Trh-gly-lys (BioDeep_00000184463)
human metabolite blood metabolite
代谢物信息卡片
化学式: C24H36N8O7 (548.2706826)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(NC1)C(=O)C(C(CCN)C(=O)C2CCC(=O)N2)(C(=O)C(CC3=CN=CN3)N)C(C(=O)CN)(C(=O)O)N
InChI: InChI=1S/C24H36N8O7/c25-6-5-13(19(35)15-3-4-18(34)32-15)23(21(37)16-2-1-7-30-16,24(28,22(38)39)17(33)9-26)20(36)14(27)8-12-10-29-11-31-12/h10-11,13-16,30H,1-9,25-28H2,(H,29,31)(H,32,34)(H,38,39)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
10 个代谢物同义名
2,5-Diamino-3-[4-amino-1-(5-hydroxy-3,4-dihydro-2H-pyrrol-2-yl)-1-oxobutan-2-yl]-2-(2-aminoacetyl)-6-(1H-imidazol-5-yl)-4-oxo-3-(pyrrolidine-2-carbonyl)hexanoate; 2,5-Diamino-2-(2-aminoacetyl)-3-[4-amino-1-oxo-1-(5-oxopyrrolidin-2-yl)butan-2-yl]-6-(1H-imidazol-5-yl)-4-oxo-3-(pyrrolidine-2-carbonyl)hexanoic acid; 2,5-diamino-3-[4-amino-1-oxo-1-(5-oxopyrrolidin-2-yl)butan-2-yl]-2-(2-aminoacetyl)-6-(1H-imidazol-5-yl)-4-oxo-3-(pyrrolidine-2-carbonyl)hexanoic acid; 2,5-diamino-3-[4-amino-1-oxo-1-(5-oxopyrrolidin-2-yl)butan-2-yl]-2-(2-aminoacetyl)-6-(3H-imidazol-4-yl)-4-oxo-3-(pyrrolidine-2-carbonyl)hexanoic acid; Pyroglutamyl-histidyl-prolyl-glycyl-lysine; Thyrotropin releasing hormone precursor; Pro-thyrotropin releasing hormone; PGlu-his-pro-gly-lys; Trh-gly-lys; Pro-TRH
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- I Sotelo-Rivera, L Jaimes-Hoy, A Cote-Vélez, C Espinoza-Ayala, J-L Charli, P Joseph-Bravo. An acute injection of corticosterone increases thyrotrophin-releasing hormone expression in the paraventricular nucleus of the hypothalamus but interferes with the rapid hypothalamus pituitary thyroid axis response to cold in male rats.
Journal of neuroendocrinology.
2014 Dec; 26(12):861-9. doi:
10.1111/jne.12224. [PMID: 25283355] - F Aréchiga-Ceballos, E Alvarez-Salas, G Matamoros-Trejo, M I Amaya, C García-Luna, P de Gortari. Pro-TRH and pro-CRF expression in paraventricular nucleus of small litter-reared fasted adult rats.
The Journal of endocrinology.
2014 Apr; 221(1):77-88. doi:
10.1530/joe-13-0458. [PMID: 24464021] - Edith Sánchez, Miguel Angel Vargas, Praful S Singru, Isel Pascual, Fidelia Romero, Csaba Fekete, Jean-Louis Charli, Ronald M Lechan. Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence.
Endocrinology.
2009 May; 150(5):2283-91. doi:
10.1210/en.2008-1643. [PMID: 19179432] - Sumit Sarkar, Ronald M Lechan. Central administration of neuropeptide Y reduces alpha-melanocyte-stimulating hormone-induced cyclic adenosine 5'-monophosphate response element binding protein (CREB) phosphorylation in pro-thyrotropin-releasing hormone neurons and increases CREB phosphorylation in corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus.
Endocrinology.
2003 Jan; 144(1):281-91. doi:
10.1210/en.2002-220675. [PMID: 12488356] - L Pérez-Martínez, J L Charli, P Joseph-Bravo. Development of pro-TRH gene expression in primary cultures of fetal hypothalamic cells.
Brain research. Developmental brain research.
2001 Sep; 130(1):73-81. doi:
10.1016/s0165-3806(01)00214-0. [PMID: 11557095] - J Niquet, L Pérez-Martínez, M Guerra, D Grouselle, P Joseph-Bravo, J Charli. Extracellular matrix proteins increase the expression of pro-TRH and pro-protein convertase PC1 in fetal hypothalamic neurons in vitro.
Brain research. Developmental brain research.
