Famciclovir (BioDeep_00000018454)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetic acid

化学式: C14H19N5O4 (321.1436974)
中文名称: 泛昔洛韦
谱图信息: 最多检出来源 Homo sapiens(blood) 20%

分子结构信息

SMILES: CC(=O)OCC(CCN1C=NC2=CN=C(N)N=C12)COC(C)=O
InChI: InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)

描述信息

Famciclovir is a guanine analogue antiviral drug used for the treatment of various herpes virus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AD - Antivirals
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Famciclovir (BRL 42810) is an orally active nucleoside analogue. Famciclovir is an antiviral agent with potent activities against HBV, HSV and VZV. Famciclovir can be used for the research of herpesvirus infection[1].

同义名列表

13 个代谢物同义名

2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetic acid; Acetic acid 2-acetoxymethyl-4-(2-amino-purin-9-yl)-butyl ester; 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate; Acetate 2-acetoxymethyl-4-(2-amino-purin-9-yl)-butyl ester; 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine; 9-(4-Acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine; Famciclovirum; famciclovir; BRL-42810; Famvir; FCV; BRL 42810



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rahul Sharma, Ashwini Deshpande, Abhishek Kanugo. Formulation Optimization and Evaluation of Nanocochleate Gel of Famciclovir for the Treatment of Herpes Zoster. Recent patents on nanotechnology. 2022 Jun; ?(?):. doi: 10.2174/1872210516666220622115553. [PMID: 35733311]
  • Maya L Iyer, Christine M Molter, Joseph P Flanagan, Kendra L Bauer, Rob Bernardy, Daryl Hoffman, Lily Parkinson, Benjamin M Brainard, Tierra Smiley Evans, Taylor Pursell, Paul D Ling. NOVEL DIAGNOSTIC AND THERAPEUTIC APPROACHES TO ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 1A HEMORRHAGIC DISEASE IN A CAPTIVE JUVENILE ASIAN ELEPHANT (ELEPHAS MAXIMUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2022 Mar; 53(1):232-240. doi: 10.1638/2021-0096. [PMID: 35339171]
  • Ashley Crouch, Mariesa Le, Christin Rogers, Sarah Shao, Camille Kotton. Evaluation of low dose famciclovir as herpes simplex virus and varicella zoster virus prophylaxis in cytomegalovirus low-risk solid organ transplant recipients. Transplant infectious disease : an official journal of the Transplantation Society. 2021 Oct; 23(5):e13711. doi: 10.1111/tid.13711. [PMID: 34379876]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Nathalie Wissink-Argilaga, Akbar Dastjerdi, Fieke M Molenaar. USING IN-HOUSE HEMATOLOGY TO DIRECT DECISION-MAKING IN THE SUCCESSFUL TREATMENT AND MONITORING OF A CLINICAL AND SUBSEQUENTLY SUBCLINICAL CASE OF ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 1B. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2019 Jun; 50(2):498-502. doi: 10.1638/2018-0096. [PMID: 31260223]
  • Akbar Dastjerdi, Katharina Seilern-Moy, Karin Darpel, Falko Steinbach, Fieke Molenaar. Surviving and fatal Elephant Endotheliotropic Herpesvirus-1A infections in juvenile Asian elephants - lessons learned and recommendations on anti-herpesviral therapy. BMC veterinary research. 2016 Aug; 12(1):178. doi: 10.1186/s12917-016-0806-5. [PMID: 27567895]
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  • Lionel Sebbag, Sara M Thomasy, Andrew P Woodward, Heather K Knych, David J Maggs. Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. American journal of veterinary research. 2016 Aug; 77(8):833-45. doi: 10.2460/ajvr.77.8.833. [PMID: 27463546]
  • Hanan Polansky, Adrian Javaherian, Edan Itzkovitz. Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir. Drug design, development and therapy. 2016; 10(?):2713-22. doi: 10.2147/dddt.s112852. [PMID: 27621592]
