Vindesine (BioDeep_00000018485)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

化学式: C43H55N5O7 (753.410128)
中文名称: 长春地辛
谱图信息: 最多检出来源 Mentha canadensis(plant) 50%

分子结构信息

SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O
InChI: InChI=1S/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)

描述信息

Vindesine is only found in individuals that have used or taken this drug. It is a vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols). [PubChem]Vindesine acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic funcitoning. The drug is cell-cycle specific for the S phase.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CA - Vinca alkaloids and analogues
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
C1907 - Drug, Natural Product

同义名列表

15 个代谢物同义名

methyl (13S,15S,17S)-13-[(1R,9R,10S,11R,12R,19R)-10-carbamoyl-12-ethyl-10,11-dihydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraen-4-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.0⁴,¹².0⁵,¹⁰]nonadeca-4(12),5,7,9-tetraene-13-carboxylate; 3-(Aminocarbonyl)-O(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine; 3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine; EG labo brand OF vindesine sulfate; Desacetylvinblastine amide sulfate; Lilly brand OF vindesine sulfate; Desacetylvinblastine Amide; Sulfate, Vindesine; Vindesine sulfate; Compound 112531; CID 429017; Vindesine; Vindesin; Eldisine; Enison

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:36373
PubChem: 11643449
PubChem: 429017
PubChem: 40839
HMDB: HMDB0014454
DrugBank: DB00309
ChEMBL: CHEMBL219146
ChEMBL: CHEMBL238071
Wikipedia: Vindesine
MeSH: Vindesine
chemspider: 37302
CAS: 53643-48-4
PMhub: MS000008450

分类词条

Vinca alkaloids

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

Vindesine Action Pathway: Adenosine triphosphate + Vindesine + Water ⟶ Adenosine diphosphate + Phosphate + Vindesine

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Simin Luo, Xuan Zhang, Xiang Xiao, Wenting Luo, Zixuan Yang, Songqi Tang, Wei Huang. Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology. International journal of molecular sciences. 2023 Mar; 24(7):. doi: 10.3390/ijms24076511. [PMID: 37047484]
S Bernard, L Hachon, J F Diasonama, C Madaoui, L Aguinaga, E Miekoutima, H Moatti, Emeline Perrial, I Madelaine, P Brice, Catherine Thieblemont. Ambulatory high-dose methotrexate administration as central nervous system prophylaxis in patients with aggressive lymphoma. Annals of hematology. 2021 Apr; 100(4):979-986. doi: 10.1007/s00277-020-04341-7. [PMID: 33608849]
Chenrong Huang, Fan Xia, Ling Xue, Linsheng Liu, Yicong Bian, Zhengming Jin, Liyan Miao. Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3. Cancer chemotherapy and pharmacology. 2020 02; 85(2):433-441. doi: 10.1007/s00280-019-03972-6. [PMID: 31691080]
Jin-Hu Wang, Min-Ju Li, Da-Xing Tang, Shan Xu, Jun-Qing Mao, Jia-Bin Cai, Min He, Qiang Shu, Can Lai. Neoadjuvant transcatheter arterial chemoembolization and systemic chemotherapy for treatment of clear cell sarcoma of the kidney in children. Journal of pediatric surgery. 2019 Mar; 54(3):550-556. doi: 10.1016/j.jpedsurg.2018.09.012. [PMID: 30318310]
Xueping Lei, Minfeng Chen, Maohua Huang, Xiaobo Li, Changzheng Shi, Dong Zhang, Liangping Luo, Youwei Zhang, Nan Ma, Heru Chen, Huafeng Liang, Wencai Ye, Dongmei Zhang. Desacetylvinblastine Monohydrazide Disrupts Tumor Vessels by Promoting VE-cadherin Internalization. Theranostics. 2018; 8(2):384-398. doi: 10.7150/thno.22222. [PMID: 29290815]
Kui Liu, Yue-Lu Guo, Zi-Long Yao, Xiang-Shu Jin, Ran Zhang, Xiao-Pin Han, Xiao-Ning Gao, Li Yu, Yu Jing. [Imatinib Combined with VP Low Dose Regiment for Treating Newly Diagnosed Adult Patients with Ph-positive ALL]. Zhongguo shi yan xue ye xue za zhi. 2015 Dec; 23(6):1560-3. doi: 10.7534/j.issn.1009-2137.2015.06.006. [PMID: 26708871]
Rong-Hua Zhu, Huan-De Li, Hua-Lin Cai, Zhi-Ping Jiang, Ping Xu, Li-Bo Dai, Wen-Xing Peng. Validated HILIC-MS/MS assay for determination of vindesine in human plasma: Application to a population pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2014 Aug; 96(?):31-6. doi: 10.1016/j.jpba.2014.03.017. [PMID: 24721203]