2000 Mar; 120(1):49-56. doi:
10.1016/s0165-3806(99)00190-x. [PMID: 10727729] - P Q Yuan, H Yang. Hyperthyroidism decreases thyrotropin-releasing hormone gene expression in the caudal raphe nuclei and the parapyramidal regions in rats.
Neuroscience letters.
1999 Dec; 276(3):189-92. doi:
10.1016/s0304-3940(99)00830-7. [PMID: 10612637] - G Legradi, C H Emerson, R S Ahima, W M Rand, J S Flier, R M Lechan. Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus.
Neuroendocrinology.
1998 Aug; 68(2):89-97. doi:
10.1159/000054354. [PMID: 9705575] - G Légrádi, C H Emerson, R S Ahima, J S Flier, R M Lechan. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus.
Endocrinology.
1997 Jun; 138(6):2569-76. doi:
10.1210/endo.138.6.5209. [PMID: 9165050] - G Croissandeau, N Schussler, D Grouselle, P Pagesy, C Rauch, M C Bayet, F Peillon, M Le Dafniet. Evidence of thyrotropin-releasing hormone (TRH) gene expression in rat anterior pituitaries and modulation by estrogens of TRH-like immunoreactivity and TRH-elongated peptide contents.
The Journal of endocrinology.
1996 Oct; 151(1):87-96. doi:
10.1677/joe.0.1510087. [PMID: 8943772] - G A van Haasteren, E Linkels, H van Toor, W Klootwijk, E Kaptein, F H de Jong, M J Reymond, T J Visser, W J de Greef. Effects of long-term food reduction on the hypothalamus-pituitary-thyroid axis in male and female rats.
The Journal of endocrinology.
1996 Aug; 150(2):169-78. doi:
10.1677/joe.0.1500169. [PMID: 8869583] - G A van Haasteren, H van Toor, W Klootwijk, B Handler, E Linkels, P van der Schoot, J van Ophemert, F H de Jong, T J Visser, W J de Greef. Studies on the role of TRH and corticosterone in the regulation of prolactin and thyrotrophin secretion during lactation.
The Journal of endocrinology.
1996 Feb; 148(2):325-36. doi:
10.1677/joe.0.1480325. [PMID: 8699147] - G A van Haasteren, E Linkels, W Klootwijk, H van Toor, J M Rondeel, A P Themmen, F H de Jong, K Valentijn, H Vaudry, K Bauer. Starvation-induced changes in the hypothalamic content of prothyrotrophin-releasing hormone (proTRH) mRNA and the hypothalamic release of proTRH-derived peptides: role of the adrenal gland.
The Journal of endocrinology.
1995 Apr; 145(1):143-53. doi:
10.1677/joe.0.1450143. [PMID: 7798020] - G A van Haasteren, M J van der Meer, A R Hermus, E Linkels, W Klootwijk, E Kaptein, H van Toor, C G Sweep, T J Visser, W J de Greef. Different effects of continuous infusion of interleukin-1 and interleukin-6 on the hypothalamic-hypophysial-thyroid axis.
Endocrinology.
1994 Oct; 135(4):1336-45. doi:
10.1210/endo.135.4.7925094. [PMID: 7925094] - T O Bruhn, T G Bolduc, J M Rondeel, I M Jackson. Thyrotropin-releasing hormone gene expression in the anterior pituitary. II. Stimulation by glucocorticoids.
Endocrinology.
1994 Feb; 134(2):821-5. doi:
10.1210/endo.134.2.8299577. [PMID: 8299577] - T O Bruhn, J M Rondeel, T G Bolduc, I M Jackson. Thyrotropin-releasing hormone gene expression in the anterior pituitary. III. Stimulation by thyroid hormone: potentiation by glucocorticoids.
Endocrinology.
1994 Feb; 134(2):826-30. doi:
10.1210/endo.134.2.8299578. [PMID: 8299578] - I Kakucska, W Rand, R M Lechan. Thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is dependent upon feedback regulation by both triiodothyronine and thyroxine.
Endocrinology.
1992 May; 130(5):2845-50. doi:
10.1210/endo.130.5.1572297. [PMID: 1572297] - T Mitsuma, Y Hirooka, K Yuasa, T Nogimori. Effects of thyroid hormone, TRH and TSH on pro-TRH concentrations in various organs of rats.
Endocrinologia experimentalis.
1990 Dec; 24(4):395-402. doi:
NULL. [PMID: 2128932] - D Grouselle, A Tixier-Vidal, P Pradelles. Enzyme immunoassays for thyroliberin (TRH) and TRH-elongated peptides in mouse and rat hypothalamus.
Neuropeptides.
1990 Nov; 17(3):155-62. doi:
10.1016/0143-4179(90)90079-e. [PMID: 2128111]