Benzonitrile, 3-amino-4-((2-((dimethylamino)methyl)phenyl)thio)- (BioDeep_00000184823)
human metabolite blood metabolite
代谢物信息卡片
3-Amino-4-({2-[(dimethylamino)methyl]phenyl}sulphanyl)benzonitrile
化学式: C16H17N3S (283.11431220000003)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 98.46%
分子结构信息
SMILES: CN(C)CC1=CC=CC=C1SC1=C(N)C=C(C=C1)C#N
InChI: InChI=1S/C16H17N3S/c1-19(2)11-13-5-3-4-6-15(13)20-16-8-7-12(10-17)9-14(16)18/h3-9H,11,18H2,1-2H3
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 10446567
- HMDB: HMDB0259640
- ChEMBL: CHEMBL106939
- chemspider: 8621986
- CAS: 627490-01-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nina Bl Urban, Ragy R Girgis, Peter S Talbot, Lawrence S Kegeles, X Xu, W Gordon Frankle, Carl L Hart, Mark Slifstein, Anissa Abi-Dargham, Marc Laruelle. Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2012 May; 37(6):1465-73. doi:
10.1038/npp.2011.332. [PMID: 22353758] - N Pavese, B S Simpson, V Metta, A Ramlackhansingh, K Ray Chaudhuri, D J Brooks. [¹⁸F]FDOPA uptake in the raphe nuclei complex reflects serotonin transporter availability. A combined [¹⁸F]FDOPA and [¹¹C]DASB PET study in Parkinson's disease.
NeuroImage.
2012 Jan; 59(2):1080-4. doi:
10.1016/j.neuroimage.2011.09.034. [PMID: 21963917] - Federico E Turkheimer, Sudhakar Selvaraj, Rainer Hinz, Venkatesha Murthy, Zubin Bhagwagar, Paul Grasby, Oliver Howes, Lula Rosso, Subrata K Bose. Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an example.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2012 Jan; 32(1):70-80. doi:
10.1038/jcbfm.2011.108. [PMID: 21811290] - Ragy R Girgis, Mark Slifstein, Xiaoyan Xu, W Gordon Frankle, Evdokia Anagnostou, Stacey Wasserman, Lauren Pepa, Alexander Kolevzon, Anissa Abi-Dargham, Marc Laruelle, Eric Hollander. The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASB.
Psychiatry research.
2011 Dec; 194(3):230-234. doi:
10.1016/j.pscychresns.2011.04.007. [PMID: 22079057] - Elseline Hoekzema, Santiago Rojas, Raúl Herance, Deborah Pareto, Sergio Abad, Xavier Jiménez, Francisca P Figueiras, Foteini Popota, Alba Ruiz, Núria Flotats, Francisco J Fernández, Milagros Rocha, Mariana Rovira, Víctor M Víctor, Juan D Gispert. [(11)C]-DASB microPET imaging in the aged rat: frontal and meso-thalamic increases in serotonin transporter binding.
Experimental gerontology.
2011 Dec; 46(12):1020-5. doi:
10.1016/j.exger.2011.09.007. [PMID: 21983171] - Gwenn S Smith, Alan Kahn, Julia Sacher, Pablo Rusjan, Thilo van Eimeren, Alastair Flint, Alan A Wilson. Serotonin transporter occupancy and the functional neuroanatomic effects of citalopram in geriatric depression.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2011 Dec; 19(12):1016-25. doi:
10.1097/jgp.0b013e318227f83f. [PMID: 21841458] - Marios Politis, Clare Loane, Kit Wu, David J Brooks, Paola Piccini. Serotonergic mediated body mass index changes in Parkinson's disease.
Neurobiology of disease.
2011 Sep; 43(3):609-15. doi:
10.1016/j.nbd.2011.05.009. [PMID: 21624463] - Harumasa Takano, Hiroshi Ito, Hidehiko Takahashi, Ryosuke Arakawa, Masaki Okumura, Fumitoshi Kodaka, Tatsui Otsuka, Motoichiro Kato, Tetsuya Suhara. Serotonergic neurotransmission in the living human brain: a positron emission tomography study using [¹¹C]dasb and [¹¹C]WAY100635 in young healthy men.
