Temozolomide (BioDeep_00000018482)
human metabolite blood metabolite
代谢物信息卡片
3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide
化学式: C6H6N6O2 (194.0552)
中文名称: 替莫唑胺
谱图信息:
最多检出来源 Homo sapiens(blood) 78.69%
分子结构信息
SMILES: CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
InChI: InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
描述信息
Temozolomide (Temodar and Temodal) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC).
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents
同义名列表
29 个代谢物同义名
3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-D)-as-tetrazine-8-carboxamide; 3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo(5,1-D)-1,2,3,5-tetrazin-4(3H)-one; Temozolomide hexyl ester; TMZ-Bioshuttle; Methazolastone; TMZ Bioshuttle; Temozolomidum; m And b-39831; m And b 39831; Temozolomida; temozolomide; m And b39831; Temozolamide; BRN 5547136; m & b 39831; CCRG 81045; NSC 362856; CCRG-81045; CCRIS 8996; M&B 39831; SCH 52365; MB 39831; Temodal; TMZA-he; Temodar; TMZ
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:72564
- PubChem: 5394
- HMDB: HMDB0014991
- DrugBank: DB00853
- ChEMBL: CHEMBL810
- Wikipedia: Temozolomide
- MeSH: Temozolomide
- chemspider: 5201
- CAS: 85622-93-1
- PMhub: MS000008410
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yuheng Zou, Lanyang Xu, Wanyu Wang, Xiao Zhu, Jiaqi Lin, Huazhao Li, Jiali Chen, Wei Xu, Haiqiong Gao, Xianghui Wu, Zhixin Yin, Qirui Wang. Muscone restores anoikis sensitivity in TMZ-resistant glioblastoma cells by suppressing TOP2A via the EGFR/Integrin β1/FAK signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155714. doi:
10.1016/j.phymed.2024.155714. [PMID: 38723526] - Zongyang Li, Ke Sai, Guoxu Ma, Fanfan Chen, Xudong Xu, Lei Chen, Sicen Wang, Weiping Li, Guodong Huang, Ping Cui. Diterpenoid honatisine overcomes temozolomide resistance in glioblastoma by inducing mitonuclear protein imbalance through disruption of TFAM-mediated mtDNA transcription.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155328. doi:
10.1016/j.phymed.2023.155328. [PMID: 38522316] - Aleksandra Majchrzak-Celińska, Elżbieta Studzińska-Sroka. New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy.
Molecules (Basel, Switzerland).
2024 Apr; 29(7):. doi:
10.3390/molecules29071682. [PMID: 38611962] - Xudong Cai, Ahmed Refaat, Poh-Yi Gan, Bo Fan, Haitao Yu, San H Thang, Calum J Drummond, Nicolas H Voelcker, Nhiem Tran, Jiali Zhai. Angiopep-2-Functionalized Lipid Cubosomes for Blood-Brain Barrier Crossing and Glioblastoma Treatment.
ACS applied materials & interfaces.
2024 Mar; 16(10):12161-12174. doi:
10.1021/acsami.3c14709. [PMID: 38416873] - Jiao Meng, Wei Qian, Zhenkun Yang, Lingli Gong, Daxing Xu, Hongbo Huang, Xinyi Jiang, Zhening Pu, Ying Yin, Jian Zou. p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme.
BMC cancer.
2024 Mar; 24(1):317. doi:
10.1186/s12885-024-12017-y. [PMID: 38454344] - Haili He, Zhihuang Zhao, Chenghong Xiao, Liangyuan Li, Yu-E Liu, Juan Fu, Hongyu Liao, Tao Zhou, Jinqiang Zhang. Gut microbiome promotes mice recovery from stress-induced depression by rescuing hippocampal neurogenesis.
Neurobiology of disease.
2024 Feb; 191(?):106396. doi:
10.1016/j.nbd.2023.106396. [PMID: 38176570] - Divyalakshmi Bhaskaran, Joshua Savage, Amit Patel, Fiona Collinson, Rhys Mant, Florien Boele, Lucy Brazil, Sara Meade, Peter Buckle, Siân Lax, Lucinda Billingham, Susan C Short. A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): protocol for a multi-centre, double-blind, placebo-controlled trial.
BMC cancer.
2024 Jan; 24(1):83. doi:
10.1186/s12885-023-11792-4. [PMID: 38225549] - Luting Lin, Jingming Luo, Zeng Wang, Xinjun Cai. Borneol promotes autophagic degradation of HIF-1α and enhances chemotherapy sensitivity in malignant glioma.
PeerJ.
2024; 12(?):e16691. doi:
10.7717/peerj.16691. [PMID: 38188151] - Herwig Strik, Thomas Efferth, Bernd Kaina. Artesunate in glioblastoma therapy: Case reports and review of clinical studies.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 123(?):155274. doi:
10.1016/j.phymed.2023.155274. [PMID: 38142662] - Xiaoteng Cui, Jixing Zhao, Guanzhang Li, Chao Yang, Shixue Yang, Qi Zhan, Junhu Zhou, Yunfei Wang, Menglin Xiao, Biao Hong, Kaikai Yi, Fei Tong, Yanli Tan, Hu Wang, Qixue Wang, Tao Jiang, Chuan Fang, Chunsheng Kang. Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma.
Cancer communications (London, England).
2023 Nov; ?(?):. doi:
10.1002/cac2.12502. [PMID: 37920878] - Ceyhan Hacioglu, Cengiz Tuncer. Boric acid Increases Susceptibility to Chemotherapy by Targeting the Ferritinophagy Signaling Pathway in TMZ Resistant Glioblastoma Cells.
