Tulathromycin A (BioDeep_00000184620)
human metabolite blood metabolite
代谢物信息卡片
11-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-({5-hydroxy-4-methoxy-4,6-dimethyl-5-[(propylamino)methyl]oxan-2-yl}oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
化学式: C41H79N3O12 (805.5663)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 83.33%
分子结构信息
SMILES: CCCNCC1(C(OC(CC1(C)OC)OC2C(C(C(CC(CNC(C(C(C(OC(=O)C2C)CC)(C)O)O)C)C)(C)O)OC3C(C(CC(O3)C)N(C)C)O)C)C)O
InChI: InChI=1S/C41H79N3O12/c1-15-17-42-22-41(50)28(8)53-31(20-39(41,10)51-14)55-33-25(5)35(56-37-32(45)29(44(12)13)18-24(4)52-37)38(9,48)19-23(3)21-43-27(7)34(46)40(11,49)30(16-2)54-36(47)26(33)6/h23-35,37,42-43,45-46,48-50H,15-22H2,1-14H3
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
4 个代谢物同义名
11-{[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-({5-hydroxy-4-methoxy-4,6-dimethyl-5-[(propylamino)methyl]oxan-2-yl}oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one; 11-[4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one; Tulathromycin A; Tulathromycin
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- JeongWoo Kang, HyunYoung Chae, SungHoon Jeong, Rokeya Pervin, Md Akil Hossain. Evaluation of Biological Equivalence for Generic Tulathromycin Injections in Cattle.
International journal of molecular sciences.
2023 Nov; 24(22):. doi:
10.3390/ijms242216262. [PMID: 38003452] - Juan E Romano, Andrea Barbarossa, Giampiero Pagliuca, Graciela B Villadóniga, Teresa Gazzotti, Beatrice Mislei, Elisa Zironi, Gaetano Mari. Pharmacokinetics of tulathromycin on plasma and semen of beef bulls.
Theriogenology.
2022 Jan; 177(?):50-55. doi:
10.1016/j.theriogenology.2021.09.019. [PMID: 34656837] - Lauren N Smith, Claire Bublitz, Emma Nixon, James Yeatts, Ray L Ball, Ronald E Baynes. EVALUATION OF THE PHARMACOKINETIC BEHAVIOR OF TULATHROMYCIN (DRAXXIN) IN FLORIDA MANATEES (TRICHECHUS MANATUS LATIROSTRIS) UNDERGOING MEDICAL REHABILITATION.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Sep; 52(3):880-885. doi:
10.1638/2021-0025. [PMID: 34687503] - Hannah R Leventhal, Harold C McKenzie, Krista Estell, McAlister Council-Troche, Jennifer L Davis. Pharmacokinetics and pulmonary distribution of Draxxin® (tulathromycin) in healthy adult horses.
Journal of veterinary pharmacology and therapeutics.
2021 Sep; 44(5):714-723. doi:
10.1111/jvp.12968. [PMID: 33719056] - Gizem Levent, Ashlynn Schlochtermeier, Samuel E Ives, Keri N Norman, Sara D Lawhon, Guy H Loneragan, Robin C Anderson, Javier Vinasco, Henk C den Bakker, H Morgan Scott. High-Resolution Genomic Comparisons within Salmonella enterica Serotypes Derived from Beef Feedlot Cattle: Parsing the Roles of Cattle Source, Pen, Animal, Sample Type, and Production Period.
Applied and environmental microbiology.
2021 05; 87(12):e0048521. doi:
10.1128/aem.00485-21. [PMID: 33863705] - Hande Sultan Şahiner, Cavit Kum. Effects of rifampicin on plasma pharmacokinetics of tulathromycin in goats.
Journal of veterinary pharmacology and therapeutics.
2021 May; 44(3):374-380. doi:
10.1111/jvp.12928. [PMID: 33155304] - Camila Cecilia Martin, Camila Costa Baccili, Mario Julio Avila-Campos, David John Hurley, Viviani Gomes. Effect of prophylactic use of tulathromycin on gut bacterial populations, inflammatory profile and diarrhea in newborn Holstein calves.
Research in veterinary science.
