Thymin (BioDeep_00000184407)

   

human metabolite blood metabolite


代谢物信息卡片


3-({6-amino-2-[(2-amino-5-carbamimidamido-1-hydroxypentylidene)amino]-1-hydroxyhexylidene}amino)-3-[(1-{[1-carboxy-2-(4-hydroxyphenyl)ethyl]-C-hydroxycarbonimidoyl}-2-methylpropyl)-C-hydroxycarbonimidoyl]propanoate

化学式: C30H49N9O9 (679.3653064)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 98.21%

分子结构信息

SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)N
InChI: InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D007155 - Immunologic Factors

同义名列表

12 个代谢物同义名

3-({6-amino-2-[(2-amino-5-carbamimidamido-1-hydroxypentylidene)amino]-1-hydroxyhexylidene}amino)-3-[(1-{[1-carboxy-2-(4-hydroxyphenyl)ethyl]-C-hydroxycarbonimidoyl}-2-methylpropyl)-C-hydroxycarbonimidoyl]propanoate; 3-(6-amino-2-{2-amino-5-[(diaminomethylidene)amino]pentanamido}hexanamido)-3-[(1-{[1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl)carbamoyl]propanoic acid; Thymopoietin pentapeptide; Thymopoietin II; Thymopoietin I; Thymopoietins; Thymopoietin; Thymopentin; Thymins; Thymin; TP-49; TP 49



