Valpromide (BioDeep_00000184904)
human metabolite blood metabolite
代谢物信息卡片
2-propylpentanamide
化学式: C8H17NO (143.131)
中文名称: 丙戊酰胺, 丙戊酸钠
谱图信息:
最多检出来源 Homo sapiens(not specific) 50%
分子结构信息
SMILES: CCCC(CCC)C(=O)N
InChI: InChI=1S/C8H17NO/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H2,9,10)
描述信息
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AG - Fatty acid derivatives
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:74562
- PubChem: 71113
- HMDB: HMDB0259756
- DrugBank: DB04165
- ChEMBL: CHEMBL93836
- Wikipedia: Valpromide
- MetaCyc: CPD-10097
- chemspider: 64264
- CAS: 2430-27-5
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Lucy M Elphick, Nadine Pawolleck, Irina A Guschina, Leila Chaieb, Daniel Eikel, Heinz Nau, John L Harwood, Nick J Plant, Robin S B Williams. Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.
Disease models & mechanisms.
2012 Mar; 5(2):231-40. doi:
10.1242/dmm.008391. [PMID: 22003123] - H Steve White, Anitha B Alex, Amanda Pollock, Naama Hen, Tawfeeq Shekh-Ahmad, Karen S Wilcox, John H McDonough, James P Stables, Dan Kaufmann, Boris Yagen, Meir Bialer. A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
Epilepsia.
2012 Jan; 53(1):134-46. doi:
10.1111/j.1528-1167.2011.03338.x. [PMID: 22150444] - Danièle Bentué-Ferrer, Olivier Tribut, Marie-Clémence Verdier. [Therapeutic drug monitoring of valproate].
Therapie.
2010 May; 65(3):233-40. doi:
NULL. [PMID: 20699076] - Xing-hua Chen, Hai-tou Yang. [Effects of acupuncture under guidance of qi street theory on endocrine function in the patient of epilepsy].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2008 Jul; 28(7):481-4. doi:
NULL. [PMID: 18678157] - D Deepa, B Jayakumari, Sanjeev V Thomas. Lipid peroxidation in women with epilepsy.
Annals of Indian Academy of Neurology.
2008 Jan; 11(1):44-6. doi:
10.4103/0972-2327.40225. [PMID: 19966978] - Ilan Winkler, Simcha Blotnik, Jakob Shimshoni, Boris Yagen, Marshall Devor, Meir Bialer. Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain.
British journal of pharmacology.
2005 Sep; 146(2):198-208. doi:
10.1038/sj.bjp.0706310. [PMID: 15997234] - D Blayac, A Roch, P Michelet, E De Francheschi, J-P Auffray. [Deep lactic acidosis after valproate self-poisoning].
Annales francaises d'anesthesie et de reanimation.
2004 Oct; 23(10):1007-10. doi:
10.1016/j.annfar.2004.07.006. [PMID: 15501631] - C Payen, P Frantz, O Martin, F Parant, M Moulsma, C Pulce, J Descotes. Delayed toxicity following acute ingestion of valpromide.
Human & experimental toxicology.
2004 Mar; 23(3):145-8. doi:
10.1191/0960327104ht430oa. [PMID: 15119534] - Nina Isoherranen, H Steve White, Brian D Klein, Michael Roeder, José H Woodhead, Volker Schurig, Boris Yagen, Meir Bialer. Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.
Pharmaceutical research.
2003 Aug; 20(8):1293-301. doi:
10.1023/a:1025069519218. [PMID: 12948028] - Nancy Detich, Veronica Bovenzi, Moshe Szyf. Valproate induces replication-independent active DNA demethylation.
The Journal of biological chemistry.
2003 Jul; 278(30):27586-92. doi:
10.1074/jbc.m303740200. [PMID: 12748177] - M Wasserman, B Yagen, S Blotnik, N Papo, M Bialer. Stereoselective pharmacokinetic analysis and antiepileptic activity of N-2-hydroxypropyl valpromide, a central nervous system--active chiral valproylamide.
Therapeutic drug monitoring.
2001 Aug; 23(4):414-20. doi:
10.1097/00007691-200108000-00016. [PMID: 11477326] - G Dumortier, V Mahé, D Pons, A Zerrouk, D Januel, K Degrassat. Clonic seizure associated with high clozapine plasma level.
The Journal of neuropsychiatry and clinical neurosciences.
2001; 13(2):302-3. doi:
10.1176/appi.neuropsych.13.2.302-a. [PMID: 11449038] - M Radatz, K Ehlers, B Yagen, M Bialer, H Nau. Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid.
Epilepsy research.
1998 Mar; 30(1):41-8. doi:
10.1016/s0920-1211(97)00095-8. [PMID: 9551843] - S Blotnik, F Bergman, M Bialer. Disposition of valpromide, valproic acid, and valnoctamide in the brain, liver, plasma, and urine of rats.
Drug metabolism and disposition: the biological fate of chemicals.
1996 May; 24(5):560-4. doi:
NULL. [PMID: 8723737] - S Hadad, M Bialer. Pharmacokinetic analysis and antiepileptic activity of N-valproyl derivatives of GABA and glycine.
Pharmaceutical research.
1995 Jun; 12(6):905-10. doi:
10.1023/a:1016277507865. [PMID: 7667199] - H G Wieser. [Comparison of valproate level in human plasma, cerebrospinal fluid and brain tissue following administration of various preparations of valproate and valpromide].
Praxis.
1994 Oct; 83(40):1111-6. doi:
NULL. [PMID: 7939081] - F Pisani, A Haj-Yehia, A Fazio, C Artesi, G Oteri, E Perucca, D L Kroetz, R H Levy, M Bialer. Carbamazepine-valnoctamide interaction in epileptic patients: in vitro/in vivo correlation.
