Tezosentan (BioDeep_00000184314)
human metabolite blood metabolite
代谢物信息卡片
N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-1,2,3,4-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-(propan-2-yl)pyridine-2-sulfonamide
化学式: C27H27N9O6S (605.1804922000001)
中文名称: 替唑生坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=CN=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC(=NC=C3)C4=NNN=N4)OCCO)OC5=CC=CC=C5OC
InChI: InChI=1S/C27H27N9O6S/c1-16(2)18-8-9-22(29-15-18)43(38,39)34-26-23(42-21-7-5-4-6-20(21)40-3)27(41-13-12-37)31-24(30-26)17-10-11-28-19(14-17)25-32-35-36-33-25/h4-11,14-16,37H,12-13H2,1-3H3,(H,30,31,34)(H,32,33,35,36)
描述信息
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C28313 - Endothelin Receptor Antagonist
同义名列表
5 个代谢物同义名
N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-1,2,3,4-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-(propan-2-yl)pyridine-2-sulfonamide; 5-Isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-1H-tetrazol-5-yl--pyridin-4-yl)--pyrimidin-4-ylamide; N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-propan-2-ylpyridine-2-sulfonamide; Tezosentan; Veletri
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 151174
- HMDB: HMDB0258945
- DrugBank: DB06558
- ChEMBL: CHEMBL61780
- Wikipedia: Tezosentan
- chemspider: 133242
- CAS: 180384-57-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Richard W B van Duin, Kelly Stam, Zongye Cai, André Uitterdijk, Ana Garcia-Alvarez, Borja Ibanez, A H Jan Danser, Irwin K M Reiss, Dirk J Duncker, Daphne Merkus. Transition from post-capillary pulmonary hypertension to combined pre- and post-capillary pulmonary hypertension in swine: a key role for endothelin.
The Journal of physiology.
2019 02; 597(4):1157-1173. doi:
10.1113/jp275987. [PMID: 29799120] - Gad Cotter, Marco Metra, Beth A Davison, Guillaume Jondeau, John G F Cleland, Robert C Bourge, Olga Milo, Christopher M O'Connor, John D Parker, Guillermo Torre-Amione, Dirk J van Veldhuisen, Isaac Kobrin, Maurizio Rainisio, Stefanie Senger, Christopher Edwards, John J V McMurray, John R Teerlink. Systolic blood pressure reduction during the first 24 h in acute heart failure admission: friend or foe?.
European journal of heart failure.
2018 02; 20(2):317-322. doi:
10.1002/ejhf.889. [PMID: 28871621] - René Duarte Martins, Roberta Jeane Bezerra Jorge, Renata de Sousa Alves, Antônio Gomes da Silva Neto, Paulo Sergio F Barbosa, Alice Maria Costa Martins, Marcos H Toyama, Helena Serra Azul Monteiro. Renal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothelin involvement.
Toxicon : official journal of the International Society on Toxinology.
2017 Nov; 138(?):78-81. doi:
10.1016/j.toxicon.2017.08.019. [PMID: 28837825] - John G F Cleland, John R Teerlink, Beth A Davison, Ahmad Shoaib, Marco Metra, Stefanie Senger, Olga Milo, Gad Cotter, Robert C Bourge, John D Parker, Guillaume Jondeau, Henry Krum, Christopher M O'Connor, Guillermo Torre-Amione, Dirk J van Veldhuisen, John J V McMurray. Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure-does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS).
European journal of heart failure.
2017 06; 19(6):739-747. doi:
10.1002/ejhf.786. [PMID: 28296139] - Yonis Abukar, Clive N May, Rohit Ramchandra. Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failure.
American journal of physiology. Regulatory, integrative and comparative physiology.
2016 Jan; 310(1):R94-9. doi:
10.1152/ajpregu.00205.2015. [PMID: 26468257] - Agata Kowalczyk, Paulina Kleniewska, Michal Kolodziejczyk, Beata Skibska, Anna Goraca. The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis.
Archivum immunologiae et therapiae experimentalis.
2015 Feb; 63(1):41-52. doi:
10.1007/s00005-014-0310-1. [PMID: 25288367] - Arnaud Mommerot, André Y Denault, Jocelyn Dupuis, Michel Carrier, Louis P Perrault. Cardiopulmonary bypass is associated with altered vascular reactivity of isolated pulmonary artery in a porcine model: therapeutic potential of inhaled tezosentan.
Journal of cardiothoracic and vascular anesthesia.
2014 Jun; 28(3):698-708. doi:
10.1053/j.jvca.2013.12.013. [PMID: 24917060] - B P Persson, H Halldorsdottir, L Lindbom, P Rossi, H Herwald, E Weitzberg, A Oldner. Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?.
Acta anaesthesiologica Scandinavica.