A Jarfaut, R Santucci, D Levêque, R Herbrecht. Severe methotrexate toxicity due to a concomitant administration of ciprofloxacin. Medecine et maladies infectieuses. 2013 Jan; 43(1):39-41. doi: 10.1016/j.medmal.2012.11.006. [PMID: 23332768]
Yukitaka Nakano, Tetsuya Saita, Hiroshi Fujito. [Development of a specific and sensitive enzyme-linked immunosorbent assay for vindesine]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2012; 132(6):727-32. doi: 10.1248/yakushi.132.727. [PMID: 22687732]
Haoyuan Zhang, Rending Wang, Huiping Wang, Ying Xu, Jianghua Chen. Membranoproliferative glomerulonephritis in Castleman's disease: a systematic review of the literature and 2 case reports. Internal medicine (Tokyo, Japan). 2012; 51(12):1537-42. doi: 10.2169/internalmedicine.51.6298. [PMID: 22728487]
Evan B Kelly, Jack A Tuszynski, M Klobukowski. QM and QM/MD simulations of the Vinca alkaloids docked to tubulin. Journal of molecular graphics & modelling. 2011 Sep; 30(?):54-66. doi: 10.1016/j.jmgm.2011.06.005. [PMID: 21798777]
De-Hai Yu, Jin-Hui Li, Yi-Chun Wang, Jian-Guo Xu, Peng-Tao Pan, Li Wang. Serum anti-p53 antibody detection in carcinomas and the predictive values of serum p53 antibodies, carcino-embryonic antigen and carbohydrate antigen 12-5 in the neoadjuvant chemotherapy treatment for III stage non-small cell lung cancer patients. Clinica chimica acta; international journal of clinical chemistry. 2011 May; 412(11-12):930-5. doi: 10.1016/j.cca.2011.01.028. [PMID: 21277290]
Serkan Sertel, Yujie Fu, Yuangang Zu, Blanka Rebacz, Badireenath Konkimalla, Peter K Plinkert, Alwin Krämer, Jürg Gertsch, Thomas Efferth. Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine. Biochemical pharmacology. 2011 Mar; 81(6):723-35. doi: 10.1016/j.bcp.2010.12.026. [PMID: 21219884]
Min-Ju Li, Yin-Bao Zhou, Yong Huang, Da-Xing Tang, Shan Xu, De-Hua Wu, Yi-Ying Zhang, Hong-Feng Tang. A retrospective study of the preoperative treatment of advanced Wilms tumor in children with chemotherapy versus transcatheter arterial chemoembolization alone or combined with short-term systemic chemotherapy. Journal of vascular and interventional radiology : JVIR. 2011 Mar; 22(3):279-86. doi: 10.1016/j.jvir.2010.11.025. [PMID: 21353980]
Astha Varma, Harish Padh, Neeta Shrivastava. Andrographolide: a new plant-derived antineoplastic entity on horizon. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):815390. doi: 10.1093/ecam/nep135. [PMID: 19752167]
Priyanka Sharma, Jyoti Parmar, Priyanka Sharma, Preeti Verma, P K Goyal. Radiation-Induced Testicular Injury and Its Amelioration by Tinospora cordifolia (An Indian Medicinal Plant) Extract. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):643847. doi: 10.1155/2011/643847. [PMID: 21350610]
Nobuyuki Yamamoto, Kazuhiko Nakagawa, Yasumasa Nishimura, Kayoko Tsujino, Miyako Satouchi, Shinzoh Kudo, Toyoaki Hida, Masaaki Kawahara, Koji Takeda, Nobuyuki Katakami, Toshiyuki Sawa, Soichiro Yokota, Takashi Seto, Fumio Imamura, Hideo Saka, Yasuo Iwamoto, Hiroshi Semba, Yasutaka Chiba, Hisao Uejima, Masahiro Fukuoka. Phase III study comparing second- and third-generation regimens with concurrent thoracic radiotherapy in patients with unresectable stage III non-small-cell lung cancer: West Japan Thoracic Oncology Group WJTOG0105. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 Aug; 28(23):3739-45. doi: 10.1200/jco.2009.24.5050. [PMID: 20625120]
Sanehito Haruyama, Kazunari Sugita, Chika Kawakami, Motonobu Nakamura, Yoshiki Tokura. Spinal cord compression presumably due to metastasized cutaneous squamous cell carcinoma to the thoracic spine. Journal of UOEH. 2010 Jun; 32(2):155-9. doi: 10.7888/juoeh.32.155. [PMID: 20549904]
Michael Staehler, N Haseke, A Roosen, T Stadler, M Bader, M Siebels, A Karl, C G Stief. Sorafenib after combination therapy with gemcitabine plus doxorubicine in patients with sarcomatoid renal cell carcinoma: a prospective evaluation. European journal of medical research. 2010; 15(?):287-91. doi: 10.1186/2047-783x-15-7-287. [PMID: 20696639]
