Goserelin (BioDeep_00000018462)

   

human metabolite blood metabolite


代谢物信息卡片


(2S)-1-[(2S)-2-{[(2S)-2-{[(2R)-3-(tert-butoxy)-2-{[(2S)-2-{[(2S)-1,3-dihydroxy-2-{[(2S)-1-hydroxy-2-{[(2S)-1-hydroxy-2-({hydroxy[(2S)-5-hydroxy-3,4-dihydro-2H-pyrrol-2-yl]methylidene}amino)-3-(1H-imidazol-5-yl)propylidene]amino}-3-(1H-indol-3-yl)propylidene]amino}propylidene]amino}-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxypropylidene]amino}-1-hydroxy-4-methylpentylidene]amino}-5-carbamimidamidopentanoyl]-N-[(C-hydroxycarbonimidoyl)amino]pyrrolidine-2-carboximidate

化学式: C59H84N18O14 (1268.6414083999998)
中文名称: 戈舍瑞林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
InChI: InChI=1S/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1

描述信息

Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AE - Gonadotropin releasing hormone analogues
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1910 - Gonadotropin-releasing Hormone Analog
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D000970 - Antineoplastic Agents

同义名列表

10 个代谢物同义名

(2S)-1-[(2S)-2-{[(2S)-2-{[(2R)-3-(tert-butoxy)-2-{[(2S)-2-{[(2S)-1,3-dihydroxy-2-{[(2S)-1-hydroxy-2-{[(2S)-1-hydroxy-2-({hydroxy[(2S)-5-hydroxy-3,4-dihydro-2H-pyrrol-2-yl]methylidene}amino)-3-(1H-imidazol-5-yl)propylidene]amino}-3-(1H-indol-3-yl)propylidene]amino}propylidene]amino}-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxypropylidene]amino}-1-hydroxy-4-methylpentylidene]amino}-5-carbamimidamidopentanoyl]-N-[(C-hydroxycarbonimidoyl)amino]pyrrolidine-2-carboximidate; (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(tert-butoxy)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-5-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4-hydroxyphenyl)propanamido]propanamido]-4-methylpentanamido]-5-[(diaminomethylidene)amino]pentanoyl]-N-(carbamoylamino)pyrrolidine-2-carboxamide; (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(tert-butoxy)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(3H-imidazol-4-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4-hydroxyphenyl)propanamido]propanamido]-4-methylpentanamido]-5-[(diaminomethylidene)amino]pentanoyl]-N-(carbamoylamino)pyrrolidine-2-carboxamide; Acetate, goserelin; Goserelin acetate; ICI-118630Zoladex; GOSERELINACETATE; Goserelin; Zoladex; ICI 118



