Tretazicar (BioDeep_00000184461)

   

human metabolite blood metabolite


代谢物信息卡片


5-(Aziridin-1-yl)-2,4-dinitrobenzene-1-carboximidate

化学式: C9H8N4O5 (252.0494678)
中文名称: 曲他齐卡
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN1C2=C(C=C(C(=C2)C(=O)N)[N+](=O)[O-])[N+](=O)[O-]
InChI: InChI=1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14)

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
COVID info from PDB, Protein Data Bank
D011838 - Radiation-Sensitizing Agents
D000970 - Antineoplastic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

8 个代谢物同义名

5-(Aziridin-1-yl)-2,4-dinitrobenzene-1-carboximidate; 5-(aziridin-1-yl)-2,4-dinitrobenzamide; 5-(1-Aziridinyl)-2,4-dinitrobenzamide; 5-Aziridinyl-2,4-dinitrobenzamide; Aziridine dinitrobenzamide; CB-1954Tretazicar; Tretazicar; CB 1954



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • John T Heap, Jan Theys, Muhammad Ehsaan, Aleksandra M Kubiak, Ludwig Dubois, Kim Paesmans, Lieve Van Mellaert, Richard Knox, Sarah A Kuehne, Phillipe Lambin, Nigel P Minton. Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo. Oncotarget. 2014 04; 5(7):1761-9. doi: 10.18632/oncotarget.1761. [PMID: 24732092]
  • Guillaume Macary, Jérome Rossert, Patrick Bruneval, Chantal Mandet, Marie-France Bélair, Pascal Houillier, Jean-Paul Duong Van Huyen. Transgenic mice expressing nitroreductase gene under the control of the podocin promoter: a new murine model of inductible glomerular injury. Virchows Archiv : an international journal of pathology. 2010 Mar; 456(3):325-37. doi: 10.1007/s00428-009-0840-9. [PMID: 19806361]
  • Magdalene Huen Yin Tang, Nuala A Helsby, Michael A Goldthorpe, Kirsty M Thompson, Saad Al-Ali, Malcolm D Tingle. Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat. Toxicology. 2007 Oct; 240(1-2):70-85. doi: 10.1016/j.tox.2007.07.018. [PMID: 17804142]
  • Nicola K Green, David J Kerr, Vivien Mautner, Peter A Harris, Peter F Searle. The nitroreductase/CB1954 enzyme-prodrug system. Methods in molecular medicine. 2004; 90(?):459-77. doi: 10.1385/1-59259-429-8:459. [PMID: 14657579]
  • G Chung-Faye, D Palmer, D Anderson, J Clark, M Downes, J Baddeley, S Hussain, P I Murray, P Searle, L Seymour, P A Harris, D Ferry, D J Kerr. Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001 Sep; 7(9):2662-8. doi: NULL. [PMID: 11555577]
  • S J Weedon, N K Green, I A McNeish, M G Gilligan, V Mautner, C J Wrighton, A Mountain, L S Young, D J Kerr, P F Searle. Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase. International journal of cancer. 2000 Jun; 86(6):848-54. doi: 10.1002/(sici)1097-0215(20000615)86:6<848::aid-ijc14>3.0.co;2-b. [PMID: 10842200]
  • P Kestell, F B Pruijn, B G Siim, B D Palmer, W R Wilson. Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5. Cancer chemotherapy and pharmacology. 2000; 46(5):365-74. doi: 10.1007/s002800000165. [PMID: 11127940]
  • V Miŝkiniene, E Sergediene, A Nemeikaite, J Segura-Aguilar, N Cenas. Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs. Cancer letters. 1999 Nov; 146(2):217-22. doi: 10.1016/s0304-3835(99)00271-2. [PMID: 10656629]
  • D Anderson, D R Ferry, R J Knox, S J Andrews, A J Downes, D J Kerr, L W Seymour. High-performance liquid chromatographic method for sensitive determination of the alkylating agent CB1954 in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 1999 Aug; 731(2):293-8. doi: 10.1016/s0378-4347(99)00245-5. [PMID: 10510783]
  • V Miskiniene, E Dickancaite, A Nemeikaite, N Cenas. Nitroaromatic betulin derivatives as redox cycling agents. Biochemistry and molecular biology international. 1997 Jun; 42(2):391-7. doi: 10.1080/15216549700202791. [PMID: 9238538]
  • R J Knox, F Friedlos, M Jarman, L C Davies, P Goddard, G M Anlezark, R G Melton, R F Sherwood. Virtual cofactors for an Escherichia coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT). Biochemical pharmacology. 1995 May; 49(11):1641-7. doi: 10.1016/0006-2952(95)00077-d. [PMID: 7786305]
  • R J Knox, F Friedlos, P J Biggs, W D Flitter, M Gaskell, P Goddard, L Davies, M Jarman. Identification, synthesis and properties of 5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide, a novel DNA crosslinking agent derived from CB1954. Biochemical pharmacology. 1993 Sep; 46(5):797-803. doi: 10.1016/0006-2952(93)90487-h. [PMID: 8373433]
  • F Friedlos, P J Biggs, J A Abrahamson, R J Knox. Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity. Biochemical pharmacology. 1992 Nov; 44(9):1739-43. doi: 10.1016/0006-2952(92)90067-s. [PMID: 1449531]
  • F Friedlos, R J Knox. Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system. Biochemical pharmacology. 1992 Aug; 44(4):631-5. doi: 10.1016/0006-2952(92)90396-z. [PMID: 1387314]
  • P Workman, R A White, K Talbot. CB 1954 revisited. I. Disposition kinetics and metabolism. Cancer chemotherapy and pharmacology. 1986; 16(1):1-8. doi: 10.1007/bf00255278. [PMID: 3940216]
  • P Workman, M I Walton. Pharmacology of the mixed-function radio- and chemosensitizers CB 1954 and RSU 1069. International journal of radiation oncology, biology, physics. 1984 Aug; 10(8):1307-10. doi: 10.1016/0360-3016(84)90337-7. [PMID: 6547936]