Biological trace element research.
2023 Oct; ?(?):. doi:
10.1007/s12011-023-03930-7. [PMID: 37906374] - Yang Wu, Sophie Franzmeier, Friederike Liesche-Starnecker, Jürgen Schlegel. Enhanced Sensitivity to ALDH1A3-Dependent Ferroptosis in TMZ-Resistant Glioblastoma Cells.
Cells.
2023 10; 12(21):. doi:
10.3390/cells12212522. [PMID: 37947601] - Rosaria Bassi, Michele Dei Cas, Cristina Tringali, Federica Compostella, Rita Paroni, Paola Giussani. Ceramide Is Involved in Temozolomide Resistance in Human Glioblastoma U87MG Overexpressing EGFR.
International journal of molecular sciences.
2023 Oct; 24(20):. doi:
10.3390/ijms242015394. [PMID: 37895074] - Lilianne Beola, Nerea Iturrioz-Rodríguez, Carlotta Pucci, Rosalia Bertorelli, Gianni Ciofani. Drug-Loaded Lipid Magnetic Nanoparticles for Combined Local Hyperthermia and Chemotherapy against Glioblastoma Multiforme.
ACS nano.
2023 Sep; ?(?):. doi:
10.1021/acsnano.3c06085. [PMID: 37698887] - Wanyu Wang, Xiaopeng Yuan, Jiasheng Mu, Yuheng Zou, Lanyang Xu, Jiali Chen, Xiao Zhu, Biaoping Li, Zhiyun Zeng, Xianghui Wu, Zhixin Yin, Qirui Wang. Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Sep; 118(?):154933. doi:
10.1016/j.phymed.2023.154933. [PMID: 37451151] - Nian Tan, Wei Zhao, Yiyang Wang, Ping Li, Jianwei Liu, Zhaoying Sun, Jianming Pan, Shilin Song, Shunyao Li, Ziyi Liu, Yuhong Bian. AHR, a novel inhibitory immune checkpoint receptor, is a potential therapeutic target for chemoresistant glioblastoma.
Journal of cancer research and clinical oncology.
2023 Sep; 149(12):9705-9720. doi:
10.1007/s00432-023-04894-w. [PMID: 37233762] - Aryan Rezaee, Pooya M Tehrany, Farimah Jafari Tirabadi, Negin Sanadgol, Asal Sadat Karimi, Atra Ajdari, Sepideh Eydivandi, Sara Etemad, Romina Rajabi, Parham Rahmanian, Ramin Khorrami, Noushin Nabavi, Amir Reza Aref, Xiaoping Fan, Rongjun Zou, Mohsen Rashidi, Mohammad Arad Zandieh, Kiavash Hushmandi. Epigenetic regulation of temozolomide resistance in human cancers with an emphasis on brain tumors: Function of non-coding RNAs.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Sep; 165(?):115187. doi:
10.1016/j.biopha.2023.115187. [PMID: 37499452] - Nana Wang, Jiejun Wang, Pu Wang, Nan Ji, Shuhua Yue. Label-Free Raman Spectromicroscopy Unravels the Relationship between MGMT Methylation and Intracellular Lipid Accumulation in Glioblastoma.
Analytical chemistry.
2023 08; 95(31):11567-11571. doi:
10.1021/acs.analchem.3c00967. [PMID: 37417930] - Ryosuke Maeoka, Yukiteru Ouji, Tsutomu Nakazawa, Ryosuke Matsuda, Takayuki Morimoto, Shohei Yokoyama, Shuichi Yamada, Fumihiko Nishimura, Ichiro Nakagawa, Young-Soo Park, Masahide Yoshikawa, Hiroyuki Nakase. Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Aug; 166(?):115296. doi:
10.1016/j.biopha.2023.115296. [PMID: 37557011] - Tzu-Jen Kao, Chien-Liang Lin, Wen-Bin Yang, Hao-Yi Li, Tsung-I Hsu. Dysregulated lipid metabolism in TMZ-resistant glioblastoma: pathways, proteins, metabolites and therapeutic opportunities.
Lipids in health and disease.
2023 Aug; 22(1):114. doi:
10.1186/s12944-023-01881-5. [PMID: 37537607] - Moli Wu, Danyang Song, Hui Li, Nisar Ahmad, Hong Xu, Xiaobo Yang, Qian Wang, Xiaoxin Cheng, Sa Deng, Xiaohong Shu. Resveratrol Enhances Temozolomide Efficacy in Glioblastoma Cells through Downregulated MGMT and Negative Regulators-Related STAT3 Inactivation.
International journal of molecular sciences.
2023 May; 24(11):. doi:
10.3390/ijms24119453. [PMID: 37298405] - Wenqin Lian, Xiao Zheng. Identification and validation of TME-related signatures to predict prognosis and response to anti-tumor therapies in skin cutaneous melanoma.
Functional & integrative genomics.
2023 May; 23(2):153. doi:
10.1007/s10142-023-01051-x. [PMID: 37160578] - Qiong Liang, Yanhang Zhuo, Xiaoran Wu, Shihao Zheng, Jie Zhuang, Kaiyu Wang, Sunhui Chen. Curcumin combining temozolomide formed localized nanogel for inhibition of postsurgical chemoresistant glioblastoma.
Nanomedicine (London, England).
