therapeutic approach to menopausal sudden flushes and psychofunctional disorders (author's transl)]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1980 Oct; 56(37-38):1453-9. doi: NULL. [PMID: 6254160]
  • R Sadrin, G Evrard, J J Adnet, P Wahl, C Quereux. [Vaginal smear cytology and hormonal tests before and after treatment with veralipride. Results in eleven cases (author's transl)]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1980 Oct; 56(37-38):1460-4. doi: NULL. [PMID: 6254161]