Dilatan (BioDeep_00000184544)
human metabolite blood metabolite
代谢物信息卡片
Biopharma brand OF trimetazidine dihydrochloride
化学式: C14H22N2O3 (266.16303419999997)
中文名称: 曲美他嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 21.05%
分子结构信息
SMILES: COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC
InChI: InChI=1S/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C - Cardiovascular system > C01 - Cardiac therapy
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
14 个代谢物同义名
Biopharma brand OF trimetazidine dihydrochloride; Alpharma brand OF trimetazidine dihydrochloride; Danval brand OF trimetazidine dihydrochloride; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; Irex brand OF trimetazidine dihydrochloride; Dihydrochloride, trimetazidine; trimetazidine dihydrochloride; Trimétazidine irex; TRIMETAZIDINE; Centrophène; Vasartel; Vastarel; Dilatan; Idaptan
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:94789
- PubChem: 21109
- HMDB: HMDB0259235
- DrugBank: DB09069
- ChEMBL: CHEMBL203266
- Wikipedia: Trimetazidine
- MeSH: Trimetazidine
- chemspider: 19853
- CAS: 5011-34-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaochun Ye, Shaohui Zhang. Clinical Observation of Trimetazidine Combined With Coenzyme Q10 in the Treatment of Myocardial Damage Caused by COVID-19.
American journal of therapeutics.
2024 Jan; 31(1):e59-e61. doi:
10.1097/mjt.0000000000001488. [PMID: 38231584] - Xinyu Tong, Lijuan Shen, Xiaomin Zhou, Yudan Wang, Sheng Chang, Shu Lu. Comparative Efficacy of Different Drugs for the Treatment of Dilated Cardiomyopathy: A Systematic Review and Network Meta-analysis.
Drugs in R&D.
2023 Aug; ?(?):. doi:
10.1007/s40268-023-00435-5. [PMID: 37556093] - Houman Kamranian, Hadi Asoudeh, Roya Kamrani Sharif, Fereshteh Taheri, A Wallace Hayes, Mina Gholami, Ahmad Alavi, Majid Motaghinejad. Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways.
Toxicology mechanisms and methods.
2023 Apr; ?(?):1-17. doi:
10.1080/15376516.2023.2202785. [PMID: 37051630] - David C Klonoff, Nicole Y Xu, Kevin T Nguyen, David Kerr, Chhavi Mehta, Guillermo E Umpierrez, George A Brooks. Trimetazidine Blocks Lipid Oxidation-Should it be Repurposed for Prevention and Treatment of Diabetic Ketoacidosis?.
Journal of diabetes science and technology.
2022 09; 16(5):1063-1068. doi:
10.1177/19322968221100196. [PMID: 35652624] - Rehab S Abdelrahman, Noha M Shawky. Trimetazidine, a metabolic modulator, attenuates silica-induced pulmonary fibrosis and decreases lactate levels and LDH activity in rats.
Journal of biochemical and molecular toxicology.
2022 Jul; 36(7):e23071. doi:
10.1002/jbt.23071. [PMID: 35403780] - Hayder M Al-Kuraishy, Ali I Al-Gareeb, Nermeen N Welson, Gaber El-Saber Batiha. Trimetazidine and COVID-19-induced acute cardiac injury: a missed key.
International journal of clinical pharmacy.
2022 Jun; 44(3):832-833. doi:
10.1007/s11096-022-01408-5. [PMID: 35449348] - Rehab S Abdelrahman, Ramy A Abdelsalam, Marwa S Zaghloul. Beneficial effect of trimetazidine on folic acid-induced acute kidney injury in mice: Role of HIF-1α/HO-1.
Journal of biochemical and molecular toxicology.
2022 May; 36(5):e23011. doi:
10.1002/jbt.23011. [PMID: 35191561] - Yingyi Lu, Fenglian Wang, Haoxuan Ni, Ying Sun, Hailing Shi. Observation of Curative Effect of Trimetazidine Combined with Metoprolol in Elderly Patients with Coronary Heart Disease Complicated with Heart Failure and the Effect of Myocardial Remodeling by Integrated Traditional Chinese and Western Medicine.
BioMed research international.
2022; 2022(?):6098799. doi:
10.1155/2022/6098799. [PMID: 36246960] - Kaijing Yang, Yitao Xue, Miao Yu, Huachen Jiao, Yan Li, Xijin Wei, Wenwen Liu, Yang Sun, Nannan Chen, Linlin Song, Ting Yu, Kaiming Chen, Dadong Guo. Protective Effect of Trimetazidine on Potassium Ion Homeostasis in Myocardial Tissue in Mice with Heart Failure.
BioMed research international.
2022; 2022(?):2387860. doi:
10.1155/2022/2387860. [PMID: 35097112] - Kirti Gupta, Sneha Pandey, Newly Bagang, Kamalpreet Mehra, Gaaminepreet Singh. Trimetazidine an emerging paradigm in renal therapeutics: Preclinical and clinical insights.
European journal of pharmacology.