Afshin Azhir, Nahid Reisi, Diana Taheri, Atoosa Adibi. Post transplant anaplastic large T-cell lymphoma. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2009 Jul; 20(4):646-51. doi: NULL. [PMID: 19587509]
Gunver S Kienle, Anja Glockmann, Michael Schink, Helmut Kiene. Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. Journal of experimental & clinical cancer research : CR. 2009 Jun; 28(?):79. doi: 10.1186/1756-9966-28-79. [PMID: 19519890]
Friederike Egberts, Wolfgang N Hitschler, Michael Weichenthal, Axel Hauschild. Prospective monitoring of adjuvant treatment in high-risk melanoma patients: lactate dehydrogenase and protein S-100B as indicators of relapse. Melanoma research. 2009 Feb; 19(1):31-5. doi: 10.1097/cmr.0b013e32831993cc. [PMID: 19104452]
Yuangang Zu, Yu Zhang, Xiuhua Zhao, Qi Zhang, Yang Liu, Ru Jiang. Optimization of the preparation process of vinblastine sulfate (VBLS)-loaded folate-conjugated bovine serum albumin (BSA) nanoparticles for tumor-targeted drug delivery using response surface methodology (RSM). International journal of nanomedicine. 2009; 4(?):321-33. doi: 10.2147/ijn.s8501. [PMID: 20054435]
Guang-Yao Li, Xiao-Min Yu, Hong-Wei Zhang, Bin Zhang, Chun-Bo Wang, Yan-Chun Xin, Chun-Zheng Yang, Ren-Xiang Zhou, Le-Xin Wang. Haishengsu as an adjunct therapy to conventional chemotherapy in patients with non-small cell lung cancer: a pilot randomized and placebo-controlled clinical trial. Complementary therapies in medicine. 2009 Jan; 17(1):51-5. doi: 10.1016/j.ctim.2008.10.002. [PMID: 19114229]
R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
Nagio Takigawa, Mitsune Tanimoto. [Vinca alkaloid and MDR1]. Gan to kagaku ryoho. Cancer & chemotherapy. 2008 Jul; 35(7):1086-9. doi: NULL. [PMID: 18633246]
Tatsuya Nakamura, Nobukazu Fuwa, Takeshi Kodaira, Hiroyuki Tachibana, Takuya Tomoda, Rie Nakahara, Haruo Inokuchi. Clinical outcome of stage III non-small-cell lung cancer patients after definitive radiotherapy. Lung. 2008 Mar; 186(2):91-6. doi: 10.1007/s00408-007-9063-5. [PMID: 18097718]
J H Beumer, R C Garner, M B Cohen, S Galbraith, G F Duncan, T Griffin, J H Beijnen, J H M Schellens. Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry. Investigational new drugs. 2007 Aug; 25(4):327-34. doi: 10.1007/s10637-007-9041-z. [PMID: 17347871]
Tobias Paffhausen, Manfred Schwab, Frank Westermann. Targeted MYCN expression affects cytotoxic potential of chemotherapeutic drugs in neuroblastoma cells. Cancer letters. 2007 May; 250(1):17-24. doi: 10.1016/j.canlet.2006.09.010. [PMID: 17141950]
Sasha Bernatsky, Rosalind Ramsey-Goldman, Silvy Lachance, Christian A Pineau, Ann E Clarke. Lymphoma in a patient with systemic lupus erythematosus. Nature clinical practice. Rheumatology. 2006 Oct; 2(10):570-4; quiz 575. doi: 10.1038/ncprheum0295. [PMID: 17016483]
Cécile Fohrer, Sophie Caillard, Argyro Koumarianou, Bernard Ellero, Marie-Lorraine Woehl-Jaeglé, Carole Meyer, Eric Epailly, Marie-Pierre Chenard, Bruno Lioure, Shanti Natarajan-Ame, Frédéric Maloisel, Philippe Lutun, Romain Kessler, Bruno Moulin, Jean-Pierre Bergerat, Philippe Wolf, Raoul Herbrecht. Long-term survival in post-transplant lymphoproliferative disorders with a dose-adjusted ACVBP regimen. British journal of haematology. 2006 Sep; 134(6):602-12. doi: 10.1111/j.1365-2141.2006.06228.x. [PMID: 16889621]
Yuichi Kakudo, Takashi Yoshioka, Santaro Noguchi, Masahito Hanada, Kazunori Otsuka, Masato Sakayori, Natsuko Chiba, Hiroyuki Shibata, Shunsuke Kato, Hideki Shimodaira, Hisatsugu Ohori, Shin Takahashi, Masanobu Takahashi, Gengo Yamaura, Katsuhiro Yasuda, Chikashi Ishioka. [A case of malignant melanoma from the esophagus responding to weekly paclitaxel therapy]. Gan to kagaku ryoho. Cancer & chemotherapy. 2006 Jul; 33(7):969-72. doi: NULL. [PMID: 16835489]