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Si-Jia Peng, Ya Feng, Xuan Li, Xi-Xi Wang, Yu Wang, Bu-Tian Zhou, Ye Liu, Te Liu, Yun-Cheng Wu. Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF-κB/NLRP3 signaling pathway. International immunopharmacology. 2023 Jun; 119(?):110109. doi: 10.1016/j.intimp.2023.110109. [PMID: 37121113]
  • Mengyang Liu, Darren Svirskis, Thomas Proft, Jacelyn Loh, Shuo Chen, Dali Kang, Jingyuan Wen. Exploring ex vivo peptideolysis of thymopentin and lipid-based nanocarriers towards oral formulations. International journal of pharmaceutics. 2022 Sep; 625(?):122123. doi: 10.1016/j.ijpharm.2022.122123. [PMID: 35995317]
  • Te Liu, Fangyuan Jing, Peirong Huang, Zixiang Geng, Jianghong Xu, Jiahui Li, Danping Chen, Ying Zhu, Zhenxin Wang, Willian Huang, Chuan Chen. Thymopentin alleviates premature ovarian failure in mice by activating YY2/Lin28A and inhibiting the expression of let-7 family microRNAs. Cell proliferation. 2021 Aug; 54(8):e13089. doi: 10.1111/cpr.13089. [PMID: 34180104]
  • Xueqin Zhu, Jianjun Liu, Hao Pan, Zixiang Geng, William Huang, Te Liu, Bimeng Zhang. Thymopentin treatment of murine premature ovarian failure via attenuation of immune cell activity and promotion of the BMP4/Smad9 signalling pathway. International journal of medical sciences. 2021; 18(15):3544-3555. doi: 10.7150/ijms.61975. [PMID: 34522181]
  • Jiao Feng, Yan Chen, Feng Li, Lili Cui, Nianqiu Shi, Wei Kong, Yong Zhang. Synthesis, Characterization and In Vitro Evaluation of a Novel Glycol Chitosan-EDTA Conjugate to Inhibit Aminopeptidase-Mediated Degradation of Thymopoietin Oligopeptides. Molecules (Basel, Switzerland). 2017 Jul; 22(8):. doi: 10.3390/molecules22081253. [PMID: 28933740]
  • Han-Ning Huang, Yi-Lin Chan, Cho-Fat Hui, Jen-Leih Wu, Chang-Jer Wu, Jyh-Yih Chen. Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries. Oncotarget. 2015 May; 6(15):12955-69. doi: 10.18632/oncotarget.4102. [PMID: 25992774]
  • Ying Zhong, Liyu Chen, Yu Zhang, Wenhao Li, Xun Sun, Tao Gong, Zhirong Zhang. Vesicular phospholipid gels using low concentrations of phospholipids for the sustained release of thymopentin: pharmacokinetics and pharmacodynamics. Die Pharmazie. 2013 Oct; 68(10):811-5. doi: ". [PMID: 24273885]
  • S M Lunin, O V Glushkova, M O Khrenov, T V Novoselova, S B Parfenyuk, E E Fesenko, E G Novoselova. Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis. Immunobiology. 2013 Mar; 218(3):402-7. doi: 10.1016/j.imbio.2012.05.023. [PMID: 22727332]
  • Rui Yang, Renchao Gao, Fang Li, Haibing He, Xing Tang. The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein-loaded SLN prepared by the double emulsion process. Drug development and industrial pharmacy. 2011 Feb; 37(2):139-48. doi: 10.3109/03639045.2010.497151. [PMID: 20578879]
  • Yan-Zhen Li, Xun Sun, Tao Gong, Jie Liu, Jiao Zuo, Zhi-Rong Zhang. Inhalable microparticles as carriers for pulmonary delivery of thymopentin-loaded solid lipid nanoparticles. Pharmaceutical research. 2010 Sep; 27(9):1977-86. doi: 10.1007/s11095-010-0201-z. [PMID: 20625801]
  • Rui Yang, Ren-Chao Gao, Cui-Fang Cai, Hui Xu, Fang Li, Hai-Bing He, Xing Tang. Preparation of gel-core-solid lipid nanoparticle: a novel way to improve the encapsulation of protein and peptide. Chemical & pharmaceutical bulletin. 2010 Sep; 58(9):1195-202. doi: 10.1248/cpb.58.1195. [PMID: 20823599]
  • Yashu Yin, Dawei Chen, Mingxi Qiao, Zhe Lu, Haiyang Hu. Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin. Journal of controlled release : official journal of the Controlled Release Society. 2006 Dec; 116(3):337-45. doi: 10.1016/j.jconrel.2006.09.015. [PMID: 17097180]
  • Qiuping Zhang, Cassandra D Ragnauth, Jeremy N Skepper, Nathalie F Worth, Derek T Warren, Roland G Roberts, Peter L Weissberg, Juliet A Ellis, Catherine M Shanahan. Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. Journal of cell science. 2005 Feb; 118(Pt 4):673-87. doi: 10.1242/jcs.01642. [PMID: 15671068]
