Toosendanin (BioDeep_00000184443)

Main id: BioDeep_00000230446

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


21-(acetyloxy)-6-(furan-3-yl)-12,16,19-trihydroxy-5,11,15-trimethyl-3-oxo-9,17-dioxahexacyclo[13.3.3.0¹,¹⁴.0²,¹¹.0⁵,¹⁰.0⁸,¹⁰]henicosan-4-yl acetate

化学式: C30H38O11 (574.2413998)
中文名称: 川楝素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1CC(C23COC(C1(C2CC(C4(C3C(=O)C(C5(C46C(O6)CC5C7=COC=C7)C)OC(=O)C)C)O)C)O)O
InChI: InChI=1S/C30H38O11/c1-13(31)39-20-10-19(34)29-12-38-25(36)26(20,3)17(29)9-18(33)28(5)23(29)22(35)24(40-14(2)32)27(4)16(15-6-7-37-11-15)8-21-30(27,28)41-21/h6-7,11,16-21,23-25,33-34,36H,8-10,12H2,1-5H3

描述信息

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities[1].
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities[1].

同义名列表

3 个代谢物同义名

21-(acetyloxy)-6-(furan-3-yl)-12,16,19-trihydroxy-5,11,15-trimethyl-3-oxo-9,17-dioxahexacyclo[13.3.3.0¹,¹⁴.0²,¹¹.0⁵,¹⁰.0⁸,¹⁰]henicosan-4-yl acetate; CID 22556220; Toosendanin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sixin Chen, Jiajie Ni, Li Luo, Jinxian Lin, Hongjie Peng, Feihai Shen, Zhiying Huang. Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024 May; 187(?):114631. doi: 10.1016/j.fct.2024.114631. [PMID: 38570025]
  • Minghao Hu, Min Xu, Yuchen Chen, Zhangkai Ye, Shunpeng Zhu, Jia Cai, Mengxue Zhang, Chi Zhang, Ruizhen Huang, Qiang Ye, Hui Ao. Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Nov; 167(?):115541. doi: 10.1016/j.biopha.2023.115541. [PMID: 37738795]
  • Benshui Shu, Yanzheng Lin, Yuting Huang, Luyang Liu, Xueming Cai, Jintian Lin, Jingjing Zhang. Characterization and transcriptomic analyses of the toxicity induced by toosendanin in Spodoptera frugipreda. Gene. 2023 Oct; 893(?):147928. doi: 10.1016/j.gene.2023.147928. [PMID: 37898452]
  • Juan Zhang, Hong-Xi Xu, Yu-Lin Wu, William Chi Shing Cho, Yan-Fang Xian, Zhi-Xiu Lin. Synergistic Anti-Tumor Effect of Toosendanin and Paclitaxel on Triple-Negative Breast Cancer via Regulating ADORA2A-EMT Related Signaling. Advanced biology. 2023 08; 7(8):e2300062. doi: 10.1002/adbi.202300062. [PMID: 37401656]
  • Xuechao Jia, Penglei Wang, Chuntian Huang, Dengyun Zhao, Qiong Wu, Bingbing Lu, Wenna Nie, Limeng Huang, Xueli Tian, Pan Li, Kyle Vaughn Laster, Yanan Jiang, Xiang Li, Honglin Li, Zigang Dong, Kangdong Liu. Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growth. Journal of experimental & clinical cancer research : CR. 2023 Apr; 42(1):97. doi: 10.1186/s13046-023-02666-5. [PMID: 37088855]
  • Yonghong Liang, Sixin Chen, Suqin Han, Li Luo, Feihai Shen, Zhiying Huang. Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis. Toxicology letters. 2023 Mar; 377(?):51-61. doi: 10.1016/j.toxlet.2023.02.006. [PMID: 36801351]
  • Honglin Zhang, Yiyan Chen, Qiuyu Liu, Wen-Wen Xiao, Li-Dong Shao, Zheng-Hong Pan, Chuan-Huizi Chen, Dashan Li. Design, synthesis, and anti-triple negative breast cancer activity of novel Toosendanin derivatives. Bioorganic & medicinal chemistry letters. 2023 03; 83(?):129187. doi: 10.1016/j.bmcl.2023.129187. [PMID: 36781147]
  • Ge Wang, Lu Li, Yan Li, Li-Hong Zhang. Toosendanin reduces cisplatin resistance in ovarian cancer through modulating the miR-195/ERK/β-catenin pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154571. doi: 10.1016/j.phymed.2022.154571. [PMID: 36610147]