2014 May; 58(5):549-59. doi:
10.1111/aas.12301. [PMID: 24611481] - Shawn B Bender, Vincent J de Beer, Darla L Tharp, Elza D van Deel, Douglas K Bowles, Dirk J Duncker, M Harold Laughlin, Daphne Merkus. Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia.
The Journal of physiology.
2014 Apr; 592(8):1757-69. doi:
10.1113/jphysiol.2013.267351. [PMID: 24421352] - Gerard Sánchez-Etayo, Xavier Borrat, Bibiana Escobar, Amelia Hessheimer, Gonzalo Rodriguez-Laiz, Pilar Taura. Effect of intra-abdominal pressure on hepatic microcirculation: implications of the endothelin-1 receptor.
Journal of digestive diseases.
2012 Sep; 13(9):478-85. doi:
10.1111/j.1751-2980.2012.00613.x. [PMID: 22908974] - André P Lourenço, Francisco Vasques-Nóvoa, José Oliveira-Pinto, Dulce Fontoura, Roberto Roncon-Albuquerque, Adelino F Leite-Moreira. Haemodynamic and neuroendocrine effects of tezosentan in chronic experimental pulmonary hypertension.
Intensive care medicine.
2012 Jun; 38(6):1050-60. doi:
10.1007/s00134-012-2484-5. [PMID: 22349420] - Didier Lebrec, Jaime Bosch, Rajiv Jalan, Francis J Dudley, Rada Jessic, Richard Moreau, Juan Carlos Garcia-Pagan, Rajeshwar P Mookerjee, Eleonora Chiossi, Paul L M Van Giersbergen, Andjela Kusic-Pajic, Jasper Dingemanse. Hemodynamics and pharmacokinetics of tezosentan, a dual endothelin receptor antagonist, in patients with cirrhosis.
European journal of clinical pharmacology.
2012 May; 68(5):533-41. doi:
10.1007/s00228-011-1157-6. [PMID: 22101624] - Shirin Bruderer, Päivi Aänismaa, Marie-Claude Homery, Stephanie Häusler, Kyle Landskroner, Patricia N Sidharta, Alexander Treiber, Jasper Dingemanse. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist.
The AAPS journal.
2012 Mar; 14(1):68-78. doi:
10.1208/s12248-011-9316-3. [PMID: 22189899] - Ovidiu Constantin Baltatu, Radu Iliescu, Christian E Zaugg, Jane F Reckelhoff, Pat Louie, Christoph Schumacher, Luciana Aparecida Campos. Antidiuretic effects of the endothelin receptor antagonist avosentan.
Frontiers in physiology.
2012; 3(?):103. doi:
10.3389/fphys.2012.00103. [PMID: 22529820] - Hannu-Ville Leskelä, Olli Vuolteenaho, Marja-Kaisa Koivula, Panu Taskinen, Heikki Ruskoaho, Tuomas Peltonen, Petri Lehenkari. Tezosentan inhibits uptake of proinflammatory endothelin-1 in stenotic aortic valves.
The Journal of heart valve disease.
2012 Jan; 21(1):23-30. doi:
NULL. [PMID: 22474738] - Jia Li, Jing Li, Fengxia Liang, Yaqun Hong, Song Wu, Hongtu Tang, Hua Wang. Electroacupuncture at PC6 (Neiguan) Improves Extracellular Signal-Regulated Kinase Signaling Pathways Through the Regulation of Neuroendocrine Cytokines in Myocardial Hypertrophic Rats.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):792820. doi:
10.1155/2012/792820. [PMID: 21876715] - Patricia N Sidharta, Paul L M van Giersbergen, Atef Halabi, Jasper Dingemanse. Macitentan: entry-into-humans study with a new endothelin receptor antagonist.
European journal of clinical pharmacology.
2011 Oct; 67(10):977-84. doi:
10.1007/s00228-011-1043-2. [PMID: 21541781] - Vincent J de Beer, Yannick J Taverne, Diederik W Kuster, Aref Najafi, Dirk J Duncker, Daphne Merkus. Prostanoids suppress the coronary vasoconstrictor influence of endothelin after myocardial infarction.
American journal of physiology. Heart and circulatory physiology.
2011 Sep; 301(3):H1080-9. doi:
10.1152/ajpheart.01307.2010. [PMID: 21685265] - Johan Fenhammar, Andreas Andersson, Jakob Forestier, Eddie Weitzberg, Alf Sollevi, Hans Hjelmqvist, Robert Frithiof. Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs.
PloS one.
2011; 6(7):e21534. doi:
10.1371/journal.pone.0021534. [PMID: 21760895] - Olga Milo-Cotter, Beth Cotter-Davison, Carlo Lombardi, Hengrui Sun, Luca Bettari, Silvia Bugatti, Michele Rund, Marco Metra, Edo Kaluski, Isaac Kobrin, Aline Frey, Maurizio Rainisio, John J V McMurray, John R Teerlink, Gad Cotter-Davison. Neurohormonal activation in acute heart failure: results from VERITAS.