2021 Dec; 913(?):174624. doi:
10.1016/j.ejphar.2021.174624. [PMID: 34774496] - Yan Yang, Qinqin Xu, Tao Li, Shiying Shao. Trimetazidine ameliorates hindlimb ischaemic damage in type 2 diabetic mice.
Annals of medicine.
2021 12; 53(1):1099-1107. doi:
10.1080/07853890.2021.1925147. [PMID: 34259103] - Wenliang Zhang, Baiyang You, Dake Qi, Ling Qiu, Jeffrey W Ripley-Gonzalez, Fan Zheng, Siqian Fu, Cui Li, Yaoshan Dun, Suixin Liu. Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control.
Scientific reports.
2021 09; 11(1):19116. doi:
10.1038/s41598-021-98771-6. [PMID: 34580406] - Fathalla Belal, Mokhtar Mabrouk, Sherin Hammad, Aya Barseem, Hytham Ahmed. One-pot synthesis of fluorescent nitrogen and sulfur-carbon quantum dots as a sensitive nanosensor for trimetazidine determination.
Luminescence : the journal of biological and chemical luminescence.
2021 Sep; 36(6):1435-1443. doi:
10.1002/bio.4083. [PMID: 33982840] - Han Fu, Jing Zhang, Hong Zhang, Peng Zhang, Xiaofeng Fu, Zhican Zeng, Xue Zhang, Wenyuan Li, Shicheng Yang, Xiaogang Liu, Naikuan Fu. Trimetazidine can prevent the occurrence of contrast-induced nephropathy after percutaneous coronary intervention in elderly patients with renal insufficiency.
Perfusion.
2021 Sep; 36(6):603-609. doi:
10.1177/0267659120957856. [PMID: 32909511] - Negin Amini, Alireza Sarkaki, Mahin Dianat, Seyyed Ali Mard, Akram Ahangarpour, Mohammad Badavi. Naringin and Trimetazidine Improve Baroreflex Sensitivity and Nucleus Tractus Solitarius Electrical Activity in Renal Ischemia-Reperfusion Injury.
Arquivos brasileiros de cardiologia.
2021 08; 117(2):290-297. doi:
10.36660/abc.20200121. [PMID: 34495221] - Philipp J Hohensinner, Max Lenz, Patrick Haider, Julia Mayer, Manuela Richter, Christoph Kaun, Laura Goederle, Mira Brekalo, Manuel Salzmann, Smriti Sharma, Michael B Fischer, Stefan Stojkovic, Daniel Ramsmayer, Christian Hengstenberg, Bruno K Podesser, Kurt Huber, Christoph J Binder, Johann Wojta, Walter S Speidl. Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation.
Biochemical pharmacology.
2021 08; 190(?):114634. doi:
10.1016/j.bcp.2021.114634. [PMID: 34058186] - Xue Zhang, Peng Zhang, Shicheng Yang, Wenyuan Li, Xiuzhen Men, Naikuan Fu. Preventive effect of trimetazidine on contrast-induced nephropathy undergoing percutaneous coronary intervention in elderly moderate and high risk diabetics stratified by mehran score.
Perfusion.
2021 Jul; 36(5):491-500. doi:
10.1177/0267659120952057. [PMID: 32838661] - Chang Wang, Weiwei Chen, Ming Yu, Ping Yang. Efficacy of Trimetazidine in Limiting Periprocedural Myocardial Injury in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.
Angiology.
2021 07; 72(6):511-523. doi:
10.1177/0003319720987745. [PMID: 33472383] - J W Martha, R Pranata, A Wibowo, I Irvan, R Afrianti, M R Akbar. The effect of trimetazidine on contrast-induced nephropathy in patients undergoing coronary angiography and/or percutaneous coronary intervention - A systematic review and meta-analysis.
European review for medical and pharmacological sciences.
2021 04; 25(7):3045-3053. doi:
10.26355/eurrev_202104_25558. [PMID: 33877668] - Ashkan Heshmatzadeh Behzadi, Behzad Amoozgar, Shalini Jain, Noel Velasco, Umar Zahid, Hamidreza Abbasi, Lutfi Alasadi, Martin R Prince. Trimetazidine reduces contrast-induced nephropathy in patients with renal insufficiency undergoing coronary angiography and angioplasty: A systematic review and meta-analysis (PRISMA).
Medicine.
2021 Mar; 100(10):e24603. doi:
10.1097/md.0000000000024603. [PMID: 33725824] - María Herminia Hazelhoff, Romina Paula Bulacio, Adriana Monica Torres. Trimetazidine Protects from Mercury-Induced Kidney Injury.
Pharmacology.
2021; 106(5-6):332-340. doi:
10.1159/000514843. [PMID: 33849026] - Ye Lin, Zhen Lian Wang, Min Yan, Fei Yu Zhu, Ye Duan, Zhi Qin Sun. Effect of Trimetazidine on Diabetic Patients with Coronary Heart Diseases: A Meta-Analysis of Randomized, Controlled Trials.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.
2020 Sep; 35(3):226-238. doi:
10.24920/003678. [PMID: 32972500] - Ying Zhang, Can Li, Xiuqi Li, Cheng Wu, Haiyan Zhou, Shuang Lu, Xingde Liu. Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway.