  • Chuangpeng Shen, Zhisen Pan, Xiaojie Wu, Chong Zhong, Qiao Li, Yuqi Si, Changhui Liu, Haitao Tu, Zhijun Deng, Zhangzhi Zhu, Jiewen Guo, Xiaoyi Xin, Min Liu. A Sensitive Liquid Chromatography-Mass Spectrometry Method for Determination of Toosendanin in Rat Plasma and its Application to Pharmacokinetic Study. Journal of chromatographic science. 2022 Jun; 60(5):478-485. doi: 10.1093/chromsci/bmab135. [PMID: 34929736]
  • Jingnan Zhang, Fan Yang, Xiyu Mei, Rui Yang, Bin Lu, Zhengtao Wang, Lili Ji. Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy. Chemico-biological interactions. 2022 Jan; 351(?):109739. doi: 10.1016/j.cbi.2021.109739. [PMID: 34742683]
  • Meng Sun, Qing Liu, Qiuxia Liang, Shuo Gao, Kaiyan Zhuang, Yun Zhang, Huazheng Zhang, Kechun Liu, Gaimei She, Qing Xia. Toosendanin triggered hepatotoxicity in zebrafish via inflammation, autophagy, and apoptosis pathways. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Dec; 250(?):109171. doi: 10.1016/j.cbpc.2021.109171. [PMID: 34454086]
  • Akiko Kawasaki, Hiroshi Hashimoto, Yoshie Shimotoyodome, Shotaro Ito, Junko Ishikawa, Yoshiya Sugai, Taketoshi Fujimori. Limonoids and unsaturated fatty acids present in Melia toosendan increase ceramide production in keratinocytes. Fitoterapia. 2021 Nov; 155(?):105058. doi: 10.1016/j.fitote.2021.105058. [PMID: 34637887]
  • Tianfeng Yang, Rui Xu, Jian Huo, Bo Wang, Xia Du, Bingling Dai, Man Zhu, Yingzhuan Zhan, Dongdong Zhang, Yanmin Zhang. WWOX activation by toosendanin suppresses hepatocellular carcinoma metastasis through JAK2/Stat3 and Wnt/β-catenin signaling. Cancer letters. 2021 08; 513(?):50-62. doi: 10.1016/j.canlet.2021.05.010. [PMID: 34015398]
  • Tianfeng Yang, Jian Huo, Rui Xu, Yanmin Zhang. Synergistic effect of toosendanin and regorafenib against cell proliferation and migration by regulating WWOX signaling pathway in hepatocellular carcinoma. Phytotherapy research : PTR. 2021 Aug; 35(8):4567-4578. doi: 10.1002/ptr.7174. [PMID: 34058790]
  • Yue Zhuo, Yida Zhang, Meng Li, Haiying Wu, Shilin Gong, Xiaolan Hu, Yu Fu, Xinzi Shen, Baoqing Sun, Jian-Lin Wu, Na Li. Hepatotoxic evaluation of toosendanin via biomarker quantification and pathway mapping of large-scale chemical proteomics. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Jul; 153(?):112257. doi: 10.1016/j.fct.2021.112257. [PMID: 34000341]
  • Hai Li, Siqi He, Guilin Liu, Chao Li, Zhiqing Ma, Xing Zhang. Residue and dissipation kinetics of toosendanin in cabbage, tobacco and soil using IC-ELISA detection. Food chemistry. 2021 Jan; 335(?):127600. doi: 10.1016/j.foodchem.2020.127600. [PMID: 32736155]
  • Ge Wang, Xiu-Qi Fan, Lu Li, Yan Li, Bian Shi, Ke-Xin Xing, Qi-Long Gao. Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway. The American journal of Chinese medicine. 2021; 49(7):1757-1772. doi: 10.1142/s0192415x2150083x. [PMID: 34521317]
  • Sarah A Long, Shan Huang, Anusha Kambala, Ling Ren, Jennifer Wilson, Michael Goetz, Xiaojiang Hao, Xiaosheng Yang, Ekaterina I Goncharova, Libin Jia, Amy LeBlanc, Chand Khanna, Curtis J Henrich, John A Beutler. Identification of potential modulators of osteosarcoma metastasis by high-throughput cellular screening of natural products. Chemical biology & drug design. 2021 01; 97(1):77-86. doi: 10.1111/cbdd.13762. [PMID: 32666679]
