Tubeimoside-1 (BioDeep_00000184614)
human metabolite blood metabolite
代谢物信息卡片
化学式: C65H102O29 (1346.6506442)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2C(C(C(O1)OC3C(C(COC3OC(=O)C45CCC(CC4(C6=CCC7(C(C6(CC5)C)(CCC8C7(CC(C(C8(C)CO)OC9C(C(C(C(O9)CO)O)O)OC1C(C(C(C(O1)C(=O)CC(CC(=O)O2)(C)O)O)O)O)O)C)C)C)C)(C)C)O)O)O)OC1C(C(C(CO1)O)O)O
InChI: InChI=1S/C65H102O29/c1-27-45-47(90-51-42(79)36(73)30(70)23-84-51)44(81)53(86-27)91-48-37(74)31(71)24-85-54(48)94-56(82)65-17-15-57(2,3)25-62(65,8)34-12-14-64(10)61(7)20-29(69)50(59(5,26-67)33(61)11-13-63(64,9)60(34,6)16-18-65)93-55-49(40(77)38(75)32(22-66)87-55)92-52-43(80)39(76)41(78)46(89-52)28(68)19-58(4,83)21-35(72)88-45/h12,27,29-33,36-55,66-67,69-71,73-81,83H,11,13-26H2,1-10H3
描述信息
同义名列表
3 个代谢物同义名
7,8,18,22,23,24,28,29,35,57-decahydroxy-30,54-bis(hydroxymethyl)-13,18,37,41,42,46,48,48,53,54-decamethyl-56-[(3,4,5-trihydroxyoxan-2-yl)oxy]-3,5,10,12,15,26,31,33,55-nonaoxadecacyclo[39.9.3.2^{11,14}.1^{21,25}.1^{34,38}.0^{1,46}.0^{4,9}.0^{27,32}.0^{37,42}.0^{45,53}]heptapentacont-44-ene-2,16,20-trione; 7,8,18,22,23,24,28,29,35,57-Decahydroxy-30,54-bis(hydroxymethyl)-13,18,37,41,42,46,48,48,53,54-decamethyl-56-(3,4,5-trihydroxyoxan-2-yl)oxy-3,5,10,12,15,26,31,33,55-nonaoxadecacyclo[39.9.3.211,14.121,25.134,38.01,46.04,9.027,32.037,42.045,53]heptapentacont-44-ene-2,16,20-trione; Tubeimoside-1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dongsheng Hu, Lingzhi Cui, Sijia Zhang, Siqi He, Yuzhen Zhuo, Dihua Li, Lanqiu Zhang, Yanli Wang, Lei Yang, Ximo Wang. Antitumor effect of tubeimoside-I on murine colorectal cancers through PKM2-dependent pyroptosis and immunomodulation.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Nov; ?(?):. doi:
10.1007/s00210-023-02855-1. [PMID: 38010398] - So Rae Song, Seung Un Seo, Seon Min Woo, Ji Yun Yoon, Simmyung Yook, Taeg Kyu Kwon. Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation.
International journal of molecular sciences.
2023 Jul; 24(14):. doi:
10.3390/ijms241411840. [PMID: 37511599] - Ziyi Han, Junjie Jin, Xiangfeng Chen, Yanfei He, Hongxiang Sun. Adjuvant activity of tubeimosides by mediating the local immune microenvironment.
Frontiers in immunology.
2023; 14(?):1108244. doi:
10.3389/fimmu.2023.1108244. [PMID: 36845089] - Xiyang Yang, Xingbing Li, Minghao Luo, Yongzheng Guo, Chang Li, Dingyi Lv, Zhe Cheng, Longxiang Huang, Fei-Fei Shang, Bi Huang, Jian Shen, Suxin Luo, Jianghong Yan. Tubeimoside I promotes angiogenesis via activation of eNOS-VEGF signaling pathway.
Journal of ethnopharmacology.
