Triclabendazole (BioDeep_00000184500)
human metabolite blood metabolite
代谢物信息卡片
6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylsulphanyl)-1H-1,3-benzodiazole
化学式: C14H9Cl3N2OS (357.9501154)
中文名称: 三氯苯达唑
谱图信息:
最多检出来源 Homo sapiens(blood) 93.88%
分子结构信息
SMILES: CSC1=NC2=C(N1)C=C(Cl)C(OC1=CC=CC(Cl)=C1Cl)=C2
InChI: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
描述信息
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02B - Antitrematodals
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
同义名列表
13 个代谢物同义名
6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylsulphanyl)-1H-1,3-benzodiazole; 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole; 6-chloro-5-(2,3-Dichlorophenoxy)-2-methylsulphanyl-1H-benzimidazole; 6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthiobenzimidazole; Novartis brand OF triclabendazole; Virbac brand OF triclabendazole; Jurox brand OF triclabendazole; Triclabendazole; Tremacide; Fasicare; Flukare; Fasinex; Egaten
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:94759
- PubChem: 50248
- HMDB: HMDB0259181
- DrugBank: DB12245
- ChEMBL: CHEMBL1086440
- Wikipedia: Triclabendazole
- MeSH: Triclabendazole
- chemspider: 45565
- CAS: 68786-66-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nicola J Beesley, Krystyna Cwiklinski, Katherine Allen, Rebecca C Hoyle, Terry W Spithill, E James La Course, Diana J L Williams, Steve Paterson, Jane E Hodgkinson. A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance.
PLoS pathogens.
2023 01; 19(1):e1011081. doi:
10.1371/journal.ppat.1011081. [PMID: 36701396] - Snehal Daware, Manali Patki, Aishwarya Saraswat, Siddhant Palekar, Ketan Patel. Development of a safe pediatric liquisolid self-nanoemulsifying system of triclabendazole for the treatment of fascioliasis.
International journal of pharmaceutics.
2022 Oct; 626(?):122163. doi:
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Experimental parasitology.
2022 Jul; 238(?):108285. doi:
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Acta tropica.
2011 Jun; 118(3):177-83. doi:
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2011 Apr; 28(4):438-45. doi:
10.1080/19440049.2010.551422. [PMID: 21337234] - A Flanagan, H W J Edgar, A Gordon, R E B Hanna, G P Brennan, I Fairweather. Comparison of two assays, a faecal egg count reduction test (FECRT) and a coproantigen reduction test (CRT), for the diagnosis of resistance to triclabendazole in Fasciola hepatica in sheep.
Veterinary parasitology.
2011 Mar; 176(2-3):170-6. doi:
10.1016/j.vetpar.2010.10.057. [PMID: 21112153] - A M Flanagan, H W J Edgar, F Forster, A Gordon, R E B Hanna, M McCoy, G P Brennan, I Fairweather. Standardisation of a coproantigen reduction test (CRT) protocol for the diagnosis of resistance to triclabendazole in Fasciola hepatica.
Veterinary parasitology.
2011 Feb; 176(1):34-42. doi:
10.1016/j.vetpar.2010.10.037. [PMID: 21093156] - C Devine, G P Brennan, C E Lanusse, L I Alvarez, A Trudgett, E Hoey, I Fairweather. Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica.
Parasitology.
2011 Feb; 138(2):224-36. doi:
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Journal of parasitology research.
2011; 2011(?):240807. doi:
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The Turkish journal of pediatrics.
2011 Jan; 53(1):111-3. doi:
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Veterinary parasitology.
2010 Dec; 174(3-4):218-27. doi:
10.1016/j.vetpar.2010.09.008. [PMID: 20933333] - Cengiz Gokbulut, Murat Boyacioglu, Umit Karademir, Dilek Aksit. The effect of fasting on the plasma disposition of triclabendazole following oral administration in goats.
Research in veterinary science.
2010 Dec; 89(3):415-7. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Nov; 878(30):3106-12. doi:
10.1016/j.jchromb.2010.09.018. [PMID: 20951102] - Roger Daniel, Jan van Dijk, Diana Williams. Faecal egg count reduction test to detect lack of efficacy of triclabendazole.
The Veterinary record.
2010 Nov; 167(19):759. doi:
10.1136/vr.c6031. [PMID: 21257517] - Maria Martínez-Valladares, Maria del Rosario Famularo, Nelida Fernández-Pato, Luciano Castañón-Ordóñez, Coral Cordero-Pérez, Francisco Antonio Rojo-Vázquez. Efficacy of nitroxynil against Fasciola hepatica resistant to triclabendazole in a naturally infected sheep flock.
