1H-Cyclohepta(ghi)perylene-5,12-dione, 3-acetyl-6,11-dihydroxy-4,8,9,13-tetramethoxy-2-methyl- (BioDeep_00000184859)
human metabolite blood metabolite
代谢物信息卡片
19-acetyl-12,13-dihydroxy-7,9,14,20-tetramethoxy-17-methylhexacyclo[13.8.0.0^{2,11}.0^{3,8}.0^{4,22}.0^{18,23}]tricosa-1(23),2,4(22),6,8,10,12,14,17,19-decaene-5,21-dione
化学式: C30H24O9 (528.1420254)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 50%
分子结构信息
SMILES: CC1=C2C3=C(C4=C5C6=C3C(=C(C(=C(C6=CC(=C5C(=CC4=O)OC)OC)O)O)OC)C1)C(=O)C(=C2C(=O)C)OC
InChI: InChI=1S/C30H24O9/c1-10-7-13-20-19-12(26(33)28(35)29(13)38-5)8-15(36-3)22-16(37-4)9-14(32)21(24(19)22)25-23(20)17(10)18(11(2)31)30(39-6)27(25)34/h8-9,33,35H,7H2,1-6H3
描述信息
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
D003879 - Dermatologic Agents
同义名列表
4 个代谢物同义名
19-acetyl-12,13-dihydroxy-7,9,14,20-tetramethoxy-17-methylhexacyclo[13.8.0.0^{2,11}.0^{3,8}.0^{4,22}.0^{18,23}]tricosa-1(23),2,4(22),6,8,10,12,14,17,19-decaene-5,21-dione; 1H-Cyclohepta(ghi)perylene-5,12-dione, 3-acetyl-6,11-dihydroxy-4,8,9,13-tetramethoxy-2-methyl-; Unii-xnp7UO129A; Hypocrellin b
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhiqiang Zhang, Dan Li, Yiming Cao, Yupeng Wang, Feixia Wang, Feng Zhang, Shizhong Zheng. Biodegradable Hypocrellin B nanoparticles coated with neutrophil membranes for hepatocellular carcinoma photodynamics therapy effectively via JUNB/ROS signaling.
International immunopharmacology.
2021 Oct; 99(?):107624. doi:
10.1016/j.intimp.2021.107624. [PMID: 34343939] - Siukan Law, Chuiman Lo, Jie Han, Albert Wingnang Leung, Chuanshan Xu. Antimicrobial photodynamic therapy with hypocrellin B against SARS-CoV-2 infection?.
Photodiagnosis and photodynamic therapy.
2021 06; 34(?):102297. doi:
10.1016/j.pdpdt.2021.102297. [PMID: 33892181] - Hongjing Dong, Xue Yao, Lanping Guo, Shuai Yu, Wenjuan Duan, Wei Liu, Xiao Wang. Purification of hypocrellins from Shiraia bambusicola by coordinated high-speed countercurrent chromatography using cupric chloride as a complexing agent.
Journal of separation science.
2021 Apr; 44(7):1383-1390. doi:
10.1002/jssc.202001133. [PMID: 33471412] - Jie Li, Shu Yao, Kai Wang, Zaijun Lu, Xuantao Su, Li Li, Cunzhong Yuan, Jinbo Feng, Shi Yan, Beihua Kong, Kun Song. Hypocrellin B-loaded, folate-conjugated polymeric micelle for intraperitoneal targeting of ovarian cancer in vitro and in vivo.
Cancer science.
2018 Jun; 109(6):1958-1969. doi:
10.1111/cas.13605. [PMID: 29617063] - Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Senthilkumar Sankareswaran, Muthuselvam Paulsamy, Ragupathy Madiyalakan, Rajaguru Palanichamy, Ruckmani Kandasamy, Subramanian Natesan. Development of copolymeric nanoparticles of hypocrellin B: Enhanced phototoxic effect and ocular distribution.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Apr; 116(?):26-36. doi:
10.1016/j.ejps.2017.10.023. [PMID: 29055734] - Subramanian Natesan, Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Madi Madiyalakan, Thomas Woo, Rajaguru Palanisamy. Hypocrellin B and nano silver loaded polymeric nanoparticles: Enhanced generation of singlet oxygen for improved photodynamic therapy.
Materials science & engineering. C, Materials for biological applications.
2017 Aug; 77(?):935-946. doi:
10.1016/j.msec.2017.03.179. [PMID: 28532114] - Chenchen Qin, Jinbo Fei, Anhe Wang, Yang Yang, Junbai Li. Rational assembly of a biointerfaced core@shell nanocomplex towards selective and highly efficient synergistic photothermal/photodynamic therapy.
Nanoscale.
2015 Dec; 7(47):20197-210. doi:
10.1039/c5nr06501a. [PMID: 26574662] - Zhao Li, Liping Sun, Zaijun Lu, Xuantao Su, Qifeng Yang, Xun Qu, Li Li, Kun Song, Beihua Kong. Enhanced effect of photodynamic therapy in ovarian cancer using a nanoparticle drug delivery system.
International journal of oncology.
2015 Sep; 47(3):1070-6. doi:
10.3892/ijo.2015.3079. [PMID: 26165140] - Yuan Jiang, Albert Wingnang Leung, Xinna Wang, Hongwei Zhang, Chuanshan Xu. Inactivation of Staphylococcus aureus by photodynamic action of hypocrellin B.
Photodiagnosis and photodynamic therapy.
2013 Dec; 10(4):600-6. doi:
10.1016/j.pdpdt.2013.06.004. [PMID: 24284117] - C Pellicciari, M Giagnacovo, B Cisterna, M Costanzo, A C Croce, G Bottiroli, M Malatesta. Ultrastructural detection of photosensitizing molecules by fluorescence photoconversion of diaminobenzidine.