2021 Mar; 267(?):113642. doi:
10.1016/j.jep.2020.113642. [PMID: 33264658] - Dingyi Lv, Minghao Luo, Zhe Cheng, Ruiyu Wang, Xiyang Yang, Yongzheng Guo, Longxiang Huang, Xiang Li, Bi Huang, Jian Shen, Suxin Luo, Jianghong Yan. Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Oxidative medicine and cellular longevity.
2021; 2021(?):5577019. doi:
10.1155/2021/5577019. [PMID: 34795840] - Kun Wang, Yujuan Zhan, Bonan Chen, Yuhua Lu, Ting Yin, Shikun Zhou, Weibin Zhang, Xiaodong Liu, Biaoyan Du, Xianli Wei, Jianyong Xiao. Tubeimoside I-induced lung cancer cell death and the underlying crosstalk between lysosomes and mitochondria.
Cell death & disease.
2020 08; 11(8):708. doi:
10.1038/s41419-020-02915-x. [PMID: 32848130] - Li-Juan Cao, Hai-Tang Xie, Zhong-Xia Chu, Yue Ma, Ming-Ming Wang, Zhuang Shi. Tubeimoside‑1 induces apoptosis in human glioma U251 cells by suppressing PI3K/Akt‑mediated signaling pathways.
Molecular medicine reports.
2020 08; 22(2):1527-1535. doi:
10.3892/mmr.2020.11224. [PMID: 32627020] - Jianghong Yan, Xiaoyun Dou, Jing Zhou, Yuanfeng Xiong, Ling Mo, Longhao Li, Yunlong Lei. Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation.
Journal of experimental & clinical cancer research : CR.
2019 Aug; 38(1):353. doi:
10.1186/s13046-019-1355-0. [PMID: 31412953] - Jiangjun Cao, Erhu Zhao, Qingzong Zhu, Juanli Ji, Zekun Wei, Bo Xu, Hongjuan Cui. Tubeimoside-1 Inhibits Glioblastoma Growth, Migration, and Invasion via Inducing Ubiquitylation of MET.
Cells.
2019 07; 8(8):. doi:
10.3390/cells8080774. [PMID: 31349699] - Shi-Long Jiang, Yi-di Guan, Xi-Sha Chen, Peng Ge, Xin-Luan Wang, Yuan-Zhi Lao, Song-Shu Xiao, Yi Zhang, Jin-Ming Yang, Xiao-Jun Xu, Dong-Sheng Cao, Yan Cheng. Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway.
Acta pharmacologica Sinica.
2019 Jul; 40(7):919-928. doi:
10.1038/s41401-018-0165-9. [PMID: 30315250] - Md Sodrul Islam, Chenying Wang, Jingyou Zheng, Narayan Paudyal, Yongliang Zhu, Hongxiang Sun. The potential role of tubeimosides in cancer prevention and treatment.
European journal of medicinal chemistry.
2019 Jan; 162(?):109-121. doi:
10.1016/j.ejmech.2018.11.001. [PMID: 30439592] - Ying Li, Lifang Wang, Xianzhao Yang, Yongan Ye, Pengfei Tu, Jinling Wang. A hybrid method for the determination of tubeimoside I in rat plasma after oral administration by LC-IT-TOF and UPLC-MS/MS.
Biomedical chromatography : BMC.
2018 Nov; 32(11):e4337. doi:
10.1002/bmc.4337. [PMID: 30003566] - Wenli Hao, Shuai Wang, Zhenli Zhou. Tubeimoside-1 (TBMS1) inhibits lung cancer cell growth and induces cells apoptosis through activation of MAPK-JNK pathway.
International journal of clinical and experimental pathology.
2015; 8(10):12075-83. doi:
". [PMID: 26722392] - Tao Zhang, Shengli Han, Qi Liu, Ying Guo, Langchong He. Analysis of allergens in tubeimu saponin extracts by using rat basophilic leukemia 2H3 cell-based affinity chromatography coupled to liquid chromatography and mass spectrometry.
Journal of separation science.
2014 Nov; 37(22):3384-91. doi:
10.1002/jssc.201400280. [PMID: 25243709] - Xiaogang Lin, Wenchao Li, Changbin Ye, Xiaozhu Liu, Hao Zhu, Wenbing Peng, Jie Rong. Research on the interaction between tubeimoside 1 and HepG2 cells using the microscopic imaging and fluorescent spectra method.