2023 05; 18(12):907-921. doi:
10.2217/nnm-2023-0058. [PMID: 37466022] - Jen-Tsung Yang, I-Neng Lee, Cheng Huang, Hsiu-Chen Huang, Yu-Ping Wu, Zhi-Yong Chong, Jui-Chieh Chen. ADAM17 Confers Temozolomide Resistance in Human Glioblastoma Cells and miR-145 Regulates Its Expression.
International journal of molecular sciences.
2023 Apr; 24(9):. doi:
10.3390/ijms24097703. [PMID: 37175410] - Yi Sun, Xingdong Liu, Zhiqiang Wu, Xiefeng Wang, Yong Zhang, Wei Yan, Yongping You. SRSF4 Confers Temozolomide Resistance of Glioma via Accelerating Double Strand Break Repair.
Journal of molecular neuroscience : MN.
2023 Apr; ?(?):. doi:
10.1007/s12031-023-02115-0. [PMID: 37014544] - Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang. Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting.
Journal of liposome research.
2023 Mar; ?(?):1-15. doi:
10.1080/08982104.2023.2191718. [PMID: 36974836] - Munki Choo, Van-Hieu Mai, Han Sun Kim, Dong-Hwa Kim, Ja-Lok Ku, Sang Kook Lee, Chul-Kee Park, Yong Jin An, Sunghyouk Park. Involvement of cell shape and lipid metabolism in glioblastoma resistance to temozolomide.
Acta pharmacologica Sinica.
2023 Mar; 44(3):670-679. doi:
10.1038/s41401-022-00984-6. [PMID: 36100765] - Luana Roberta Michels, Flávia Nathiely Silveira Fachel, Roselena Silvestri Schuh, Juliana Hofstätter Azambuja, Priscila Oliveira de Souza, Nicolly Espindola Gelsleichter, Gabriela Spies Lenz, Fernanda Visioli, Elizandra Braganhol, Helder Ferreira Teixeira. Nasal administration of a temozolomide-loaded thermoresponsive nanoemulsion reduces tumor growth in a preclinical glioblastoma model.
Journal of controlled release : official journal of the Controlled Release Society.
2023 03; 355(?):343-357. doi:
10.1016/j.jconrel.2023.01.070. [PMID: 36731799] - Shiao Tong, Yu Hong, Yang Xu, Qian Sun, Liguo Ye, Jiayang Cai, Zhang Ye, Qianxue Chen, Daofeng Tian. TFR2 regulates ferroptosis and enhances temozolomide chemo-sensitization in gliomas.
Experimental cell research.
2023 03; 424(1):113474. doi:
10.1016/j.yexcr.2023.113474. [PMID: 36702193] - Jiefen Yang, Youfa Xu, Zhiqin Fu, Jianming Chen, Wei Fan, Xin Wu. Progress in research and development of temozolomide brain-targeted preparations: a review.
Journal of drug targeting.
2023 02; 31(2):119-133. doi:
10.1080/1061186x.2022.2119243. [PMID: 36039767] - Yuan Xie, Liqun He, Yanyu Zhang, Hua Huang, Fan Yang, Min Chao, Haiyan Cao, Jianhao Wang, Yaling Li, Lingxue Zhang, Lele Xin, Bing Xiao, Xinxin Shi, Xue Zhang, Jiefu Tang, Lene Uhrbom, Anna Dimberg, Liang Wang, Lei Zhang. Wnt Signaling Regulates MFSD2A-dependent Drug Delivery through Endothelial Transcytosis in Glioma.
Neuro-oncology.
2023 Jan; ?(?):. doi:
10.1093/neuonc/noac288. [PMID: 36591963] - Nerea Iturrioz-Rodríguez, Nicolas Sampron, Ander Matheu. Current advances in temozolomide encapsulation for the enhancement of glioblastoma treatment.
Theranostics.
2023; 13(9):2734-2756. doi:
10.7150/thno.82005. [PMID: 37284445] - Wenhui Jia, Hailong Tian, Jingwen Jiang, Li Zhou, Lei Li, Maochao Luo, Ning Ding, Edouard C Nice, Canhua Huang, Haiyuan Zhang. Brain-Targeted HFn-Cu-REGO Nanoplatform for Site-Specific Delivery and Manipulation of Autophagy and Cuproptosis in Glioblastoma.
Small (Weinheim an der Bergstrasse, Germany).
2023 01; 19(2):e2205354. doi:
10.1002/smll.202205354. [PMID: 36399643] - İlknur Sur Erdem. Impact of Ferroptosis Inducers on Chronic Radiation-exposed Survivor Glioblastoma Cells.
Anti-cancer agents in medicinal chemistry.
2023; 23(19):2154-2160. doi:
10.2174/1871520623666230825110346. [PMID: 37622695] - Yosif Almoshari, Haroon Iqbal, Anam Razzaq, Khalil Ali Ahmad, Muhammad Khalid Khan, Saad Saeed Alqahtani, Muhammad Hadi Sultan, Barkat Ali Khan. Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective Colon cancer therapy.
Drug delivery.
2022 Dec; 29(1):2633-2643. doi:
10.1080/10717544.2022.2108938. [PMID: 35942514] - Shu-Yuan Shuai, Shan-Shan Liu, Xiao-Jin Liu, Guo-Song Zhang, Qin Zheng, Peng-Fei Yue, Ming Yang, Peng-Yi Hu. Essential oil of Ligusticum chuanxiong Hort. Regulated P-gp protein and tight junction protein to change pharmacokinetic parameters of temozolomide in blood, brain and tumor.
Journal of ethnopharmacology.
