Transfectam (BioDeep_00000184444)
human metabolite blood metabolite
代谢物信息卡片
N-{2,5-bis[(3-aminopropyl)amino]pentanoyl}-2-(dioctadecylamino)ethanimidate
化学式: C49H102N6O2 (806.8063832)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.44%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CC(=O)NC(=O)C(CCCNCCCN)NCCCN
InChI: InChI=1S/C49H102N6O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-44-55(45-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)46-48(56)54-49(57)47(53-43-37-40-51)38-35-41-52-42-36-39-50/h47,52-53H,3-46,50-51H2,1-2H3,(H,54,56,57)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Osama A A Ahmed, Charareh Pourzand, Ian S Blagbrough. Varying the unsaturation in N4,N9-dioctadecanoyl spermines: nonviral lipopolyamine vectors for more efficient plasmid DNA formulation.
Pharmaceutical research.
2006 Jan; 23(1):31-40. doi:
10.1007/s11095-005-8717-3. [PMID: 16382281] - Jérôme Gaucheron, Catherine Santaella, Pierre Vierling. Transfection with fluorinated lipoplexes based on fluorinated analogues of DOTMA, DMRIE and DPPES.
Biochimica et biophysica acta.
2002 Aug; 1564(2):349-58. doi:
10.1016/s0005-2736(02)00469-8. [PMID: 12175917] - C Jacopin, H Hofland, D Scherman, J Herscovici. Synthesis and transfecting properties of a glycosylated polycationic DNA vector.
Bioorganic & medicinal chemistry letters.
2001 Feb; 11(3):419-22. doi:
10.1016/s0960-894x(00)00683-1. [PMID: 11212125] - J S Matsumura, R Kim, V P Shively, R C MacDonald, W H Pearce. Characterization of vascular gene transfer using a novel cationic lipid.
The Journal of surgical research.
1999 Aug; 85(2):339-45. doi:
10.1006/jsre.1999.5678. [PMID: 10423338] - W Yu, A Shimoyama, T Uneda, S Obika, K Miyashita, T Doi, T Imanishi. Gene transfer mediated by YKS-220 cationic particles: convenient and efficient gene delivery reagent.
Journal of biochemistry.
1999 Jun; 125(6):1034-8. doi:
10.1093/oxfordjournals.jbchem.a022383. [PMID: 10348904] - A Kichler, W Zauner, M Ogris, E Wagner. Influence of the DNA complexation medium on the transfection efficiency of lipospermine/DNA particles.
Gene therapy.
1998 Jun; 5(6):855-60. doi:
10.1038/sj.gt.3300658. [PMID: 9747467] - D D Dunlap, A Maggi, M R Soria, L Monaco. Nanoscopic structure of DNA condensed for gene delivery.
Nucleic acids research.
1997 Aug; 25(15):3095-101. doi:
10.1093/nar/25.15.3095. [PMID: 9224610] - A Boletta, A Benigni, J Lutz, G Remuzzi, M R Soria, L Monaco. Nonviral gene delivery to the rat kidney with polyethylenimine.
Human gene therapy.
1997 Jul; 8(10):1243-51. doi:
10.1089/hum.1997.8.10-1243. [PMID: 9215741] - T Boukhnikachvili, O Aguerre-Chariol, M Airiau, S Lesieur, M Ollivon, J Vacus. Structure of in-serum transfecting DNA-cationic lipid complexes.
FEBS letters.
1997 Jun; 409(2):188-94. doi:
10.1016/s0014-5793(97)00505-x. [PMID: 9202143] - A R Thierry, P Rabinovich, B Peng, L C Mahan, J L Bryant, R C Gallo. Characterization of liposome-mediated gene delivery: expression, stability and pharmacokinetics of plasmid DNA.
Gene therapy.
1997 Mar; 4(3):226-37. doi:
10.1038/sj.gt.3300350. [PMID: 9135736] - O Boussif, M A Zanta, J P Behr. Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold.
Gene therapy.
1996 Dec; 3(12):1074-80. doi:
NULL. [PMID: 8986433] - Y Yoshikawa, N Emi, T Kanbe, K Yoshikawa, H Saito. Folding and aggregation of DNA chains induced by complexation with lipospermine: formation of a nucleosome-like structure and network assembly.