Cardiology.
2011; 119(2):96-105. doi:
10.1159/000330409. [PMID: 21912122] - Laura Caracuel, Francesc Jiménez-Altayó, Mónica Romo, Ana Márquez-Martín, Ana P Dantas, Elisabet Vila. Transient mesenteric ischemia leads to remodeling of rat mesenteric resistance arteries.
Frontiers in physiology.
2011; 2(?):118. doi:
10.3389/fphys.2011.00118. [PMID: 22291659] - Catherine R Mikus, R Scott Rector, Arturo A Arce-Esquivel, Jessica L Libla, Frank W Booth, Jamal A Ibdah, M Harold Laughlin, John P Thyfault. Daily physical activity enhances reactivity to insulin in skeletal muscle arterioles of hyperphagic Otsuka Long-Evans Tokushima Fatty rats.
Journal of applied physiology (Bethesda, Md. : 1985).
2010 Oct; 109(4):1203-10. doi:
10.1152/japplphysiol.00064.2010. [PMID: 20634354] - Vincent J de Beer, Henri J D de Graaff, Maaike Hoekstra, Dirk J Duncker, Daphne Merkus. Integrated control of pulmonary vascular tone by endothelin and angiotensin II in exercising swine depends on gender.
American journal of physiology. Heart and circulatory physiology.
2010 Jun; 298(6):H1976-85. doi:
10.1152/ajpheart.00459.2009. [PMID: 20348226] - Dirk J A Lok, Peter Van Der Meer, Pieta W Bruggink-André de la Porte, Erik Lipsic, Jan Van Wijngaarden, Hans L Hillege, Dirk J van Veldhuisen. Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from the DEAL-HF study.
Clinical research in cardiology : official journal of the German Cardiac Society.
2010 May; 99(5):323-8. doi:
10.1007/s00392-010-0125-y. [PMID: 20130888] - Senol Gulmen, Ilker Kiris, Cuneyt Narin, Berit Gokce Ceylan, Betul Mermi, Recep Sutcu, Ibrahim Meteoglu. Tezosentan reduces the renal injury induced by abdominal aortic ischemia-reperfusion in rats.
The Journal of surgical research.
2009 Nov; 157(1):e7-e13. doi:
10.1016/j.jss.2008.08.011. [PMID: 19329125] - Björn P Persson, Patrik Rossi, Eddie Weitzberg, Anders Oldner. Inhaled tezosentan reduces pulmonary hypertension in endotoxin-induced lung injury.
Shock (Augusta, Ga.).
2009 Oct; 32(4):427-34. doi:
10.1097/shk.0b013e31819e2cbb. [PMID: 19197226] - Ilker Kiriş, Cüneyt Narin, Senol Gülmen, Nigar Yilmaz, Recep Sütçü, Nilgün Kapucuoğlu. Endothelin receptor antagonism by tezosentan attenuates lung injury induced by aortic ischemia-reperfusion.
Annals of vascular surgery.
2009 May; 23(3):382-91. doi:
10.1016/j.avsg.2008.10.003. [PMID: 19135850] - Jasper Dingemanse, Atef Halabi, Paul L M van Giersbergen. Influence of liver cirrhosis on the pharmacokinetics, pharmacodynamics, and safety of tezosentan.
Journal of clinical pharmacology.
2009 Apr; 49(4):455-64. doi:
10.1177/0091270008330157. [PMID: 19318695] - J Fenhammar, A Andersson, R Frithiof, J Forestier, E Weitzberg, A Sollevi, H Hjelmqvist. The endothelin receptor antagonist tezosentan improves renal microcirculation in a porcine model of endotoxemic shock.
Acta anaesthesiologica Scandinavica.
2008 Nov; 52(10):1385-93. doi:
10.1111/j.1399-6576.2008.01768.x. [PMID: 19025532] - Cüneyt Narin, Ilker Kiris, Senol Gülmen, Hatice Toy, Nigar Yilmaz, Recep Sütcü. Endothelin receptor blockade with tezosentan ameliorates myocardial injury induced by abdominal aortic ischemia-reperfusion.
The Tohoku journal of experimental medicine.
2008 Nov; 216(3):267-76. doi:
10.1620/tjem.216.267. [PMID: 18987461] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - J Pham, U H Beier, L Fornell, A Chin, S Samuel, J Radhakrishnan, E John. The effect of tezosentan after cold ischemia and renal artery clamping as a model of reperfusion injury in newborn piglets.
Transplantation proceedings.