2022 Nov; 298(?):115646. doi:
10.1016/j.jep.2022.115646. [PMID: 36031103] - Ai-Jung Tseng, Tsung-Hsi Tu, Wei-Jyun Hua, Hsin Yeh, Ching-Jung Chen, Zhi-Hu Lin, Wei-Hung Hsu, Ying-Lan Chen, Chuan-Chih Hsu, Tung-Yi Lin. GMI, Ganoderma microsporum protein, suppresses cell mobility and increases temozolomide sensitivity through induction of Slug degradation in glioblastoma multiforme cells.
International journal of biological macromolecules.
2022 Oct; 219(?):940-948. doi:
10.1016/j.ijbiomac.2022.08.024. [PMID: 35952817] - Dong-Yi Yang, Xue Cheng, Xing-Yao Bu, Zhao-Yue Yan, Ming-Qi Qu, Yue-Wu Zhao, Ling-Fei Kong, Yao-Wei Wang, Jian-Chao Luo. Granulocyte-macrophage colony stimulating factor enhances efficacy of nimustine rendezvousing with temozolomide plus irradiation in patients with glioblastoma.
Technology and health care : official journal of the European Society for Engineering and Medicine.
2022 Oct; ?(?):. doi:
10.3233/thc-220194. [PMID: 36314174] - Xiaodong Su, Yuan Xie, Junwen Zhang, Mingxin Li, Qing Zhang, Guishan Jin, Fusheng Liu. HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis.
Cell death & disease.
2022 10; 13(10):861. doi:
10.1038/s41419-022-05304-8. [PMID: 36209275] - Lihong Qin, Mao Huiwen, Jianguo Wang, Yuanyaun Wang, Salman A Khan, Ying Zhang, Hong Qiu, Longwei Jiang, Lingfeng He, Yan Zhang, Shaochang Jia. A novel polymerase β inhibitor from phage displayed peptide library augments the anti-tumour effects of temozolomide on colorectal cancer.
Journal of chemotherapy (Florence, Italy).
2022 Oct; 34(6):391-400. doi:
10.1080/1120009x.2021.2009987. [PMID: 34870566] - Reena Jatyan, Prabhjeet Singh, Deepak Kumar Sahel, Y G Karthik, Anupama Mittal, Deepak Chitkara. Polymeric and small molecule-conjugates of temozolomide as improved therapeutic agents for glioblastoma multiforme.
Journal of controlled release : official journal of the Controlled Release Society.
2022 10; 350(?):494-513. doi:
10.1016/j.jconrel.2022.08.024. [PMID: 35985493] - Kaiqiang Li, Bingyu Chen, Aibo Xu, Jinglan Shen, Kaixuan Li, Ke Hao, Rongrong Hao, Wei Yang, Wanli Jiang, Yongfa Zheng, Feihang Ge, Zhen Wang. TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells.
Redox biology.
2022 10; 56(?):102451. doi:
10.1016/j.redox.2022.102451. [PMID: 36067704] - Saurabh Mittal, Javed Ali, Sanjula Baboota. DoE Engineered Development and Validation of an RP-HPLC Method for Simultaneous Estimation of Temozolomide and Resveratrol in Nanostructured Lipid Carrier.
Journal of AOAC International.
2022 Sep; 105(5):1258-1267. doi:
10.1093/jaoacint/qsac045. [PMID: 35441690] - José Marcos Jiménez-Morales, Yanet Elisa Hernández-Cuenca, Ander Reyes-Abrahantes, Henry Ruiz-García, Francisco Barajas-Olmos, Humberto García-Ortiz, Lorena Orozco, Alfredo Quiñones-Hinojosa, Jesús Reyes-González, María Del Carmen Abrahantes-Pérez. MicroRNA delivery systems in glioma therapy and perspectives: A systematic review.
Journal of controlled release : official journal of the Controlled Release Society.
2022 09; 349(?):712-730. doi:
10.1016/j.jconrel.2022.07.027. [PMID: 35905783] - Sui Li, Xiaofang Xie, Fu Peng, Junrong Du, Cheng Peng. Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review).
International journal of oncology.
2022 Sep; 61(3):. doi:
10.3892/ijo.2022.5391. [PMID: 35796022] - Jin Luo, Rui Bai, Yunxiao Liu, Hong Bi, Xiangzhen Shi, Chongxiao Qu. Long non-coding RNA ATXN8OS promotes ferroptosis and inhibits the temozolomide-resistance of gliomas through the ADAR/GLS2 pathway.
Brain research bulletin.
2022 08; 186(?):27-37. doi:
10.1016/j.brainresbull.2022.04.005. [PMID: 35460867] - Xiuchao Geng, Yuhao Zhang, Xiaomeng Lin, Zhaomu Zeng, Jun Hu, Liangchao Hao, Jianglong Xu, Xinjuan Wang, Hong Wang, Qiang Li. Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma.
Cell death & disease.
2022 07; 13(7):596. doi:
10.1038/s41419-022-05056-5. [PMID: 35817771] - Federico Cucchiara, Giacomo Luci, Noemi Giannini, Filippo Sean Giorgi, Paola Orlandi, Marta Banchi, Antonello Di Paolo, Francesco Pasqualetti, Romano Danesi, Guido Bocci. Association of plasma levetiracetam concentration, MGMT methylation and sex with survival of chemoradiotherapy-treated glioblastoma patients.
Pharmacological research.