  • Xufan Lian, Xiuli Zhang, Fei Wang, Xiaoning Wang, Zheyong Xue, Xiaoquan Qi. Characterization of a 2,3-oxidosqualene cyclase in the toosendanin biosynthetic pathway of Melia toosendan. Physiologia plantarum. 2020 Dec; 170(4):528-536. doi: 10.1111/ppl.13189. [PMID: 32794175]
  • Hai Li, Jing Zhang, Ting Ma, Chao Li, Zhiqing Ma, Xing Zhang. Acting target of toosendanin locates in the midgut epithelium cells of Mythimna separate Walker larvae (lepidoptera: Noctuidae). Ecotoxicology and environmental safety. 2020 Sep; 201(?):110828. doi: 10.1016/j.ecoenv.2020.110828. [PMID: 32531576]
  • Michel N Mifundu, Nobutoshi Murakami, Tomikazu Kawano, Satoru Tamura. Toosendanin relatives, trypanocidal principles from Meliae Cortex. Journal of natural medicines. 2020 Sep; 74(4):702-709. doi: 10.1007/s11418-020-01422-9. [PMID: 32529328]
  • Jiaoyan Yu, Ruitao Zhang, Tian Zhang, Jun Zhao, Yang Zhang, Qingwei Wang, Linna Liu, Yuan Xu, Lei Shi. Determination of toosendanin and trans-anethole in Fructus Meliae Toosendan and Fructus Foeniculi by HPLC-MS/MS and GC-MS/MS in rat plasma and their potential herb-herb interactions. Biomedical chromatography : BMC. 2020 Jul; 34(7):e4837. doi: 10.1002/bmc.4837. [PMID: 32246844]
  • Tian Gao, An Xie, Xuqiang Liu, Haibo Zhan, Jin Zeng, Min Dai, Bin Zhang. Toosendanin induces the apoptosis of human Ewing's sarcoma cells via the mitochondrial apoptotic pathway. Molecular medicine reports. 2019 Jul; 20(1):135-140. doi: 10.3892/mmr.2019.10224. [PMID: 31115517]
  • Fan Yang, Li Li, Rui Yang, Mengjuan Wei, Yuchen Sheng, Lili Ji. Identification of serum microRNAs as potential toxicological biomarkers for toosendanin-induced liver injury in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 May; 58(?):152867. doi: 10.1016/j.phymed.2019.152867. [PMID: 30844585]
  • Xiaojing Yan, Yue Zhuo, Xiqing Bian, Jianmin Li, Yida Zhang, Lidong Ma, Guanghua Lu, Ming-Quan Guo, Jian-Lin Wu, Na Li. Integrated Proteomics, Biological Functional Assessments, and Metabolomics Reveal Toosendanin-Induced Hepatic Energy Metabolic Disorders. Chemical research in toxicology. 2019 04; 32(4):668-680. doi: 10.1021/acs.chemrestox.8b00350. [PMID: 30848893]
  • Sha Zhang, Liang Cao, Zong-Ren Wang, Zhe Li, Jing Ma. Anti-cancer effect of toosendanin and its underlying mechanisms. Journal of Asian natural products research. 2019 Mar; 21(3):270-283. doi: 10.1080/10286020.2018.1451516. [PMID: 29629572]
  • Yao Jin, Zhen-Lin Huang, Li Li, Yang Yang, Chang-Hong Wang, Zheng-Tao Wang, Li-Li Ji. Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway. Acta pharmacologica Sinica. 2019 Jan; 40(1):75-85. doi: 10.1038/s41401-018-0024-8. [PMID: 29921882]
  • Rui Yang, Qi Zhao, Dan-Dan Hu, Xue-Rong Xiao, Fei Li. Optimization of extraction and analytical protocol for mass spectrometry-based metabolomics analysis of hepatotoxicity. Biomedical chromatography : BMC. 2018 Dec; 32(12):e4359. doi: 10.1002/bmc.4359. [PMID: 30091800]