Synapse (New York, N.Y.).
2011 Jul; 65(7):624-33. doi:
10.1002/syn.20883. [PMID: 21484882] - David Erritzoe, Vibe G Frokjaer, Klaus K Holst, Maria Christoffersen, Sys S Johansen, Claus Svarer, Jacob Madsen, Peter M Rasmussen, Thomas Ramsøy, Terry L Jernigan, Gitte M Knudsen. In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users.
Archives of general psychiatry.
2011 Jun; 68(6):562-76. doi:
10.1001/archgenpsychiatry.2011.56. [PMID: 21646575] - X Liu, D M Cannon, N Akula, P R Moya, G M Knudsen, T E Arentzen, J Steele, G Laje, W C Drevets, F J McMahon. A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study.
Molecular psychiatry.
2011 Jun; 16(6):584-5. doi:
10.1038/mp.2011.1. [PMID: 21339755] - Sergio Abanades, Jasper van der Aart, Julien A R Barletta, Carmine Marzano, Graham E Searle, Cristian A Salinas, Javaad J Ahmad, Richard R Reiley, Sabina Pampols-Maso, Stefano Zamuner, Vincent J Cunningham, Eugenii A Rabiner, Marc A Laruelle, Roger N Gunn. Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2011 Mar; 31(3):944-52. doi:
10.1038/jcbfm.2010.175. [PMID: 20940733] - Sudhakar Selvaraj, Naga Venkatesha Murthy, Zubin Bhagwagar, Subrata K Bose, Rainer Hinz, Paul M Grasby, Philip J Cowen. Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB.
Psychopharmacology.
2011 Feb; 213(2-3):555-62. doi:
10.1007/s00213-009-1660-y. [PMID: 19756523] - Ron Kupers, Vibe G Frokjaer, David Erritzoe, Arne Naert, Esben Budtz-Joergensen, Finn Aarup Nielsen, Henrik Kehlet, Gitte M Knudsen. Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: a [11C]DASB PET study.
NeuroImage.
2011 Jan; 54(2):1336-43. doi:
10.1016/j.neuroimage.2010.09.010. [PMID: 20851771] - M Politis, K Wu, C Loane, F E Turkheimer, S Molloy, D J Brooks, P Piccini. Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures.
Neurology.
2010 Nov; 75(21):1920-7. doi:
10.1212/wnl.0b013e3181feb2ab. [PMID: 21098407] - Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudsen. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2010 Nov; 30(11):e1-7. doi:
10.1038/jcbfm.2010.114. [PMID: 20736957] - Chihiro Yokoyama, Hajime Yamanaka, Kayo Onoe, Akihiro Kawasaki, Hiroko Nagata, Keiko Shirakami, Hisashi Doi, Hirotaka Onoe. Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys.
Synapse (New York, N.Y.).
2010 Aug; 64(8):594-601. doi:
10.1002/syn.20766. [PMID: 20340166] - N V Murthy, S Selvaraj, P J Cowen, Z Bhagwagar, W J Riedel, P Peers, J L Kennedy, B J Sahakian, M A Laruelle, E A Rabiner, P M Grasby. Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.
NeuroImage.
2010 Aug; 52(1):50-4. doi:
10.1016/j.neuroimage.2010.04.032. [PMID: 20406689] - D Erritzoe, V G Frokjaer, M T Haahr, J Kalbitzer, C Svarer, K K Holst, D L Hansen, T L Jernigan, S Lehel, G M Knudsen. Cerebral serotonin transporter binding is inversely related to body mass index.
NeuroImage.
2010 Aug; 52(1):284-9. doi:
10.1016/j.neuroimage.2010.03.086. [PMID: 20382236] - Gonzalo Laje, Dara M Cannon, Andrew S Allen, Jackie M Klaver, Summer A Peck, Xinmin Liu, Husseini K Manji, Wayne C Drevets, Francis J McMahon. Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB.
The international journal of neuropsychopharmacology.