2022 07; 181(?):106290. doi:
10.1016/j.phrs.2022.106290. [PMID: 35680010] - Keke Zhang, Yihang Yang, Jianfeng Zhuang, Gengyin Guo, Xin Chao, Zhen Zhang. Intracranial dissemination of glioblastoma multiforme: a case report and literature review.
The Journal of international medical research.
2022 Jul; 50(7):3000605221112047. doi:
10.1177/03000605221112047. [PMID: 35854630] - Sarwar Beg, Sagar S Panda, Kamalinder K Singh. Chemometrics-assisted development of a validated LC method for simultaneous estimation of temozolomide and γ-linolenic acid: Greenness assessment and application to lipidic nanoparticles.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Jun; 1200(?):123261. doi:
10.1016/j.jchromb.2022.123261. [PMID: 35533423] - Hong-Chieh Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang, Ko-Ting Chen, Ya-Jui Lin, Hsiao-Wei Cheng, Chun-Hao Huang, Hsiang-Tsui Wang. Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines.
Neuromolecular medicine.
2022 06; 24(2):113-124. doi:
10.1007/s12017-021-08667-x. [PMID: 34075570] - Zheng Wang, Yuhong Zhou, Aoxiang Luo, Xing Heng, Jinqiu Liu, Huafu Wang, Weihua Chu. Lactobacillus salivarius CPU-01 Ameliorates Temozolomide-Induced Intestinal Mucositis by Modulating Gut Microbiota, Maintaining Intestinal Barrier, and Blocking Pro-inflammatory Cytokines.
Probiotics and antimicrobial proteins.
2022 May; ?(?):. doi:
10.1007/s12602-022-09955-z. [PMID: 35639268] - Daria Petrenko, Vladimir Chubarev, Nikita Syzrantsev, Nafeeza Ismail, Vadim Merkulov, Susanna Sologova, Ekaterina Grigorevskikh, Elena Smolyarchuk, Renad Alyautdin. Temozolomide Efficacy and Metabolism: The Implicit Relevance of Nanoscale Delivery Systems.
Molecules (Basel, Switzerland).
2022 May; 27(11):. doi:
10.3390/molecules27113507. [PMID: 35684445] - Daozhou Liu, Ying Cheng, Sai Qiao, Miao Liu, Qifeng Ji, Bang-Le Zhang, Qi-Bing Mei, Siyuan Zhou. Nano-Codelivery of Temozolomide and siPD-L1 to Reprogram the Drug-Resistant and Immunosuppressive Microenvironment in Orthotopic Glioblastoma.
ACS nano.
2022 05; 16(5):7409-7427. doi:
10.1021/acsnano.1c09794. [PMID: 35549164] - Sören Büsker, Walter Jäger, Stefan Poschner, Lisa Mayr, Valentin Al Jalali, Johannes Gojo, Amedeo A Azizi, Sami Ullah, Muhammad Bilal, Lobna El Tabei, Uwe Fuhr, Andreas Peyrl. Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors.
Cancer chemotherapy and pharmacology.
2022 05; 89(5):617-627. doi:
10.1007/s00280-022-04424-4. [PMID: 35355137] - Li Zhou, Xuming Huang, Yu Zhang, Jihui Wang, Haiyan Li, Haiwei Huang. PSMG3-AS1 enhances glioma resistance to temozolomide via stabilizing c-Myc in the nucleus.
Brain and behavior.
2022 05; 12(5):e2531. doi:
10.1002/brb3.2531. [PMID: 35380741] - Tingting Ye, Rongrong Chen, Yu Zhou, Juan Zhang, Zhongqin Zhang, Hui Wei, Yan Xu, Yulan Wang, Yinlan Zhang. Salvianolic acid A (Sal A) suppresses malignant progression of glioma and enhances temozolomide (TMZ) sensitivity via repressing transgelin-2 (TAGLN2) mediated phosphatidylinositol-3-kinase (PI3K) / protein kinase B (Akt) pathway.
Bioengineered.
2022 05; 13(5):11646-11655. doi:
10.1080/21655979.2022.2070963. [PMID: 35505656] - Xiaoliang Yao, Dayun Yan, Li Lin, Jonathan H Sherman, Katherine B Peters, Stephen T Keir, Michael Keidar. Cold Plasma Discharge Tube Enhances Antitumoral Efficacy of Temozolomide.
ACS applied bio materials.
2022 04; 5(4):1610-1623. doi:
10.1021/acsabm.2c00018. [PMID: 35324138] - Xiaosong Wang, Xiaojun Yu, Haoran Xu, Kang Wei, Shanxi Wang, Yingguang Wang, Junfei Han. Serum-derived extracellular vesicles facilitate temozolomide resistance in glioblastoma through a HOTAIR-dependent mechanism.
Cell death & disease.
2022 04; 13(4):344. doi:
10.1038/s41419-022-04699-8. [PMID: 35418162] - Yawen Yu, Aiping Wang, Siqi Wang, Yuchen Sun, Liuxiang Chu, Lin Zhou, Xiaoyue Yang, Xincui Liu, Chunjie Sha, Kaoxiang Sun, Lixiao Xu. Efficacy of Temozolomide-Conjugated Gold Nanoparticle Photothermal Therapy of Drug-Resistant Glioblastoma and Its Mechanism Study.
Molecular pharmaceutics.
