N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide (BioDeep_00000184729)

   

human metabolite blood metabolite


代谢物信息卡片


N-(4-(4-amino-2-Ethyl-1H-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide

化学式: C17H23N5O2S (361.1572378)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=NC2=C(N1CCCCNS(=O)(=O)C)C3=CC=CC=C3N=C2N
InChI: InChI=1S/C17H23N5O2S/c1-3-14-21-15-16(12-8-4-5-9-13(12)20-17(15)18)22(14)11-7-6-10-19-25(2,23)24/h4-5,8-9,19H,3,6-7,10-11H2,1-2H3,(H2,18,20)

描述信息

C308 - Immunotherapeutic Agent > C2139 - Immunostimulant > C177174 - Toll-like Receptor Agonist

同义名列表

7 个代谢物同义名

N-(4-(4-amino-2-Ethyl-1H-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide; N-(4-{4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl}butyl)methanesulfonamide; N-(4-(4-amino-2-Ethyl-1H-imidazo(4,5C)quinolin-1-yl)butyl)methanesulfonamide; N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide; N-(4-{4-amino-2-ethylimidazo[4,5-c]quinolin-1-yl}butyl)methanesulfonamide; Toll-like receptor 7 agonist 852a; 852a Compound



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hannah Perkins, Tansi Khodai, Houria Mechiche, Peter Colman, Frances Burden, Carl Laxton, Nigel Horscroft, Tom Corey, Deborah Rodrigues, Jaiessh Rawal, Jonathan Heyen, Mark Fidock, Mike Westby, Helen Bright. Therapy with TLR7 agonists induces lymphopenia: correlating pharmacology to mechanism in a mouse model. Journal of clinical immunology. 2012 Oct; 32(5):1082-92. doi: 10.1007/s10875-012-9687-y. [PMID: 22476912]
  • Melissa A Geller, Sarah Cooley, Peter A Argenta, Levi S Downs, Linda F Carson, Patricia L Judson, Rahel Ghebre, Brenda Weigel, Angela Panoskaltsis-Mortari, Julie Curtsinger, Jeffrey S Miller. Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers. Cancer immunology, immunotherapy : CII. 2010 Dec; 59(12):1877-1884. doi: 10.1007/s00262-010-0914-1. [PMID: 20820775]
  • Jeffrey A Martinson, Carlos J Montoya, Xiomara Usuga, Rollie Ronquillo, Alan L Landay, Seema N Desai. Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation. Antimicrobial agents and chemotherapy. 2010 Feb; 54(2):871-81. doi: 10.1128/aac.01246-09. [PMID: 19949061]
  • Calvin Astry, Woubalem Birmachu, Lester I Harrison, Tze-Chiang Meng. Cutaneous pharmacodynamics of a toll-like receptor 7 agonist, 852A, in humans. Journal of clinical pharmacology. 2008 Jun; 48(6):755-62. doi: 10.1177/0091270008314466. [PMID: 18401016]
  • Reinhard Dummer, Axel Hauschild, Juergen C Becker, Jean-Jacques Grob, Dirk Schadendorf, Veronica Tebbs, Jeannine Skalsky, Katharina C Kaehler, Stephanie Moosbauer, Ruth Clark, Tze-Chiang Meng, Mirjana Urosevic. An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 Feb; 14(3):856-64. doi: 10.1158/1078-0432.ccr-07-1938. [PMID: 18245549]
  • Lester I Harrison, Calvin Astry, Sandeep Kumar, Carla Yunis. Pharmacokinetics of 852A, an imidazoquinoline Toll-like receptor 7-specific agonist, following intravenous, subcutaneous, and oral administrations in humans. Journal of clinical pharmacology. 2007 Aug; 47(8):962-9. doi: 10.1177/0091270007303766. [PMID: 17660481]