A López-Pousa, R Losa, J Martín, J Maurel, J Fra, M Sierra, A Casado, J García Del Muro, A Poveda, C Balañá, J Martínez-Trufero, E Esteban, J M Buesa. Phase I/II trial of doxorubicin and fixed dose-rate infusion gemcitabine in advanced soft tissue sarcomas: a GEIS study. British journal of cancer. 2006 Jun; 94(12):1797-802. doi: 10.1038/sj.bjc.6603187. [PMID: 16721358]
Hiroshi Handa, Hiroyuki Irisawa, Satoru Komatsumoto, Takafumi Matsushima, Norifumi Tsukamoto, Yoshihisa Nojima, Hirokazu Murakami. [Plasmacytoma with multiple hypervascular lesions revealed by angiography in a patient with multiple myeloma]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2006 Jun; 47(6):521-5. doi: NULL. [PMID: 16862980]
Jinhan Li, Shudong Ma, Shijun Kang, Jianming Xie, Xinxiu Sheng, Rongcheng Luo. [Evaluation on survival in locally advanced non-small cell lung cancer (NSCLC) for multimodality treatment with or without operation]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. 2005 Dec; 8(6):535-7. doi: 10.3779/j.issn.1009-3419.2005.06.11. [PMID: 21208544]
Sabine Brennecke, Martin Deichmann, Helmut Naeher, Hjalmar Kurzen. Decline in angiogenic factors, such as interleukin-8, indicates response to chemotherapy of metastatic melanoma. Melanoma research. 2005 Dec; 15(6):515-22. doi: 10.1097/00008390-200512000-00006. [PMID: 16314737]
Mario Ojeda-Uribe, Annick Brunot, Monique Issler. [Successful treatment of idiopathic acquired refractory thrombotic thrombocytopenic purpura with an association of rituximab-vindesine. Report of one case]. Revista medica de Chile. 2005 Nov; 133(11):1349-54. doi: 10.4067/s0034-98872005001100011. [PMID: 16446859]
Marianne Ryberg, Dorte Nielsen, Kell Osterlind, Per Kragh Andersen, Torben Skovsgaard, Per Dombernowsky. Predictors of central nervous system metastasis in patients with metastatic breast cancer. A competing risk analysis of 579 patients treated with epirubicin-based chemotherapy. Breast cancer research and treatment. 2005 Jun; 91(3):217-25. doi: 10.1007/s10549-005-0323-x. [PMID: 15952055]
Walter Rhomberg, Franz Boehler, Helmut Eiter, Heinz Fritzsche, Gerhard Breitfellner. Treatment options for malignant hemangioendotheliomas of the thyroid. International journal of radiation oncology, biology, physics. 2004 Oct; 60(2):401-5. doi: 10.1016/j.ijrobp.2004.03.023. [PMID: 15380572]
José Rodrigues Pereira, Sandro J Martins, Sueli M Nikaedo, Flora K Ikari. Chemotherapy with cisplatin and vinorelbine for elderly patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC). BMC cancer. 2004 Sep; 4(?):69. doi: 10.1186/1471-2407-4-69. [PMID: 15456520]
J B Bartlett, A Michael, I A Clarke, K Dredge, S Nicholson, H Kristeleit, A Polychronis, H Pandha, G W Muller, D I Stirling, J Zeldis, A G Dalgleish. Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers. British journal of cancer. 2004 Mar; 90(5):955-61. doi: 10.1038/sj.bjc.6601579. [PMID: 14997189]
M Mabed, L El-Helw, S Shamaa. Phase II study of viscum fraxini-2 in patients with advanced hepatocellular carcinoma. British journal of cancer. 2004 Jan; 90(1):65-9. doi: 10.1038/sj.bjc.6601463. [PMID: 14710208]
F M Wachters, J W G Van Putten, H Kramer, Z Erjavec, P Eppinga, J H Strijbos, G P J de Leede, H M Boezen, E G E de Vries, H J M Groen. First-line gemcitabine with cisplatin or epirubicin in advanced non-small-cell lung cancer: a phase III trial. British journal of cancer. 2003 Oct; 89(7):1192-9. doi: 10.1038/sj.bjc.6601283. [PMID: 14520444]
J H M Schellens, A S T Planting, N van Zandwijk, J Ma, M Maliepaard, M E L van der Burg, M de Boer-Dennert, E Brouwer, A van der Gaast, M J van den Bent, J Verweij. Adaptive intrapatient dose escalation of cisplatin in combination with low-dose vp16 in patients with nonsmall cell lung cancer. British journal of cancer. 2003 Mar; 88(6):814-21. doi: 10.1038/sj.bjc.6600794. [PMID: 12644815]
F Prignano, M Coronnello, N Pimpinelli, P Cappugi, E Mini, B Giannotti. Immunophenotypical markers, ultrastructure and chemosensitivity profile of metastatic melanoma cells. Cancer letters. 2002 Dec; 186(2):183-92. doi: 10.1016/s0304-3835(02)00343-9. [PMID: 12213288]