2010 Jul; 13(6):715-24. doi:
10.1017/s1461145709991027. [PMID: 20047709] - Stephen J Kish, Jason Lerch, Yoshiaki Furukawa, Junchao Tong, Tina McCluskey, Diana Wilkins, Sylvain Houle, Jeffrey Meyer, Emanuela Mundo, Alan A Wilson, Pablo M Rusjan, Jean A Saint-Cyr, Mark Guttman, D Louis Collins, Colin Shapiro, Jerry J Warsh, Isabelle Boileau. Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study.
Brain : a journal of neurology.
2010 Jun; 133(Pt 6):1779-97. doi:
10.1093/brain/awq103. [PMID: 20483717] - H P Jedema, P J Gianaros, P J Greer, D D Kerr, S Liu, J D Higley, S J Suomi, A S Olsen, J N Porter, B J Lopresti, A R Hariri, C W Bradberry. Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission.
Molecular psychiatry.
2010 May; 15(5):512-22, 446. doi:
10.1038/mp.2009.90. [PMID: 19721434] - David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudsen. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Mar; 30(9):3391-7. doi:
10.1523/jneurosci.2852-09.2010. [PMID: 20203198] - Peter S Talbot, Stefan Bradley, Cyril P Clarke, Kola O Babalola, Andrew W Philipp, Gavin Brown, Adam W McMahon, Julian C Matthews. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2010 Feb; 35(3):741-51. doi:
10.1038/npp.2009.182. [PMID: 19890256] - Dima A Hammoud, Christopher J Endres, Edward Hammond, Ovsev Uzuner, Amanda Brown, Avindra Nath, Adam I Kaplin, Martin G Pomper. Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIV.
NeuroImage.
2010 Feb; 49(3):2588-95. doi:
10.1016/j.neuroimage.2009.10.037. [PMID: 19853044] - Ryohei Matsumoto, Masanori Ichise, Hiroshi Ito, Tomomichi Ando, Hidehiko Takahashi, Yoko Ikoma, Jun Kosaka, Ryosuke Arakawa, Yota Fujimura, Miho Ota, Akihiro Takano, Kenji Fukui, Kazuhiko Nakayama, Tetsuya Suhara. Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study.
NeuroImage.
2010 Jan; 49(1):121-6. doi:
10.1016/j.neuroimage.2009.07.069. [PMID: 19660554] - B T Christian, A S Fox, J A Oler, N T Vandehey, D Murali, J Rogers, T R Oakes, S E Shelton, R J Davidson, N H Kalin. Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET.
NeuroImage.
2009 Oct; 47(4):1230-6. doi:
10.1016/j.neuroimage.2009.05.090. [PMID: 19505582] - Takeaki Saijo, Jun Maeda, Takashi Okauchi, Jun-Ichi Maeda, Yasunori Morio, Yasuhiro Kuwahara, Masayuki Suzuki, Nobuharu Goto, Kazutoshi Suzuki, Makoto Higuchi, Tetsuya Suhara. Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter.
The international journal of neuropsychopharmacology.
2009 Sep; 12(8):1021-32. doi:
10.1017/s1461145709000042. [PMID: 19236731] - D Haeusler, L-K Mien, L Nics, J Ungersboeck, C Philippe, R R Lanzenberger, K Kletter, R Dudczak, M Mitterhauser, W Wadsak. Simple and rapid preparation of [11C]DASB with high quality and reliability for routine applications.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2009 Sep; 67(9):1654-60. doi:
10.1016/j.apradiso.2009.03.005. [PMID: 19359188] - Jonathan A Oler, Andrew S Fox, Steven E Shelton, Bradley T Christian, Dhanabalan Murali, Terrence R Oakes, Richard J Davidson, Ned H Kalin. Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Aug; 29(32):9961-6. doi:
10.1523/jneurosci.0795-09.2009. [PMID: 19675230] - Yasuomi Ouchi, Etsuji Yoshikawa, Masami Futatsubashi, Shunsuke Yagi, Takatoshi Ueki, Kazuhiko Nakamura. Altered brain serotonin transporter and associated glucose metabolism in Alzheimer disease.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2009 Aug; 50(8):1260-6. doi:
10.2967/jnumed.109.063008. [PMID: 19617327] - Vibe G Frokjaer, Maj Vinberg, David Erritzoe, Claus Svarer, William Baaré, Esben Budtz-Joergensen, Karine Madsen, Jacob Madsen, Lars V Kessing, Gitte M Knudsen. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding.