  • Mao Dong Zheng, Nai Dong Wang, Xiao Liang Li, Juan Yan, Jian Hua Tang, Xiu Hua Zhao, Zhihua Zhang. Toosendanin mediates cisplatin sensitization through targeting Annexin A4/ATP7A in non-small cell lung cancer cells. Journal of natural medicines. 2018 Jun; 72(3):724-733. doi: 10.1007/s11418-018-1211-0. [PMID: 29627895]
  • Wang Kai, Shan Yating, Ma Lin, Yang Kaiyong, Hua Baojin, Yin Wu, Yin Fangzhou, Chen Yan. Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor. Biochemical pharmacology. 2018 06; 152(?):153-164. doi: 10.1016/j.bcp.2018.03.022. [PMID: 29574068]
  • Tian-Xing Chen, Xiao-Ying Cheng, Yun Wang, Wu Yin. Toosendanin inhibits adipogenesis by activating Wnt/β-catenin signaling. Scientific reports. 2018 03; 8(1):4626. doi: 10.1038/s41598-018-22873-x. [PMID: 29545541]
  • Jie Zheng, Lingqi Yu, Wen Chen, Xiaoyan Lu, Xiaohui Fan. Circulating exosomal microRNAs reveal the mechanism of Fructus Meliae Toosendan-induced liver injury in mice. Scientific reports. 2018 02; 8(1):2832. doi: 10.1038/s41598-018-21113-6. [PMID: 29434260]
  • T Zhang, J Li, F Yin, B Lin, Z Wang, J Xu, H Wang, D Zuo, G Wang, Y Hua, Z Cai. Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3. Oncogene. 2017 11; 36(47):6627-6639. doi: 10.1038/onc.2017.270. [PMID: 28783167]
  • Zhe Pei, Wei Fu, Gongping Wang. A natural product toosendanin inhibits epithelial-mesenchymal transition and tumor growth in pancreatic cancer via deactivating Akt/mTOR signaling. Biochemical and biophysical research communications. 2017 11; 493(1):455-460. doi: 10.1016/j.bbrc.2017.08.170. [PMID: 28870807]
  • Liang Cao, Dingding Qu, Huan Wang, Sha Zhang, Chenming Jia, Zixuan Shi, Zongren Wang, Jian Zhang, Jing Ma. Toosendanin Exerts an Anti-Cancer Effect in Glioblastoma by Inducing Estrogen Receptor β- and p53-Mediated Apoptosis. International journal of molecular sciences. 2016 Nov; 17(11):. doi: 10.3390/ijms17111928. [PMID: 27869737]
  • Xiaoyan Lu, Cai Ji, Wei Tong, Xueping Lian, Ying Wu, Xiaohui Fan, Yue Gao. Integrated analysis of microRNA and mRNA expression profiles highlights the complex and dynamic behavior of toosendanin-induced liver injury in mice. Scientific reports. 2016 10; 6(?):34225. doi: 10.1038/srep34225. [PMID: 27703232]
  • Rahab W Kamau, Benard F Juma, Lilechi D Baraza. Antimicrobial compounds from root, stem bark and seeds of Melia volkensii. Natural product research. 2016 Sep; 30(17):1984-7. doi: 10.1080/14786419.2015.1101104. [PMID: 26517430]
  • Xiao-Ling Liu, Hong Wang, Ling Zhang, You-Liang Wang, Jin Wang, Peng Wang, Xiao He, Yu-Juan He. Anticancer effects of crude extract from Melia toosendan Sieb. et Zucc on hepatocellular carcinoma in vitro and in vivo. Chinese journal of integrative medicine. 2016 May; 22(5):362-9. doi: 10.1007/s11655-015-2084-7. [PMID: 26383159]
  • Ge Wang, Cheng-Cheng Feng, Shao-Jun Chu, Rui Zhang, Yun-Min Lu, Jin-Shui Zhu, Jing Zhang. Toosendanin inhibits growth and induces apoptosis in colorectal cancer cells through suppression of AKT/GSK-3β/β-catenin pathway. International journal of oncology. 2015 Nov; 47(5):1767-74. doi: 10.3892/ijo.2015.3157. [PMID: 26398368]
  • Jianming Ju, Zhichao Qi, Xueting Cai, Peng Cao, Nan Liu, Shuzhen Wang, Yijun Chen. Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells. Toxicology in vitro : an international journal published in association with BIBRA. 2013 Feb; 27(1):232-8. doi: 10.1016/j.tiv.2012.09.013. [PMID: 23111283]