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nanhui Chen, Zengjun Wang, Ming Chen, Qi Ma, Yi He, Yujie Wang, Xin Li, Mingxing Qiu, Lei Shi, Shaoxing Zhu, Qun Xie, Xiuheng Liu, Benkang Shi, Guowen Lin, Weizhong Yang, Yongbin Liao, Haibin Zhang, Shusheng Wang, Jiexian Li, Shaogang Wang, Lijun Dong, Hui Chen, Jiaju Lu, Yongyi Cheng, Xiaoping Zhang, Lulin Ma, Liqun Zhou, He Wang, Shen Li, Dingwei Ye. Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer. Cancer biology & medicine. 2024 02; 20(12):. doi: 10.20892/j.issn.2095-3941.2023.0335. [PMID: 38318809]
  • Chengyuan Gu, Zengjun Wang, Tianxin Lin, Zhiyu Liu, Weiqing Han, Xuhui Zhang, Chao Liang, Hao Liu, Yang Yu, Zhenzhou Xu, Shuang Liu, Jingen Wang, Linghua Jia, Xin Yao, Wenfeng Liao, Cheng Fu, Zhaohui Tan, Guohua He, Guoxi Zhu, Rui Fan, Wenzeng Yang, Xin Chen, Zhizhong Liu, Liqiang Zhong, Benkang Shi, Degang Ding, Shubo Chen, Junli Wei, Xudong Yao, Ming Chen, Zhanpeng Lu, Qun Xie, Zhiquan Hu, Yinhuai Wang, Hongqian Guo, Tiwu Fan, Zhaozhao Liang, Peng Chen, Wei Wang, Tao Xu, Chunsheng Li, Jinchun Xing, Hong Liao, Dalin He, Zhibin Wu, Jiandi Yu, Zhongwen Feng, Mengxiang Yang, Qifeng Dou, Quan Zeng, Yuanwei Li, Xin Gou, Guangchen Zhou, Xiaofeng Wang, Rujian Zhu, Zhonghua Zhang, Bo Zhang, Wanlong Tan, Xueling Qu, Hongliang Sun, Tianyi Gan, Dingwei Ye. Efficacy and safety of LY01005 versus goserelin implant in Chinese patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial. Chinese medical journal. 2023 May; 136(10):1207-1215. doi: 10.1097/cm9.0000000000002638. [PMID: 37010251]
  • Tianyang Ren, Jin Chen, Pan Qi, Peifu Xiao, Puxiu Wang. Goserelin/PLGA solid dispersion used to prepare long-acting microspheres with reduced initial release and reduced fluctuation of drug serum concentration in vivo. International journal of pharmaceutics. 2022 Mar; 615(?):121474. doi: 10.1016/j.ijpharm.2022.121474. [PMID: 35041918]
  • Hiroshi Sasaki, Kenta Miki, Kojiro Tashiro, Keiichiro Mori, Fumihiko Urabe, Wataru Fukuokaya, Takahiro Kimura, Shun Sato, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa. Differences in sex hormone recovery profile after cessation of 12-week gonadotropin-releasing hormone antagonist versus agonist therapy. Andrology. 2022 02; 10(2):270-278. doi: 10.1111/andr.13107. [PMID: 34510814]
  • Ho Hyun Ryu, Sei Hyun Ahn, Seon Ok Kim, Jeong Eun Kim, Ji Sun Kim, Jin-Hee Ahn, Kyung Hae Jung, Sung-Bae Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Hee Jung Shin, Hak Hee Kim, Gyung Yub Gong, Hee Jeong Kim. Comparison of metabolic changes after neoadjuvant endocrine and chemotherapy in ER-positive, HER2-negative breast cancer. Scientific reports. 2021 05; 11(1):10510. doi: 10.1038/s41598-021-89651-0. [PMID: 34006898]
  • Yoko Koh, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Kazutoshi Fujita, Hiroshi Kiuchi, Ryoichi Imamura, Yasushi Miyagawa, Norio Nonomura, Motohide Uemura. Failure to achieve castrate level of serum testosterone during luteinizing hormone-releasing hormone agonist therapy in a patient with prostate cancer. Anti-cancer drugs. 2020 11; 31(10):1099-1102. doi: 10.1097/cad.0000000000000986. [PMID: 32804697]
  • Ahmad Pourahadi, Saeed Nojavan, Saied Saeed Hosseiny Davarani. Gel-electromembrane extraction of peptides: Determination of five hypothalamic agents in human plasma samples. Talanta. 2020 Sep; 217(?):121025. doi: 10.1016/j.talanta.2020.121025. [PMID: 32498910]