NeuroImage.
2009 Jun; 46(2):360-6. doi:
10.1016/j.neuroimage.2009.02.008. [PMID: 19233297] - Jan Kalbitzer, Claus Svarer, Vibe G Frokjaer, David Erritzoe, William F C Baaré, Jacob Madsen, Steen G Hasselbalch, Gitte M Knudsen. A probabilistic approach to delineating functional brain regions.
Journal of nuclear medicine technology.
2009 Jun; 37(2):91-5. doi:
10.2967/jnmt.108.054056. [PMID: 19447857] - N V Riddick, P W Czoty, H D Gage, J R Kaplan, S H Nader, M Icenhower, P J Pierre, A Bennett, P K Garg, S Garg, M A Nader. Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys.
Neuroscience.
2009 Feb; 158(4):1257-65. doi:
10.1016/j.neuroscience.2008.11.016. [PMID: 19059311] - Isabelle Boileau, Jerry J Warsh, Mark Guttman, Jean A Saint-Cyr, Tina McCluskey, Pablo Rusjan, Sylvain Houle, Alan A Wilson, Jeffrey H Meyer, Stephen J Kish. Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB.
Movement disorders : official journal of the Movement Disorder Society.
2008 Sep; 23(12):1776-80. doi:
10.1002/mds.22212. [PMID: 18661545] - Nicole Praschak-Rieder, Matthaeus Willeit, Alan A Wilson, Sylvain Houle, Jeffrey H Meyer. Seasonal variation in human brain serotonin transporter binding.
Archives of general psychiatry.
2008 Sep; 65(9):1072-8. doi:
10.1001/archpsyc.65.9.1072. [PMID: 18762593] - Rainer Hinz, Sudhakar Selvaraj, N Venkatesha Murthy, Zubin Bhagwagar, Matthew Taylor, Philip J Cowen, Paul M Grasby. Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2008 Aug; 28(8):1478-90. doi:
10.1038/jcbfm.2008.41. [PMID: 18478022] - M Reimold, A Batra, A Knobel, M N Smolka, A Zimmer, K Mann, C Solbach, G Reischl, F Schwärzler, G Gründer, H-J Machulla, R Bares, A Heinz. Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: a [11C]DASB PET study.
Molecular psychiatry.
2008 Jun; 13(6):606-13, 557. doi:
10.1038/sj.mp.4002149. [PMID: 18268503] - Dagmar E Ettlinger, Daniela Häusler, Wolfgang Wadsak, Friedrich Girschele, Karoline M Sindelar, Leonhard-Key Mien, Johanna Ungersböck, Helmut Viernstein, Kurt Kletter, Robert Dudczak, Markus Mitterhauser. Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT.
Nuclear medicine and biology.
2008 May; 35(4):475-9. doi:
10.1016/j.nucmedbio.2008.02.008. [PMID: 18482685] - Zubin Bhagwagar, Naga Murthy, Sudhakar Selvaraj, Rainer Hinz, Matthew Taylor, Sabrina Fancy, Paul Grasby, Philip Cowen. 5-HTT binding in recovered depressed patients and healthy volunteers: a positron emission tomography study with [11C]DASB.
The American journal of psychiatry.
2007 Dec; 164(12):1858-65. doi:
10.1176/appi.ajp.2007.06111933. [PMID: 18056241] - Dara M Cannon, Masanori Ichise, Denise Rollis, Jacqueline M Klaver, Shilpa K Gandhi, Dennis S Charney, Husseini K Manji, Wayne C Drevets. Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder.
Biological psychiatry.
2007 Oct; 62(8):870-7. doi:
10.1016/j.biopsych.2007.03.016. [PMID: 17678634] - Akihiro Takano, Ryosuke Arakawa, Mika Hayashi, Hidehiko Takahashi, Hiroshi Ito, Tetsuya Suhara. Relationship between neuroticism personality trait and serotonin transporter binding.