Molecular medicine reports.
2020 09; 22(3):2174-2182. doi:
10.3892/mmr.2020.11309. [PMID: 32705195] - Hakan Ergücük, Sevil Işık, Nidal İflazoğlu, Cüneyt Kayaalp, Mehmet Saraç, Serdar Gürsul. The effect of trimethazidine on mortality in an experimental acute pancreatitis model1.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2020 08; 31(8):549-557. doi:
10.5152/tjg.2020.18666. [PMID: 32915142] - Nencho Nenchev, Jiri Skopek, Deepa Arora, Abdus Samad, Sigal Kaplan, Mónika Domahidy, Hanka de Voogd, Stella Böhmert, Rita S Ramos, Shashank Jain. Effect of age and renal impairment on the pharmacokinetics and safety of trimetazidine: An open-label multiple-dose study.
Drug development research.
2020 08; 81(5):564-572. doi:
10.1002/ddr.21654. [PMID: 32128844] - Pallavi Chandra, Li He, Matthew Zimmerman, Guozhe Yang, Stefan Köster, Mireille Ouimet, Han Wang, Kathyrn J Moore, Véronique Dartois, Joel D Schilling, Jennifer A Philips. Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis.
mBio.
2020 07; 11(4):. doi:
10.1128/mbio.01139-20. [PMID: 32636249] - Anna Toso, Mario Leoncini, Mauro Maioli, Francesco Bellandi. Pharmacologic Prophylaxis of Contrast-Induced Nephropathy.
Interventional cardiology clinics.
2020 07; 9(3):369-383. doi:
10.1016/j.iccl.2020.02.006. [PMID: 32471677] - Saad Rasool Shaker, Fadhil Al-Amran, Ghizal Fatima, Hayder Al-Aubaid, Najah R Hadi. Trimetazidine Improves the Outcome of EECP Therapy in Patients with Refractory Angina Pectoris.
Medical archives (Sarajevo, Bosnia and Herzegovina).
2020 Jun; 74(3):199-204. doi:
10.5455/medarh.2020.74.199-204. [PMID: 32801436] - Jinhai Lin, Bin Zhong, Jinling Yan, Lili Chen. Effect of trimetazidine combined with perindopril on NT-proBNP level in rats with dilated cardiomyopathy.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 May; 66(2):198-203. doi:
. [PMID: 32415948] - Xingji Lian, Wenfei He, Huimin Zhan, Jiyan Chen, Ning Tan, Pengcheng He, Yuanhui Liu. The effect of trimetazidine on preventing contrast-induced nephropathy after cardiac catheterization.
International urology and nephrology.
2019 Dec; 51(12):2267-2272. doi:
10.1007/s11255-019-02308-w. [PMID: 31641999] - Dongfeng Yao, Chuan Wang, Lihua Han, Pan Zhang, Jiping Liu, Bin Wang, Enhu Zhang. Compound danshen dripping pills combined with trimetazidine in treating unstable angina pectoris: Protocol for a systematic review of randomized controlled trials.
Medicine.
2019 Dec; 98(49):e18238. doi:
10.1097/md.0000000000018238. [PMID: 31804349] - Negin Amini, Alireza Sarkaki, Mahin Dianat, Seyyed Ali Mard, Akram Ahangarpour, Mohammad Badavi. Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation.
Pharmacological reports : PR.
2019 Dec; 71(6):1059-1066. doi:
10.1016/j.pharep.2019.06.007. [PMID: 31604166] - Pingxian Ye, Pingzhen Ye, Jinping He. [Effect of trimetazidine on cardiac function and exercise tolerance in hypertension patients with diabetic].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
2019 05; 48(3):282-288. doi:
10.3785/j.issn.1008-9292.2019.06.08. [PMID: 31496160] - Amirhossein Mirhosseni, Behzad Farahani, Alireza Gandomi-Mohammadabadi, Hossein Keyvani, Maryam Biglari-Abhari, Alireza Davari, Mohammad Hossein Vazirizade-Mahabadi, Shokufeh Savaj. Preventive Effect of Trimetazidine on Contrast-Induced Acute Kidney Injury in CKD Patients Based on Urinary Neutrophil Gelatinase-associated Lipocalin (uNGAL): A randomized Clinical Trial.
Iranian journal of kidney diseases.
2019 05; 13(3):191-197. doi:
NULL. [PMID: 31209192] - Negin Amini, Alireza Sarkaki, Mahin Dianat, Seyyed Ali Mard, Akram Ahangarpour, Mohammad Badavi. The renoprotective effects of naringin and trimetazidine on renal ischemia/reperfusion injury in rats through inhibition of apoptosis and downregulation of micoRNA-10a.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Apr; 112(?):108568. doi:
10.1016/j.biopha.2019.01.029. [PMID: 30780111] - Sheng-Gao Tang, Xiao-Yu Liu, Shan-Ping Wang, Hong-Hui Wang, Aleksandar Jovanović, Wen Tan. Trimetazidine prevents diabetic cardiomyopathy by inhibiting Nox2/TRPC3-induced oxidative stress.
Journal of pharmacological sciences.