  • Xintang Wang, Changhong Wang, Zhengtao Wang. Determination of toosendanin in rat plasma by ultra-performance liquid chromatography-electrospray ionization-mass spectrometry and its application in a pharmacokinetic study. Biomedical chromatography : BMC. 2013 Feb; 27(2):222-7. doi: 10.1002/bmc.2779. [PMID: 22733597]
  • Zhipeng Deng, Hao Zhong, Shaochao Liu, Shuxiang Cui, Yanying Xie, Qingqiang Yao. Determination of isotoosendanin in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetics study. Journal of chromatographic science. 2013 Jan; 51(1):82-6. doi: 10.1093/chromsci/bms110. [PMID: 22815211]
  • Jianming Ju, Zhichao Qi, Xueting Cai, Peng Cao, Yan Huang, Shuzhen Wang, Nan Liu, Yijun Chen. The apoptotic effects of toosendanin are partially mediated by activation of deoxycytidine kinase in HL-60 cells. PloS one. 2012; 7(12):e52536. doi: 10.1371/journal.pone.0052536. [PMID: 23300702]
  • Peng Wang, Jin Wang, Hui Jiang. [Human hepatocarcinoma cell apoptosis induced by toosendanin through mitochondria-dependent pathway]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2011 Feb; 31(2):218-22. doi: ". [PMID: 21425578]
  • Yujuan He, Jin Wang, Xiaoling Liu, Ling Zhang, Gang Yi, Chenwei Li, Xiao He, Peng Wang, Hui Jiang. Toosendanin inhibits hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis. Planta medica. 2010 Sep; 76(13):1447-53. doi: 10.1055/s-0029-1240902. [PMID: 20157879]
  • Yuya Nakai, Sabine Pellett, William H Tepp, Eric A Johnson, Kim D Janda. Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II). Bioorganic & medicinal chemistry. 2010 Feb; 18(3):1280-7. doi: 10.1016/j.bmc.2009.12.030. [PMID: 20044261]
  • Jian-Lou Zhang, Wang-Yu Shi, Wei Zhong, Ai-Tuan Ma, Xiao-Dan Wang, Yan-Tao Zhao, Meng Wang, Xiu-Hui Zhong. Effects of toosendanin on pregnancy and uterine immunity alterations in mice. The American journal of Chinese medicine. 2010; 38(2):319-28. doi: 10.1142/s0192415x10007877. [PMID: 20387228]
  • Audrey Fischer, Yuya Nakai, Lisa M Eubanks, Colin M Clancy, William H Tepp, Sabine Pellett, Tobin J Dickerson, Eric A Johnson, Kim D Janda, Mauricio Montal. Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proceedings of the National Academy of Sciences of the United States of America. 2009 Feb; 106(5):1330-5. doi: 10.1073/pnas.0812839106. [PMID: 19164566]
  • Yuya Nakai, William H Tepp, Tobin J Dickerson, Eric A Johnson, Kim D Janda. Function-oriented synthesis applied to the anti-botulinum natural product toosendanin. Bioorganic & medicinal chemistry. 2009 Feb; 17(3):1152-7. doi: 10.1016/j.bmc.2008.12.042. [PMID: 19131252]
  • Yu-Liang Shi, Mu-Feng Li. Biological effects of toosendanin, a triterpenoid extracted from Chinese traditional medicine. Progress in neurobiology. 2007 May; 82(1):1-10. doi: 10.1016/j.pneurobio.2007.02.002. [PMID: 17363132]
  • Eng Shi Ong, Choon Nam Ong. Qualitative and quantitative analysis of toosendanin in Melia toosendan Sieb. Et Zucc (Meliaceae) with liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2007; 21(4):589-98. doi: 10.1002/rcm.2878. [PMID: 17262897]
  • Yu-Liang Shi, Wen-Ping Wang. [Biological effects of toosendanin, an active ingredient of herbal vermifuge in Chinese traditional medicine]. Sheng li xue bao : [Acta physiologica Sinica]. 2006 Oct; 58(5):397-406. doi: ". [PMID: 17041722]