2021 May; 136(?):268-276. doi:
10.1016/j.rvsc.2021.02.026. [PMID: 33721714] - Michael Yaeger, Jonathan P Mochel, Zuowei Wu, Paul Plummer, Orhan Sahin, Joseph Smith, Melda Ocal, Ashenafi Beyi, Changyun Xu, Qijing Zhang, Ronald W Griffith. Pharmacokinetics of tulathromycin in pregnant ewes (Ovis aries) challenged with Campylobacter jejuni.
PloS one.
2021; 16(8):e0256862. doi:
10.1371/journal.pone.0256862. [PMID: 34449832] - R V Pereira, C Foditsch, J D Siler, S C Dulièpre, C Altier, A Garzon, L D Warnick. Genotypic antimicrobial resistance characterization of E. coli from dairy calves at high risk of respiratory disease administered enrofloxacin or tulathromycin.
Scientific reports.
2020 11; 10(1):19327. doi:
10.1038/s41598-020-76232-w. [PMID: 33168881] - R V Pereira, C Altier, J D Siler, S Mann, D Jordan, L D Warnick. Longitudinal effects of enrofloxacin or tulathromycin use in preweaned calves at high risk of bovine respiratory disease on the shedding of antimicrobial-resistant fecal Escherichia coli.
Journal of dairy science.
2020 Nov; 103(11):10547-10559. doi:
10.3168/jds.2019-17989. [PMID: 32861496] - Audrey Martinez, Seenivasan Subbiah, Paul Stonum, Tiffanie Brooks, Shanoy Anderson, Odia Osemwegie, Ernest E Smith. Characterization of serotonin following exposure to antibiotics in white-tailed deer.
General and comparative endocrinology.
2020 01; 285(?):113265. doi:
10.1016/j.ygcen.2019.113265. [PMID: 31473183] - Gizem Levent, Ashlynn Schlochtermeier, Samuel E Ives, Keri N Norman, Sara D Lawhon, Guy H Loneragan, Robin C Anderson, Javier Vinasco, H Morgan Scott. Population Dynamics of Salmonella enterica within Beef Cattle Cohorts Followed from Single-Dose Metaphylactic Antibiotic Treatment until Slaughter.
Applied and environmental microbiology.
2019 12; 85(23):. doi:
10.1128/aem.01386-19. [PMID: 31519659] - J Daniel Rivera, Amelia R Woolums, Steeve Giguère, Joseph T Johnson, Alexis G Lutz, Paige N Tipton, William B Crosby, Ivy Hice, Merrilee Thoresen. Pharmacokinetics of tulathromycin following administration to stocker cattle with remote delivery devices.
Journal of animal science.
2019 Nov; 97(11):4482-4487. doi:
10.1093/jas/skz311. [PMID: 31583406] - Zhoumeng Lin, Chunla He, Drew R Magstadt, Vickie L Cooper, Michael D Kleinhenz, Joseph S Smith, Patrick J Gorden, Larry W Wulf, Johann F Coetzee. Tissue residue depletion and estimation of extralabel meat withdrawal intervals for tulathromycin in calves after pneumatic dart administration.
Journal of animal science.
2019 Sep; 97(9):3714-3726. doi:
10.1093/jas/skz231. [PMID: 31342061] - Joe S Smith, Jonathan P Mochel, David J Borts, Ronald W Griffith. Effects of experimentally induced respiratory disease on the pharmacokinetics and tissue residues of tulathromycin in meat goats.
Journal of veterinary pharmacology and therapeutics.
2019 Jul; 42(4):420-429. doi:
10.1111/jvp.12764. [PMID: 31183876] - Evelyn E MacKay, Kevin E Washburn, Ashley L Padgett, Virginia R Fajt, Chih-Ping Lo, Travis P Mays, Shannon E Washburn. Pharmacokinetics of tulathromycin in fetal sheep and pregnant ewes.
Journal of veterinary pharmacology and therapeutics.
2019 Jul; 42(4):373-379. doi:
10.1111/jvp.12744. [PMID: 30656702] - Devin B Holman, Wenzhu Yang, Trevor W Alexander. Antibiotic treatment in feedlot cattle: a longitudinal study of the effect of oxytetracycline and tulathromycin on the fecal and nasopharyngeal microbiota.
Microbiome.
2019 06; 7(1):86. doi:
10.1186/s40168-019-0696-4. [PMID: 31167657] - Danielle A Mzyk, Claire M Bublitz, Marilyn N Martinez, Jennifer L Davis, Ronald E Baynes, Geof W Smith. Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves.
PloS one.
