N,N-Diethyl-2-(2-(4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide (BioDeep_00000184824)
human metabolite blood metabolite
代谢物信息卡片
化学式: C21H26N4O2 (366.2055656)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)C(=O)CC1=C2N=C(C)C=C(C)N2N=C1C1=CC=C(OC)C=C1
InChI: InChI=1S/C21H26N4O2/c1-6-24(7-2)19(26)13-18-20(16-8-10-17(27-5)11-9-16)23-25-15(4)12-14(3)22-21(18)25/h8-12H,6-7,13H2,1-5H3
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 11595759
- HMDB: HMDB0259641
- ChEMBL: CHEMBL480041
- chemspider: 9770519
- CAS: 386297-97-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda, Masanori Ichise, Takashi Sakurai, Kengo Ito, Takashi Kato. Kinetic modeling and non-invasive approach for translocator protein quantification with 11C-DPA-713.
Nuclear medicine and biology.
2022 May; 108-109(?):76-84. doi:
10.1016/j.nucmedbio.2022.02.005
. [PMID: 35349913] - Camilo A Ruiz-Bedoya, Filipa Mota, Alvaro A Ordonez, Catherine A Foss, Alok K Singh, Monali Praharaj, Farina J Mahmud, Ali Ghayoor, Kelly Flavahan, Patricia De Jesus, Melissa Bahr, Santosh Dhakal, Ruifeng Zhou, Clarisse V Solis, Kathleen R Mulka, William R Bishai, Andrew Pekosz, Joseph L Mankowski, Jason Villano, Sabra L Klein, Sanjay K Jain. 124I-Iodo-DPA-713 Positron Emission Tomography in a Hamster Model of SARS-CoV-2 Infection.
Molecular imaging and biology.
2022 02; 24(1):135-143. doi:
10.1007/s11307-021-01638-5
. [PMID: 34424479] - Catherine A Foss, Donika Plyku, Alvaro A Ordonez, Julian Sanchez-Bautista, Hailey B Rosenthal, Il Minn, Martin A Lodge, Martin G Pomper, George Sgouros, Sanjay K Jain. Biodistribution and Radiation Dosimetry of 124I-DPA-713, a PET Radiotracer for Macrophage-Associated Inflammation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2018 11; 59(11):1751-1756. doi:
10.2967/jnumed.117.207431
. [PMID: 29700124] - Renee Sokias, Eryn L Werry, Sook W Chua, Tristan A Reekie, Lenka Munoz, Erick C N Wong, Lars M Ittner, Michael Kassiou. Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination.
MedChemComm.
2017 Jan; 8(1):202-210. doi:
10.1039/c6md00523c
. [PMID: 30108706] - J M Coughlin, Y Wang, E B Ambinder, R E Ward, I Minn, M Vranesic, P K Kim, C N Ford, C Higgs, L N Hayes, D J Schretlen, R F Dannals, M Kassiou, A Sawa, M G Pomper. In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [(11)C]DPA-713 PET and analysis of CSF and plasma.
Translational psychiatry.
2016 Apr; 6(?):e777. doi:
10.1038/tp.2016.40
. [PMID: 27070405] - Samuel D Banister, Corinne Beinat, Shane M Wilkinson, Bin Shen, Cecilia Bartoli, Silvia Selleri, Eleonora Da Pozzo, Claudia Martini, Frederick T Chin, Michael Kassiou. Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).
European journal of medicinal chemistry.
2015 Mar; 93(?):392-400. doi:
10.1016/j.ejmech.2015.02.004
. [PMID: 25725375] - Yoony Y J Gent, Karin Weijers, Carla F M Molthoff, Albert D Windhorst, Marc C Huisman, Michael Kassiou, Gerrit Jansen, Adriaan A Lammertsma, Conny J van der Laken. Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis.
Arthritis research & therapy.
2014 Mar; 16(2):R70. doi:
10.1186/ar4509
. [PMID: 24625077] - Christopher J Endres, Jennifer M Coughlin, Kenneth L Gage, Crystal C Watkins, Michael Kassiou, Martin G Pomper. Radiation dosimetry and biodistribution of the TSPO ligand 11C-DPA-713 in humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 Feb; 53(2):330-5. doi:
10.2967/jnumed.111.094565
. [PMID: 22241913] - Christopher J Endres, Martin G Pomper, Michelle James, Ovsev Uzuner, Dima A Hammoud, Crystal C Watkins, Aaron Reynolds, John Hilton, Robert F Dannals, Michael Kassiou. Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2009 Aug; 50(8):1276-82. doi:
10.2967/jnumed.109.062265
. [PMID: 19617321]