Computational and mathematical methods in medicine.
2014; 2014(?):470452. doi:
10.1155/2014/470452. [PMID: 24963337] - Lixia Pei, Yuanwu Bao, Lei Ma, Qiqi Wang, Yiyi Ye, Xianghui Han, Sheng Liu, Xiuping Chen. A sensitive method for determination of platycodin d in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.
Planta medica.
2012 Feb; 78(3):244-51. doi:
10.1055/s-0031-1280372. [PMID: 22095263] - Yashu Wang, Linhong Deng, Yajie Wang, Hongzhe Zhong, Xuemei Jiang, Jun Chen. Natural plant extract tubeimoside I induces cytotoxicity via the mitochondrial pathway in human normal liver cells.
Molecular medicine reports.
2011 Jul; 4(4):713-8. doi:
10.3892/mmr.2011.483. [PMID: 21537846] - Yi Zhang, Xiaoman Xu, Ping He. Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells.
Molecular medicine reports.
2011 Jan; 4(1):25-9. doi:
10.3892/mmr.2010.379. [PMID: 21461558] - Yashu Wang, Linhong Deng, Hongzhe Zhong, Yajie Wang, Xuemei Jiang, Jun Chen. Natural plant extract tubeimoside I promotes apoptosis-mediated cell death in cultured human hepatoma (HepG2) cells.
Biological & pharmaceutical bulletin.
2011; 34(6):831-8. doi:
10.1248/bpb.34.831. [PMID: 21628880] - Yang Xu, Jen-Fu Chiu, Qing-Yu He, Feng Chen. Tubeimoside-1 exerts cytotoxicity in HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways.
Journal of proteome research.
2009 Mar; 8(3):1585-93. doi:
10.1021/pr801001j. [PMID: 19215086] - Cui-qin Li, Zhe-zhi Wang. [Study on tissue culture of Bolbostemma paniculatum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2006 Mar; 31(5):369-72. doi:
". [PMID: 16711416] - Ping Yang, Ting-xi Yu, Run-di Ma, Li-jian Yu, Wei-ming Su, Hai-yan Shao, Ming-neng Liao, Lai-zhen Huang. [Cell cycle arrest and apoptosis induced by tubeimoside in HeLa cell].
Ai zheng = Aizheng = Chinese journal of cancer.
2002 Apr; 21(4):346-50. doi:
". [PMID: 12452008] - T X Yu, R D Ma, L J Yu. Structure-activity relationship of tubeimosides in anti-inflammatory, antitumor, and antitumor-promoting effects.
Acta pharmacologica Sinica.
2001 May; 22(5):463-8. doi:
". [PMID: 11743898] - L Yu, R Ma, T Yu. Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by Tubeimoside 1.
Planta medica.
1996 Apr; 62(2):119-21. doi:
10.1055/s-2006-957831. [PMID: 8657741] - L Yu, R Ma, Y Wang, H Nishino. Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum.
Planta medica.
1994 Jun; 60(3):204-8. doi:
10.1055/s-2006-959459. [PMID: 8073083] - L J Yu, R D Ma, S B Jiang. Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1994 Mar; 15(2):103-6. doi:
". [PMID: 8010099] - L J Yu, R D Ma, Y Q Wang, H Nishino, J Takayasu, W Z He, M Chang, J Zhen, W S Liu, S X Fan. Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet.
International journal of cancer.
1992 Feb; 50(4):635-8. doi:
10.1002/ijc.2910500425. [PMID: 1537629] - R Kasai, M Miyakoshi, K Matsumoto, R L Nie, J Zhou, T Morita, O Tanaka. Tubeimoside I, a new cyclic bisdesmoside from Chinese cucurbitaceous folk medicine 'tu bei mu', a tuber of Bolbostemma paniculatum.
Chemical & pharmaceutical bulletin.
1986 Sep; 34(9):3974-7. doi:
10.1248/cpb.34.3974. [PMID: 3815619]