Sachio Fushida, Furui Nao, Shinichi Kinami, Itasu Ninomiya, Takashi Fujimura, Genichi Nishimura, Tetsuo Ohta, Koichi Yokogawa, Kenichi Miyamoto, Koichi Miwa. [Pharmacologic study of intraperitoneal docetaxel in gastric cancer patients with peritoneal dissemination]. Gan to kagaku ryoho. Cancer & chemotherapy. 2002 Oct; 29(10):1759-63. doi: NULL. [PMID: 12402426]
Charles Dumontet, Nicolas Mounier, Jean Nicolas Munck, André Bosly, Frank Morschauser, Daniele Simon, Gérald Marit, Olivier Casasnovas, Oumédaly Reman, Thierry Molina, Felix Reyes, Bertrand Coiffier. Factors predictive of early death in patients receiving high-dose CHOP (ACVB regimen) for aggressive non-Hodgkin's lymphoma: a GELA study. British journal of haematology. 2002 Jul; 118(1):210-7. doi: 10.1046/j.1365-2141.2002.03565.x. [PMID: 12100150]
Motoo Kikuchi, Toshiaki Inagaki, Ryuzo Ueda. [A case of multiple myeloma with infiltration into skeletal muscle after injections of a granulocyte-colony stimulating-factor]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. 2002 Jul; 39(4):433-8. doi: 10.3143/geriatrics.39.433. [PMID: 12187809]
R Moog, A M Burger, M Brandl, J Schüler, R Schubert, C Unger, H H Fiebig, U Massing. Change in pharmacokinetic and pharmacodynamic behavior of gemcitabine in human tumor xenografts upon entrapment in vesicular phospholipid gels. Cancer chemotherapy and pharmacology. 2002 May; 49(5):356-66. doi: 10.1007/s00280-002-0428-4. [PMID: 11976829]
Kazuhiko Kakihana, Daisuke Mizuchi, Mitsuko Yamaguchi, Chizuko Sakashita, Tetsuya Fukuda, Koh Yamamoto, Tohru Miki, Shuji Tohda, Takatoshi Koyama, Naomi Murakami, Osamu Miura. [Hypercalcemia mediated by parathyroid hormone-related protein in the blastic phase of chronic myelogenous leukemia]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2002 Feb; 43(2):102-6. doi: NULL. [PMID: 11925871]
Jacek Zych, Monika Szturmowicz, Anna Sakowicz, Janina Słodkowska, Monika Załeska, Elzbieta Radzikowska, Jolanta Załeska, Zbigniew Jodkiewicz, Ewa Rowińska-Zakrzewska. [Neuron-specific enolase (NSE) serum level as a prognostic factor in non-small cell lung cancer]. Pneumonologia i alergologia polska. 2002; 70(5-6):278-83. doi: NULL. [PMID: 12518626]
H Kunikane, K Watanabe, M Fukuoka, N Saijo, K Furuse, H Ikegami, Y Ariyoshi, S Kishimoto. Double-blind randomized control trial of the effect of recombinant human erythropoietin on chemotherapy-induced anemia in patients with non-small cell lung cancer. International journal of clinical oncology. 2001 Dec; 6(6):296-301. doi: 10.1007/s10147-001-8031-y. [PMID: 11828949]
C M Jiang, M R Pang, L Y Gong. [Clinical observation on effect of chemotherapy combined with Chinese medicine in treating advanced tumor patients and on immunologic parameters]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2001 Dec; 21(12):885-7. doi: ". [PMID: 12575585]
S Tsuchiya, Y Ohe, T Sugiura, N Fuwa, Y Kitamoto, K Mori, H Kobayashi, K Nakata, T Sawa, K Hirai, T Etoh, H Saka, A Saito, H Fukuda, N Ishizuka, N Saijo. Randomized phase I study of standard-fractionated or accelerated-hyperfractionated radiotherapy with concurrent cisplatin and vindesine for unresectable non-small cell lung cancer: a report of Japan Clinical Oncology Group Study (JCOG 9601). Japanese journal of clinical oncology. 2001 Oct; 31(10):488-94. doi: 10.1093/jjco/hye106. [PMID: 11696618]
B Hero, D H Hunneman, M Gahr, F Berthold. Evaluation of catecholamine metabolites, mIBG scan, and bone marrow cytology as response markers in stage 4 neuroblastoma. Medical and pediatric oncology. 2001 Jan; 36(1):220-3. doi: 10.1002/1096-911x(20010101)36:1<220::aid-mpo1053>3.0.co;2-6. [PMID: 11464889]
M Colombi, A Guffanti, A Alietti, M L Latargia, C Vener, A T Maiolo, L Baldini. OPP-EBV-CAD regimen as salvage treatment in advanced refractory or resistant multiple myeloma. Leukemia & lymphoma. 2000 Dec; 40(1-2):87-94. doi: 10.3109/10428190009054884. [PMID: 11426632]
P G Gobbi, C Broglia, R Bertè, M P Petrilli, S Molica, F Angrilli, E Iannitto, M L Ghirardelli, N Di Renzo, L Cavanna, E Ascari. Lomustine and melphalan cannot be replaced by cyclophosphamide and etoposide without reducing efficacy in MOPPEBVCAD chemotherapy for advanced Hodgkin's disease. Haematologica. 2000 Jul; 85(7):722-8. doi: NULL. [PMID: 10897124]
