Tildipirosin (BioDeep_00000184431)

   

human metabolite blood metabolite


代谢物信息卡片


6-{[4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-[2-(piperidin-1-yl)ethyl]-15-[(piperidin-1-yl)methyl]-1-oxacyclohexadeca-11,13-diene-2,10-dione

化学式: C41H71N3O8 (733.5240886)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 24.04%

分子结构信息

SMILES: CCC1OC(=O)CC(O)C(C)C(OC2OC(C)C(O)C(C2O)N(C)C)C(CCN2CCCCC2)CC(C)C(=O)C=CC(C)=CC1CN1CCCCC1
InChI: InChI=1S/C41H71N3O8/c1-8-35-32(26-44-20-13-10-14-21-44)23-27(2)15-16-33(45)28(3)24-31(17-22-43-18-11-9-12-19-43)40(29(4)34(46)25-36(47)51-35)52-41-39(49)37(42(6)7)38(48)30(5)50-41/h15-16,23,28-32,34-35,37-41,46,48-49H,8-14,17-22,24-26H2,1-7H3

描述信息

同义名列表

4 个代谢物同义名

6-{[4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-[2-(piperidin-1-yl)ethyl]-15-[(piperidin-1-yl)methyl]-1-oxacyclohexadeca-11,13-diene-2,10-dione; 6-{[4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-[2-(piperidin-1-yl)ethyl]-15-(piperidin-1-ylmethyl)-1-oxacyclohexadeca-11,13-diene-2,10-dione; 20,23-Dipiperidinyl-mycaminosyl-tylonolide; Tildipirosin



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ehab A Abu-Basha, Zuhair Bani Ismail, Mohammed M Ababneh, Eyad Hamzeh, Ronette Gehring. Pharmacokinetics and bioavailability of tildipirosin following intravenous and subcutaneous administration in horses. Journal of veterinary pharmacology and therapeutics. 2021 Jul; 44(4):544-551. doi: 10.1111/jvp.12958. [PMID: 33609061]
  • Leonardo Bringhenti, Mariana Pallu, Josiane Silva, Tiago Tomazi, Ana C Tomazi, Marjory X Rodrigues, Livia M Duarte, Todd R Bilby, Rodrigo C Bicalho. Effect of metaphylactic administration of tildipirosin on the incidence of pneumonia and otitis and on the upper respiratory tract and fecal microbiome of preweaning Holstein calves. Journal of dairy science. 2021 May; 104(5):6020-6038. doi: 10.3168/jds.2020-19572. [PMID: 33685693]
  • Ehab A Abu-Basha, Zuhair Bani Ismail, Hind Abu Alhaijaa, Eyad Hamzeh, Nasir M Idkaidek. Pharmacokinetics and bioavailability of tildipirosin following intravenous and subcutaneous administration in sheep. Journal of veterinary pharmacology and therapeutics. 2021 Jan; 44(1):79-85. doi: 10.1111/jvp.12901. [PMID: 32748450]
  • Jincheng Xiong, Yuliang Xu, Shuang He, Yanfang Zhang, Zile Wang, Sihan Wang, Haiyang Jiang. Pharmacokinetics and bioavailability of tildipirosin in rabbits following single-dose intravenous and intramuscular administration. Journal of veterinary pharmacology and therapeutics. 2020 Sep; 43(5):448-453. doi: 10.1111/jvp.12882. [PMID: 32542744]
  • J Wang, T Zhao, X Sun, Y Liu, J Zhu, S Zhang, X Cao. Pharmacokinetics of tildipirosin in beagle dogs. Journal of veterinary pharmacology and therapeutics. 2018 Feb; 41(1):e49-e52. doi: 10.1111/jvp.12453. [PMID: 28892155]
  • M Rose, A Pridmore, A Shaw, C Wilhelm, M Menge, S Kilp, R Röpke, M Nürnberger. A microbiological assay to estimate the antimicrobial activity of parenteral tildipirosin against foodborne pathogens and commensals in the colon of beef cattle and pigs. Journal of veterinary pharmacology and therapeutics. 2016 Jun; 39(3):277-86. doi: 10.1111/jvp.12277. [PMID: 26538405]
  • F Torres, R Santamaria, M Jimenez, R Menjón, A Ibanez, M Collell, O Azlor, L Fraile. Pharmacokinetics of tildipirosin in pig tonsils. Journal of veterinary pharmacology and therapeutics. 2016 Apr; 39(2):199-201. doi: 10.1111/jvp.12258. [PMID: 26935349]
  • M Rose, M Menge, C Bohland, E Zschiesche, C Wilhelm, S Kilp, W Metz, M Allan, R Röpke, M Nürnberger. Pharmacokinetics of tildipirosin in porcine plasma, lung tissue, and bronchial fluid and effects of test conditions on in vitro activity against reference strains and field isolates of Actinobacillus pleuropneumoniae. Journal of veterinary pharmacology and therapeutics. 2013 Apr; 36(2):140-53. doi: 10.1111/j.1365-2885.2012.01397.x. [PMID: 22500881]
  • M Menge, M Rose, C Bohland, E Zschiesche, S Kilp, W Metz, M Allan, R Röpke, M Nürnberger. Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). Journal of veterinary pharmacology and therapeutics. 2012 Dec; 35(6):550-9. doi: 10.1111/j.1365-2885.2011.01349.x. [PMID: 22188102]