Cholylsarcosine (BioDeep_00000184802)
human metabolite blood metabolite
代谢物信息卡片
化学式: C27H45NO6 (479.324671)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 88.89%
分子结构信息
SMILES: CC(CCC(=O)N(C)CC(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
InChI: InChI=1S/C27H45NO6/c1-15(5-8-23(32)28(4)14-24(33)34)18-6-7-19-25-20(13-22(31)27(18,19)3)26(2)10-9-17(29)11-16(26)12-21(25)30/h15-22,25,29-31H,5-14H2,1-4H3,(H,33,34)
描述信息
同义名列表
5 个代谢物同义名
2-[methyl-[4-(3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl]amino]acetic acid; 2-(N-methyl-4-{5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl}pentanamido)acetic acid; (N-methyl-4-{5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl}pentanamido)acetic acid; 2-(N-Methyl-4-{5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0,.0,]heptadecan-14-yl}pentanamido)acetate; Cholylsarcosine
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kim Frisch, Steen Jakobsen, Michael Sørensen, Ole Lajord Munk, Aage K O Alstrup, Peter Ott, Alan F Hofmann, Susanne Keiding. [N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: radiosynthesis and proof-of-concept studies in pigs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 May; 53(5):772-8. doi:
10.2967/jnumed.111.098731. [PMID: 22454486] - Johannes Parmentier, Felix J Hartmann, Gert Fricker. In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2010 Nov; 76(3):394-403. doi:
10.1016/j.ejpb.2010.09.002. [PMID: 20849953] - Th Fürst, C Bott, J Stein, J B Dressman. Enteric-coated cholylsarcosine microgranules for the treatment of short bowel syndrome.
The Journal of pharmacy and pharmacology.
2005 Jan; 57(1):53-60. doi:
10.1211/0022357055155. [PMID: 15638993] - Michael Emmett, Michael J Guirl, Carol A Santa Ana, Jack L Porter, Sidney Neimark, Alan F Hofmann, John S Fordtran. Conjugated bile acid replacement therapy reduces urinary oxalate excretion in short bowel syndrome.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2003 Jan; 41(1):230-7. doi:
10.1053/ajkd.2003.50012. [PMID: 12500242] - S Heydorn, P B Jeppesen, P B Mortensen. Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome.
Scandinavian journal of gastroenterology.
1999 Aug; 34(8):818-23. doi:
10.1080/003655299750025769. [PMID: 10499484] - C Gruy-Kapral, K H Little, J S Fordtran, T L Meziere, L R Hagey, A F Hofmann. Conjugated bile acid replacement therapy for short-bowel syndrome.
Gastroenterology.
1999 Jan; 116(1):15-21. doi:
10.1016/s0016-5085(99)70223-4. [PMID: 9869597] - P Ricci, A F Hofmann, L R Hagey, R A Jorgensen, E Rolland Dickson, K D Lindor. Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis.
Digestive diseases and sciences.
1998 Jun; 43(6):1292-5. doi:
10.1023/a:1018868126743. [PMID: 9635620] - A Schmassmann, H F Fehr, J Locher, J Lillienau, C D Schteingart, S S Rossi, A F Hofmann. Cholylsarcosine, a new bile acid analogue: metabolism and effect on biliary secretion in humans.
Gastroenterology.
1993 Apr; 104(4):1171-81. doi:
10.1016/0016-5085(93)90289-o. [PMID: 7681796] - D M Heuman, Z R Vlahcevic, W M Pandak, P B Hylemon, Y S Kim, J Lillienau, A F Hofmann. Effect of cholylsarcosine on hepatic cholesterol and bile acid synthesis and bile secretion in rats.
Gastroenterology.
1992 Nov; 103(5):1641-8. doi:
10.1016/0016-5085(92)91190-f. [PMID: 1385253] - A Schmassmann, M A Angellotti, H T Ton-Nu, C D Schteingart, S N Marcus, S S Rossi, A F Hofmann. Transport, metabolism, and effect of chronic feeding of cholylsarcosine, a conjugated bile acid resistant to deconjugation and dehydroxylation.
Gastroenterology.
1990 Jan; 98(1):163-74. doi:
10.1016/0016-5085(90)91306-q. [PMID: 1688373]