2019; 14(6):e0218864. doi:
10.1371/journal.pone.0218864. [PMID: 31233558] - Carla Foditsch, Richard V V Pereira, Julie D Siler, Craig Altier, Lorin D Warnick. Effects of treatment with enrofloxacin or tulathromycin on fecal microbiota composition and genetic function of dairy calves.
PloS one.
2019; 14(12):e0219635. doi:
10.1371/journal.pone.0219635. [PMID: 31825967] - Danielle A Mzyk, Claire M Bublitz, Ginger D Hobgood, Marilyn N Martinez, Geof W Smith, Ronald E Baynes. Effect of age on the pharmacokinetics and distribution of tulathromycin in interstitial and pulmonary epithelial lining fluid in healthy calves.
American journal of veterinary research.
2018 Nov; 79(11):1193-1203. doi:
10.2460/ajvr.79.11.1193. [PMID: 30372149] - Johann F Coetzee, Michael D Kleinhenz, Drew R Magstadt, Vickie L Cooper, Larry W Wulf, Nicholas K Van Engen, Joseph S Smith, Nathan Rand, Butch KuKanich, Patrick J Gorden. Pneumatic dart delivery of tulathromycin in calves results in lower antimicrobial concentrations and increased biomarkers of stress and injection site inflammation compared with subcutaneous injection.
Journal of animal science.
2018 Jul; 96(8):3089-3101. doi:
10.1093/jas/sky222. [PMID: 29873747] - Mohamed Zeineldin, Brian Aldridge, Benjamin Blair, Katherine Kancer, James Lowe. Impact of parenteral antimicrobial administration on the structure and diversity of the fecal microbiota of growing pigs.
Microbial pathogenesis.
2018 May; 118(?):220-229. doi:
10.1016/j.micpath.2018.03.035. [PMID: 29578067] - Mohamed M Abdel-Daim, Rasha Eltaysh, Azza Hassan, Shaker A Mousa. Lycopene Attenuates Tulathromycin and Diclofenac Sodium-Induced Cardiotoxicity in Mice.
International journal of molecular sciences.
2018 Jan; 19(2):. doi:
10.3390/ijms19020344. [PMID: 29364179] - Yongda Zhao, Li-Li Guo, Binghu Fang, Baotao Liu. Pharmacokinetic/pharmacodynamic (PK/PD) evaluation of tulathromycin against Haemophilus parasuis in an experimental neutropenic guinea pig model.
PloS one.
2018; 13(12):e0209177. doi:
10.1371/journal.pone.0209177. [PMID: 30596709] - P Lees, J Illambas, T J Potter, L Pelligand, A Rycroft, P-L Toutain. A large potentiation effect of serum on the in vitro potency of tulathromycin against Mannheimia haemolytica and Pasteurella multocida.
Journal of veterinary pharmacology and therapeutics.
2017 Oct; 40(5):419-428. doi:
10.1111/jvp.12372. [PMID: 27891615] - P-L Toutain, T Potter, L Pelligand, M Lacroix, J Illambas, P Lees. Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf.
Journal of veterinary pharmacology and therapeutics.
2017 Jan; 40(1):16-27. doi:
10.1111/jvp.12333. [PMID: 27501187] - Zhoumeng Lin, Matthew Cuneo, Joan D Rowe, Mengjie Li, Lisa A Tell, Shayna Allison, Jan Carlson, Jim E Riviere, Ronette Gehring. Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach.
BMC veterinary research.
2016 Nov; 12(1):258. doi:
10.1186/s12917-016-0884-4. [PMID: 27863483] - K A Bachtold, J M Alcorn, J O Boison, J L Matus, M R Woodbury. Pharmacokinetics and lung and muscle concentrations of tulathromycin following subcutaneous administration in white-tailed deer (Odocoileus virginianus).
Journal of veterinary pharmacology and therapeutics.
2016 Jun; 39(3):292-8. doi:
10.1111/jvp.12281. [PMID: 26669905] - Joe O Boison, Kali Bachtold, Johanna Matus, Jane Alcorn, Murray Woodbury. A single laboratory-validated LC-MS method for the analysis of tulathromycin residues in bison and deer sera and selected tissues of white-tailed deer.
Drug testing and analysis.