FEBS letters.
1996 Oct; 396(1):71-6. doi:
10.1016/0014-5793(96)01057-5. [PMID: 8906869] - C Plank, K Mechtler, F C Szoka, E Wagner. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery.
Human gene therapy.
1996 Aug; 7(12):1437-46. doi:
10.1089/hum.1996.7.12-1437. [PMID: 8844203] - E Fortunati, A Bout, M A Zanta, D Valerio, M Scarpa. In vitro and in vivo gene transfer to pulmonary cells mediated by cationic liposomes.
Biochimica et biophysica acta.
1996 Apr; 1306(1):55-62. doi:
10.1016/0167-4781(95)00217-0. [PMID: 8611625] - S Kaech, J B Kim, M Cariola, E Ralston. Improved lipid-mediated gene transfer into primary cultures of hippocampal neurons.
Brain research. Molecular brain research.
1996 Jan; 35(1-2):344-8. doi:
10.1016/0169-328x(95)00238-n. [PMID: 8717375] - W M Mitchell, S T Rosenbloom, J Gabriel. Induction of mucosal anti-HIV antibodies by facilitated transfection of airway epithelium with lipospermine/DNA complexes.
Immunotechnology : an international journal of immunological engineering.
1995 Dec; 1(3-4):211-9. doi:
10.1016/1380-2933(95)00022-4. [PMID: 9373349] - B Schwartz, C Benoist, B Abdallah, D Scherman, J P Behr, B A Demeneix. Lipospermine-based gene transfer into the newborn mouse brain is optimized by a low lipospermine/DNA charge ratio.
Human gene therapy.
1995 Dec; 6(12):1515-24. doi:
10.1089/hum.1995.6.12-1515. [PMID: 8664376] - J S Remy, C Sirlin, P Vierling, J P Behr. Gene transfer with a series of lipophilic DNA-binding molecules.
Bioconjugate chemistry.
1994 Nov; 5(6):647-54. doi:
10.1021/bc00030a021. [PMID: 7873668] - C Staedel, J S Remy, Z Hua, T R Broker, L T Chow, J P Behr. High-efficiency transfection of primary human keratinocytes with positively charged lipopolyamine:DNA complexes.
The Journal of investigative dermatology.
1994 May; 102(5):768-72. doi:
10.1111/1523-1747.ep12377673. [PMID: 8176262] - B A Demeneix, H Abdel-Taweb, C Benoist, I Seugnet, J P Behr. Temporal and spatial expression of lipospermine-compacted genes transferred into chick embryos in vivo.
BioTechniques.
1994 Mar; 16(3):496-501. doi:
". [PMID: 8185924] - K D Mack, R Walzem, J B Zeldis. Cationic lipid enhances in vitro receptor-mediated transfection.
The American journal of the medical sciences.
1994 Feb; 307(2):138-43. doi:
10.1097/00000441-199402000-00013. [PMID: 8141140] - S Capaccioli, G Di Pasquale, E Mini, T Mazzei, A Quattrone. Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum.
Biochemical and biophysical research communications.
1993 Dec; 197(2):818-25. doi:
10.1006/bbrc.1993.2552. [PMID: 8267621] - F Barthel, J S Remy, J P Loeffler, J P Behr. Gene transfer optimization with lipospermine-coated DNA.
DNA and cell biology.
1993 Jul; 12(6):553-60. doi:
10.1089/dna.1993.12.553. [PMID: 8329121] - B A Demeneix, G Fredriksson, F Lezoual'ch, N Daugeras-Bernard, J P Behr, J P Loeffler. Gene transfer into intact vertebrate embryos.
The International journal of developmental biology.
1991 Dec; 35(4):481-4. doi:
". [PMID: 1801872] - J P Loeffler, F Barthel, P Feltz, J P Behr, P Sassone-Corsi, A Feltz. Lipopolyamine-mediated transfection allows gene expression studies in primary neuronal cells.
Journal of neurochemistry.
1990 May; 54(5):1812-5. doi:
10.1111/j.1471-4159.1990.tb01240.x. [PMID: 2378652]