  • Joel S Finkelstein, Hang Lee, Sherri-Ann M Burnett-Bowie, Karin Darakananda, Emily C Gentile, David W Goldstein, Sarah H Prizand, Laura M Krivicich, Alexander P Taylor, Kendra E Wulczyn, Benjamin Z Leder, Elaine W Yu. Dose-Response Relationships Between Gonadal Steroids and Bone, Body Composition, and Sexual Function in Aging Men. The Journal of clinical endocrinology and metabolism. 2020 08; 105(8):. doi: 10.1210/clinem/dgaa318. [PMID: 32480409]
  • Cicero P Albuquerque, Fatima R Freitas, Ana Elisa M Martinelli, Josefa H Lima, Rafael F Coelho, Carlos V Serrano, Willian C Nahas, Roberto Kalil Filho, Raul C Maranhão. Androgen deprivation therapy improves the in vitro capacity of high-density lipoprotein (HDL) to receive cholesterol and other lipids in patients with prostate carcinoma. Lipids in health and disease. 2020 Jun; 19(1):133. doi: 10.1186/s12944-020-01305-8. [PMID: 32522195]
  • Nadia H Mohammed, Anmar Al-Taie, Zahraa Albasry. Evaluation of goserelin effectiveness based on assessment of inflammatory cytokines and symptoms in uterine leiomyoma. International journal of clinical pharmacy. 2020 Jun; 42(3):931-937. doi: 10.1007/s11096-020-01030-3. [PMID: 32350747]
  • Jessica E Hawley, Samuel Pan, William D Figg, Zoila A Lopez-Bujanda, Jonathan D Strope, David H Aggen, Matthew C Dallos, Emerson A Lim, Mark N Stein, Jianhua Hu, Charles G Drake. Association between immunosuppressive cytokines and PSA progression in biochemically recurrent prostate cancer treated with intermittent hormonal therapy. The Prostate. 2020 03; 80(4):336-344. doi: 10.1002/pros.23948. [PMID: 31899823]
  • John Takyi-Williams, Linnè Erasmus, Rose Hayeshi, Anne Grobler. Development and validation of an LC-MS/MS method for the quantification of goserelin in a Pheroid® formulation, in simulated intestinal fluid. Journal of pharmaceutical and biomedical analysis. 2020 Feb; 180(?):113044. doi: 10.1016/j.jpba.2019.113044. [PMID: 31865209]
  • Myungsun Shim, Woo Jin Bang, Cheol Young Oh, Yong Seong Lee, Jin Seon Cho. Effectiveness of three different luteinizing hormone-releasing hormone agonists in the chemical castration of patients with prostate cancer: Goserelin versus triptorelin versus leuprolide. Investigative and clinical urology. 2019 07; 60(4):244-250. doi: 10.4111/icu.2019.60.4.244. [PMID: 31294133]
  • Katherine N Bachmann, Shi Huang, Hang Lee, Laura E Dichtel, Deepak K Gupta, John C Burnett, Karen K Miller, Thomas J Wang, Joel S Finkelstein. Effect of Testosterone on Natriuretic Peptide Levels. Journal of the American College of Cardiology. 2019 03; 73(11):1288-1296. doi: 10.1016/j.jacc.2018.12.062. [PMID: 30898204]
  • Aideen M Campbell, Melanie Morris, Rebecca Gallagher, Ruth Boyd, Hazel Carson, D Paul Harkin, Ewa Wielogorska, Christopher Elliott, Kienan I Savage, Stuart A McIntosh. Chemoprevention in BRCA1 mutation carriers (CIBRAC): protocol for an open allocation crossover feasibility trial assessing mechanisms of chemoprevention with goserelin and anastrozole versus tamoxifen and acceptability of treatment. BMJ open. 2018 12; 8(12):e023115. doi: 10.1136/bmjopen-2018-023115. [PMID: 30580266]