2019 Apr; 139(4):311-318. doi:
10.1016/j.jphs.2019.01.016. [PMID: 30962089] - Manolis S Kallistratos, Leonidas E Poulimenos, Sofia Giannitsi, Pavlos Tsinivizov, Athanasios J Manolis. Trimetazidine in the Prevention of Tissue Ischemic Conditions.
Angiology.
2019 Apr; 70(4):291-298. doi:
10.1177/0003319718780551. [PMID: 29888611] - Caroline J Coats, Menelaos Pavlou, Oliver T Watkinson, Alexandros Protonotarios, Linda Moss, Rebecca Hyland, Khadija Rantell, Antonis A Pantazis, Maite Tome, William J McKenna, Michael P Frenneaux, Rumana Omar, Perry M Elliott. Effect of Trimetazidine Dihydrochloride Therapy on Exercise Capacity in Patients With Nonobstructive Hypertrophic Cardiomyopathy: A Randomized Clinical Trial.
JAMA cardiology.
2019 03; 4(3):230-235. doi:
10.1001/jamacardio.2018.4847. [PMID: 30725091] - Weidai Zhang, Kefei Wu, Hanfei Lin, Jiawei Zhang, Songming Chen. Effect of Trimetazidine on Preventing Contrast-Induced Acute Kidney Injury in Patients With Diabetes.
The American journal of the medical sciences.
2018 12; 356(6):576-577. doi:
10.1016/j.amjms.2018.06.011. [PMID: 30180939] - Jianxia Wen, Xiao Ma, Lu Zhang, Xiaohua Lu, Yuxue Yang, Jian Wang, Yanling Zhao. Therapeutic efficacy and safety of Shexiang Baoxin Pill combined with trimetazidine in elderly patients with heart failure secondary to ischaemic cardiomyopathy: A systematic review and meta-analysis.
Medicine.
2018 Dec; 97(51):e13580. doi:
10.1097/md.0000000000013580. [PMID: 30572460] - Shuzhan Zheng, Yanfei Du, Qiqi Peng, Xinrong Fan, Jiafu Li, Mao Chen. Trimetazidine Protects Against Atherosclerosis by Changing Energy Charge and Oxidative Stress.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Nov; 24(?):8459-8468. doi:
10.12659/msm.911317. [PMID: 30468686] - Masato Okano, Mitsuhiko Sato, Shinji Kageyama. Lomerizine, trimetazidine and bis-(4-fluorophenyl)-methylpiperazine in human urine after oral administration of lomerizine dihydrochloride: analysis by liquid chromatography-high resolution-tandem mass spectrometry.
Drug testing and analysis.
2018 Nov; 10(11-12):1689-1697. doi:
10.1002/dta.2504. [PMID: 30240154] - Yanhong Li, Wenli Hou, Tan Li, Jihong Zhao. [Trimetazidine reduces cholesterol content of foam cells by up-regulating autophagy and macrophage extracellular traps, and inhibiting inflammasome].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2018 Nov; 34(11):969-976. doi:
". [PMID: 30591104] - Shiyong Wu, Guanglei Chang, Lei Gao, Dan Jiang, Liyou Wang, Guoxing Li, Xuexiu Luo, Shu Qin, Xueli Guo, Dongying Zhang. Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy.
Journal of molecular medicine (Berlin, Germany).
2018 08; 96(8):791-806. doi:
10.1007/s00109-018-1664-3. [PMID: 29955901] - Yongseok Kim, Mijin Jeon, Hophil Min, Junghyun Son, Jaeick Lee, Oh-Seung Kwon, Myeong Hee Moon, Ki Hun Kim. Development of a multi-functional concurrent assay using weak cation-exchange solid-phase extraction (WCX-SPE) and reconstitution with a diluted sample aliquot for anti-doping analysis.
Rapid communications in mass spectrometry : RCM.
2018 Jun; 32(11):897-905. doi:
10.1002/rcm.8119. [PMID: 29572989] - Li-Jun Zhang, Mei-Yan Liu, Radhika Rastogi, Jessie N Ding. Psychocardiological disorder and brain serotonin after comorbid myocardial infarction and depression: an experimental study.
Neurological research.
2018 Jun; 40(6):516-523. doi:
10.1080/01616412.2018.1455460. [PMID: 29577822] - Fei Chen, Fan Liu, Jingchao Lu, Xiuchun Yang, Bing Xiao, Yaqiong Jin, Jie Zhang. Coenzyme Q10 combined with trimetazidine in the prevention of contrast-induced nephropathy in patients with coronary heart disease complicated with renal dysfunction undergoing elective cardiac catheterization: a randomized control study and in vivo study.
European journal of medical research.
2018 May; 23(1):23. doi:
10.1186/s40001-018-0320-2. [PMID: 29776437] - Ming Song, Fang-Fang Chen, Yi-Hui Li, Lei Zhang, Feng Wang, Ran-Ran Qin, Zhi-Hao Wang, Ming Zhong, Meng-Xiong Tang, Wei Zhang, Lu Han. Trimetazidine restores the positive adaptation to exercise training by mitigating statin-induced skeletal muscle injury.