2016 May; 8(5-6):584-95. doi:
10.1002/dta.2018. [PMID: 27443215] - Karla Cameron-Veas, Miguel A Moreno, Lorenzo Fraile, Lourdes Migura-Garcia. Shedding of cephalosporin resistant Escherichia coli in pigs from conventional farms after early treatment with antimicrobials.
Veterinary journal (London, England : 1997).
2016 May; 211(?):21-5. doi:
10.1016/j.tvjl.2016.02.017. [PMID: 27053016] - A Gajda, T Bladek, A Jablonski, A Posyniak. The influence of Actinobacillus pleuropneumoniae infection on tulathromycin pharmacokinetics and lung tissue disposition in pigs.
Journal of veterinary pharmacology and therapeutics.
2016 Apr; 39(2):176-82. doi:
10.1111/jvp.12259. [PMID: 26270490] - Derek M Foster, Luke G Martin, Mark G Papich. Comparison of Active Drug Concentrations in the Pulmonary Epithelial Lining Fluid and Interstitial Fluid of Calves Injected with Enrofloxacin, Florfenicol, Ceftiofur, or Tulathromycin.
PloS one.
2016; 11(2):e0149100. doi:
10.1371/journal.pone.0149100. [PMID: 26872361] - J Oultram, E Phipps, A G V Teixeira, C Foditsch, M L Bicalho, V S Machado, R C Bicalho, G Oikonomou. Effects of antibiotics (oxytetracycline, florfenicol or tulathromycin) on neonatal calves' faecal microbial diversity.
The Veterinary record.
2015 Dec; 177(23):598. doi:
10.1136/vr.103320. [PMID: 26645721] - Joseph M Blondeau, Shantelle D Shebelski, Christine K Hesje. Bactericidal effects of various concentrations of enrofloxacin, florfenicol, tilmicosin phosphate, and tulathromycin on clinical isolates of Mannheimia haemolytica.
American journal of veterinary research.
2015 Oct; 76(10):860-8. doi:
10.2460/ajvr.76.10.860. [PMID: 26413823] - K Bachtold, J Alcorn, J Matus, J Boison, M Woodbury. Pharmacokinetics of tulathromycin after subcutaneous injection in North American bison (Bison bison).
Journal of veterinary pharmacology and therapeutics.
2015 Oct; 38(5):471-4. doi:
10.1111/jvp.12222. [PMID: 25772094] - K Washburn, V R Fajt, J F Coetzee, S Rice, L W Wulf, S Washburn. Pharmacokinetics of tulathromycin in nonpregnant adult ewes.
Journal of veterinary pharmacology and therapeutics.
2015 Aug; 38(4):414-6. doi:
10.1111/jvp.12196. [PMID: 25488837] - Rick W Fedeniuk, Del McKenzie, Massey Mizuno, Connie Neiser, Collin O'Byrne, Bryn Shurmer. Development and validation of determinative and confirmatory LC-MS/MS methodologies for total florfenicol and tulathromycin residues in bovine, equine and porcine kidney, liver and muscle tissues.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Mar; 983-984(?):1-9. doi:
10.1016/j.jchromb.2014.12.035. [PMID: 25612770] - Meredyth L Jones, Kevin E Washburn, Virginia R Fajt, Somchai Rice, Johann F Coetzee. Synovial fluid pharmacokinetics of tulathromycin, gamithromycin and florfenicol after a single subcutaneous dose in cattle.
BMC veterinary research.
2015 Feb; 11(?):26. doi:
10.1186/s12917-015-0346-4. [PMID: 25886555] - Tomasz Bladek, Andrzej Posyniak, Artur Jablonski, Anna Gajda. Pharmacokinetics of tulathromycin in edible tissues of healthy and experimentally infected pigs with Actinobacillus pleuropneumoniae.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2015; 32(11):1823-32. doi:
10.1080/19440049.2015.1078915. [PMID: 26247868] - M E Kinney, N Lamberski, R Wack, R Foster, M Neely, L Tell, R Gehring. Population pharmacokinetics of a single intramuscular administration of tulathromycin in adult desert tortoises (Gopherus agassizii).
Journal of veterinary pharmacology and therapeutics.
2014 Oct; 37(5):500-7. doi:
10.1111/jvp.12118. [PMID: 24611596] - Carrie D Fischer, Stephanie C Duquette, Bernard S Renaux, Troy D Feener, Douglas W Morck, Morley D Hollenberg, Merlyn J Lucas, Andre G Buret. Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.
Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4298-307. doi:
10.1128/aac.02813-14. [PMID: 24820086] - B Grismer, J D Rowe, J Carlson, S E Wetzlich, L A Tell. Pharmacokinetics of tulathromycin in plasma and milk samples after a single subcutaneous injection in lactating goats (Capra hircus).
Journal of veterinary pharmacology and therapeutics.
2014 Apr; 37(2):205-8. doi:
10.1111/jvp.12071. [PMID: 23889045] - Mehdi Rashnavadi, Mohammad Nouri, Mohammad R Haji Hajikolaei, Housain Najafzadeh, Peter D Constable. Effect of spiramycin and tulathromycin on abomasal emptying rate in milk-fed calves.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2014 Jan; 78(1):61-7. doi:
. [PMID: 24396182] - K E Washburn, V R Fajt, S D Lawhon, L G Adams, L A Tell, W T Bissett. Caprine abscess model of tulathromycin concentrations in interstitial fluid from tissue chambers inoculated with Corynebacterium pseudotuberculosis following subcutaneous or intrachamber administration.
Antimicrobial agents and chemotherapy.
2013 Dec; 57(12):6295-304. doi:
10.1128/aac.00936-13. [PMID: 24100501] - N Villarino, S Lesman, A Fielder, D García-Tapia, S Cox, M Lucas, J Robinson, S A Brown, T Martín-Jiménez. Pulmonary pharmacokinetics of tulathromycin in swine. Part I: Lung homogenate in healthy pigs and pigs challenged intratracheally with lipopolysaccharide of Escherichia coli.
Journal of veterinary pharmacology and therapeutics.
2013 Aug; 36(4):329-39. doi:
10.1111/jvp.12016. [PMID: 23072251] - F Yang, X H Huang, G H Li, H J Ni, Y D Zhao, H Z Ding, Z L Zeng. Estimating tulathromycin withdrawal time in pigs using a physiologically based pharmacokinetics model.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2013; 30(7):1255-63. doi:
10.1080/19440049.2013.797113. [PMID: 23767965] - Jessica Romanet, Geof W Smith, Teresa L Leavens, Ronald E Baynes, Scott E Wetzlich, Jim E Riviere, Lisa A Tell. Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats.
American journal of veterinary research.
2012 Oct; 73(10):1634-40. doi:
10.2460/ajvr.73.10.1634. [PMID: 23013191] - N Villarino, S A Brown, T Martín-Jiménez. Pharmacokinetics of tulathromycin in healthy and neutropenic mice challenged intranasally with lipopolysaccharide from Escherichia coli.
Antimicrobial agents and chemotherapy.
2012 Aug; 56(8):4078-86. doi:
10.1128/aac.00218-12. [PMID: 22585224] - X Wang, Y F Tao, L L Huang, D M Chen, S Z Yin, A Ihsan, W Zhou, S J Su, Z L Liu, Y H Pan, Z H Yuan. Pharmacokinetics of tulathromycin and its metabolite in swine administered with an intravenous bolus injection and a single gavage.
Journal of veterinary pharmacology and therapeutics.
2012 Jun; 35(3):282-9. doi:
10.1111/j.1365-2885.2011.01322.x. [PMID: 21749408] - T L Leavens, L A Tell, K A Clothier, R W Griffith, R E Baynes, J E Riviere. Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats.
Journal of veterinary pharmacology and therapeutics.
2012 Apr; 35(2):121-31. doi:
10.1111/j.1365-2885.2011.01304.x. [PMID: 21671946] - K A Clothier, T Leavens, R W Griffith, S E Wetzlich, R E Baynes, J E Riviere, L A Tell. Tulathromycin assay validation and tissue residues after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus).
Journal of veterinary pharmacology and therapeutics.
2012 Apr; 35(2):113-20. doi:
10.1111/j.1365-2885.2011.01300.x. [PMID: 21762403] - John D Mitchell, Quintin A McKellar, Declan J McKeever. Pharmacodynamics of antimicrobials against Mycoplasma mycoides mycoides small colony, the causative agent of contagious bovine pleuropneumonia.
PloS one.
2012; 7(8):e44158. doi:
10.1371/journal.pone.0044158. [PMID: 22952911] - K A Clothier, T Leavens, R W Griffith, S E Wetzlich, R E Baynes, J E Riviere, L A Tell. Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus).
Journal of veterinary pharmacology and therapeutics.
