trimebutine (BioDeep_00000184539)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C22H29NO5 (387.20456240000004)
中文名称: 曲美布汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(COC(=O)C1=CC(=C(C(=C1)OC)OC)OC)(C2=CC=CC=C2)N(C)C
InChI: InChI=1S/C22H29NO5/c1-7-22(23(2)3,17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5/h8-14H,7,15H2,1-6H3
描述信息
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AA - Synthetic anticholinergics, esters with tertiary amino group
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D005765 - Gastrointestinal Agents
Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects. Target: Opioid Receptor Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].
同义名列表
13 个代谢物同义名
2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoic acid; 2-(dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate; Maleate salt, trimebutine; Salt, trimebutine maleate; Trimebutine maleate salt; Maleate, trimebutine; Trimebutine Maleate; Trimebutina; trimebutine; Transacalm; Polibutin; Debridat; Modulon
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:94458
- PubChem: 5573
- HMDB: HMDB0259230
- DrugBank: DB09089
- ChEMBL: CHEMBL190044
- Wikipedia: Trimebutine
- MeSH: Trimebutine
- chemspider: 5372
- CAS: 58997-89-0
- CAS: 39133-31-8
- medchemexpress: HY-B0380
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Amira Motawea, Walaa Ebrahim Abd El Hady, Ghada Ahmed El-Emam. The protective impact of adapted trimebutine maleate-loaded nanostructured lipid carriers for alleviating the severity of acute colitis.
Drug delivery.
2022 Dec; 29(1):906-924. doi:
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Journal of analytical toxicology.
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Clinica chimica acta; international journal of clinical chemistry.
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Life sciences.
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Yao xue xue bao = Acta pharmaceutica Sinica.
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. [PMID: 15171657] - Hongyun Wang, Hui Zhou, Shingo Horimoto, Ji Jiang, Tsuyoshi Mayumi, Pei Hu. Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Nov; 779(2):173-87. doi:
10.1016/s1570-0232(02)00369-0
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
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The Journal of pharmacology and experimental therapeutics.
2001 Aug; 298(2):559-64. doi:
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. [PMID: 11454917] - F Li, L Yu. Determination of trimebutine maleate in rat plasma and tissues by using capillary zone electrophoresis.
Biomedical chromatography : BMC.
2001 Jun; 15(4):248-51. doi:
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. [PMID: 11438965] - L N Yu, F M Li. [HPCE determination of trimebutine maleate in rat plasma and its pharmacokinetics].
Yao xue xue bao = Acta pharmaceutica Sinica.
2001 Feb; 36(2):131-3. doi:
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. [PMID: 12579881] - S Saivin, M Lavit, F Michel, J P Labaune, A Martin, G Cahiez, C Donazzolo, J M Chomard, G Houin. Pharmacokinetics and bioequivalence of two trimebutine formulations in healthy volunteers using desmethyl-trimebutine levels.
Arzneimittel-Forschung.
2000 Aug; 50(8):717-21. doi:
10.1055/s-0031-1300278
. [PMID: 10994155] - M Lavit, S Saivin, H Boudra, F Michel, A Martin, G Cahiez, J P Labaune, J M Chomard, G Houin. Determination of trimebutine and desmethyl-trimebutine in human plasma by HPLC.
Arzneimittel-Forschung.
2000 Jul; 50(7):640-4. doi:
10.1055/s-0031-1300264
. [PMID: 10965422] - E H Joo, W I Chang, I Oh, S C Shin, H K Na, Y B Lee. High-performance liquid chromatographic determination of trimebutine and its major metabolite, N-monodesmethyl trimebutine, in rat and human plasma.
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1999 Feb; 723(1-2):239-46. doi:
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1989 Aug; 3(4):387-93. doi:
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The American journal of physiology.
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. [PMID: 2546442] - Y Miura, S Takeyama, M Yoshikawa, H Endo, S Furuuchi, S Harigaya. [Metabolism of trimebutine maleate, a gastrointestinal tract motility regulator in rats and mice: characterization and quantification of metabolites in urine, bile and plasma].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1988 Oct; 108(10):989-1000. doi:
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. [PMID: 2898425] - P Poitras, C Hondé, R Goyer, J L Junien, X Pascaud, G R Greenberg. [Effect of trimebutine on the plasma postprandial release of gastrointestinal hormones in the dog].
Gastroenterologie clinique et biologique.
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. [PMID: 3301510] - S Chaussade, S Grandjouan, D Couturier, D Thierman-Duffaud, J F Henry. [Effect of trimebutine on the motility of the normal human small intestines: mechanism of action].
Gastroenterologie clinique et biologique.
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. [PMID: 3609631] - P Poitras, C Honde, J Havrankova, R G Lahaie, L Trudel, R Goyer, J L Junien, X Pascaud. Effect of trimebutine on intestinal motility and plasma motilin in the dog.
The American journal of physiology.
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