Histochemistry and cell biology.
2013 Jun; 139(6):863-71. doi:
10.1007/s00418-012-1071-8. [PMID: 23275068] - Cuiling Du, Jie Zhao, Jinbo Fei, Liang Gao, Wei Cui, Yang Yang, Junbai Li. Alginate-based microcapsules with a molecule recognition linker and photosensitizer for the combined cancer treatment.
Chemistry, an Asian journal.
2013 Apr; 8(4):736-42. doi:
10.1002/asia.201201088. [PMID: 23401337] - Ming Kong, Zhanli Chen, Zhiqi Yin, Jian Zhang. [Simultaneous determination of hypocrellin A, hypocrellin B, and hypocrellin C by HPLC].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Jan; 37(1):75-8. doi:
". [PMID: 22741466] - Zhixiang Zhou, Lina Zhang, Huimin Liu, Qi Zhang, Boya Liu, Ping Ai, Hongtao Ma, Wei Liu, Zelin Li, Wang Sheng, Yi Zeng, Rugang Zhong. Photocytotoxicity of hypocrellin B (HB) was enhanced by liposomalization in vitro.
International journal of toxicology.
2011 Mar; 30(2):174-80. doi:
10.1177/1091581810394548. [PMID: 21536921] - Yang Yang, Weixing Song, Anhe Wang, Pengli Zhu, Jinbo Fei, Junbai Li. Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers.
Physical chemistry chemical physics : PCCP.
2010 May; 12(17):4418-22. doi:
10.1039/b924370d. [PMID: 20407714] - Yang Zhang, Liming Song, Jie Xie, Haixia Qiu, Ying Gu, Jingquan Zhao. Novel surfactant-like hypocrellin derivatives to achieve simultaneous drug delivery in blood plasma and cell uptake.
Photochemistry and photobiology.
2010 May; 86(3):667-72. doi:
10.1111/j.1751-1097.2010.00711.x. [PMID: 20331522] - Ping Wang, Chuan-Shan Xu, Jing Xu, Xinna Wang, Albert Wingnang Leung. Hypocrellin B enhances ultrasound-induced cell death of nasopharyngeal carcinoma cells.
Ultrasound in medicine & biology.
2010 Feb; 36(2):336-42. doi:
10.1016/j.ultrasmedbio.2009.09.007. [PMID: 20018428] - Liming Song, Jie Xie, Chunxi Zhang, Cong Li, Jingquan Zhao. Recognition of various biomolecules by the environment-sensitive spectral responses of hypocrellin B.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2007 Jun; 6(6):683-8. doi:
10.1039/b618678e. [PMID: 17549271] - Baozhong Zhao, Liming Song, Xin Liu, Jie Xie, Jingquan Zhao. Spectroscopic studies of the interaction between hypocrellin B and human serum albumin.
Bioorganic & medicinal chemistry.
2006 Apr; 14(7):2428-32. doi:
10.1016/j.bmc.2005.11.022. [PMID: 16321544] - William Chin, Weber Lau, Christopher Cheng, Malini Olivo. Evaluation of Hypocrellin B in a human bladder tumor model in experimental photodynamic therapy: biodistribution, light dose and drug-light interval effects.
International journal of oncology.
2004 Sep; 25(3):623-9. doi:
10.3892/ijo.25.3.623. [PMID: 15289863] - Seyed Mohamed Ali, Malini Olivo, Gan Yik Yuen, Soo Khee Chee. Apoptosis induced by photosensitizers (Perylquinone derivatives) in human carcinoma cells: a possible relevance to photodynamic therapy.
Asian journal of surgery.
2002 Jan; 25(1):18-26. doi:
". [PMID: 17585441] - S M Ali, S K Chee, G Y Yuen, M Olivo. Hypericin and hypocrellin induced apoptosis in human mucosal carcinoma cells.
Journal of photochemistry and photobiology. B, Biology.
2001 Dec; 65(1):59-73. doi:
10.1016/s1011-1344(01)00252-4. [PMID: 11748006] - S M Ali, M Olivo, G Y Yuen, S K Chee. Photodynamic-induced apoptosis of human nasopharyngeal carcinoma cells using Hypocrellins.
International journal of oncology.
2001 Sep; 19(3):633-43. doi:
10.3892/ijo.19.3.633. [PMID: 11494047] - C Yu, S Chen, M Zhang, T Shen. Spectroscopic studies and photodynamic actions of hypocrellin B in liposomes.
Photochemistry and photobiology.
2001 May; 73(5):482-8. doi:
10.1562/0031-8655(2001)073<0482:ssapao>2.0.co;2. [PMID: 11367568] - Y P Tu, F Y Yang. Fluorescence study on transmembrane Ca2+ gradient-mediated conformation changes of sarcoplasmic reticulum Ca(2+)-ATPase.
Bioscience reports.
1994 Dec; 14(6):309-17. doi:
10.1007/bf01199055. [PMID: 7620082] - J C Yue, S Z Pang, L Zhang. [Hypocrellin B photosensitization effected a change of cytoplasmic free calcium concentration in ascitic hepatoma cells].
Shi yan sheng wu xue bao.
1993 Sep; 26(3):233-7. doi:
". [PMID: 8191800] - J S Sun, S Z Pang, L Zhang, J F Qin, Y J Chen, J C Yue. [Hypocrellin B-sensitized photodamage on Na(+)-K+ ATPase and sodium permeability of human erythrocytes].
Shi yan sheng wu xue bao.
1991 Sep; 24(3):223-8. doi:
. [PMID: 1661546]