2011 Oct; 34(5):448-54. doi:
10.1111/j.1365-2885.2010.01261.x. [PMID: 21366621] - Ayse Er, Feray Altan, Gul Cetin, Burak Dik, Muammer Elmas, Enver Yazar. Assessment of the cardiotoxicity of tulathromycin in rabbits.
Acta veterinaria Hungarica.
2011 Sep; 59(3):327-35. doi:
10.1556/avet.2011.015. [PMID: 21727065] - Gabrielle Young, Geof W Smith, Teresa L Leavens, Scott E Wetzlich, Ronald E Baynes, Sharon E Mason, Jim E Riviere, Lisa A Tell. Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats.
Research in veterinary science.
2011 Jun; 90(3):477-9. doi:
10.1016/j.rvsc.2010.06.025. [PMID: 20638089] - Pamela L Boner, David W Gottschall, Heasook Kim-Kang. Determination and confirmation of tulathromycin residues in bovine liver and porcine kidney via their common hydrolytic fragment using high-performance liquid chromatography/tandem mass spectrometry.
Journal of AOAC International.
2011 Mar; 94(2):436-45. doi:
10.1093/jaoac/94.2.436. [PMID: 21563676] - Monica Venner, Jette Peters, Nina Höhensteiger, Birthe Schock, Alexa Bornhorst, Markus Grube, Ulrike Adam, Eberhard Scheuch, Werner Weitschies, Dieter Rosskopf, Heyo K Kroemer, Werner Siegmund. Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals.
Naunyn-Schmiedeberg's archives of pharmacology.
2010 Feb; 381(2):161-9. doi:
10.1007/s00210-009-0481-1. [PMID: 20012942] - K E Washburn, W Bissett, V Fajt, F Clubb, G T Fosgate, M Libal, K E Smyre, K L Cass. The safety of tulathromycin administration in goats.
Journal of veterinary pharmacology and therapeutics.
2007 Jun; 30(3):267-70. doi:
10.1111/j.1365-2885.2007.00837.x. [PMID: 17472660] - Eberhard Scheuch, Janina Spieker, Monica Venner, Werner Siegmund. Quantitative determination of the macrolide antibiotic tulathromycin in plasma and broncho-alveolar cells of foals using tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 May; 850(1-2):464-70. doi:
10.1016/j.jchromb.2006.12.034. [PMID: 17267304] - Victor S Cortese, Stephen Behan, Jeff E Galvin, Dan R Penka, Deborah Ramsey, W Lawrence Bryson, Merlyn J Lucas. Evaluation of two antimicrobial therapies in the treatment of Leptospira borgpetersenii serovar hardjo infection in experimentally infected cattle.
Veterinary therapeutics : research in applied veterinary medicine.
2007; 8(3):201-8. doi:
NULL. [PMID: 17926305] - Kevin S Godinho, Sue G Keane, Ian A Nanjiani, Hafid A Benchaoui, Simon J Sunderland, M Anne Jones, Andrew J Weatherley, Thomas D Gootz, Tim G Rowan. Minimum inhibitory concentrations of tulathromycin against respiratory bacterial pathogens isolated from clinical cases in European cattle and swine and variability arising from changes in in vitro methodology.
Veterinary therapeutics : research in applied veterinary medicine.
2005; 6(2):113-21. doi:
NULL. [PMID: 16094559] - H A Benchaoui, M Nowakowski, J Sherington, T G Rowan, S J Sunderland. Pharmacokinetics and lung tissue concentrations of tulathromycin in swine.
Journal of veterinary pharmacology and therapeutics.
2004 Aug; 27(4):203-10. doi:
10.1111/j.1365-2885.2004.00586.x. [PMID: 15305848] - Diana Gáler, Scott Hessong, Brian Beato, James Risk, Philip Inskeep, Chandralal Weerasinghe, Richard P Schneider, Connie Langer, Jennifer LaPerle, Donald Renouf, Andrew Bessire, Eden Español, Robert Rafka, Colman Ragan, Wayne Boettner, Trisha Murphy, David Keller, Hafid Benchaoui, Marcus A Nowakowski. An analytical method for the analysis of tulathromycin, an equilibrating triamilide, in bovine and porcine plasma and lung.
Journal of agricultural and food chemistry.
2004 Apr; 52(8):2179-91. doi:
10.1021/jf0351624. [PMID: 15080618]