  • Allyson D Groth, Marcos T Contreras, Helen K Kado-Fong, Kyvan Q Nguyen, Sara M Thomasy, David J Maggs. In vitro cytotoxicity and antiviral efficacy against feline herpesvirus type 1 of famciclovir and its metabolites. Veterinary ophthalmology. 2014 Jul; 17(4):268-74. doi: 10.1111/vop.12094. [PMID: 24112415]
  • Fanny Schenkel, Chantal Csajka, Edoardo Baglivo, Mitsuko Kondo-Oestreicher, Pierre Dayer, Marianne Gex-Fabry, Youssef Daali. Intraocular penetration of penciclovir after oral administration of famciclovir: a population pharmacokinetic model. The Journal of antimicrobial chemotherapy. 2013 Jul; 68(7):1635-41. doi: 10.1093/jac/dkt064. [PMID: 23539240]
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  • Mohamed S Rezk, Rasha M El Nashar. Dissolution testing and potentiometric determination of famciclovir in pure, dosage forms and biological fluids. Bioelectrochemistry (Amsterdam, Netherlands). 2013 Feb; 89(?):26-33. doi: 10.1016/j.bioelechem.2012.08.006. [PMID: 23017353]
  • A Paige Brock, Ramiro Isaza, Robert P Hunter, Laura K Richman, Richard J Montali, Dennis L Schmitt, David E Koch, William A Lindsay. Estimates of the pharmacokinetics of famciclovir and its active metabolite penciclovir in young Asian elephants (Elephas maximus). American journal of veterinary research. 2012 Dec; 73(12):1996-2000. doi: 10.2460/ajvr.73.12.1996. [PMID: 23176429]
  • Sara M Thomasy, Jill C Covert, Scott D Stanley, David J Maggs. Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study. Veterinary ophthalmology. 2012 Sep; 15(5):299-306. doi: 10.1111/j.1463-5224.2011.00984.x. [PMID: 22339892]
  • Sara M Thomasy, Ted Whittem, Jerry L Bales, Marcus Ferrone, Scott D Stanley, David J Maggs. Pharmacokinetics of penciclovir in healthy cats following oral administration of famciclovir or intravenous infusion of penciclovir. American journal of veterinary research. 2012 Jul; 73(7):1092-9. doi: 10.2460/ajvr.73.7.1092. [PMID: 22738064]
  • Hye-In Kim, Shin-Woo Kim, Ga-Young Park, Eu-Gene Kwon, Hyo-Hoon Kim, Ju-Young Jeong, Hyun-Ha Chang, Jong-Myung Lee, Neung-Su Kim. Causes and treatment outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in 82 adult patients. The Korean journal of internal medicine. 2012 Jun; 27(2):203-10. doi: 10.3904/kjim.2012.27.2.203. [PMID: 22707893]
  • Stan L Block, Ram Yogev, Felix Waldmeier, Kamal Hamed. Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis. The Pediatric infectious disease journal. 2011 Jun; 30(6):525-8. doi: 10.1097/inf.0b013e3182067cee. [PMID: 21178655]
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  • Björn Pasternak, Anders Hviid. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA. 2010 Aug; 304(8):859-66. doi: 10.1001/jama.2010.1206. [PMID: 20736469]
  • Koji Tsujimura, Masayuki Yamada, Shun-ichi Nagata, Takashi Yamanaka, Manabu Nemoto, Takashi Kondo, Masahiko Kurosawa, Tomio Matsumura. Pharmacokinetics of penciclovir after oral administration of its prodrug famciclovir to horses. The Journal of veterinary medical science. 2010 Mar; 72(3):357-61. doi: 10.1292/jvms.09-0350. [PMID: 19959884]
  • Justin Bendig, Fiona Sindall. Chickenpox at Ninety Four: A Case for Extending the Use of Varicella Vaccine in the UK. Case reports in medicine. 2010; 2010(?):561707. doi: 10.1155/2010/561707. [PMID: 20593039]
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  • Deborah Y Chong, Mark W Johnson, Tony H Huynh, Edward F Hall, Grant M Comer, Douglas N Fish. Vitreous penetration of orally administered famciclovir. American journal of ophthalmology. 2009 Jul; 148(1):38-42.e1. doi: 10.1016/j.ajo.2009.02.010. [PMID: 19375688]
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