4-Hydroxyhippurate (BioDeep_00000018444)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


2-[(4-Hydroxyphenyl)carbonylamino]acetic acid

化学式: C9H9NO4 (195.0531554)
中文名称: [(4-羟基苯甲酰基)氨基]乙酸, 4-羟基马尿酸
谱图信息: 最多检出来源 Homo sapiens(urine) 14.94%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

4-Hydroxyhippurate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/4-hydroxyhippurate (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000018444). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC(=CC=C1C(=O)NCC(=O)O)O
InChI: InChI=1S/C9H9NO4/c11-7-3-1-6(2-4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)

描述信息

4-Hydroxyhippuric acid is a microbial end-product derived from polyphenol metabolism by the microflora in the intestine (PMID: 22932811). It is derived from 4-hydroxybenzoic acid derivatives which may undergo glycination in the liver and kidney (PMID: 20615997). 4-Hydroxyhippuric acid has been identified in the human placenta (PMID: 32033212).
A polyphenol metabolite detected in biological fluids [PhenolExplorer]

同义名列表

21 个代谢物同义名

2-[(4-Hydroxyphenyl)carbonylamino]acetic acid; 2-[(4-Hydroxyphenyl)formamido]acetic acid; [(4-hydroxyphenyl)formamido]acetic acid; 2-[(4-Hydroxybenzoyl)amino]acetic acid; [(4-Hydroxybenzoyl)amino]acetic acid; N-(p-Hydroxybenzoyl)glycine; 4’-hydroxyhippuric acid; p-Hydroxy-hippuric acid; 4-Hydroxybenzoylglycine; p-Hydroxyhippuric Acid; 4-Hydroxyhippuric acid; 4-Hydroxhippuric acid; 4-Hydroxyhippic acid; p-Hydroxyhippic acid; 4’-hydroxyhippurate; p-Hydroxyhippurate; 4-Hydroxyhippurate; 4-OH-Hippuric acid; 4-Hydroxyhippate; p-Hydroxyhippate; 4-Hydroxyhippuric acid



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li Zhang, Wei Zou, Yi Huang, Xiaoke Wen, Jianxi Huang, Yichao Wang, Xiaoqi Sheng. A Preliminary Study of Uric Metabolomic Alteration for Postpartum Depression Based on Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry. Disease markers. 2019; 2019(?):4264803. doi: 10.1155/2019/4264803. [PMID: 31178941]
  • Julian K Aschoff, Ken M Riedl, Jessica L Cooperstone, Josef Högel, Anja Bosy-Westphal, Steven J Schwartz, Reinhold Carle, Ralf M Schweiggert. Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study. Molecular nutrition & food research. 2016 12; 60(12):2602-2610. doi: 10.1002/mnfr.201600315. [PMID: 27488098]
  • Rebecca K Moos, Jürgen Angerer, Georg Dierkes, Thomas Brüning, Holger M Koch. Metabolism and elimination of methyl, iso- and n-butyl paraben in human urine after single oral dosage. Archives of toxicology. 2016 Nov; 90(11):2699-2709. doi: 10.1007/s00204-015-1636-0. [PMID: 26608183]
  • Naiara Orrego-Lagarón, Miriam Martínez-Huélamo, Anna Vallverdú-Queralt, Rosa M Lamuela-Raventos, Elvira Escribano-Ferrer. High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism. The British journal of nutrition. 2015 Jul; 114(2):169-80. doi: 10.1017/s0007114515001671. [PMID: 26083965]
  • Piotr Bialasiewicz, Anna Prymont-Przyminska, Anna Zwolinska, Agata Sarniak, Anna Wlodarczyk, Maciej Krol, Jovana Glusac, Piotr Nowak, Jaroslaw Markowski, Krzysztof P Rutkowski, Dariusz Nowak. Addition of strawberries to the usual diet decreases resting chemiluminescence of fasting blood in healthy subjects-possible health-promoting effect of these fruits consumption. Journal of the American College of Nutrition. 2014; 33(4):274-87. doi: 10.1080/07315724.2013.870502. [PMID: 24912053]
  • Doris M Jacobs, Laura Spiesser, Maxime Garnier, Niels de Roo, Ferdi van Dorsten, Boudewijn Hollebrands, Ewoud van Velzen, Richard Draijer, John van Duynhoven. SPE-NMR metabolite sub-profiling of urine. Analytical and bioanalytical chemistry. 2012 Nov; 404(8):2349-61. doi: 10.1007/s00216-012-6339-2. [PMID: 22932811]
  • Silke S Heinzmann, Claire A Merrifield, Serge Rezzi, Sunil Kochhar, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Stability and robustness of human metabolic phenotypes in response to sequential food challenges. Journal of proteome research. 2012 Feb; 11(2):643-55. doi: 10.1021/pr2005764. [PMID: 21999107]
  • Dorota Polak-Jonkisz, Leszek Purzyc, Danuta Zwolińska. Ca(2+)-Mg (2+)-dependent ATP-ase activity in hemodialyzed children. Effect of a hemodialysis session. Pediatric nephrology (Berlin, Germany). 2010 Dec; 25(12):2501-7. doi: 10.1007/s00467-010-1634-7. [PMID: 20882298]
  • Ferdinand A van Dorsten, Christian H Grün, Ewoud J J van Velzen, Doris M Jacobs, Richard Draijer, John P M van Duynhoven. The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. Molecular nutrition & food research. 2010 Jul; 54(7):897-908. doi: 10.1002/mnfr.200900212. [PMID: 20013882]
  • Gerald Cohen, Jana Raupachova, Thomas Wimmer, Robert Deicher, Walter H Hörl. The uraemic retention solute para-hydroxy-hippuric acid attenuates apoptosis of polymorphonuclear leukocytes from healthy subjects but not from haemodialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 Aug; 23(8):2512-9. doi: 10.1093/ndt/gfn098. [PMID: 18319358]
  • Masaru Motojima, Atsuko Hosokawa, Hideyuki Yamato, Takamura Muraki, Toshimasa Yoshioka. Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake. British journal of pharmacology. 2002 Jan; 135(2):555-63. doi: 10.1038/sj.bjp.0704482. [PMID: 11815391]
  • J Jankowski, M Tepel, N Stephan, M van der Giet, V Breden, W Zidek, H Schlüter. Characterization of p-hydroxy-hippuric acid as an inhibitor of Ca2+-ATPase in end-stage renal failure. Kidney international. Supplement. 2001 Feb; 78(?):S84-8. doi: 10.1046/j.1523-1755.2001.59780084.x. [PMID: 11168989]
  • A C Schoots, T P Verheggen, P M De Vries, F M Everaerts. Ultraviolet-absorbing organic anions in uremic serum separated by capillary zone electrophoresis, and quantification of hippuric acid. Clinical chemistry. 1990 Mar; 36(3):435-40. doi: . [PMID: 2311210]
  • A C Schoots, P M De Vries, R Thiemann, W A Hazejager, S L Visser, P L Oe. Biochemical and neurophysiological parameters in hemodialyzed patients with chronic renal failure. Clinica chimica acta; international journal of clinical chemistry. 1989 Oct; 185(1):91-107. doi: 10.1016/0009-8981(89)90134-4. [PMID: 2620456]
  • A C Schoots, J B Dijkstra, S M Ringoir, R Vanholder, C A Cramers. Are the classical markers sufficient to describe uremic solute accumulation in dialyzed patients? Hippurates reconsidered. Clinical chemistry. 1988 Jun; 34(6):1022-9. doi: NULL. [PMID: 3378319]