tiaden (BioDeep_00000184414)
human metabolite blood metabolite
代谢物信息卡片
2-({10-[(2-hydroxyethyl)sulfanyl]decyl}sulfanyl)ethan-1-ol
化学式: C14H30O2S2 (294.168712)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 99.57%
分子结构信息
SMILES: C(CCCCCSCCO)CCCCSCCO
InChI: InChI=1S/C14H30O2S2/c15-9-13-17-11-7-5-3-1-2-4-6-8-12-18-14-10-16/h15-16H,1-14H2
描述信息
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135235
- PubChem: 23403
- HMDB: HMDB0259066
- DrugBank: DB13348
- ChEMBL: CHEMBL1697775
- Wikipedia: Tiadenol
- chemspider: 21885
- CAS: 6964-20-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tohru Yamazaki, Akihiko Hirose, Takeshi Sakamoto, Mari Okazaki, Atsushi Mitsumoto, Naomi Kudo, Yoichi Kawashima. Peroxisome proliferators attenuate free arachidonic acid pool in the kidney through inducing lysophospholipid acyltransferases.
Journal of pharmacological sciences.
2009 Oct; 111(2):201-10. doi:
10.1254/jphs.09162fp. [PMID: 19809218] - H Mizuguchi, N Kudo, T Ohya, Y Kawashima. Effects of tiadenol and di-(2-ethylhexyl)phthalate on the metabolism of phosphatidylcholine and phosphatidylethanolamine in the liver of rats: comparison with clofibric acid.
Biochemical pharmacology.
1999 Apr; 57(8):869-76. doi:
10.1016/s0006-2952(98)00365-7. [PMID: 10086319] - T Serra, M S Gavelli, E Vitaliano, G Santini, A Catalano, F G Rossi, J Tozzi, R Caridis, G Guarini. [Therapy of hypercholesterolemia and hypertriglyceridemia. Comparison of the lipid-lowering effect of simvastatin and tiadenol].
La Clinica terapeutica.
1990 Mar; 132(5):307-13. doi:
". [PMID: 2139833] - A Aarsland, R K Berge, J Bremer, N Aarsaether. The hypolipidemic peroxisome-proliferating drug, bis(carboxymethylthio)-1.10 decane, a dicarboxylic metabolite of tiadenol, is activated to an acylcoenzyme A thioester.
Biochimica et biophysica acta.
1990 Feb; 1033(2):176-83. doi:
10.1016/0304-4165(90)90009-l. [PMID: 2306462] - Y Kawashima, T Matsunaga, A Hirose, T Ogata, H Kozuka. Induction of microsomal 1-acylglycerophosphocholine acyltransferase by peroxisome proliferators in rat kidney; co-induction with peroxisomal beta-oxidation.
Biochimica et biophysica acta.
1989 Nov; 1006(2):214-8. doi:
10.1016/0005-2760(89)90199-9. [PMID: 2597669] - H Katoh, Y Kawashima, H Watanuki, H Kozuka, H Isono. Effects of clofibric acid and tiadenol on cytosolic long-chain acyl-CoA hydrolase and peroxisomal beta-oxidation in liver and extrahepatic tissues of rats.
Biochimica et biophysica acta.
1987 Jul; 920(2):171-9. doi:
. [PMID: 2886154] - R Maffei Facino, M Carini, O Tofanetti, I Casciarri, E Longoni. Experimental studies on pharmacology, metabolism and toxicology with tiadenol-disulfoxide. Dissociation of lipid lowering effects and the induction of peroxisomal and microsomal drug-metabolizing enzymes.
Arzneimittel-Forschung.
1987 Jun; 37(6):682-91. doi:
. [PMID: 3663266] - L Schladt, R Hartmann, C Timms, M Strolin-Benedetti, P Dostert, W Wörner, F Oesch. Concomitant induction of cytosolic but not microsomal epoxide hydrolase with peroxisomal beta-oxidation by various hypolipidemic compounds.
Biochemical pharmacology.
1987 Feb; 36(3):345-51. doi:
10.1016/0006-2952(87)90292-9. [PMID: 2880593] - J P Desager, J Costermans, M Sclavons, C Harvengt. The metabolic fate of 14C or 35S labelled tiadenol in rabbit after i.v. and oral administration.
European journal of drug metabolism and pharmacokinetics.
1986 Jul; 11(3):225-32. doi:
10.1007/bf03189850. [PMID: 3816878] - R Maffei Facino, M Carini, O Tofanetti. Metabolism of the hypolipidemic agent tiadenol in man and in the rat.
Arzneimittel-Forschung.