M J Zelefsky, W K Kelly, H I Scher, H Lee, T Smart, E Metz, L Schwartz, Z Fuks, S A Leibel. Results of a phase II study using estramustine phosphate and vinblastine in combination with high-dose three-dimensional conformal radiotherapy for patients with locally advanced prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 May; 18(9):1936-41. doi: 10.1200/jco.2000.18.9.1936. [PMID: 10784635]
K Kubota, T Tamura, M Fukuoka, K Furuse, H Ikegami, Y Ariyoshi, Y Kurita, N Saijo. Phase II study of concurrent chemotherapy and radiotherapy for unresectable stage III non-small-cell lung cancer: long-term follow-up results. Japan Clinical Oncology Group Protocol 8902. Annals of oncology : official journal of the European Society for Medical Oncology. 2000 Apr; 11(4):445-50. doi: 10.1023/a:1008328207137. [PMID: 10847464]
N Takigawa, Y Segawa, H Ueoka, K Kiura, M Tabata, T Shibayama, I Takata, H Miyamoto, K Eguchi, M Harada. Combination of nedaplatin and vindesine for treatment of relapsed or refractory non-small-cell lung cancer. Cancer chemotherapy and pharmacology. 2000; 46(4):272-8. doi: 10.1007/s002800000153. [PMID: 11052624]
T Beinert, D Binder, C Oehm, S Ziemer, F Priem, M Schweigert, M Stuschke, M Fleischhacker, G Siebert, H G Mergenthaler, T G Werner, O Sezer, K Possinger. Increased levels of vascular endothelial growth factor in bronchoalveolar lavage of patients with bronchial carcinoma effect of tumour activity and oxidative stress due to radio-chemotherapy?. European journal of medical research. 1999 Aug; 4(8):328-34. doi: NULL. [PMID: 10471544]
H O Klein, G Demir. 'Multi-enzyme-targeted' immunochemotherapy: a salvage therapy protocol. Anticancer research. 1999 Jul; 19(4C):3451-8. doi: NULL. [PMID: 10629634]
Y Tada, T Yagi, F Yamagishi, F Mizutani, Y Sasaki, S Sakao, Y Takiguchi, S Nakamura, A Mikata. [A case of thymic carcinoma producing granulocyte colony-stimulating factor]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 1998 Dec; 36(12):1043-7. doi: NULL. [PMID: 10064959]
K Warzocha, P Ribeiro, J Bienvenu, P Roy, C Charlot, D Rigal, B Coiffier, G Salles. Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin's lymphoma outcome. Blood. 1998 May; 91(10):3574-81. doi: NULL. [PMID: 9572991]
N Morikawa, T Mori, M Takeyama, S Hori. Pharmacokinetics of intra-arterially administered pirarubicin in plasma and cerebrospinal fluid of patients with glioma. Biological & pharmaceutical bulletin. 1998 Mar; 21(3):297-9. doi: 10.1248/bpb.21.297. [PMID: 9556164]
N Morikawa, T Mori, T Abe, M Ghoda, M Takeyama, S Hori. Pharmacokinetics of methotrexate in plasma and cerebrospinal fluid. The Annals of pharmacotherapy. 1997 Oct; 31(10):1153-6. doi: 10.1177/106002809703101007. [PMID: 9337440]
Y Akiyama, H Kondo, R Shirono, Y Fujii. [A case of lung adenocarcinoma associated with remarkably high levels of CA 19-9 and lymphangitis carcinomatosa]. Gan to kagaku ryoho. Cancer & chemotherapy. 1997 Jan; 24(1):93-6. doi: NULL. [PMID: 9020951]
N Tanigawa, A Kitaoka, M Yamakawa, K Tanisaka, H Kobayashi. In vitro chemosensitivity testing of human tumours by collagen gel droplet culture and image analysis. Anticancer research. 1996 Jul; 16(4A):1925-30. doi: NULL. [PMID: 8712722]
M Kawasaki, Y Nakanishi, J Yatsunami, K Takayama, S Ochiai, P Xinhai, K Kuwano, N Hara. P53 immunostaining predicts chemosensitivity in non-small cell lung cancer: A preliminary report. The cancer journal from Scientific American. 1996 Jul; 2(4):217-20. doi: NULL. [PMID: 9166535]
S Matano, S Nakamura, K Kobayashi, T Misaki, T Matsuda, T Sugimoto. Decreased lymphocytic proliferation by mitogens in patients with transitional cell carcinoma of the renal pelvis subsequent to non-Hodgkin's lymphoma. American journal of hematology. 1996 Apr; 51(4):330-2. doi: 10.1002/1096-8652(199604)51:4<330::aid-ajh2830510406>3.0.co;2-7. [PMID: 8602639]