  • Xuechun Hu, Zheng Ding, Zhiwei Hong, Zhichuan Zou, Yuming Feng, Ruilou Zhu, Jinzhao Ma, Xie Ge, Chaojun Li, Bing Yao. Spermatogenesis improved by suppressing the high level of endogenous gonadotropins in idiopathic non-obstructive azoospermia: a case control pilot study. Reproductive biology and endocrinology : RB&E. 2018 Sep; 16(1):91. doi: 10.1186/s12958-018-0401-7. [PMID: 30243299]
  • Ming-Yang Chen, Yi-Ying Chen, Hsin-Tzu Tsai, Tzong-Shin Tzai, Mei-Chin Chen, Yuh-Shyan Tsai. Transdermal Delivery of Luteinizing Hormone-releasing Hormone with Chitosan Microneedles: A Promising Tool for Androgen Deprivation Therapy. Anticancer research. 2017 12; 37(12):6791-6797. doi: 10.21873/anticanres.12139. [PMID: 29187457]
  • Yang Zhang, Bo-Han Lei, Qing Zou, Qing-Yi Zhu, Zi-Jie Lu, Yue Wang. [Clinical efficacy of integrated traditional Chinese and Western medicine for castration-resistant prostate cancer]. Zhonghua nan ke xue = National journal of andrology. 2017 Oct; 23(10):922-927. doi: NULL. [PMID: 29727544]
  • Sibylle Loibl, Nicholas C Turner, Jungsil Ro, Massimo Cristofanilli, Hiroji Iwata, Seock-Ah Im, Norikazu Masuda, Sherene Loi, Fabrice André, Nadia Harbeck, Sunil Verma, Elizabeth Folkerd, Kathy Puyana Theall, Justin Hoffman, Ke Zhang, Cynthia Huang Bartlett, Mitchell Dowsett. Palbociclib Combined with Fulvestrant in Premenopausal Women with Advanced Breast Cancer and Prior Progression on Endocrine Therapy: PALOMA-3 Results. The oncologist. 2017 09; 22(9):1028-1038. doi: 10.1634/theoncologist.2017-0072. [PMID: 28652278]
  • Shinzaburo Noguchi, Hee Jeong Kim, Anita Jesena, Vani Parmar, Nobuaki Sato, Hwei-Chung Wang, Santi Lokejaroenlarb, Jofel Isidro, Ku Sang Kim, Yohji Itoh, Eisei Shin. Phase 3, open-label, randomized study comparing 3-monthly with monthly goserelin in pre-menopausal women with estrogen receptor-positive advanced breast cancer. Breast cancer (Tokyo, Japan). 2016 Sep; 23(5):771-9. doi: 10.1007/s12282-015-0637-4. [PMID: 26350351]
  • Kenta Miki, Hiroshi Sasaki, Masahito Kido, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa. A comparative study on the efficacies of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist in neoadjuvant androgen deprivation therapy combined with transperineal prostate brachytherapy for localized prostate cancer. BMC cancer. 2016 09; 16(?):708. doi: 10.1186/s12885-016-2737-8. [PMID: 27586506]
  • Masahiro Nozawa, Isao Hara, Hideyasu Matsuyama, Masayuki Iki, Kazuhiro Nagao, Tsukasa Nishioka, Takahiro Komura, Atsunobu Esa, Shigeya Uejima, Masaaki Imanishi, Yasunari Uekado, Takatoshi Ogawa, Hiroshi Kajikawa, Hirotsugu Uemura. Significance of baseline bone markers on disease progression and survival in hormone-sensitive prostate cancer with bone metastasis. World journal of urology. 2015 Sep; 33(9):1263-8. doi: 10.1007/s00345-014-1431-1. [PMID: 25354720]
  • Leonardo O Reis, Fernandes Denardi, Eliney F Faria, Elcio Dias Silva. Correlation Between Testosterone and PSA Kinetics in Metastatic Prostate Cancer Patients Treated With Diverse Chemical Castrations. American journal of men's health. 2015 Sep; 9(5):430-4. doi: 10.1177/1557988314552468. [PMID: 25294865]
  • Lili Gong, Shaofen Zhang, Yi Han, Qiqi Long, Shien Zou, Yuankui Cao. Initiation of GnRH agonist treatment on 3-5 days postoperatively in endometriosis patients: a randomized controlled trial. Journal of clinical pharmacology. 2015 Aug; 55(8):848-53. doi: 10.1002/jcph.485. [PMID: 25694383]