Journal of cachexia, sarcopenia and muscle.
2018 02; 9(1):106-118. doi:
10.1002/jcsm.12250. [PMID: 29152896] - Pravin G Vanol, Manish Yadav, Mallika Sanyal, Priyanka A Shah, Pranav S Shrivastav. Overcoming interference of plasma phospholipids using HybridSPE for the determination of trimetazidine by UPLC-MS/MS.
Biomedical chromatography : BMC.
2018 Feb; 32(2):. doi:
10.1002/bmc.4095. [PMID: 28906001] - NULL. [Effects of trimetazidine, a myocardial metabolism agent, on regulating 5-hydroxytrytamine system of rats with myocardial infarction and/or depression].
Zhonghua nei ke za zhi.
2018 Jan; 57(1):48-53. doi:
10.3760/cma.j.issn.0578-1426.2018.01.009. [PMID: 29325311] - Jin Ha Park, Ji Hae Jun, Jae-Kwang Shim, Eun Jung Shin, Eunah Shin, Young-Lan Kwak. Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression.
Oxidative medicine and cellular longevity.
2018; 2018(?):1072805. doi:
10.1155/2018/1072805. [PMID: 30057668] - Levent Cerit. Bermuda Triangle: Chronic kidney disease, contrast-induced nephropathy, and atrial fibrillation.
Cardiovascular revascularization medicine : including molecular interventions.
2018 01; 19(1 Pt A):71. doi:
10.1016/j.carrev.2017.06.003. [PMID: 28606787] - Laura Petrovics, Tibor Nagy, Peter Hardi, Laura Bognar, Gabor Pavlovics, Gyorgy Tizedes, Ildiko Takacs, Gabor Jancso. The effect of trimetazidine in reducing the ischemia-reperfusion injury in rat epigastric skin flaps.
Clinical hemorheology and microcirculation.
2018; 69(3):405-415. doi:
10.3233/ch-170335. [PMID: 29660909] - Saeed Jahandideh, Shohreh Khatami, Ali Eslami Far, Mehdi Kadivar. Anti-inflammatory effects of human embryonic stem cell-derived mesenchymal stem cells secretome preconditioned with diazoxide, trimetazidine and MG-132 on LPS-induced systemic inflammation mouse model.
Artificial cells, nanomedicine, and biotechnology.
2018; 46(sup2):1178-1187. doi:
10.1080/21691401.2018.1481862. [PMID: 29929400] - Runjun Li, Xiuying Tang, Quanmin Jing, Qingsheng Wang, Meihong Yang, Xiaoyu Han, Jiayu Zhao, Xiangyou Yu. The effect of trimetazidine treatment in patients with type 2 diabetes undergoing percutaneous coronary intervention for AMI.
The American journal of emergency medicine.
2017 Nov; 35(11):1657-1661. doi:
10.1016/j.ajem.2017.05.024. [PMID: 28587952] - Tarek A Ibrahim, Ramzy H El-Mawardy, Ahmed S El-Serafy, Ehab M El-Fekky. Trimetazidine in the prevention of contrast-induced nephropathy in chronic kidney disease.
Cardiovascular revascularization medicine : including molecular interventions.
2017 Jul; 18(5):315-319. doi:
10.1016/j.carrev.2017.02.006. [PMID: 28532702] - Sema Nur Ayyildiz, Ali Ayyildiz, Erdal Benli, Selma Cirrik, Rüştü Cankon Germiyanoğlu, Tevfik Noyan, Abdullah Çirakoğlu. The effect of trimetazidine on renal oxidative stress in partial and complete ureteral obstructions in a rat model.
Turkish journal of medical sciences.
2017 Jun; 47(3):1012-1018. doi:
10.3906/sag-1512-85. [PMID: 28618759] - Hai Zou, Xing-Xing Zhu, Ya-Hui Ding, Qin-Yang Jin, Lin-Yan Qian, Dong-Sheng Huang, Xue-Jiang Cen. Trimetazidine in conditions other than coronary disease, old drug, new tricks?.
International journal of cardiology.
2017 May; 234(?):1-6. doi:
10.1016/j.ijcard.2017.02.083. [PMID: 28256321] - Mohamed Amine Zaouali, Arnau Panisello, Alexandre Lopez, Carlos Castro, Emma Folch, Teresa Carbonell, Anabela Rolo, Carlos Marques Palmeira, Agustin Garcia-Gil, René Adam, Joan Roselló-Catafau. GSK3β and VDAC Involvement in ER Stress and Apoptosis Modulation during Orthotopic Liver Transplantation.
International journal of molecular sciences.
2017 Mar; 18(3):. doi:
10.3390/ijms18030591. [PMID: 28282906] - M Y Liu, L J Zhang. [Impact of trimetazidine pre-treatment on 5-hydroxytryptamine and serotonin transporter in rats with experimental myocardial infarction and depression].
Zhonghua xin xue guan bing za zhi.