  • James M Holaska, Amy K Kowalski, Katherine L Wilson. Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PLoS biology. 2004 Sep; 2(9):E231. doi: 10.1371/journal.pbio.0020231. [PMID: 15328537]
  • Ch B Felder, M J Blanco-Príeto, J Heizmann, H P Merkle, B Gander. Ultrasonic atomization and subsequent polymer desolvation for peptide and protein microencapsulation into biodegradable polyesters. Journal of microencapsulation. 2003 Sep; 20(5):553-67. doi: 10.1080/0265204031000148059. [PMID: 12909541]
  • M Columbaro, E Mattioli, G Lattanzi, C Rutigliano, A Ognibene, N M Maraldi, S Squarzoni. Staurosporine treatment and serum starvation promote the cleavage of emerin in cultured mouse myoblasts: involvement of a caspase-dependent mechanism. FEBS letters. 2001 Dec; 509(3):423-9. doi: 10.1016/s0014-5793(01)03203-3. [PMID: 11749967]
  • T W McDade, M A Beck, C W Kuzawa, L S Adair. Prenatal undernutrition and postnatal growth are associated with adolescent thymic function. The Journal of nutrition. 2001 Apr; 131(4):1225-31. doi: 10.1093/jn/131.4.1225. [PMID: 11285331]
  • G Goldstein, M Fava, M Culler, A Fisher, K Rickels, R B Lydiard, J Rosenbaum. Elevated plasma thymopoietin associated with therapeutic nonresponsiveness in major depression. Biological psychiatry. 2000 Jul; 48(1):65-9. doi: 10.1016/s0006-3223(00)00246-8. [PMID: 10913509]
  • C Ostlund, J Ellenberg, E Hallberg, J Lippincott-Schwartz, H J Worman. Intracellular trafficking of emerin, the Emery-Dreifuss muscular dystrophy protein. Journal of cell science. 1999 Jun; 112 ( Pt 11)(?):1709-19. doi: 10.1242/jcs.112.11.1709. [PMID: 10318763]
  • F Muntoni, E J Lichtarowicz-Krynska, C A Sewry, S Manilal, D Recan, S Llense, J Taylor, G E Morris, V Dubowitz. Early presentation of X-linked Emery-Dreifuss muscular dystrophy resembling limb-girdle muscular dystrophy. Neuromuscular disorders : NMD. 1998 Apr; 8(2):72-6. doi: 10.1016/s0960-8966(98)00006-6. [PMID: 9608559]
  • L M Tarasenko, K S Neporada, I M Skrypnyk, V Ie Klusha. [The typological characteristics of the stress activation of lipid peroxidation and its correction by thymopentin]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). 1997; 43(1-2):113-6. doi: ". [PMID: 9221111]
  • P Anderlik, K Antmann, K Cseh, L Kalabay. [Role of the thymus and normal microbial flora on plasma fibronectin concentration in mice treated with immunomodulatory drugs]. Acta pharmaceutica Hungarica. 1996 Jul; 66(4):165-9. doi: NULL. [PMID: 9082837]
  • T Abiko, H Sekino. Synthesis of [Phe(4F)3]thymopoietin II and examination of its immunological effect on the impaired blastogenic response of T-lymphocytes of uremic patients. Bioorganic & medicinal chemistry. 1995 Oct; 3(10):1369-75. doi: 10.1016/0968-0896(95)00121-v. [PMID: 8564403]
  • J Nagy, M Kapás. In vitro degradation of thymopoietin32-35 in human, dog and rat plasma. Acta physiologica Hungarica. 1995; 83(1):31-7. doi: NULL. [PMID: 7660834]
  • F Eichler, G R Krueger. Effects of non-specific immunostimulants (echinacin, isoprinosine and thymus factors) on the infection and antigen expression in herpesvirus-6 exposed human lymphoid cells. In vivo (Athens, Greece). 1994 Jul; 8(4):565-75. doi: ". [PMID: 7534493]
  • R Bräuer, A J Egg, S Henzgen, J Kriegsmann, K Thoss. The effects of immunomodulatory thymic and splenic peptides and cyclosporin A on antigen-induced arthritis in the rat. Agents and actions. 1993; 38 Spec No(?):C95-7. doi: 10.1007/bf01991149. [PMID: 8317333]
  • H U Simon, C Piesch, J Furkert, H Schubert, G Schlenvoigt. [Determination of Berlopentin in human plasma using an enzyme immunoassay]. Die Pharmazie. 1991 Feb; 46(2):139-40. doi: NULL. [PMID: 1852764]
  • V Klusa, R A Kiivet, R Muceniece, I Liepa, J Harro, S Svirskis, A Andermanis, L Rägo. Thymopentin antagonizes stress-induced changes of GABA/benzodiazepine receptor complex. Regulatory peptides. 1990 Mar; 27(3):355-65. doi: 10.1016/0167-0115(90)90124-f. [PMID: 2158126]