Biological psychiatry.
2007 Sep; 62(6):588-92. doi:
10.1016/j.biopsych.2006.11.007. [PMID: 17336939] - Sudha Garg, Shankar R Thopate, Richard C Minton, Kimberly W Black, Andrew J H Lynch, Pradeep K Garg. 3-Amino-4-(2-((4-[18F]fluorobenzyl)methylamino)methylphenylsulfanyl)benzonitrile, an F-18 fluorobenzyl analogue of DASB: synthesis, in vitro binding, and in vivo biodistribution studies.
Bioconjugate chemistry.
2007 Sep; 18(5):1612-8. doi:
10.1021/bc070112g. [PMID: 17705553] - Shigeyuki Yamamoto, Hirotaka Onoe, Hideo Tsukada, Yasuyoshi Watanabe. Effects of increased endogenous serotonin on the in vivo binding of [11C]DASB to serotonin transporters in conscious monkey brain.
Synapse (New York, N.Y.).
2007 Sep; 61(9):724-31. doi:
10.1002/syn.20422. [PMID: 17559093] - Rebecca A Rhodes, Naga Venkatesha Murthy, M Alex Dresner, Sudhakar Selvaraj, Nikolaos Stavrakakis, Syed Babar, Philip J Cowen, Paul M Grasby. Human 5-HT transporter availability predicts amygdala reactivity in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007 Aug; 27(34):9233-7. doi:
10.1523/jneurosci.1175-07.2007. [PMID: 17715358] - Nicole Praschak-Rieder, James Kennedy, Alan A Wilson, Douglas Hussey, Anahita Boovariwala, Matthaeus Willeit, Nathalie Ginovart, Subi Tharmalingam, Mario Masellis, Sylvain Houle, Jeffrey H Meyer. Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study.
Biological psychiatry.
2007 Aug; 62(4):327-31. doi:
10.1016/j.biopsych.2006.09.022. [PMID: 17210141] - Paul Cumming, Mette Møller, Kjeld Benda, Luciano Minuzzi, Steen Jakobsen, Svend B Jensen, Bente Pakkenberg, Anette K Stark, Jan Bert Gramsbergen, Mette F Andreasen, Aage K Olsen. A PET study of effects of chronic 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on serotonin markers in Göttingen minipig brain.
Synapse (New York, N.Y.).
2007 Jul; 61(7):478-87. doi:
10.1002/syn.20377. [PMID: 17415793] - Pinelopi Lundquist, Magnus Roman, Stina Syvänen, Per Hartvig, Gunnar Blomquist, Margareta Hammarlund-Udenaes, Bengt Långström. Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats.
Synapse (New York, N.Y.).
2007 Jun; 61(6):440-9. doi:
10.1002/syn.20382. [PMID: 17372973] - Jeffrey H Meyer, Alan A Wilson, Nathalie Ginovart, Sylvain Houle. Misunderstandings about how to choose a reference region.
Biological psychiatry.
2007 Jun; 61(11):1314; author reply 1314-5. doi:
10.1016/j.biopsych.2006.06.007. [PMID: 16989780] - M Guttman, I Boileau, J Warsh, J A Saint-Cyr, N Ginovart, T McCluskey, S Houle, A Wilson, E Mundo, P Rusjan, J Meyer, S J Kish. Brain serotonin transporter binding in non-depressed patients with Parkinson's disease.
European journal of neurology.
2007 May; 14(5):523-8. doi:
10.1111/j.1468-1331.2007.01727.x. [PMID: 17437611] - M Reimold, M N Smolka, A Zimmer, A Batra, A Knobel, C Solbach, A Mundt, H U Smoltczyk, D Goldman, K Mann, G Reischl, H-J Machulla, R Bares, A Heinz. Reduced availability of serotonin transporters in obsessive-compulsive disorder correlates with symptom severity - a [11C]DASB PET study.
Journal of neural transmission (Vienna, Austria : 1996).