Parasitology research.
2010 Oct; 107(5):1205-11. doi:
10.1007/s00436-010-1989-5. [PMID: 20680341] - Emma Chambers, Elizabeth M Hoey, Alan Trudgett, Ian Fairweather, David J Timson. Binding of serum albumin to the anthelmintic drugs albendazole, triclabendazole and their sulphoxides.
Veterinary parasitology.
2010 Jul; 171(1-2):172-5. doi:
10.1016/j.vetpar.2010.02.043. [PMID: 20307939] - Catherine Devine, Gerard P Brennan, Carlos E Lanusse, Luis I Alvarez, Alan Trudgett, Elizabeth Hoey, Ian Fairweather. Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole.
Parasitology research.
2010 Jul; 107(2):337-53. doi:
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Journal of helminthology.
2010 Jun; 84(2):123-31. doi:
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Tropical medicine & international health : TM & IH.
2010 Apr; 15(4):462-7. doi:
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Journal of medical case reports.
2010 Mar; 4(?):83. doi:
10.1186/1752-1947-4-83. [PMID: 20205932] - Zeynep Tas Cengiz, Hasan Yilmaz, Ahmet Cumhur Dulger, Mutalip Cicek. Human infection with Dicrocoelium dendriticum in Turkey.
Annals of Saudi medicine.
2010 Mar; 30(2):159-61. doi:
10.4103/0256-4947.60525. [PMID: 20220269] - Laura Ceballos, Laura Moreno, Luis Alvarez, Laura Shaw, Ian Fairweather, Carlos Lanusse. Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.
BMC veterinary research.
2010 Feb; 6(?):8. doi:
10.1186/1746-6148-6-8. [PMID: 20128898] - Jennifer Keiser, Vincenzo Veneziano, Laura Rinaldi, Laura Mezzino, Urs Duthaler, Giuseppe Cringoli. Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep.
Research in veterinary science.
2010 Feb; 88(1):107-10. doi:
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Journal of wildlife diseases.
2010 Jan; 46(1):283-6. doi:
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Veterinary journal (London, England : 1997).
2009 Nov; 182(2):261-8. doi:
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Journal of wildlife diseases.
2009 Oct; 45(4):1217-20. doi:
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Annals of tropical medicine and parasitology.
2009 Oct; 103(7):605-16. doi:
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Experimental parasitology.
2009 Aug; 122(4):289-98. doi:
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Journal of helminthology.
2009 Jun; 83(2):151-63. doi:
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Journal of helminthology.
2009 Jun; 83(2):139-50. doi:
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Australian veterinary journal.
2009 May; 87(5):200-3. doi:
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Veterinary parasitology.
2009 Apr; 161(1-2):133-7. doi:
10.1016/j.vetpar.2008.12.012. [PMID: 19167826] - E Toner, F McConvery, G P Brennan, M Meaney, I Fairweather. A scanning electron microscope study on the route of entry of triclabendazole into the liver fluke, Fasciola hepatica.
Parasitology.
2009 Apr; 136(5):523-35. doi:
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Journal of veterinary pharmacology and therapeutics.
2009 Feb; 32(1):79-86. doi:
10.1111/j.1365-2885.2008.01006.x. [PMID: 19161459] - Mercedes Mezo, Marta González-Warleta, José Antonio Castro-Hermida, Florencio M Ubeira. Evaluation of the flukicide treatment policy for dairy cattle in Galicia (NW Spain).
Veterinary parasitology.
2008 Nov; 157(3-4):235-43. doi:
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Preventive veterinary medicine.
2008 Apr; 84(1-2):152-60. doi:
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Meditsinskaia parazitologiia i parazitarnye bolezni.
2008 Apr; ?(2):57-9. doi:
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Veterinary research communications.
2008 Jan; 32(1):21-33. doi:
10.1007/s11259-007-9000-3. [PMID: 17457687] - Cengiz Gokbulut, Umit Karademir, Murat Boyacioglu, Ferda Akar. The effect of diet type on the plasma disposition of triclabendazole in goats.
Research in veterinary science.
2007 Jun; 82(3):388-91. doi:
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Pharmacy world & science : PWS.
2007 Jun; 29(3):190-8. doi:
10.1007/s11096-006-9069-8. [PMID: 17265093] - Mercedes Mezo, Marta González-Warleta, Florencio M Ubeira. The use of MM3 monoclonal antibodies for the early immunodiagnosis of ovine fascioliasis.
The Journal of parasitology.
2007 Feb; 93(1):65-72. doi:
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