Trofosfamide (BioDeep_00000184593)

   

human metabolite blood metabolite


代谢物信息卡片


2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)-1,3,2lambda5-oxazaphosphinan-2-one

化学式: C9H18Cl3N2O2P (322.01714280000004)
中文名称: 曲磷胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(P(=O)(OC1)N(CCCl)CCCl)CCCl
InChI: InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,15)14(7-3-11)8-4-12/h1-9H2

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AA - Nitrogen mustard analogues
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D009676 - Noxae > D000477 - Alkylating Agents
D009676 - Noxae > D009153 - Mutagens

同义名列表

7 个代谢物同义名

2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)-1,3,2lambda5-oxazaphosphinan-2-one; N,N,N-tris(2-chloroethyl)-n-O-propylene phosphoric acid ester diamide; Z-4828a-4828Trophosphamide; Genoxal trofosfamida; Trophosphamide; Trofosfamide; Ixoten



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Joost M Riphagen, Inez H G M Ramakers, Whitney M Freeze, Linda H G Pagen, Bernard J Hanseeuw, Marcel M Verbeek, Frans R J Verhey, Heidi I L Jacobs. Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology. Neurobiology of aging. 2020 01; 85(?):96-103. doi: 10.1016/j.neurobiolaging.2019.09.020. [PMID: 31733942]
  • Venkata V V R Marada, Saskia Flörl, Annett Kühne, Gerhard Burckhardt, Yohannes Hagos. Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds. European journal of medicinal chemistry. 2015 Mar; 92(?):723-31. doi: 10.1016/j.ejmech.2015.01.011. [PMID: 25618019]
  • Stephanie Stoelting, Tanja Trefzer, Jens Kisro, A Steinke, Thomas Wagner, Stefan O Peters. Low-dose oral metronomic chemotherapy prevents mobilization of endothelial progenitor cells into the blood of cancer patients. In vivo (Athens, Greece). 2008 Nov; 22(6):831-6. doi: NULL. [PMID: 19181016]
  • G Allegrini, A Falcone, A Fioravanti, M T Barletta, P Orlandi, F Loupakis, E Cerri, G Masi, A Di Paolo, R S Kerbel, R Danesi, M Del Tacca, G Bocci. A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients. British journal of cancer. 2008 Apr; 98(8):1312-9. doi: 10.1038/sj.bjc.6604311. [PMID: 18362940]
  • Liliane Michalik, Walter Wahli. PPARs Mediate Lipid Signaling in Inflammation and Cancer. PPAR research. 2008; 2008(?):134059. doi: 10.1155/2008/134059. [PMID: 19125181]
  • Rainer Preiss, Frank Baumann, Dragan Stefanovic, Ulf Niemeyer, Wolfgang Pönisch, Dietger Niederwieser. Investigations on the pharmacokinetics of trofosfamide and its metabolites-first report of 4-hydroxy-trofosfamide kinetics in humans. Cancer chemotherapy and pharmacology. 2004 Jun; 53(6):496-502. doi: 10.1007/s00280-003-0757-y. [PMID: 15138712]
  • K Plikat, A Reichle, M W Elmlinger, J Schölmerich. [Hypoglycemia associated with the production of insulin-like growth factor (IGF)-II by a hemangiopericytoma]. Deutsche medizinische Wochenschrift (1946). 2003 Feb; 128(6):257-60. doi: 10.1055/s-2003-37075. [PMID: 12571793]
  • B Kremens, B Gruhn, T Klingebiel, C Hasan, H-J Laws, E Koscielniak, B Hero, B Selle, C Niemeyer, F G Finckenstein, A Schulz, A Wawer, F Zintl, N Graf. High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma. Bone marrow transplantation. 2002 Dec; 30(12):893-8. doi: 10.1038/sj.bmt.1703771. [PMID: 12476282]