2007; 114(12):1603-9. doi:
10.1007/s00702-007-0785-6. [PMID: 17713719] - M Reimold, M N Smolka, G Schumann, A Zimmer, J Wrase, K Mann, X-Z Hu, D Goldman, G Reischl, C Solbach, H-J Machulla, R Bares, A Heinz. Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype.
Journal of neural transmission (Vienna, Austria : 1996).
2007; 114(5):635-9. doi:
10.1007/s00702-006-0609-0. [PMID: 17225932] - Amira K Brown, David T George, Masahiro Fujita, Jeih-San Liow, Masanori Ichise, Joseph Hibbeln, Subroto Ghose, Janet Sangare, Daniel Hommer, Robert B Innis. PET [11C]DASB imaging of serotonin transporters in patients with alcoholism.
Alcoholism, clinical and experimental research.
2007 Jan; 31(1):28-32. doi:
10.1111/j.1530-0277.2006.00261.x. [PMID: 17207098] - R Todd Ogden, Ashish Ojha, Kjell Erlandsson, Maria A Oquendo, J John Mann, Ramin V Parsey. In vivo quantification of serotonin transporters using [(11)C]DASB and positron emission tomography in humans: modeling considerations.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2007 Jan; 27(1):205-17. doi:
10.1038/sj.jcbfm.9600329. [PMID: 16736050] - Ramin V Parsey, Ashish Ojha, R Todd Ogden, Kjell Erlandsson, Dileep Kumar, Marguerite Landgrebe, Ronald Van Heertum, J John Mann. Metabolite considerations in the in vivo quantification of serotonin transporters using 11C-DASB and PET in humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2006 Nov; 47(11):1796-802. doi:
NULL. [PMID: 17079812] - Dara M Cannon, Masanori Ichise, Stephen J Fromm, Allison C Nugent, Denise Rollis, Shilpa K Gandhi, Jacqueline M Klaver, Dennis S Charney, Husseini K Manji, Wayne C Drevets. Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography.
Biological psychiatry.
2006 Aug; 60(3):207-17. doi:
10.1016/j.biopsych.2006.05.005. [PMID: 16875929] - Zhizhen Zeng, Tsing-Bau Chen, Patricia J Miller, Dennis Dean, Yui Sing Tang, Cyrille Sur, David L Williams. The serotonin transporter in rhesus monkey brain: comparison of DASB and citalopram binding sites.
Nuclear medicine and biology.
2006 May; 33(4):555-63. doi:
10.1016/j.nucmedbio.2006.02.007. [PMID: 16720249] - W Gordon Frankle, Mark Slifstein, Roger N Gunn, Yiyun Huang, Dah-Ren Hwang, E Ashlie Darr, Rajesh Narendran, Anissa Abi-Dargham, Marc Laruelle. Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2006 May; 47(5):815-26. doi:
NULL. [PMID: 16644752] - Ramin V Parsey, Justine M Kent, Maria A Oquendo, Misty C Richards, Mali Pratap, Thomas B Cooper, Victoria Arango, J John Mann. Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography.
Biological psychiatry.
2006 May; 59(9):821-8. doi:
10.1016/j.biopsych.2005.08.010. [PMID: 16213473] - Masanori Ichise, Douglass C Vines, Tami Gura, George M Anderson, Stephen J Suomi, J Dee Higley, Robert B Innis. Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Apr; 26(17):4638-43. doi:
10.1523/jneurosci.5199-05.2006. [PMID: 16641244] - Akihiro Takano, Tetsuya Suhara, Tetsuya Ichimiya, Fumihiko Yasuno, Kazutoshi Suzuki. Time course of in vivo 5-HTT transporter occupancy by fluvoxamine.
Journal of clinical psychopharmacology.
2006 Apr; 26(2):188-91. doi:
10.1097/01.jcp.0000203201.34323.d3. [PMID: 16633150] - Jae Seung Kim, Masanori Ichise, Janet Sangare, Robert B Innis. PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2006 Feb; 47(2):208-14. doi:
NULL. [PMID: 16455625] - Nicole Praschak-Rieder, Alan A Wilson, Douglas Hussey, Anna Carella, Corie Wei, Nathalie Ginovart, Markus J Schwarz, Johanna Zach, Sylvain Houle, Jeffrey H Meyer. Effects of tryptophan depletion on the serotonin transporter in healthy humans.