  • T Abiko, H Sekino. Synthesis of human splenin (hSP) and examination of its immunological effects on the impaired T- and B-lymphocytes in uremic patients. Chemical & pharmaceutical bulletin. 1990 Feb; 38(2):487-91. doi: 10.1248/cpb.38.487. [PMID: 2337963]
  • W E Beyer, T C Noordzij, P Kramer, P P Diderich, C T Op den Hoek, J Janssen, N Masurel, W Weimar. Effect of immunomodulator thymopentin on impaired seroresponse to influenza vaccine in patients on haemodialysis. Nephron. 1990; 54(4):296-301. doi: 10.1159/000185883. [PMID: 2183079]
  • T A Deviatkina, V V Brechko, L M Tarasenko, I N Zviago'lskaia, Iu V Bezuglyĭ, I R Rituma, V E Klusha. [Correction of lipid peroxidation in stress with the peptide bioregulator thymopentin]. Fiziologicheskii zhurnal. 1989 Sep; 35(5):14-8. doi: ". [PMID: 2687033]
  • A V Shevchenko, V V Korpachev, V A Tychinin. [Effect of splenic humoral factors on the cholinesterase activity of liver tissue and blood serum in experimental toxic hepatitis in rats]. Fiziologicheskii zhurnal. 1989 Jul; 35(4):24-7. doi: NULL. [PMID: 2792437]
  • T A Deviatkina, L M Tarasenko, V E Klusha, O I Tsebrzhinskiĭ, R K Mutsenietse. [The protective action of thymopentin on stress damage to the stomach]. Biulleten' eksperimental'noi biologii i meditsiny. 1989 Jun; 107(6):673-5. doi: ". [PMID: 2676006]
  • V E Klusha, R K Mutsenietse, I R Liepa, Sh V Svirskis, A V Andermanis. [Thymus hormones--precursors of new psychoneuromodulatory peptides]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. 1989 May; 75(5):691-6. doi: NULL. [PMID: 2569989]
  • O L Isakova, N F Sepetov, K Forner, A Erlikh. [A study of enzymatic hydrolysis of splenopentin and its analogs in human serum]. Bioorganicheskaia khimiia. 1989 Apr; 15(4):453-9. doi: NULL. [PMID: 2751705]
  • R S Pinals. Drug therapy in rheumatoid arthritis--a perspective. British journal of rheumatology. 1989 Apr; 28(2):93-5. doi: 10.1093/rheumatology/28.2.93. [PMID: 2650801]
  • E L Ochoa, S Medrano, M C de Carlin, A M Dilonardo. Arg-Lys-Asp-Val-Tyr (thymopentin) accelerates the cholinergic-induced inactivation (desensitization) of reconstituted nicotinic receptor. Cellular and molecular neurobiology. 1988 Sep; 8(3):325-31. doi: 10.1007/bf00711174. [PMID: 3066488]
  • J C Monier, C Auger, N Corvee, C Stahli, N Fabien. Immunoreactivity of aqueous extracts of rat and mouse tissue with anti-thymosin alpha 1, anti-bovine thymopoietin and anti-thymulin antibodies. Studies using immunoblotting. Thymus. 1988; 11(3):173-83. doi: NULL. [PMID: 3363629]
  • Iu A Grinevich, L Ia Kamenets, T N Selezneva, V L Ganul, L V Okulov. [Serum thymic activity in patients with cancer of the stomach and esophagus and its changes after the combined treatment including immunotherapy]. Klinicheskaia khirurgiia. 1988; ?(5):19-22. doi: NULL. [PMID: 3419029]
  • E Morel, B Vernet-der Garabedian, F Raimond, T K Audhya, G Goldstein, J F Bach. Myasthenic sera recognize the human acetylcholine receptor bound to thymopoietin. European journal of immunology. 1987 Aug; 17(8):1109-13. doi: 10.1002/eji.1830170806. [PMID: 3622601]
  • V E Klusha, R K Mutsenietse, Sh V Svirskis, G M Zalitis, I R Liepa. [Neuroimmunoregulatory properties of short protein fragments in rats exposed to immobilization stress]. Biulleten' eksperimental'noi biologii i meditsiny. 1987 Aug; 104(8):186-7. doi: NULL. [PMID: 2887222]
  • T Abiko. Syntheses and structure-activity relationships of thymopoietin. Advances in experimental medicine and biology. 1987; 223(?):153-5. doi: 10.1007/978-1-4684-5445-1_24. [PMID: 3447432]
  • G A Heavner, D J Kroon, T Audhya, G Goldstein. Biologically active analogs of thymopentin with enhanced enzymatic stability. Peptides. 1986 Nov; 7(6):1015-9. doi: 10.1016/0196-9781(86)90131-2. [PMID: 3031628]
  • G V Tiuleneva, A V Shevchenko, S V Pokrovskaia. [Effect of splenin on histamine inactivation in the plasma and liver of the rat during anaphylactic shock]. Fiziologicheskii zhurnal. 1986 Sep; 32(5):607-10. doi: NULL. [PMID: 3770236]