  • A Brinker, J Kisro, C Letsch, S K Brüggemann, T Wagner. New insights into the clinical pharmacokinetics of trofosfamide. International journal of clinical pharmacology and therapeutics. 2002 Aug; 40(8):376-81. doi: 10.5414/cpp40376. [PMID: 12467306]
  • A D Huitema, C Reinders, M M Tibben, S Rodenhuis, J H Beijnen. Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 2001 Jun; 757(2):349-57. doi: 10.1016/s0378-4347(01)00178-5. [PMID: 11417881]
  • N Sannolo, N Miraglia, M Biglietto, A Acampora, A Malorni. Determination of cyclophosphamide and ifosphamide in urine at trace levels by gas chromatography/tandem mass spectrometry. Journal of mass spectrometry : JMS. 1999 Aug; 34(8):845-9. doi: 10.1002/(sici)1096-9888(199908)34:8<845::aid-jms839>3.0.co;2-q. [PMID: 10423565]
  • B Tillmann, S Krümpelmann, G Würthwein, A Wagner, P Schulze-Westhoff, G Hempel, H Jürgens, J Boos. [Pharmacokinetic aspects of oral administration of etoposide]. Klinische Padiatrie. 1998 Jul; 210(4):159-64. doi: 10.1055/s-2008-1043872. [PMID: 9743946]
  • G Hempel, S Krümpelmann, A May-Manke, B Hohenlöchter, G Blaschke, H Jürgens, J Boos. Pharmacokinetics of trofosfamide and its dechloroethylated metabolites. Cancer chemotherapy and pharmacology. 1997; 40(1):45-50. doi: 10.1007/s002800050623. [PMID: 9137528]
  • G P Kaijser, J H Beijnen, A Bult, G Wiese, J de Kraker, W J Underberg. Gas chromatographic determination of ifosfamide in microvolumes of urine and plasma. Journal of chromatography. 1991 Nov; 571(1-2):121-31. doi: 10.1016/0378-4347(91)80439-j. [PMID: 1810941]
  • D Masurel, I W Wainer. Analytical and preparative high-performance liquid chromatographic separation of the enantiomers of ifosfamide, cyclophosphamide and trofosfamide and their determination in plasma. Journal of chromatography. 1989 May; 490(1):133-43. doi: 10.1016/s0378-4347(00)82768-1. [PMID: 2760146]
  • H Burkert, P W Lücker, N Wetzelsberger, H P Breuel. Bioavailability of orally administered mesna. Arzneimittel-Forschung. 1984; 34(11):1597-600. doi: NULL. [PMID: 6441581]
  • F M Fouad, M Goldberg, G Ruhenstroth-Bauer. Plasma protein determination as a clinical probe for liver injury in rats induced by thioacetamide, alloxan or ixoten. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1983 Apr; 21(4):203-8. doi: 10.1515/cclm.1983.21.4.203. [PMID: 6854232]
  • N Brock, J Pohl, J Stekar. Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--I. Experimental studies on the urotoxicity of alkylating compounds. European journal of cancer. 1981 Jun; 17(6):595-607. doi: 10.1016/0014-2964(81)90261-9. [PMID: 7308258]
  • N Brock, J Pohl, J Stekar. Detoxification of urotoxic oxazaphosphorines by sulfhydryl compounds. Journal of cancer research and clinical oncology. 1981; 100(3):311-20. doi: 10.1007/bf00410691. [PMID: 6792207]
  • G Deysson, M Adolphe, H Semont. [Comparative study of the antimitotic effects of cyclophosphamide, trofosfamide and ifosfamide on meristema plant cells and animal cells in in vitro culture]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1981; 175(2):177-81. doi: NULL. [PMID: 6454463]
  • N Brock, J Stekar, J Pohl. [Antidote against the urotoxic effects of the oxazaphorine derivatives cyclophosphamide, ifosfamide and trofosfamide]. Die Naturwissenschaften. 1979 Jan; 66(1):60-1. doi: 10.1007/bf00369371. [PMID: 106307]