  • Mu-feng Li, Yu-liang Shi. Toosendanin interferes with pore formation of botulinum toxin type A in PC12 cell membrane. Acta pharmacologica Sinica. 2006 Jan; 27(1):66-70. doi: 10.1111/j.1745-7254.2006.00236.x. [PMID: 16364212]
  • Bin Zhang, Zhong-Feng Wang, Mian-Zhi Tang, Yu-Liang Shi. Growth inhibition and apoptosis-induced effect on human cancer cells of toosendanin, a triterpenoid derivative from chinese traditional medicine. Investigational new drugs. 2005 Dec; 23(6):547-53. doi: 10.1007/s10637-005-0909-5. [PMID: 16034516]
  • Mian-Zhi Tang, Zhong-Feng Wang, Yu-Liang Shi. Involvement of cytochrome c release and caspase activation in toosendanin-induced PC12 cell apoptosis. Toxicology. 2004 Sep; 201(1-3):31-8. doi: 10.1016/j.tox.2004.03.023. [PMID: 15297017]
  • Jowie C H Yu, Zhi-Da Min, Nancy Y Ip. Melia toosendan regulates PC12 Cell differentiation via the activation of protein kinase A and extracellular signal-regulated kinases. Neuro-Signals. 2004 Sep; 13(5):248-57. doi: 10.1159/000079339. [PMID: 15305092]
  • Yu-Liang Shi, Zhong-Feng Wang. Cure of experimental botulism and antibotulismic effect of toosendanin. Acta pharmacologica Sinica. 2004 Jun; 25(6):839-48. doi: ". [PMID: 15169642]
  • Jian-Ying Zhou, Zhong-Feng Wang, Xiao-Mei Ren, Mian-Zhi Tang, Yu-Liang Shi. Antagonism of botulinum toxin type A-induced cleavage of SNAP-25 in rat cerebral synaptosome by toosendanin. FEBS letters. 2003 Dec; 555(2):375-9. doi: 10.1016/s0014-5793(03)01291-2. [PMID: 14644446]
  • C L Céspedes, M Martínez-Vázquez, J S Calderón, J R Salazar, E Aranda. Insect growth regulatory activity of some extracts and compounds from Parthenium argentatum on fall armyworm Spodoptera frugiperda. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2001 Jan; 56(1-2):95-105. doi: 10.1515/znc-2001-1-216. [PMID: 11302221]
  • G G Shen, X L Zhuo, Y L Shi. [The binding sites of 3H-toosendanin in rat cerebral cortex homogenate]. Sheng li xue bao : [Acta physiologica Sinica]. 1994 Dec; 46(6):546-52. doi: ". [PMID: 7878482]
  • Y L Shih. Abolishment of non-quantal release of acetylcholine from the mouse phrenic nerve endings by toosendanin. The Japanese journal of physiology. 1986; 36(3):601-5. doi: 10.2170/jjphysiol.36.601. [PMID: 3773334]
  • C S Xiong. [The interaction between toosedanin and botulinum toxin at the neuromuscular junction; an ultrastructural observation]. Yao xue xue bao = Acta pharmaceutica Sinica. 1985 Jul; 20(7):495-9. doi: ". [PMID: 4096241]
  • J Zou, W Y Miao, F H Ding, J Y Meng, H J Ye, G R Jia, X Y He, G Z Sun, P Z Li. The effect of toosendanin on monkey botulism. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 1985 Mar; 5(1):29-30. doi: ". [PMID: 3849628]
  • Y L Shih, K Hsu. Anti-botulismic effect of toosendanin and its facilitatory action on miniature end-plate potentials. The Japanese journal of physiology. 1983; 33(4):677-80. doi: 10.2170/jjphysiol.33.677. [PMID: 6315997]
  • C S Xiong. [Effect of toosendanin on the ultrastructure of the rat neuromuscular junction]. Yao xue xue bao = Acta pharmaceutica Sinica. 1982 Jun; 17(6):407-12. doi: ". [PMID: 7148462]