Trehalose 6,6'-dicorynomycolate (BioDeep_00000184451)
human metabolite blood metabolite
代谢物信息卡片
化学式: C76H146O15 (1299.0661)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(C(CCCCCCCCCCCCCC)C(=O)OCC1C(C(C(C(O1)OC2C(C(C(C(O2)COC(=O)C(CCCCCCCCCCCCCC)C(CCCCCCCCCCCCCCC)O)O)O)O)O)O)O)O
InChI: InChI=1S/C76H146O15/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-63(77)61(55-51-47-43-39-35-31-27-23-19-15-11-7-3)73(85)87-59-65-67(79)69(81)71(83)75(89-65)91-76-72(84)70(82)68(80)66(90-76)60-88-74(86)62(56-52-48-44-40-36-32-28-24-20-16-12-8-4)64(78)58-54-50-46-42-38-34-30-26-22-18-14-10-6-2/h61-72,75-84H,5-60H2,1-4H3
描述信息
D007155 - Immunologic Factors > D000276 - Adjuvants, Immunologic > D003311 - Cord Factors
同义名列表
3 个代谢物同义名
{3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-{[(3-hydroxy-2-tetradecyloctadecanoyl)oxy]methyl}oxan-2-yl)oxy]oxan-2-yl}methyl 3-hydroxy-2-tetradecyloctadecanoic acid; {3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-{[(3-hydroxy-2-tetradecyloctadecanoyl)oxy]methyl}oxan-2-yl)oxy]oxan-2-yl}methyl 3-hydroxy-2-tetradecyloctadecanoate; Trehalose 6,6-dicorynomycolate
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 13001927
- HMDB: HMDB0259116
- chemspider: 11194898
- LOTUS: LTS0047133
- wikidata: Q104170900
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Allison M Dyevoich, Nataya S Disher, Marcela A Haro, Karen M Haas. A TLR4-TRIF-dependent signaling pathway is required for protective natural tumor-reactive IgM production by B1 cells.
Cancer immunology, immunotherapy : CII.
2020 Oct; 69(10):2113-2124. doi:
10.1007/s00262-020-02607-7. [PMID: 32448982] - Allison M Dyevoich, Karen M Haas. Type I IFN, Ly6C+ cells, and Phagocytes Support Suppression of Peritoneal Carcinomatosis Elicited by a TLR and CLR Agonist Combination.
Molecular cancer therapeutics.
2020 06; 19(6):1232-1242. doi:
10.1158/1535-7163.mct-19-0885. [PMID: 32188623] - Marcela A Haro, Allison M Dyevoich, James P Phipps, Karen M Haas. Activation of B-1 Cells Promotes Tumor Cell Killing in the Peritoneal Cavity.
Cancer research.
2019 01; 79(1):159-170. doi:
10.1158/0008-5472.can-18-0981. [PMID: 30224373] - Thomas B Elliott, David L Bolduc, G David Ledney, Juliann G Kiang, Oluseyi O Fatanmi, Stephen Y Wise, Patricia L P Romaine, Victoria L Newman, Vijay K Singh. Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice.
International journal of radiation biology.
2015; 91(9):690-702. doi:
10.3109/09553002.2015.1054526. [PMID: 25994812] - Amrita Das, Nahid Ali. Combining cationic liposomal delivery with MPL-TDM for cysteine protease cocktail vaccination against Leishmania donovani: evidence for antigen synergy and protection.
PLoS neglected tropical diseases.
2014 Aug; 8(8):e3091. doi:
10.1371/journal.pntd.0003091. [PMID: 25144181] - Rajesh Ravindran, Mithun Maji, Nahid Ali. Vaccination with liposomal leishmanial antigens adjuvanted with monophosphoryl lipid-trehalose dicorynomycolate (MPL-TDM) confers long-term protection against visceral leishmaniasis through a human administrable route.
Molecular pharmaceutics.
2012 Jan; 9(1):59-70. doi:
10.1021/mp2002494. [PMID: 22133194] - Saumyabrata Mazumder, Mithun Maji, Nahid Ali. Potentiating effects of MPL on DSPC bearing cationic liposomes promote recombinant GP63 vaccine efficacy: high immunogenicity and protection.
PLoS neglected tropical diseases.
2011 Dec; 5(12):e1429. doi:
10.1371/journal.pntd.0001429. [PMID: 22206029] - Rajesh Ravindran, Sudipta Bhowmick, Amrita Das, Nahid Ali. Comparison of BCG, MPL and cationic liposome adjuvant systems in leishmanial antigen vaccine formulations against murine visceral leishmaniasis.
BMC microbiology.
2010 Jun; 10(?):181. doi:
10.1186/1471-2180-10-181. [PMID: 20576102] - T Trotta, A Fasanella, D Scaltrito, L Gradoni, V Mitolo, O Brandonisio, A Acquafredda, M A Panaro. Comparison between three adjuvants for a vaccine against canine leishmaniasis: In vitro evaluation of macrophage killing ability.
Comparative immunology, microbiology and infectious diseases.
2010 Mar; 33(2):175-82. doi:
10.1016/j.cimid.2009.12.003. [PMID: 20061026] - Aklile Berhanu, Rebecca L Wilson, Dana L Kirkwood-Watts, David S King, Travis K Warren, Susan A Lund, Lindsay L Brown, Alex K Krupkin, Erin Vandermay, Will Weimers, Kady M Honeychurch, Douglas W Grosenbach, Kevin F Jones, Dennis E Hruby. Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge.
Journal of virology.
2008 Apr; 82(7):3517-29. doi:
10.1128/jvi.01854-07. [PMID: 18199639] - Jon Oscherwitz, F C Hankenson, Fen Yu, Kemp B Cease. Low-dose intraperitoneal Freund's adjuvant: toxicity and immunogenicity in mice using an immunogen targeting amyloid-beta peptide.
Vaccine.
2006 Apr; 24(15):3018-25. doi:
10.1016/j.vaccine.2005.10.046. [PMID: 16307832] - M R Barber, R A Fayrer-Hosken. Evaluation of somatic and reproductive immunotoxic effects of the porcine zona pellucida vaccination.
The Journal of experimental zoology.
2000 May; 286(6):641-6. doi:
10.1002/(sici)1097-010x(20000501)286:6<641::aid-jez11>3.0.co;2-#. [PMID: 10766973] - J A Price, J M McGee, M R Patten, D Snyder. Effects of the adjuvant MPL + TDM on tumor challenge in the B16 mouse melanoma model.
International journal of immunopharmacology.
1996 Feb; 18(2):163-5. doi:
10.1016/0192-0561(96)00003-3. [PMID: 8799366] - H Imasato, J Procópio, M Tabak, T Ioneda. Effect of low mole fraction of trehalose dicorynomycolate from Corynebacterium diphtheriae on water permeability and electrical capacitance of lipid bilayer membranes.
Chemistry and physics of lipids.
1990 Feb; 52(3-4):259-62. doi:
10.1016/0009-3084(90)90122-8. [PMID: 2111231]
