Trimazosin hydrochloride (BioDeep_00000184538)

   

human metabolite blood metabolite


代谢物信息卡片


2-Hydroxy-2-methylpropyl 4-(4-imino-6,7,8-trimethoxy-3,4-dihydroquinazolin-2-yl)piperazine-1-carboxylic acid

化学式: C20H29N5O6 (435.2117734)
中文名称: 盐酸曲马唑嗪
谱图信息: 最多检出来源 Homo sapiens(blood) 60%

分子结构信息

SMILES: CC(C)(COC(=O)N1CCN(CC1)C2=NC3=C(C(=C(C=C3C(=N2)N)OC)OC)OC)O
InChI: InChI=1S/C20H29N5O6/c1-20(2,27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15(29-4)16(14)30-5/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23)

描述信息

C - Cardiovascular system > C02 - Antihypertensives > C02C - Antiadrenergic agents, peripherally acting > C02CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

7 个代谢物同义名

2-Hydroxy-2-methylpropyl 4-(4-imino-6,7,8-trimethoxy-3,4-dihydroquinazolin-2-yl)piperazine-1-carboxylic acid; (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate; 2-Hydroxy-2-methylpropyl 4-(4-amino-6,7,8-trimethoxy-2-quinqzolinyl)-1-piperazinecar boxylate; 2-hydroxy-2-methylpropyl 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate; Trimazosin hydrochloride, monohydrate; Trimazosin hydrochloride; TRIMAZOSIN



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Dirk Gründemann, Ann-Cathrin Koschker, Christine Haag, Cornelius Honold, Tim Zimmermann, Edgar Schömig. Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. British journal of pharmacology. 2002 Nov; 137(6):910-8. doi: 10.1038/sj.bjp.0704926. [PMID: 12411423]
  • C K van Kalken, J van der Meulen, P L Oe, R Vriesendorp, A J Donker. Pharmacokinetics of trimazosin and its effects on blood pressure, renal function and proteinuria during short-term therapy of patients with impaired renal function and hypertension. European journal of clinical pharmacology. 1986; 31(1):63-8. doi: 10.1007/bf00870988. [PMID: 3780829]
  • M J Kern, J D Horowitz, P Ganz, J Gaspar, W S Colucci, B H Lorell, W H Barry, G H Mudge. Attenuation of coronary vascular resistance by selective alpha 1-adrenergic blockade in patients with coronary artery disease. Journal of the American College of Cardiology. 1985 Apr; 5(4):840-6. doi: 10.1016/s0735-1097(85)80421-6. [PMID: 2857738]
  • D J Webb, M J Hutcheson, M P Robertson, G D Murray, A R Lorimer, J I Robertson. A comparison of atenolol and long-acting trimazosin in mild to moderate essential hypertension. Scottish medical journal. 1985 Apr; 30(2):106-10. doi: 10.1177/003693308503000207. [PMID: 3892676]
  • A Lehtonen. The effects of trimazosin and pindolol on serum lipids, blood glucose and serum insulin levels. Acta medica Scandinavica. 1985; 218(2):213-6. doi: 10.1111/j.0954-6820.1985.tb08849.x. [PMID: 3904336]
  • G I Nelson, M Hussain, D Forsyth, J Wilson, B Silke, S H Taylor. Haemodynamic effects of selective alpha 1-blockade (trimazosin) in essential hypertension. Journal of cardiovascular pharmacology. 1984 Jan; 6(1):176-81. doi: NULL. [PMID: 6199601]
  • B Flouvat, F Fodor, A Roux, J R Bianchine. Pharmacokinetics of a sustained-release trimazosin tablet formulation. American heart journal. 1983 Nov; 106(5 Pt 2):1228-34. doi: 10.1016/0002-8703(83)90180-1. [PMID: 6637789]
  • W Singleton, C R Taylor. Effect of trimazosin on serum lipid profiles in hypertensive patients. American heart journal. 1983 Nov; 106(5 Pt 2):1265-8. doi: 10.1016/0002-8703(83)90187-4. [PMID: 6356856]
  • A Helgeland. Double-blind comparison of trimazosin and propranolol in essential hypertension. American heart journal. 1983 Nov; 106(5 Pt 2):1253-8. doi: 10.1016/0002-8703(83)90185-0. [PMID: 6356854]
  • C R Taylor, J P Leader, W Singleton, E W Munster, F C Falkner, J A O'Neil. Profile of trimazosin: an effective and safe antihypertensive agent. American heart journal. 1983 Nov; 106(5 Pt 2):1269-81. doi: 10.1016/0002-8703(83)90188-6. [PMID: 6227228]
  • S G Chrysant. Autonomic, systemic, and renal hemodynamic actions of trimazosin in hypertensive patients. American heart journal. 1983 Nov; 106(5 Pt 2):1243-50. doi: 10.1016/0002-8703(83)90183-7. [PMID: 6356852]
  • M A Weber, D D Brewer, J I Drayer, W S Aronow, J L Lipson, B A Ricci. A vasodilator that avoids renin stimulation and fluid retention: antihypertensive treatment with trimazosin. Clinical pharmacology and therapeutics. 1982 May; 31(5):572-8. doi: 10.1038/clpt.1982.80. [PMID: 7042174]
  • S G Chrysant, R F Miller, J L Brown, K Danisa. Long-term hemodynamic and metabolic effects of trimazosin in essential hypertension. Clinical pharmacology and therapeutics. 1981 Nov; 30(5):600-4. doi: 10.1038/clpt.1981.210. [PMID: 7028356]
  • S G Chrysant, T M Luu, K Danisa, D C Kem, C V Manion. Systemic and renal hemodynamic effects of trimazosin: a new vasodilator. Journal of cardiovascular pharmacology. 1980; 2(2):205-14. doi: 10.1097/00005344-198003000-00011. [PMID: 6171687]
  • D De Gula, M Mendlowitz, C Russo, N D Vlachakis, S Antram. The effect of trimazosin in essential hypertension. Current therapeutic research, clinical and experimental. 1973 Jul; 15(7):339-48. doi: NULL. [PMID: 4198294]