2017 Feb; 45(2):137-141. doi:
10.3760/cma.j.issn.0253-3758.2017.02.013. [PMID: 28260320] - Qiang Su, Lang Li, Jinmin Zhao, Yuhan Sun, Huafeng Yang. Effects of Trimetazidine on PDCD4/NF-κB/TNF-α Pathway in Coronary Microembolization.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 42(2):753-760. doi:
10.1159/000478067. [PMID: 28683436] - Ailan Chen, Wanglin Li, Xinyu Chen, Yuechun Shen, Wenjun Dai, Qi Dong, Xinchun Li, Caiwen Ou, Minsheng Chen. Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction.
BMC cardiovascular disorders.
2016 11; 16(1):225. doi:
10.1186/s12872-016-0399-8. [PMID: 27855650] - Masato Okano, Mario Thevis, Mitsuhiko Sato, Shinji Kageyama. Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis.
Drug testing and analysis.
2016 Aug; 8(8):869-74. doi:
10.1002/dta.1893. [PMID: 26560081] - Liang Shao, Aiqun Ma, Gemma Figtree, Ping Zhang. Combination Therapy With Coenzyme Q10 and Trimetazidine in Patients With Acute Viral Myocarditis.
Journal of cardiovascular pharmacology.
2016 Aug; 68(2):150-4. doi:
10.1097/fjc.0000000000000396. [PMID: 27046339] - A R Vijayakumar, H Anuradha, Nihar Ranjan Biswas, Vimla Menon, Rohit Saxena, Nabanita Halder, T Velpandian. Evaluation of the Protective Effect of NMDA/Non-NMDA Receptor Antagonists Against Ethambutol Induced Retinal Toxicity Using ERG in Wistar Rats.
Indian journal of physiology and pharmacology.
2016 Jul; 60(3):268-81. doi:
NULL. [PMID: 29957983] - Nagla A El-Sherbeeny, Ghalia M Attia. The protective effect of trimetazidine against cisplatin-induced nephrotoxicity in rats.
Canadian journal of physiology and pharmacology.
2016 Jul; 94(7):745-51. doi:
10.1139/cjpp-2015-0472. [PMID: 27348619] - Asma Mahfoudh Boussaid, Rabi Selmi, Mohamed Bejaoui, Kaouther Hadj Ayed, Mohamed Amine Zaouali, Hassen Ben Abdennebi. Effectiveness of a single versus repeated administration of trimetazidine in the protection against warm ischemia/reperfusion injury of rat liver.
Turkish journal of medical sciences.
2016 Jun; 46(4):1258-64. doi:
10.3906/sag-1505-102. [PMID: 27513433] - Jing Chen, Jinsheng Lai, Lei Yang, Guoran Ruan, Sandip Chaugai, Qin Ning, Chen Chen, Dao Wen Wang. Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1.
British journal of pharmacology.
2016 Feb; 173(3):545-61. doi:
10.1111/bph.13386. [PMID: 26566260] - J Hao, H Du, W-W Li, Z-F Zhao, F Liu, J-C Lu, X-C Yang, W Cui. Effects of atorvastatin combined with trimetazidine on myocardial injury and inflammatory mediator in unstable angina patients during perioperative of percutaneous coronary intervention.
European review for medical and pharmacological sciences.
2015 Dec; 19(23):4642-6. doi:
. [PMID: 26698263] - Girish N Nadkarni, Ioannis Konstantinidis, Achint Patel, Rabi Yacoub, Damodar Kumbala, Rajan A G Patel, Narender Annapureddy, Krishna Chaitanya Pakanati, Priya K Simoes, Fahad Javed, Alexandre M Benjo. Trimetazidine Decreases Risk of Contrast-Induced Nephropathy in Patients With Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials.
Journal of cardiovascular pharmacology and therapeutics.
2015 Nov; 20(6):539-46. doi:
10.1177/1074248415573320. [PMID: 25715308] - Weijing Liu, Qiang Ming, Jianying Shen, Yidong Wei, Weiming Li, Wei Chen, Yawei Xu. Trimetazidine Prevention of Contrast-Induced Nephropathy in Coronary Angiography.
The American journal of the medical sciences.
2015 Nov; 350(5):398-402. doi:
10.1097/maj.0000000000000575. [PMID: 26445302] - Jinhong Wei, Hao Xu, Liang Shi, Jie Tong, Jianbao Zhang. Trimetazidine protects cardiomyocytes against hypoxia-induced injury through ameliorates calcium homeostasis.
Chemico-biological interactions.
2015 Jul; 236(?):47-56. doi:
10.1016/j.cbi.2015.04.022. [PMID: 25937560] - Eirini Pantazi, Mohamed Amine Zaouali, Mohamed Bejaoui, Emma Folch-Puy, Hassen Ben Abdennebi, Ana Teresa Varela, Anabela Pinto Rolo, Carlos Marques Palmeira, Joan Roselló-Catafau. Sirtuin 1 in rat orthotopic liver transplantation: an IGL-1 preservation solution approach.
World journal of gastroenterology.
2015 Feb; 21(6):1765-74. doi:
10.3748/wjg.v21.i6.1765. [PMID: 25684941] - Xin Xiong, Li Yang. Salting-out-assisted liquid-liquid extraction with acetonitrile for the determination of trimetazidine in rat plasma using liquid chromatography-mass spectrometry.