2022 04; 19(4):1219-1229. doi:
10.1021/acs.molpharmaceut.2c00083. [PMID: 35262365] - Danielle M Burgenske, Surabhi Talele, Jenny L Pokorny, Ann C Mladek, Katrina K Bakken, Brett L Carlson, Mark A Schroeder, Lihong He, Zeng Hu, Gautham Gampa, Matthew L Kosel, Paul A Decker, Gaspar J Kitange, Anne Schmitt-Hoffmann, Felix Bachmann, Rachael A Vaubel, Jeanette E Eckel-Passow, Caterina Giannini, Paul McSheehy, Heidi A Lane, William F Elmquist, Jann N Sarkaria. Preclinical modeling in glioblastoma patient-derived xenograft (GBM PDX) xenografts to guide clinical development of lisavanbulin-a novel tumor checkpoint controller targeting microtubules.
Neuro-oncology.
2022 03; 24(3):384-395. doi:
10.1093/neuonc/noab162. [PMID: 34232318] - Albert Maimó-Barceló, Lucía Martín-Saiz, José A Fernández, Karim Pérez-Romero, Santiago Garfias-Arjona, Mónica Lara-Almúnia, Javier Piérola-Lopetegui, Joan Bestard-Escalas, Gwendolyn Barceló-Coblijn. Polyunsaturated Fatty Acid-Enriched Lipid Fingerprint of Glioblastoma Proliferative Regions Is Differentially Regulated According to Glioblastoma Molecular Subtype.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23062949. [PMID: 35328369] - Yu-Ye Xue, Yun-Yang Lu, Guang-Qiang Sun, Fei Fang, Yu-Qiang Ji, Hai-Feng Tang, Peng-Cheng Qiu, Guang Cheng. CN-3 increases TMZ sensitivity and induces ROS-dependent apoptosis and autophagy in TMZ-resistance glioblastoma.
Journal of biochemical and molecular toxicology.
2022 Mar; 36(3):e22973. doi:
10.1002/jbt.22973. [PMID: 34967073] - Rui Lin, Yimin Xu, Sidi Xie, Yunxiao Zhang, Hai Wang, Guo-Zhong Yi, Guanglong Huang, Bowen Ni, Haimin Song, Ziyu Wang, Song-Tao Qi, Yawei Liu. Recycling of SLC38A1 to the plasma membrane by DSCR3 promotes acquired temozolomide resistance in glioblastoma.
Journal of neuro-oncology.
2022 Mar; 157(1):15-26. doi:
10.1007/s11060-022-03964-2. [PMID: 35187626] - Joanna Stalinska, Cecilia Vittori, Charles H Ingraham Iv, Sean C Carson, Karlie Plaisance-Bonstaff, Adam Lassak, Celeste Faia, Susan B Colley, Francesca Peruzzi, Krzysztof Reiss, Branko S Jursic. Anti-glioblastoma effects of phenolic variants of benzoylphenoxyacetamide (BPA) with high potential for blood brain barrier penetration.
Scientific reports.
2022 03; 12(1):3384. doi:
10.1038/s41598-022-07247-8. [PMID: 35232976] - Samantha L Gerlach, Rachael A Dunlop, James S Metcalf, Sandra A Banack, Paul Alan Cox. Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide.
Journal of natural products.
2022 01; 85(1):34-46. doi:
10.1021/acs.jnatprod.1c00595. [PMID: 35044783] - Huali Fan, Xiaofang Xie, Xi Kuang, Junrong Du, Fu Peng. MicroRNAs, Key Regulators in Glioma Progression as Potential Therapeutic Targets for Chinese Medicine.
The American journal of Chinese medicine.
2022; 50(7):1799-1825. doi:
10.1142/s0192415x22500768. [PMID: 36121713] - Xu Min, Xiang Dingchao, Zhu Xun, Wang Cunzu. Preliminary Study on Relationship Between Temozolomide Chemotherapy-Resistant Cells and Stem Cells in Gliomas.
Turkish neurosurgery.
2022; 32(3):357-363. doi:
10.5137/1019-5149.jtn.26278-19.2. [PMID: 35615767] - Ping Cui, Fanfan Chen, Guoxu Ma, Wenlan Liu, Lei Chen, Sicen Wang, Weiping Li, Zongyang Li, Guodong Huang. Oxyphyllanene B overcomes temozolomide resistance in glioblastoma: Structure-activity relationship and mitochondria-associated ER membrane dysfunction.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jan; 94(?):153816. doi:
10.1016/j.phymed.2021.153816. [PMID: 34752969] - Peng Xu, Fei-Hang Ge, Wen-Xin Li, Zhen Xu, Xue-Li Wang, Jing-Lan Shen, Ai-Bo Xu, Rong-Rong Hao. MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma.
Analytical cellular pathology (Amsterdam).
2022; 2022(?):2843990. doi:
10.1155/2022/2843990. [PMID: 35942174] - Puja Sandbhor, Jayant Goda, Bhabani Mohanty, Pradip Chaudhari, Shilpee Dutt, Rinti Banerjee. Non-invasive transferrin targeted nanovesicles sensitize resistant glioblastoma multiforme tumors and improve survival in orthotopic mouse models.
Nanoscale.
2021 Dec; 14(1):108-126. doi:
10.1039/d1nr05460k. [PMID: 34897360] - Kuo-Chen Wei, Peng-Wei Hsu, Hong-Chieh Tsai, Ya-Jui Lin, Ko-Ting Chen, Cheng-Hong Toh, Hui-Lin Huang, Shih-Ming Jung, Chen-Kan Tseng, Yu-Xiong Ke. Safety and tolerability of asunercept plus standard radiotherapy/temozolomide in Asian patients with newly-diagnosed glioblastoma: a phase I study.