  • Ji-Ming Chen, Hong-Yan Gao, Yi Ding, Xia Yuan, Qing Wang, Qin Li, Guo-Hua Jiang. Efficacy and safety investigation of Kuntai capsule for the add-back therapy of gonadotropin releasing hormone agonist administration to endometriosis patients: a randomized, double-blind, blank- and tibolone-controlled study. Chinese medical journal. 2015 Feb; 128(4):427-32. doi: 10.4103/0366-6999.151057. [PMID: 25673440]
  • Monica Sakai, Daniel B Martinez-Arguelles, Nathan H Patterson, Pierre Chaurand, Vassilios Papadopoulos. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth. PloS one. 2015; 10(3):e0120670. doi: 10.1371/journal.pone.0120670. [PMID: 25811175]
  • Chang-Qing Liu, Zi-Xin Qin, Fang-Fang Jiang, Ting Hong, Feng Wang. [Kuntai capsule combined with gonadotropin releasing hormone agonist in treatment of moderate-severe endometriosis: a clinical observation]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2014 Nov; 34(11):1288-91. doi: NULL. [PMID: 25566615]
  • Shu Zhang, Jiangbin Han, Guangyi Leng, Xin Di, Chunjie Sha, Xuemei Zhang, Youxin Li, Wanhui Liu. An LC-MS/MS method for the simultaneous determination of goserelin and testosterone in rat plasma for pharmacokinetic and pharmacodynamic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Aug; 965(?):183-9. doi: 10.1016/j.jchromb.2014.06.028. [PMID: 25038408]
  • Alexander V Uihlein, Joel S Finkelstein, Hang Lee, Benjamin Z Leder. FSH suppression does not affect bone turnover in eugonadal men. The Journal of clinical endocrinology and metabolism. 2014 Jul; 99(7):2510-5. doi: 10.1210/jc.2013-3246. [PMID: 24646101]
  • Luis Daverede, Christy Ralph, Satinder P Jagdev, Ioannis Trigonis, Sebastian Trainor, Patricia Harnden, Michael Weston, Alan Paul, Naveen S Vasudev. Metastatic castrate-resistant prostate cancer with a late, complete and durable response to docetaxel chemotherapy: a case report. Journal of medical case reports. 2014 Apr; 8(?):122. doi: 10.1186/1752-1947-8-122. [PMID: 24717107]
  • Peyman Hadji, Annette Kauka, May Ziller, Katrin Birkholz, Monika Baier, Mathias Muth, Peter Kann. Effect of adjuvant endocrine therapy on hormonal levels in premenopausal women with breast cancer: the ProBONE II study. Breast cancer research and treatment. 2014 Apr; 144(2):343-51. doi: 10.1007/s10549-014-2860-7. [PMID: 24519387]
  • Thine Hvid, Kamilla Winding, Anders Rinnov, Thomas Dejgaard, Carsten Thomsen, Peter Iversen, Klaus Brasso, Kari J Mikines, Gerrit van Hall, Birgitte Lindegaard, Thomas P J Solomon, Bente K Pedersen. Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy. Endocrine-related cancer. 2013 Oct; 20(5):621-32. doi: 10.1530/erc-12-0393. [PMID: 23744766]
  • H Yang, X Zong, Y Yu, G Shao, L Zhang, C Qian, Y Bian, X Xu, W Sun, X Meng, X Ding, D Chen, D Zou, S Xie, Y Zheng, J Zhang, X He, C Sun, X Yu, J Ni. Combined effects of goserelin and tamoxifen on estradiol level, breast density, and endometrial thickness in premenopausal and perimenopausal women with early-stage hormone receptor-positive breast cancer: a randomised controlled clinical trial. British journal of cancer. 2013 Aug; 109(3):582-8. doi: 10.1038/bjc.2013.324. [PMID: 23860520]