1986 Apr; 36(4):722-8. doi:
NULL. [PMID: 3718595] - G Fredj, M Clenet, F Rousselet. [Comparative effects of clofibrate and tiadenol on the metabolism of cholesterol in rats. II. Comparative action of clofibrate and tiadenol on biliary and fecal excretion of cholesterol and its metabolites in rats].
Annales pharmaceutiques francaises.
1986; 44(5):347-54. doi:
NULL. [PMID: 3579157] - R K Berge, J R Lillehaug. Tiadenol-mediated induction of peroxisomal enzymes in cultured C3H/10T1/2CL8 cells and in chemically transformed C3H/10T1/2 MCA16 cells.
International journal of cancer.
1985 Oct; 36(4):489-94. doi:
10.1002/ijc.2910360413. [PMID: 2864317] - R Gutman, M Z Basílico, A Chicco, M A de Rodi, B Nusimovich, Y B Lombardo. Effects of tiadenol and clofibrate on plasma post heparin lipolytic hepatic, extrahepatic and monoglyceride hydrolase activities in rats with hypertriglyceridemia induced by a sucrose rich diet.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1985 Apr; 17(4):169-75. doi:
10.1055/s-2007-1013484. [PMID: 4007766] - R K Berge, L H Hosøy, A Aarsland, O M Bakke, M Farstad. Enzymatic changes in rat liver associated with low and high doses of a peroxisome proliferator.
Toxicology and applied pharmacology.
1984 Mar; 73(1):35-41. doi:
10.1016/0041-008x(84)90050-4. [PMID: 6143426] - M Sirtori, G Montanari, G Gianfranceschi, M G Malacrida, P Battistin, G Morazzoni, E Tremoli, S Colli, P Maderna, C R Sirtori. Clofibrate and tiadenol treatment in hyperlipoproteinemias. A comparative trial of drugs affecting lipoprotein catabolism and biosynthesis.
Atherosclerosis.
1983 Nov; 49(2):149-61. doi:
10.1016/0021-9150(83)90192-2. [PMID: 6365105] - O M Bakke, R K Berge. Lipid-metabolizing enzymes, CoASH and long-chain acyl-CoA in rat liver after treatment with tiadenol, nicotinic acid and niadenate.
Biochemical pharmacology.
1982 Dec; 31(23):3930-3. doi:
10.1016/0006-2952(82)90313-6. [PMID: 7159471] - G Franceschini, A Poli, A L Catapano, E Gatti, M Sirtori, G Gianfranceschi, C R Sirtori. Pharmacological studies on tiadenol in type IV patients. Evidence for a mechanism of action different from other lipid-lowering drugs.
Atherosclerosis.
1981 Nov; 40(3-4):245-55. doi:
10.1016/0021-9150(81)90134-9. [PMID: 7332603] - P Cuchet, C Morrier, F Cand, C Keriel. Effects of clofibrate and tiadenol on the elimination of lipids and bile acids in rat bile.
Lipids.
1981 Oct; 16(10):732-8. doi:
10.1007/bf02535340. [PMID: 7300592] - R K Berge, O M Bakke. Changes in lipid metabolizing enzymes of hepatic subcellular fractions from rats treated with tiadenol and clofibrate.
Biochemical pharmacology.
1981 Aug; 30(16):2251-6. doi:
10.1016/0006-2952(81)90095-2. [PMID: 7295339] - S Ferlito, G Carrà, F Puleo, E La Spina. [Effect of tiadenol on plasma lipoprotein lipase].
La Clinica terapeutica.
1981 Mar; 96(5):487-92. doi:
NULL. [PMID: 7285519] - F Di Stefano, S Patane, A Gatto. [Thiadenol in the short-term treatment of patients with blood lipid disorders].
Minerva medica.
1980 Mar; 71(8):567-74. doi:
". [PMID: 7360386] - G Giorcelli, G Vacha, G P Icardi. Drug treatment of hypertriglyceridaemia in chronic uraemic patients: preliminary report on D,L-carnitine and thiadenol.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association.
1980; 17(?):367-71. doi:
NULL. [PMID: 7243794] - D Kritchevsky, S A Tepper, S K Czarnecki, J A Story. Influence of tiadenol, bis-(hydroxyethylthio)1,10-decane, on cholesterol metabolism in rats.
Pharmacological research communications.
1979 Nov; 11(10):861-7. doi:
10.1016/s0031-6989(79)80012-0. [PMID: 538065] - M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm.
Biochimica et biophysica acta.
1976 Apr; 428(2):525-31. doi:
10.1016/0304-4165(76)90061-1. [PMID: 6049]