Scientific reports.
2021 12; 11(1):24067. doi:
10.1038/s41598-021-02527-1. [PMID: 34911992] - Dina O Helal, Nadia Rouatbi, Shunping Han, Julie Tzu-Wen Wang, Adam A Walters, Mona M A Abdel-Mottaleb, Amany O Kamel, Ahmed-Shawky Geneidi, Gehanne A S Awad, Khuloud T Al-Jamal. A natural protein based platform for the delivery of Temozolomide acid to glioma cells.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2021 Dec; 169(?):297-308. doi:
10.1016/j.ejpb.2021.10.007. [PMID: 34678408] - Qixin Chen, Mingang Hao, Lei Wang, Linsen Li, Yang Chen, Xintian Shao, Zhiqi Tian, Richard A Pfuetzner, Qing Zhong, Axel T Brunger, Jun-Lin Guan, Jiajie Diao. Prefused lysosomes cluster on autophagosomes regulated by VAMP8.
Cell death & disease.
2021 10; 12(10):939. doi:
10.1038/s41419-021-04243-0. [PMID: 34645799] - Yawen Yu, Liangxiao Wang, Junping Han, Aiping Wang, Liuxiang Chu, Xinran Xi, Ronglin Kan, Chunjie Sha, Kaoxiang Sun. Synthesis and Characterization of a Series of Temozolomide Esters and Its Anti-glioma Study.
Journal of pharmaceutical sciences.
2021 10; 110(10):3431-3438. doi:
10.1016/j.xphs.2021.06.025. [PMID: 34147518] - Anubha Shukla, Srishti Srivastava, Jayant Darokar, Ritu Kulshreshtha. HIF1α and p53 Regulated MED30, a Mediator Complex Subunit, is Involved in Regulation of Glioblastoma Pathogenesis and Temozolomide Resistance.
Cellular and molecular neurobiology.
2021 Oct; 41(7):1521-1535. doi:
10.1007/s10571-020-00920-4. [PMID: 32705436] - Louis Larrouquère, Sylvie Berthier, Benoit Chovelon, Catherine Garrel, Véronique Vacchina, Hugues Paucot, Jean Boutonnat, Patrice Faure, Florence Hazane-Puch. Preclinical Evaluation of Sodium Selenite in Mice: Toxicological and Tumor Regression Studies after Striatum Implantation of Human Glioblastoma Stem Cells.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910646. [PMID: 34638987] - Rossella Rotondo, Sara Ragucci, Salvatore Castaldo, Maria Antonietta Oliva, Nicola Landi, Paolo V Pedone, Antonietta Arcella, Antimo Di Maro. Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells.
Toxins.
2021 09; 13(10):. doi:
10.3390/toxins13100684. [PMID: 34678977] - Tejashree Waghule, Ranendra Narayan Saha, Gautam Singhvi. UV spectroscopic method for estimation of temozolomide: Application in stability studies in simulated plasma pH, degradation rate kinetics, formulation design, and selection of dissolution media.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Sep; 258(?):119848. doi:
10.1016/j.saa.2021.119848. [PMID: 33933945] - Qingxin Song, Shanxin Peng, Zhiqing Sun, Xueyuan Heng, Xiaosong Zhu. Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells.
Yonsei medical journal.
2021 Sep; 62(9):843-849. doi:
10.3349/ymj.2021.62.9.843. [PMID: 34427071] - Bin Li, Yi Kuang, Yang Yi, Xue Qiao, Lei Liang, Min Ye. Chemical modifications of ergostane-type triterpenoids from Antrodia camphorata and their cytotoxic activities.
Bioorganic & medicinal chemistry letters.
2021 07; 43(?):128066. doi:
10.1016/j.bmcl.2021.128066. [PMID: 33915258] - Ryosuke Okamura, David E Piccioni, Amélie Boichard, Suzanna Lee, Rebecca E Jimenez, Jason K Sicklick, Shumei Kato, Razelle Kurzrock. High prevalence of clonal hematopoiesis-type genomic abnormalities in cell-free DNA in invasive gliomas after treatment.
International journal of cancer.
2021 06; 148(11):2839-2847. doi:
10.1002/ijc.33481. [PMID: 33497479] - Weimin Li, Qingqin Ma, Quan Liu, Peng Yan, Xin Wang, Xiaojun Jia. Circ-VPS18 Knockdown Enhances TMZ Sensitivity and Inhibits Glioma Progression by MiR-370/RUNX1 Axis.
Journal of molecular neuroscience : MN.
2021 Jun; 71(6):1234-1244. doi:
10.1007/s12031-020-01749-8. [PMID: 33188501] - Cédric Mahiat, Antoine Capes, Thierry Duprez, Nicolas Whenham, Lionel Duck, Laura Labriola. Central diabetes insipidus induced by temozolomide: A report of two cases.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2021 Jun; 27(4):1040-1045. doi:
10.1177/1078155220961551. [PMID: 32990192] - Tejashree Waghule, Vamshi Krishna Rapalli, Gautam Singhvi, Srividya Gorantla, Archana Khosa, Sunil Kumar Dubey, Ranendra Narayan Saha. Design of temozolomide-loaded proliposomes and lipid crystal nanoparticles with industrial feasible approaches: comparative assessment of drug loading, entrapment efficiency, and stability at plasma pH.
Journal of liposome research.
