Cloxazolam, (R)- (BioDeep_00000184675)

   

human metabolite blood metabolite


代谢物信息卡片


13-chloro-2-(2-chlorophenyl)-3-oxa-6,9-diazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),11,13-trien-8-one

化学式: C17H14Cl2N2O2 (348.0432284)
中文名称: 氯赛唑仑
谱图信息: 最多检出来源 Mus musculus(blood) 83.33%

分子结构信息

SMILES: C1COC2(N1CC(=O)NC3=C2C=C(C=C3)Cl)C4=CC=CC=C4Cl
InChI: InChI=1S/C17H14Cl2N2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)

描述信息

N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

9 个代谢物同义名

13-chloro-2-(2-chlorophenyl)-3-oxa-6,9-diazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),11,13-trien-8-one; 10-chloro-11b-(2-Chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo(6,7)-1,4-diazepino(5,4-b)oxazol-6-one; 10-chloro-11b-(2-Chlorophenyl)-2,3,7,11b(5H)-tetrahydro-oxazolo(3,2-D)(1,4)benzodiazepine-6-one; Former cas registry number OF cloxazolam; Cloxazolam, (R)-; cloxazolam; Tolestan; Olcadil; Sepazon



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Maarten Degreef, Lore Vits, Eleanor M Berry, Kristof E K Maudens, Alexander L N van Nuijs. Quantification of 54 Benzodiazepines and Z-Drugs, Including 20 Designer Ones, in Plasma. Journal of analytical toxicology. 2021 Feb; 45(2):141-153. doi: 10.1093/jat/bkaa059. [PMID: 32507898]
  • Diogo Oliveira-Silva, Celso H Oliveira, Gustavo D Mendes, Paulo Alexandre R Galvinas, Rafael E Barrientos-Astigarraga, Gilberto De Nucci. Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study. Biomedical chromatography : BMC. 2009 Dec; 23(12):1266-75. doi: 10.1002/bmc.1249. [PMID: 19488979]
  • Masatoshi Ito, Tomoko Miyajima, Tatsuya Fujii, Takehiko Okuno. Cloxazolam treatment for patients with intractable epilepsy. Pediatric neurology. 2004 Feb; 30(2):111-4. doi: 10.1016/j.pediatrneurol.2003.07.004. [PMID: 14984903]
  • F J Rodríguez, R M Jiménez, R M Alonso. Separation and determination of aminohalogenbenzophenones by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1992 Jul; 578(1):146-51. doi: 10.1016/0378-4347(92)80238-l. [PMID: 1400781]
  • B Brisse, P Tetsch, A Toye, E Schwill, F Bender. Effects of cloxazolam and pindolol on the sympathetic and adrenal stress reaction during oral surgery in man. Arzneimittel-Forschung. 1981; 31(11):1958-62. doi: NULL. [PMID: 6119097]
  • H Murata, K Kougo, A Yasumura, E Nakajma, H Shindo. Metabolism of cloxazolam I. Distribution, excretion and biotransformation in rats and mice. Chemical & pharmaceutical bulletin. 1973 Feb; 21(2):404-14. doi: 10.1248/cpb.21.404. [PMID: 4753311]