Epilepsia.
1993 Sep; 34(5):954-9. doi:
10.1111/j.1528-1157.1993.tb02117.x. [PMID: 8104783] - M Pokrajac, B Miljković, D Spiridonović, V M Varagić. An improved gas chromatographic determination of valproic acid and valpromide in plasma.
Pharmaceutica acta Helvetiae.
1992; 67(8):237-40. doi:
NULL. [PMID: 1409759] - H G Wieser. Comparison of valproate concentrations in human plasma, CSF and brain tissue after administration of different formulations of valproate or valpromide.
Epilepsy research.
1991 Jul; 9(2):154-9. doi:
10.1016/0920-1211(91)90028-e. [PMID: 1794353] - G Bertschy, S Vandel, J M Jounet, G Allers. [Valpromide-amitriptyline interaction. Increase in the bioavailability of amitriptyline and nortriptyline caused by valpromide].
L'Encephale.
1990 Jan; 16(1):43-5. doi:
NULL. [PMID: 2109680] - M Bialer, A Haj-Yehia, N Barzaghi, F Pisani, E Perucca. Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects.
European journal of clinical pharmacology.
1990; 38(3):289-91. doi:
10.1007/bf00315032. [PMID: 2111246] - A Haj-Yehia, M Bialer. Pharmacokinetics of a valpromide isomer, valnoctamide, in dogs.
Journal of pharmaceutical sciences.
1988 Oct; 77(10):831-4. doi:
10.1002/jps.2600771003. [PMID: 3148708] - F Pisani, A Fazio, G Oteri, E Spina, E Perucca, L Bertilsson. Effect of valpromide on the pharmacokinetics of carbamazepine-10, 11-epoxide.
British journal of clinical pharmacology.
1988 May; 25(5):611-3. doi:
10.1111/j.1365-2125.1988.tb03354.x. [PMID: 3136790] - S Vandel, G Bertschy, J M Jounet, G Allers. Valpromide increases the plasma concentrations of amitriptyline and its metabolite nortriptyline in depressive patients.
Therapeutic drug monitoring.
1988; 10(4):386-9. doi:
NULL. [PMID: 3144066] - G M Pacifici, M Franchi, C Bencini, A Rane. Valpromide inhibits human epoxide hydrolase.
British journal of clinical pharmacology.
1986 Sep; 22(3):269-74. doi:
10.1111/j.1365-2125.1986.tb02886.x. [PMID: 3094569] - F Pisani, A Fazio, G Oteri, C Ruello, C Gitto, F Russo, E Perucca. Sodium valproate and valpromide: differential interactions with carbamazepine in epileptic patients.
Epilepsia.
1986 Sep; 27(5):548-52. doi:
10.1111/j.1528-1157.1986.tb03582.x. [PMID: 3093212] - F L Shi. [Determination of N-Dipropylacetamide serum concentration and its clinical significance in epileptic children].
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry.
1986 Aug; 19(4):217-20. doi:
NULL. [PMID: 3095059] - P S Whitton, D Oresković, B Jernej, M Radacić, F Plavsić, M Bulat. Plasma level of dipropylacetamide and dipropylacetic acid and effect of these drugs on 5-hydroxytryptamine metabolism in mouse brain.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
1986; 40(5):191-3. doi:
NULL. [PMID: 2431727] - F Pisani, E Spina, C Trunfio, A Fazio, G Oteri, R Di Perri. Intra-daily oscillations in dipropylacetic acid plasma levels with two or three daily doses of dipropylacetamide in epileptic patients.
Italian journal of neurological sciences.
1983 Jun; 4(2):173-7. doi:
10.1007/bf02043901. [PMID: 6413455] - R Riva, F Albani, F Olivi, M Pantaloni, A Baruzzi. Quantitative determination of n-dipropylacetamide in the plasma of epileptic patients by gas--liquid chromatography with nitrogen-selective detection.
Journal of chromatography.
1982 Dec; 233(?):371-4. doi:
10.1016/s0378-4347(00)81770-3. [PMID: 6819304] - F Pisani, A A D'Agostino, A Fazio, G Oteri, G Primerano, R Di Perri. Increased dipropylacetic acid bioavailability from dipropylacetamide by food.
Epilepsia.
1982 Apr; 23(2):115-21. doi:
10.1111/j.1528-1157.1982.tb05059.x. [PMID: 6804222] - F Pisani, A Fazio, G Oteri, R Di Perri. Dipropylacetic acid plasma levels; diurnal fluctuations during chronic treatment with dipropylacetamide.
Therapeutic drug monitoring.
1981; 3(3):297-301. doi:
10.1097/00007691-198103000-00012. [PMID: 6798719] - F Pisani, R Di Perri. Some clinical pharmacological aspects of n-dipropylacetamide.
Italian journal of neurological sciences.
1980 Oct; 1(4):245-9. doi:
10.1007/bf02336705. [PMID: 6802780] - F Pisani, A De Sarro, A Fazio, G Oteri. Preliminary data on dipropylacetamide absorption in rats.
Bollettino della Societa italiana di biologia sperimentale.
1980 Aug; 56(15):1541-5. doi:
NULL. [PMID: 6779834] - F Pisani, R Di Perri, G Nistico. Rapid quantitation of N-dipropylacetamide in human plasma by gas-liquid chromatography.
Journal of chromatography.
1979 Jun; 174(1):231-3. doi:
10.1016/s0021-9673(00)87059-4. [PMID: 121122]