2021 Jun; 31(2):158-168. doi:
10.1080/08982104.2020.1748648. [PMID: 32290733] - Aditya Kumar Gupta, Mohanraj Ramachandran, Jagdish Prasad Meena, Tanima Dwivedi, Urvashi Singh, Ritu Gupta, Rachna Seth. Robust and sustained antibody response to SARS-CoV-2 in a child pre and post autologous hematopoietic stem cell transplant.
Pediatric blood & cancer.
2021 05; 68(5):e28848. doi:
10.1002/pbc.28848. [PMID: 33351985] - David O Kamson, Stuart A Grossman. The Role of Temozolomide in Patients With Newly Diagnosed Wild-Type IDH, Unmethylated MGMTp Glioblastoma During the COVID-19 Pandemic.
JAMA oncology.
2021 05; 7(5):675-676. doi:
10.1001/jamaoncol.2020.6732. [PMID: 33475680] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Murali Munisamy, Srinivasan Munisamy, Julka Pramod Kumar, Anmi Jose, Levin Thomas, Gayathri Baburaj, Vivekanandhan Subbiah. Pharmacogenetics of ATP binding cassette transporter MDR1(1236C>T) gene polymorphism with glioma patients receiving Temozolomide-based chemoradiation therapy in Indian population.
The pharmacogenomics journal.
2021 04; 21(2):262-272. doi:
10.1038/s41397-021-00206-y. [PMID: 33589792] - Zhi Dai, Hui Liu, Bei Wang, Dong Yang, Yan-Yan Zhu, Huan Yan, Pei-Feng Zhu, Ya-Ping Liu, Hui-Cheng Chen, Yun-Li Zhao, Li-Xing Zhao, Xu-Dong Zhao, Hai-Yang Liu, Xiao-Dong Luo. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.
European journal of medicinal chemistry.
2021 Jan; 210(?):113068. doi:
10.1016/j.ejmech.2020.113068. [PMID: 33310292] - Qiang Yang, Yanghao Zhou, Jin Chen, Ning Huang, Zhigang Wang, Yuan Cheng. Gene Therapy for Drug-Resistant Glioblastoma via Lipid-Polymer Hybrid Nanoparticles Combined with Focused Ultrasound.
International journal of nanomedicine.
2021; 16(?):185-199. doi:
10.2147/ijn.s286221. [PMID: 33447034] - Linlin Sui, Yuzhen Li, Zhiying Xu, Xuejun Shen. Therapeutic effect of thalidomide combined with temozolomide and three-dimensional conformal radiotherapy for patients with high-grade gliomas after operation.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 Jan; 26(1):2608-2615. doi:
. [PMID: 33721435] - Kai-Fu Chang, Jinghua Tsai Chang, Xiao-Fan Huang, Ya-Chih Huang, Chia-Yu Li, Jun-Cheng Weng, Chih-Yen Hsiao, Hui-Ju Hsu, Nu-Man Tsai. Cedrus atlantica Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: In Vitro and In Vivo Studies.
International journal of medical sciences.
2021; 18(11):2417-2430. doi:
10.7150/ijms.54468. [PMID: 33967620] - Raúl Ortiz, Gloria Perazzoli, Laura Cabeza, Cristina Jiménez-Luna, Raquel Luque, Jose Prados, Consolación Melguizo. Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications.
Current neuropharmacology.
2021; 19(4):513-537. doi:
10.2174/1570159x18666200626204005. [PMID: 32589560] - Akshay Athavale, Jack Morris, Meg Jardine, Martin Gallagher, Shaundeep Sen, Angus Ritchie, Amanda Y Wang. Acute interstitial nephritis and nephrogenic diabetes insipidus following treatment with sulfamethoxazole-trimethoprim and temozolomide.
Nephrology (Carlton, Vic.).
2021 Jan; 26(1):12-14. doi:
10.1111/nep.13783. [PMID: 32935422] - Gilbert Aaron Lee, Wan-Li Lin, Duen-Pang Kuo, Yi-Tien Li, Yu-Wei Chang, Yung-Chieh Chen, Shiu-Wen Huang, Justin Bo-Kai Hsu, Cheng-Yu Chen. Detection of PD-L1 Expression in Temozolomide-Resistant Glioblastoma by Using PD-L1 Antibodies Conjugated with Lipid‑Coated Superparamagnetic Iron Oxide.
International journal of nanomedicine.
2021; 16(?):5233-5246. doi:
10.2147/ijn.s310464. [PMID: 34366665] - Jinli Li, Weiwei Huang, Meina Piao, Zhengcao Liu, Shengjun Ji, Jing Xue, Xin Zhu. Efficacy of bevacizumab combined with temozolomide dose-dense regimen on recurrent glioma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 Jan; 26(1):145-151. doi:
NULL. [PMID: 33721445] - Catherine Hanna, Kathreena M Kurian, Karin Williams, Colin Watts, Alan Jackson, Ross Carruthers, Karen Strathdee, Garth Cruickshank, Laurence Dunn, Sara Erridge, Lisa Godfrey, Sarah Jefferies, Catherine McBain, Rebecca Sleigh, Alex McCormick, Marc Pittman, Sarah Halford, Anthony J Chalmers. Pharmacokinetics, safety, and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial.
Neuro-oncology.
2020 12; 22(12):1840-1850. doi:
10.1093/neuonc/noaa104. [PMID: 32347934] - Man Xu, Guangmeng Li, Haoxiang Zhang, Xiaoming Chen, Yi Li, Qianming Yao, Maobin Xie. Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect.
Drug delivery.
2020 Dec; 27(1):983-995. doi:
10.1080/10717544.2020.1785581. [PMID: 32611218]