Biological psychiatry.
2005 Nov; 58(10):825-30. doi:
10.1016/j.biopsych.2005.04.038. [PMID: 16026765] - Una D McCann, Zsolt Szabo, Esen Seckin, Peter Rosenblatt, William B Mathews, Hayden T Ravert, Robert F Dannals, George A Ricaurte. Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASB.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2005 Sep; 30(9):1741-50. doi:
10.1038/sj.npp.1300736. [PMID: 15841106] - W Gordon Frankle, Rajesh Narendran, Yiyun Huang, Dah-Ren Hwang, Ilise Lombardo, Claudine Cangiano, Roberto Gil, Marc Laruelle, Anissa Abi-Dargham. Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB.
Biological psychiatry.
2005 Jun; 57(12):1510-6. doi:
10.1016/j.biopsych.2005.02.028. [PMID: 15953487] - Yiyun Huang, Sung-A Bae, Zhihong Zhu, Ningning Guo, Bryan L Roth, Marc Laruelle. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.
Journal of medicinal chemistry.
2005 Apr; 48(7):2559-70. doi:
10.1021/jm0400808. [PMID: 15801845] - Peter S Talbot, W Gordon Frankle, Dah-Ren Hwang, Yiyun Huang, Raymond F Suckow, Mark Slifstein, Anissa Abi-Dargham, Marc Laruelle. Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans.
Synapse (New York, N.Y.).
2005 Mar; 55(3):164-75. doi:
10.1002/syn.20105. [PMID: 15605360] - Débora C Hipólide, Karin M Moreira, Karen B L Barlow, Alan A Wilson, José N Nobrega, Sergio Tufik. Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain.
Progress in neuro-psychopharmacology & biological psychiatry.
2005 Feb; 29(2):297-303. doi:
10.1016/j.pnpbp.2004.11.015. [PMID: 15694238] - Matthew S Milak, R Todd Ogden, Daniel N Vinocur, Ronald L Van Heertum, Thomas B Cooper, J John Mann, Ramin V Parsey. Effects of tryptophan depletion on the binding of [11C]-DASB to the serotonin transporter in baboons: response to acute serotonin deficiency.
Biological psychiatry.
2005 Jan; 57(1):102-6. doi:
10.1016/j.biopsych.2004.09.026. [PMID: 15607307] - Jeffrey H Meyer, Sylvain Houle, Sandra Sagrati, Anna Carella, Doug F Hussey, Nathalie Ginovart, Verdell Goulding, James Kennedy, Alan A Wilson. Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes.
Archives of general psychiatry.
2004 Dec; 61(12):1271-9. doi:
10.1001/archpsyc.61.12.1271. [PMID: 15583118] - Marie-José Bélanger, Norman R Simpson, Theodore Wang, Ronald L Van Heertum, J John Mann, Ramin V Parsey. Biodistribution and radiation dosimetry of [11C]DASB in baboons.
Nuclear medicine and biology.
2004 Nov; 31(8):1097-102. doi:
10.1016/j.nucmedbio.2004.09.002. [PMID: 15607492] - Hank F Kung, Suzanne Newman, Seok-Rye Choi, Shunichi Oya, Catherine Hou, Zhi-Ping Zhuang, Paul D Acton, Karl Plössl, Jeffrey Winkler, Mei-Ping Kung. 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent.
Journal of medicinal chemistry.
2004 Oct; 47(21):5258-64. doi:
10.1021/jm049917p. [PMID: 15456270] - Jian-Qiang Lu, Masanori Ichise, Jeih-San Liow, Subroto Ghose, Doug Vines, Robert B Innis. Biodistribution and radiation dosimetry of the serotonin transporter ligand 11C-DASB determined from human whole-body PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2004 Sep; 45(9):1555-9. doi:
NULL. [PMID: 15347724] - René Hummerich, Gerald Reischl, Walter Ehrlichmann, Hans-Jürgen Machulla, Andreas Heinz, Patrick Schloss. DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer.