Biomedical chromatography : BMC.
2015 Feb; 29(2):268-74. doi:
10.1002/bmc.3271. [PMID: 24954771] - A Tanoglu, L Yamanel, V Inal, R Ocal, B Comert, C Bilgi. Appreciation of trimetazidine treatment in experimental sepsis rat model.
Bratislavske lekarske listy.
2015; 116(2):124-7. doi:
10.4149/bll_2015_024. [PMID: 25665480] - J Szkodzinski, A Danikiewicz, B Hudzik, M Szewczyk, M Gąsior, B Zubelewicz-Szkodzinska. Effect of trimetazidine on serum interleukin-6 and C-reactive protein concentrations in patients with stable coronary artery disease.
Journal of biological regulators and homeostatic agents.
2015 Jan; 29(1):63-72. doi:
NULL. [PMID: 25864742] - B Acar, R M Karasen, Y Buran. Efficacy of medical therapy in the prevention of residual dizziness after successful repositioning maneuvers for Benign Paroxysmal Positional Vertigo (BPPV).
B-ENT.
2015; 11(2):117-21. doi:
". [PMID: 26563011] - Gholamreza Hassanzadeh, Amir Hosseini, Parichehr Pasbakhsh, Mohammad Akbari, Massoud Ghaffarpour, Nasrin Takzare, Maryam Zahmatkesh. Trimetazidine prevents oxidative changes induced in a rat model of sporadic type of Alzheimer's disease.
Acta medica Iranica.
2015; 53(1):17-24. doi:
". [PMID: 25597600] - Shuangjiao Sun, Chanjuan Long, Chunyao Tao, Sa Meng, Biyang Deng. Ultrasonic microdialysis coupled with capillary electrophoresis electrochemiluminescence study the interaction between trimetazidine dihydrochloride and human serum albumin.
Analytica chimica acta.
2014 Dec; 851(?):37-42. doi:
10.1016/j.aca.2014.08.012. [PMID: 25440662] - Tunay Şentürk, Sinan Çavun, Berrin Avcı, Aysun Yermezler, Zehra Serdar, Vahide Savcı. Effective inhibition of cardiomyocyte apoptosis through the combination of trimetazidine and N-acetylcysteine in a rat model of myocardial ischemia and reperfusion injury.
Atherosclerosis.
2014 Dec; 237(2):760-6. doi:
10.1016/j.atherosclerosis.2014.10.091. [PMID: 25463117] - Gerd Sigmund, Anja Koch, Anne-Katrin Orlovius, Sven Guddat, Andreas Thomas, Wilhelm Schänzer, Mario Thevis. Doping control analysis of trimetazidine and characterization of major metabolites using mass spectrometric approaches.
Drug testing and analysis.
2014 Nov; 6(11-12):1197-205. doi:
10.1002/dta.1680. [PMID: 24913825] - Anna Jarek, Marzena Wójtowicz, Dorota Kwiatkowska, Monika Kita, Ewa Turek-Lepa, Katarzyna Chajewska, Sylwia Lewandowska-Pachecka, Andrzej Pokrywka. The prevalence of trimetazidine use in athletes in Poland: excretion study after oral drug administration.
Drug testing and analysis.
2014 Nov; 6(11-12):1191-6. doi:
10.1002/dta.1755. [PMID: 25421604] - Nishi Srivastava, Rahul K Kollipara, Dinesh K Singh, Jessica Sudderth, Zeping Hu, Hien Nguyen, Shan Wang, Caroline G Humphries, Ryan Carstens, Kenneth E Huffman, Ralph J DeBerardinis, Ralf Kittler. Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.
Cell metabolism.
2014 Oct; 20(4):650-61. doi:
10.1016/j.cmet.2014.08.003. [PMID: 25264247] - Asma Mahfoudh-Boussaid, Kaouther Hadj Ayed Tka, Mohamed Amine Zaouali, Joan Roselló-Catafau, Hassen Ben Abdennebi. Effects of trimetazidine on the Akt/eNOS signaling pathway and oxidative stress in an in vivo rat model of renal ischemia-reperfusion.
Renal failure.
2014 Oct; 36(9):1436-42. doi:
10.3109/0886022x.2014.949765. [PMID: 25246344] - Jovan Kuzmicic, Valentina Parra, Hugo E Verdejo, Camila López-Crisosto, Mario Chiong, Lorena García, Michael D Jensen, David A Bernlohr, Pablo F Castro, Sergio Lavandero. Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes.
Biochemical pharmacology.
2014 Oct; 91(3):323-36. doi:
10.1016/j.bcp.2014.07.022. [PMID: 25091560] - Tugba Karadeniz, Turker Cavusoğlu, Engin Turkmen, Yigit Uyanıkgil, Muammer Karadeniz, Ovunc Akdemir, M Ibrahim Tuglu, Utku Ates, Oytun Erbas. Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.
Renal failure.
2014 Sep; 36(8):1283-90. doi:
10.3109/0886022x.2014.930331. [PMID: 25010195] - Mohamed Shehata. Impact of trimetazidine on incidence of myocardial injury and contrast-induced nephropathy in diabetic patients with renal dysfunction undergoing elective percutaneous coronary intervention.