J H Li. [A study on treatment of lung cancer by combined therapy of traditional Chinese medicine and chemotherapy]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 1996 Mar; 16(3):136-8. doi: ". [PMID: 9208532]
M Masutani, H Akusawa, A Kadota, Y Ohchi, N Takahashi, S Tanigawa, Y Koya, T Horie. A phase III randomized trial of cisplatin plus vindesine versus cisplatin plus vindesine plus mitomycin C versus cisplatin plus vindesine plus ifosfamide for advanced non-small-cell lung cancer. Respirology (Carlton, Vic.). 1996 Mar; 1(1):49-54. doi: 10.1111/j.1440-1843.1996.tb00010.x. [PMID: 9432405]
V Besnard, S Euvrard, J Kanitakis, F Mion, O Boillot, C Françès, M Faure, A Claudy. Kaposi's sarcoma after liver transplantation. Dermatology (Basel, Switzerland). 1996; 193(2):100-4. doi: 10.1159/000246221. [PMID: 8884143]
Y Takano, K Oida, Y Kohri, Y Taguchi, K Tomii, Y Matsumura, M Mino, I Gohma, T Inoue, Y Kobashi. [A case of lung cancer with choroidal metastasis]. Nihon Kyobu Shikkan Gakkai zasshi. 1995 Jun; 33(6):674-7. doi: NULL. [PMID: 7666626]
Y Myoken, T Sugata, T Kyo, M Fujihara. Oral Fusarium infection in a granulocytopenic patient with acute myelogenous leukemia: a case report. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 1995 May; 24(5):237-40. doi: 10.1111/j.1600-0714.1995.tb01174.x. [PMID: 7616464]
N Yamamoto, T Tamura, M Maeda, M Ando, T Shinkai, K Eguchi, Y Ohe, F Oshita, J Shiraishi, N Katsumata. The influence of ageing on cisplatin pharmacokinetics in lung cancer patients with normal organ function. Cancer chemotherapy and pharmacology. 1995; 36(2):102-6. doi: 10.1007/bf00689192. [PMID: 7767944]
L Brunetti, P Preziosi, E Ragazzoni, M Vacca. Effects of vindesine on hypothalamic-pituitary-adrenal axis. Toxicology letters. 1995 Jan; 75(1-3):69-73. doi: 10.1016/0378-4274(94)03162-z. [PMID: 7863539]
S Culine, M Bekradda, M J Terrier-Lacombe, J P Droz. Treatment of sarcomatoid renal cell carcinoma: is there a role for chemotherapy?. European urology. 1995; 27(2):138-41. doi: 10.1159/000475145. [PMID: 7744156]
M Delain, C Linassier, C Petitdidier, P Goupille, F Luthier, M Combe, M Reisenleiter, L Benboubker, J P Lamagnère, P Colombat. VAD-PECC regimen in the treatment of advanced-stage multiple myeloma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1994 Dec; 12(12):2706-13. doi: 10.1200/jco.1994.12.12.2706. [PMID: 7989948]
P Morel, B Dupriez, R Herbrecht, Y Bastion, H Tilly, A Delannoy, C Haioun, C Nouvel, K Bouabdallah, E Baumelou. Aggressive lymphomas with renal involvement: a study of 48 patients treated with the LNH-84 and LNH-87 regimens. Groupe d'Etude des Lymphomes de l'Adulte. British journal of cancer. 1994 Jul; 70(1):154-9. doi: 10.1038/bjc.1994.267. [PMID: 7517172]
Y Masaki, S Shimizu, S Takeshita, M Fukutoku, R Yoshioka, T Arai, Y Hirose, S Sugai, S Konda, T Takiguti. [Successful VEP-IFN-alpha therapy in a case of non-secretory plasma cell leukemia (BJ-kappa type)]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 1994 Jun; 35(6):562-8. doi: NULL. [PMID: 8078191]
T Shinkai, H Arioka, H Kunikane, K Eguchi, Y Sasaki, T Tamura, Y Ohe, F Oshita, M Nishio, A Karato. Phase I clinical trial of irinotecan (CPT-11), 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, and cisplatin in combination with fixed dose of vindesine in advanced non-small cell lung cancer. Cancer research. 1994 May; 54(10):2636-42. doi: NULL. [PMID: 8168091]
C Battista, N Panza, B Chiurazzi, G Iodice, G Esposito, E Cocorocchio, N Bevilacqua, G Pacilio. Intermediate and high grade malignant non-Hodgkin's lymphomas: preliminary results using a new combination regimen (EVE-COPEM). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 1993; 47(4):145-54. doi: 10.1016/0753-3322(93)90005-6. [PMID: 8018826]
T Miya, Y Sasaki, A Karato, N Saijo. Pharmacokinetic study of mitomycin C with emphasis on the influence of aging. Japanese journal of cancer research : Gann. 1992 Dec; 83(12):1382-5. doi: 10.1111/j.1349-7006.1992.tb02773.x. [PMID: 1336497]