  • N M Doroshenko, S V Pokrovskaia, A V Shevchenko. [Effect of splenin on the concentration of biogenic amines in the tissues and blood plasma of the rat]. Fiziologicheskii zhurnal. 1986 May; 32(3):367-70. doi: NULL. [PMID: 3721001]
  • J P Waymack, S Gonce, P Miskell, J W Alexander. Mechanisms of action of two new immunomodulators. Archives of surgery (Chicago, Ill. : 1960). 1985 Jan; 120(1):43-8. doi: 10.1001/archsurg.1985.01390250037006. [PMID: 3917663]
  • T K Audhya, G Goldstein. Thymopentin: stability considerations and potency by various routes of administration. Survey of immunologic research. 1985; 4 Suppl 1(?):17-23. doi: 10.1007/bf02919052. [PMID: 3898289]
  • E Iván, I Bodrogligeti, A Juhász-Nagy, L Német, E Cholnoky. Preclinical toxicity studies with two thymopoietin-like peptides. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 1985; 8(?):495-8. doi: 10.1007/978-3-642-69928-3_117. [PMID: 3868381]
  • M Fiorilli, I Quinti, G Russi, R Seminara, B Ensoli, F Aiuti. Thymopentin treatment of selective IgA deficiency. Survey of immunologic research. 1985; 4 Suppl 1(?):129-34. doi: 10.1007/bf02919068. [PMID: 3898285]
  • A Fuccello, T Audhya, M A Talle, G Goldstein. Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies. Archives of biochemistry and biophysics. 1984 Jan; 228(1):292-8. doi: 10.1016/0003-9861(84)90070-5. [PMID: 6364989]
  • T Audhya, G Goldstein. Comparative efficacy of various routes of administration of thymopentin (TP-5) with consideration of degradative mechanisms. International journal of peptide and protein research. 1983 Aug; 22(2):187-93. doi: 10.1111/j.1399-3011.1983.tb02085.x. [PMID: 6352534]
  • L N Gastinel, J M Pleau, G Goldstein, J F Bach. Interaction of thymopoietin peptides with the specific receptor of facteur thymique serique (FTS). Thymus. 1983 Mar; 5(2):78-87. doi: NULL. [PMID: 6304947]
  • K Kang, K D Cooper, J M Hanifin. Thymopoietin pentapeptide (TP-5) improves clinical parameters and lymphocyte subpopulations in atopic dermatitis. Journal of the American Academy of Dermatology. 1983 Mar; 8(3):372-7. doi: 10.1016/s0190-9622(83)70042-3. [PMID: 6339571]
  • R Yamanaka, R A Good, G S Incefy. Functional maturation difference between splenocytes that form autologous rosettes in adult thymectomized and aged mice. Thymus. 1983; 5(1):35-42. doi: NULL. [PMID: 6302958]
  • K D Cooper, K Kang, J M Hanifin. Effects of thymopoietin pentapeptide (TP-5) on in vitro and in vivo IgE production by atopic dermatitis cell subsets. Diagnostic immunology. 1983; 1(3):211-5. doi: NULL. [PMID: 6388971]
  • R C Williams, J D Montano, A D Bankhurst. Abrogation of in vitro suppressor cell activity in adult common variable hypogammaglobulinemia after TP5 treatment. The Journal of laboratory and clinical medicine. 1983 Jan; 101(1):152-60. doi: NULL. [PMID: 6217268]
  • T Abiko, H Sekino. Synthesis of the octadecapeptide corresponding to positions 32 to 49 of the revised amino acid sequence of thymopoietin II and its effect on low E-rosette forming cells of an aged patient with chronic renal failure. Chemical & pharmaceutical bulletin. 1982 Sep; 30(9):3271-7. doi: 10.1248/cpb.30.3271. [PMID: 7172335]
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  • O Strannegård, I L Strannegård, K Kang, K D Cooper, J M Hanifin. FcIgG receptor-bearing lymphocytes and monoclonal antibody-defined T cell subsets in atopic dermatitis: effect of treatment with thymopoietin pentapeptide (TP-5). International archives of allergy and applied immunology. 1982; 69(3):238-44. doi: 10.1159/000233177. [PMID: 6752042]
  • M Fiorilli, M C Sirianni, F Pandolfi, I Quinti, U Tosti, F Aiuti, G Goldstein. Improvement of natural killer activity and of T cells after thymopoietin pentapeptide therapy in a patient with severe combined immunodeficiency. Clinical and experimental immunology. 1981 Aug; 45(2):344-51. doi: . [PMID: 7032772]
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