The American journal of cardiology.
2014 Aug; 114(3):389-94. doi:
10.1016/j.amjcard.2014.04.052. [PMID: 24927970] - John R Ussher, Wendy Keung, Natasha Fillmore, Timothy R Koves, Jun Mori, Liyan Zhang, David G Lopaschuk, Olga R Ilkayeva, Cory S Wagg, Jagdip S Jaswal, Deborah M Muoio, Gary D Lopaschuk. Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.
The Journal of pharmacology and experimental therapeutics.
2014 Jun; 349(3):487-96. doi:
10.1124/jpet.114.214197. [PMID: 24700885] - Çağdaş Akgüllü, Tevger Saruhan, Ufuk Eryilmaz, Murat Boyacıoğlu, Osman Alper Onbaşılı, Ibrahim Meteoğlu, Cavit Kum. The first histopathological evidence of trimetazidine for the prevention of contrast-induced nephropathy.
Renal failure.
2014 May; 36(4):575-80. doi:
10.3109/0886022x.2014.880324. [PMID: 24467457] - Jianjun Zhang, Meng Fu, Minyan Zhang, Liang Xu, Yuan Gao. Synthesis of oxidized glycerol monooleate-chitosan polymer and its hydrogel formation for sustained release of trimetazidine hydrochloride.
International journal of pharmaceutics.
2014 Apr; 465(1-2):32-41. doi:
10.1016/j.ijpharm.2014.02.001. [PMID: 24508554] - Rui Zhang, Jianrui Wei, Haiyan Yin, Youfeng Zhu. [Effect of trimetazidine on renal function in patients with shock].
Zhonghua wei zhong bing ji jiu yi xue.
2014 Apr; 26(4):219-22. doi:
10.3760/cma.j.issn.2095-4352.2014.04.004. [PMID: 24709491] - Xiang Zhou, Jianchang Chen. Is treatment with trimetazidine beneficial in patients with chronic heart failure?.
PloS one.
2014; 9(5):e94660. doi:
10.1371/journal.pone.0094660. [PMID: 24797235] - Xuhe Gong, Guangpu Fan, Wei Wang, Guogan Wang. Trimetazidine protects umbilical cord mesenchymal stem cells against hypoxia and serum deprivation induced apoptosis by activation of Akt.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2014; 34(6):2245-55. doi:
10.1159/000369667. [PMID: 25562170] - Akan Yenicerioglu, Ziya Cetinkaya, Mustafa Girgin, Bilal Ustundag, Ibrahim H Ozercan, Refik Ayten, Burhan H Kanat. Effects of trimetazidine in acute pancreatitis induced by L-arginine.
Canadian journal of surgery. Journal canadien de chirurgie.
2013 Jun; 56(3):175-9. doi:
10.1503/cjs.032811. [PMID: 23484468] - Israfil Orhan, Salih Aydın, Gökhan Altın, Fahrettin Yılmaz. [An efficacy comparison of betahistin, trimetazidine and ginkgo biloba extract in patients with tinnitus].
Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat.
2013 May; 23(3):143-7. doi:
10.5606/kbbihtisas.2013.03064. [PMID: 23682937] - L Dehina, F Vaillant, A Tabib, B Bui-Xuan, Ph Chevalier, N Dizerens, C Bui-Xuan, J Descotes, V Blanc-Guillemaud, L Lerond, Q Timour. Trimetazidine demonstrated cardioprotective effects through mitochondrial pathway in a model of acute coronary ischemia.
Naunyn-Schmiedeberg's archives of pharmacology.
2013 Mar; 386(3):205-15. doi:
10.1007/s00210-012-0826-z. [PMID: 23263451] - Jiang Lv, Xu Zhao, Jing Ye, Dan Liu, Xiaohui Chen, Kaishun Bi. Hollow fiber-based liquid membrane microextraction combined with high-performance liquid chromatography for extraction and determination of trimetazidine in human plasma.
Biomedical chromatography : BMC.
2013 Mar; 27(3):292-8. doi:
10.1002/bmc.2790. [PMID: 22833220] - Marco Bucci, Ronald Borra, Kjell Någren, Jussi P Pärkkä, Silvia Del Ry, Romina Maggio, Helena Tuunanen, Tapio Viljanen, Manuela Cabiati, Sara Rigazio, Markku Taittonen, Uberto Pagotto, Riitta Parkkola, Lionel H Opie, Pirjo Nuutila, Juhani Knuuti, Patricia Iozzo. Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans.
Cardiovascular therapeutics.
2012 Dec; 30(6):333-41. doi:
10.1111/j.1755-5922.2011.00275.x. [PMID: 21884010] - Wen-fang Liu, Jing Li, Chang-sheng Ma, Yang Lin, Ke-xu Yang, Wei Suo, Wei Wu, Gui-ping Zhao. [Pharmacokinetics and bioequivalence of domestic trimetazidine formulations].
Zhonghua xin xue guan bing za zhi.
2012 Dec; 40(12):1041-4. doi:
NULL. [PMID: 23363721]