P Havránek, A Rubenson, D Güth, B Frenckner, L Olsen, S A Kornfält, G Hansson. Sacrococcygeal teratoma in Sweden: a 10-year national retrospective study. Journal of pediatric surgery. 1992 Nov; 27(11):1447-50. doi: 10.1016/0022-3468(92)90197-f. [PMID: 1282543]
H Kikuchi, R Kanamaru. [Chemotherapy-associated hemolytic uremic syndrome--a case report]. Gan to kagaku ryoho. Cancer & chemotherapy. 1992 Sep; 19(11):1927-9. doi: NULL. [PMID: 1519930]
K Mori, Y Saito, K Tominaga. Phase II study of cisplatin continuous infusion plus vindesine in the treatment of non-small-cell lung cancer. American journal of clinical oncology. 1992 Aug; 15(4):344-7. doi: 10.1097/00000421-199208000-00015. [PMID: 1325109]
K Furuse, M Fukuoka, H Asamoto, H Niitani, I Kimura, A Sakuma, Y Yamaguchi. [A randomized comparative study of 254-S plus vindesine (VDS) vs. cisplatin (CDDP) plus VDS in patients with advanced non-small cell lung cancer (NSCLC)]. Gan to kagaku ryoho. Cancer & chemotherapy. 1992 Jul; 19(7):1019-26. doi: . [PMID: 1320846]
Y K Lee, D M Shin. Renal salt wasting in patients treated with high-dose cisplatin, etoposide, and mitomycin in patients with advanced non-small cell lung cancer. The Korean journal of internal medicine. 1992 Jul; 7(2):118-21. doi: 10.3904/kjim.1992.7.2.118. [PMID: 1339077]
K Miyamoto, S Wakusawa, S Nakamura, K Tajima, H Hidaka. Multidrug resistance in Yoshida rat ascites hepatoma cell lines. Anticancer research. 1992 May; 12(3):649-53. doi: . [PMID: 1622121]
F Kimura, Y Takemura, T Ohtsuki, H Mizukami, S Takagi, K Yamamoto, N Nagata, K Motoyoshi. Serial changes of the serum macrophage colony-stimulating factor level after cytoreductive chemotherapy. International journal of hematology. 1992 Apr; 55(2):147-55. doi: NULL. [PMID: 1511164]
S Hayashi, H Ogino, K Ogata, K Yagawa. Hypercoagulopathy induced by chemotherapy in a patient with lung cancer. A possible role for a factor with thrombosis-inducing activity (TIA). Chest. 1992 Jan; 101(1):277-8. doi: 10.1378/chest.101.1.277. [PMID: 1729088]
Y Saito, K Mori, K Tominaga, K Yokoi, N Miyazawa. Phase II study of cisplatin as a 5-day continuous infusion with vindesine plus recombinant human granulocyte-colony-stimulating factor in the treatment of advanced non-small-cell lung cancer. Cancer chemotherapy and pharmacology. 1992; 31(2):81-4. doi: 10.1007/bf00685091. [PMID: 1280537]
T Shinkai, K Eguchi, Y Sasaki, T Tamura, Y Ohe, A Kojima, F Oshita, T Miya, H Okamoto, K Iemura. A prognostic-factor risk index in advanced non-small-cell lung cancer treated with cisplatin-containing combination chemotherapy. Cancer chemotherapy and pharmacology. 1992; 30(1):1-6. doi: 10.1007/bf00686477. [PMID: 1316809]
K Kaito, M Kobayashi, T Katayama, S Ochiai, M Yoshida, H Masuoka, T Shimada, K Nishiwaki, A Saito, R Watanabe. [Pharmacokinetics of BHAC, VP-16 and Ara-C derived from BHAC in a hemodialysed patient with AMMoL]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 1991 Dec; 32(12):1558-63. doi: NULL. [PMID: 1779456]
A Fujita, Y Inoue, H Sasaki, S Nakajima, K Sekine, R Honda, M Asakawa, A Suzuki. [Cisplatin, ifosfamide and vindesine in the chemotherapy of squamous cell carcinoma of the lung]. Gan to kagaku ryoho. Cancer & chemotherapy. 1991 Oct; 18(13):2283-7. doi: NULL. [PMID: 1929449]
R M Bremnes, E Smeland, L Slørdal, E Wist, J Aarbakke. The effect of vindesine on methotrexate hydroxylation in the rat. Biochemical pharmacology. 1991 Sep; 42(8):1561-8. doi: 10.1016/0006-2952(91)90425-5. [PMID: 1930283]
M Kawahara, K Furuse, N Kodama, M Yamamoto, K Kubota, M Takada, S Negoro, Y Kusunoki, K Matui, N Takifuji. A randomized study of cisplatin versus cisplatin plus vindesine for non-small cell lung carcinoma. Cancer. 1991 Aug; 68(4):714-9. doi: 10.1002/1097-0142(19910815)68:4<714::aid-cncr2820680408>3.0.co;2-j. [PMID: 1649683]
T Fukabori, T Nakamura, T Kida, Y Fujita, T Goto, N Hiramori, T Fujii, Y Iwasaki, M Nakagawa. [Syndrome of inappropriate antidiuretic hormone secretion following cisplatinum and vindesine administration in a patient with squamous cell carcinoma of the lung]. Gan to kagaku ryoho. Cancer & chemotherapy. 1991 Jun; 18(7):1213-6. doi: NULL. [PMID: 2053780]