  • Osamu Ishizuka, Osamu Nishizawa, Shuji Nishizawa, Tomoya Satoh, Masahisa Wajiki, Hideo Kiyokawa, Yoshihiro Inoue, Shinya Kobayashi, Hiroya Mizusawa, Tatsuo Nakagawa. Comparison of efficacy and safety of 1- and 3-month luteinizing hormone-releasing hormone agonist depots as initial therapies for prostate cancer. International journal of clinical oncology. 2013 Jun; 18(3):524-30. doi: 10.1007/s10147-012-0413-9. [PMID: 22552359]
  • Priti Tomar, Neeti Jain, Vinod Kumar Dixit. Nanoparticulate delivery of LHRH analogue for the treatment of prostate cancer. Pharmaceutical development and technology. 2013 May; 18(3):645-52. doi: 10.3109/10837450.2012.663389. [PMID: 22380019]
  • James P Dean, Cynthia C Sprenger, Junxiang Wan, Kathleen Haugk, William J Ellis, Daniel W Lin, John M Corman, Bruce L Dalkin, Elahe Mostaghel, Peter S Nelson, Pinchas Cohen, Bruce Montgomery, Stephen R Plymate. Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: effects of obesity and androgen deprivation. The Journal of clinical endocrinology and metabolism. 2013 May; 98(5):E820-8. doi: 10.1210/jc.2012-3856. [PMID: 23533230]
  • Ying Zhang, Jing Xin Ding, Xiang Tao, Zhi Ying Lu, Jia Jia Wang, Wei Wei Feng, Ke Qin Hua. Goserelin can inhibit ovarian cancer proliferation and simultaneously protect ovarian function from cisplatin: an in vitro and in vivo study. Journal of chemotherapy (Florence, Italy). 2013 Apr; 25(2):96-103. doi: 10.1179/1973947813y.0000000069. [PMID: 23684357]
  • Adnan Aydiner, Leyla Kilic, Ibrahim Yildiz, Serkan Keskin, Fatma Sen, Seden Kucucuk, Hasan Karanlik, Mahmut Muslumanoglu, Abdullah Igci. Two different formulations with equivalent effect? Comparison of serum estradiol suppression with monthly goserelin and trimonthly leuprolide in breast cancer patients. Medical oncology (Northwood, London, England). 2013 Mar; 30(1):354. doi: 10.1007/s12032-012-0354-1. [PMID: 23275115]
  • Karol Axcrona, Sirpa Aaltomaa, Carlos Martins da Silva, Haluk Ozen, Jan-Erik Damber, László B Tankó, Enrico Colli, Peter Klarskov. Androgen deprivation therapy for volume reduction, lower urinary tract symptom relief and quality of life improvement in patients with prostate cancer: degarelix vs goserelin plus bicalutamide. BJU international. 2012 Dec; 110(11):1721-8. doi: 10.1111/j.1464-410x.2012.11107.x. [PMID: 22500884]
  • Neil P Evans, Jane E Robinson, Hans W Erhard, Erik Ropstad, Lynne M Fleming, Ira Ronit Hebold Haraldsen. Development of psychophysiological motoric reactivity is influenced by peripubertal pharmacological inhibition of gonadotropin releasing hormone action--results of an ovine model. Psychoneuroendocrinology. 2012 Nov; 37(11):1876-84. doi: 10.1016/j.psyneuen.2012.03.020. [PMID: 22534405]
  • Noboru Hara, Itsuhiro Takizawa, Etsuko Isahaya, Tsutomu Nishiyama, Tatsuhiko Hoshii, Fumio Ishizaki, Kota Takahashi. Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer. Urologic oncology. 2012 Sep; 30(5):596-601. doi: 10.1016/j.urolonc.2010.11.001. [PMID: 21458314]
  • Élcio Dias Silva, Ubirajara Ferreira, Wagner Matheus, Eliney F Faria, Gustavo D Silva, Minori Saito, Auro A S de Souza, Azuil Laranjo, Otavio Clark, Luis Alberto Magna, Lísias Nogueira Castilho, Leonardo Oliveira Reis. Goserelin versus leuprolide in the chemical castration of patients with prostate cancer. International urology and nephrology. 2012 Aug; 44(4):1039-44. doi: 10.1007/s11255-012-0134-z. [PMID: 22315155]
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