Tyrphostin 47 (BioDeep_00000184644)
human metabolite blood metabolite
代谢物信息卡片
2-Cyano-3-(3,4-dihydroxyphenyl)prop-2-enimidothioate
化学式: C10H8N2O2S (220.0306468)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 8.33%
分子结构信息
SMILES: NC(=S)C(=CC1=CC(O)=C(O)C=C1)C#N
InChI: InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Neuroscience.
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British journal of cancer.
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1996 Apr; 1(?):a25-33. doi:
10.2741/a102. [PMID: 9159191] - P O Kwiterovich, M Motevalli. Inhibition of protein tyrosine kinase alters the effect of serum basic protein I on triacylglycerols and cholesterol differently in normal and hyperapoB fibroblasts.
Arteriosclerosis, thrombosis, and vascular biology.
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Experimental cell research.
1995 May; 218(1):223-32. doi:
10.1006/excr.1995.1150. [PMID: 7737361] - N S Chang. Transforming growth factor-beta 1 induction of novel extracellular matrix proteins that trigger resistance to tumor necrosis factor cytotoxicity in murine L929 fibroblasts.
The Journal of biological chemistry.
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Kidney international.
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British journal of pharmacology.
1995 Feb; 114(4):872-80. doi:
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Cancer chemotherapy and pharmacology.
1995; 36(4):316-24. doi:
10.1007/bf00689049. [PMID: 7628051] - J L Bailey, B T Storey. Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate.
Molecular reproduction and development.
1994 Nov; 39(3):297-308. doi:
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Journal of biochemical toxicology.
1994 Oct; 9(5):249-59. doi:
10.1002/jbt.2570090505. [PMID: 7853360] - K Miyaji, E Tani, H Shindo, A Nakano, T Tokunaga. Effect of tyrphostin on cell growth and tyrosine kinase activity of epidermal growth factor receptor in human gliomas.
Journal of neurosurgery.
1994 Sep; 81(3):411-9. doi:
10.3171/jns.1994.81.3.0411. [PMID: 8057149] - A Simm, V Hoppe, A Gazit, J Hoppe. Platelet-derived growth factor isoforms prevent cell death during starvation of AKR-2B fibroblasts.
Journal of cellular physiology.
1994 Aug; 160(2):295-302. doi:
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Journal of cell science.
1994 Jul; 107 ( Pt 7)(?):1825-32. doi:
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Cellular and molecular biology (Noisy-le-Grand, France).
1994 Jul; 40(5):687-93. doi:
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Molecular and cellular biology.
1994 May; 14(5):3186-96. doi:
10.1128/mcb.14.5.3186-3196.1994. [PMID: 8164674] - R J Fallon, M Danaher, R L Saylors, A Saxena. Defective asialoglycoprotein receptor endocytosis mediated by tyrosine kinase inhibitors. Requirement for a tyrosine in the receptor internalization signal.
The Journal of biological chemistry.
1994 Apr; 269(15):11011-7. doi:
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American journal of hypertension.
1994 Apr; 7(4 Pt 1):351-6. doi:
10.1093/ajh/7.4.351. [PMID: 8031551] - J Gillespie, J F Dye, M Schachter, P J Guillou. Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors.
British journal of cancer.
1993 Dec; 68(6):1122-6. doi:
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Anticancer research.
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Science (New York, N.Y.).
1993 Sep; 261(5127):1442-5. doi:
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Experimental cell research.
1993 Mar; 205(1):159-64. doi:
10.1006/excr.1993.1070. [PMID: 8095903] - G Peterson, S Barnes. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation.
The Prostate.
1993; 22(4):335-45. doi:
10.1002/pros.2990220408. [PMID: 8497428] - L Leyton, P LeGuen, D Bunch, P M Saling. Regulation of mouse gamete interaction by a sperm tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America.
1992 Dec; 89(24):11692-5. doi:
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Journal of cellular physiology.
1992 Aug; 152(2):302-9. doi:
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Developmental biology.
1992 Jan; 149(1):123-33. doi:
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The Journal of biological chemistry.
1991 Nov; 266(33):22564-8. doi:
10.1016/s0021-9258(18)54609-3. [PMID: 1834674] - R M Lyall, A Zilberstein, A Gazit, C Gilon, A Levitzki, J Schlessinger. Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation.
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