Journal of neurochemistry.
2004 Sep; 90(5):1218-26. doi:
10.1111/j.1471-4159.2004.02585.x. [PMID: 15312176] - Jeffrey H Meyer, Alan A Wilson, Sandra Sagrati, Doug Hussey, Anna Carella, William Z Potter, Nathalie Ginovart, Edgar P Spencer, Andy Cheok, Sylvain Houle. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study.
The American journal of psychiatry.
2004 May; 161(5):826-35. doi:
10.1176/appi.ajp.161.5.826. [PMID: 15121647] - W Gordon Frankle, Yiyun Huang, Dah-Ren Hwang, Peter S Talbot, Mark Slifstein, Ronald Van Heertum, Anissa Abi-Dargham, Marc Laruelle. Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2004 Apr; 45(4):682-94. doi:
NULL. [PMID: 15073266] - Qian Li, Li Ma, Robert B Innis, Nicholas Seneca, Masanori Ichise, Henry Huang, Marc Laruelle, Dennis L Murphy. Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB).
The Journal of pharmacology and experimental therapeutics.
2004 Feb; 308(2):481-6. doi:
10.1124/jpet.103.058636. [PMID: 14610240] - D N Tipre, J Q Lu, M Fujita, M Ichise, D Vines, R B Innis. Radiation dosimetry estimates for the PET serotonin transporter probe 11C-DASB determined from whole-body imaging in non-human primates.
Nuclear medicine communications.
2004 Jan; 25(1):81-6. doi:
10.1097/00006231-200401000-00012. [PMID: 15061269] - Masanori Ichise, Jeih-San Liow, Jian-Qiang Lu, Akihiro Takano, Kendra Model, Hiroshi Toyama, Tetsuya Suhara, Kazutoshi Suzuki, Robert B Innis, Richard E Carson. Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2003 Sep; 23(9):1096-112. doi:
10.1097/01.wcb.0000085441.37552.ca. [PMID: 12973026] - Svend B Jensen, Donald F Smith, Dirk Bender, Steen Jakobsen, Dan Peters, Elsebet Ø Nielsen, Gunnar M Olsen, Jørgen Scheel-Krüger, Alan Wilson, Paul Cumming. [11C]-NS 4194 versus [11C]-DASB for PET imaging of serotonin transporters in living porcine brain.
Synapse (New York, N.Y.).
2003 Sep; 49(3):170-7. doi:
10.1002/syn.10222. [PMID: 12774301] - Nathalie Ginovart, Alan A Wilson, Jeffrey H Meyer, Doug Hussey, Sylvain Houle. [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats.
Synapse (New York, N.Y.).
2003 Feb; 47(2):123-33. doi:
10.1002/syn.10155. [PMID: 12454950] - Shunichi Oya, Seok Rye Choi, Heinz Coenen, Hank F Kung. New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).
Journal of medicinal chemistry.
2002 Oct; 45(21):4716-23. doi:
10.1021/jm020167y. [PMID: 12361398] - Alan A Wilson, Nathalie Ginovart, Doug Hussey, Jeff Meyer, Sylvain Houle. In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography.
Nuclear medicine and biology.
2002 Jul; 29(5):509-15. doi:
10.1016/s0969-8051(02)00316-5. [PMID: 12088720] - Zsolt Szabo, Una D McCann, Alan A Wilson, Ursula Scheffel, Taofeek Owonikoko, William B Mathews, Hayden T Ravert, John Hilton, Robert F Dannals, George A Ricaurte. Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2002 May; 43(5):678-92. doi:
NULL. [PMID: 11994534] - N Ginovart, A A Wilson, J H Meyer, D Hussey, S Houle. Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2001 Nov; 21(11):1342-53. doi:
10.1097/00004647-200111000-00010. [PMID: 11702049] - A A Wilson, N Ginovart, M Schmidt, J H Meyer, P G Threlkeld, S Houle. Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines.
Journal of medicinal chemistry.
2000 Aug; 43(16):3103-10. doi:
10.1021/jm000079i. [PMID: 10956218]