2008 Jun; 40(5):1294-9. doi:
10.1016/j.transproceed.2008.02.071. [PMID: 18589090] - Florence Wong, Kevin Moore, Jasper Dingemanse, Rajiv Jalan. Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndrome.
Hepatology (Baltimore, Md.).
2008 Jan; 47(1):160-8. doi:
10.1002/hep.21940. [PMID: 17886336] - John J V McMurray, John R Teerlink, Gadi Cotter, Robert C Bourge, John G F Cleland, Guillaume Jondeau, Henry Krum, Marco Metra, Christopher M O'Connor, John D Parker, Guillermo Torre-Amione, Dirk J van Veldhuisen, Jim Lewsey, Aline Frey, Maurizio Rainisio, Isaac Kobrin. Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure: the VERITAS randomized controlled trials.
JAMA.
2007 Nov; 298(17):2009-19. doi:
10.1001/jama.298.17.2009. [PMID: 17986694] - Aysen Erdem, A Meltem Sevgili, Filiz Akbiyik, Pergin Atilla, Nur Cakar, Z Dicle Balkanci, Alper B Iskit, M Oguz Guc. Tezosentan attenuates organ injury and mesenteric blood flow decrease in endotoxemia and cecal ligation and puncture.
The Journal of surgical research.
2007 Aug; 141(2):211-9. doi:
10.1016/j.jss.2006.08.028. [PMID: 17583743] - D Konrad, M Haney, G Johansson, M Wanecek, E Weitzberg, A Oldner. Cardiac effects of endothelin receptor antagonism in endotoxemic pigs.
American journal of physiology. Heart and circulatory physiology.
2007 Aug; 293(2):H988-96. doi:
10.1152/ajpheart.01023.2006. [PMID: 17400719] - Christopher Adlbrecht, Diana Bonderman, Christian Plass, Johannes Jakowitsch, Gilbert Beran, Wolfgang Sperker, Peter Siostrzonek, Dietmar Glogar, Gerald Maurer, Irene M Lang. Active endothelin is an important vasoconstrictor in acute coronary thrombi.
Thrombosis and haemostasis.
2007 Apr; 97(4):642-9. doi:
10.1160/th06-08-0479. [PMID: 17393028] - Birgit Houweling, Daphne Merkus, Oana Sorop, Frans Boomsma, Dirk J Duncker. Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarction.
The Journal of physiology.
2006 Jul; 574(Pt 2):615-26. doi:
10.1113/jphysiol.2006.107060. [PMID: 16709643] - P S F Barbosa, A M C Martins, R S Alves, D N Amora, R D Martins, Marcos H Toyama, A Havt, N R F Nascimento, V L C Rocha, D B Menezes, M C Fonteles, H S A Monteiro. The role of indomethacin and tezosentan on renal effects induced by Bothrops moojeni Lys49 myotoxin I.
Toxicon : official journal of the International Society on Toxinology.
2006 Jun; 47(8):831-7. doi:
10.1016/j.toxicon.2006.01.012. [PMID: 16730045] - Jianpu Wang, Anders Oldner, Calle Winskog, Erik Edston, Sten M Walther. Effects of endothelin receptor antagonism on acute lung injury induced by chlorine gas.
Critical care medicine.
2006 Jun; 34(6):1731-7. doi:
10.1097/01.ccm.0000218815.46611.63. [PMID: 16625121] - Peter Oishi, Anthony Azakie, Cynthia Harmon, Robert K Fitzgerald, Albert Grobe, Jie Xu, Karen Hendricks-Munoz, Stephen M Black, Jeffrey R Fineman. Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs.
American journal of physiology. Heart and circulatory physiology.
2006 May; 290(5):H1922-32. doi:
10.1152/ajpheart.01091.2005. [PMID: 16339822] - Jasper Dingemanse, Kulasiri A Gunawardena, Paul L M van Giersbergen. Comparison of the pharmacokinetics, pharmacodynamics and tolerability of tezosentan between caucasian and Japanese subjects.
British journal of clinical pharmacology.
2006 Apr; 61(4):405-13. doi:
10.1111/j.1365-2125.2006.02586.x. [PMID: 16542201] - Walid Habre, Ferenc Peták, Isabelle Ruchonnet-Metrailler, Yves Donati, Jean-Francois Tolsa, Eniko Lele, Gergely Albu, Morice Beghetti, Constance Barazzone-Argiroffo. The role of endothelin-1 in hyperoxia-induced lung injury in mice.
Respiratory research.
2006 Mar; 7(?):45. doi:
10.1186/1465-9921-7-45. [PMID: 16566828] - Christian Wunder, Robert W Brock, Stefan Frantz, Winfried Göttsch, Henning Morawietz, Norbert Roewer, Otto Eichelbrönner. Carbon monoxide, but not endothelin-1, plays a major role for the hepatic microcirculation in a murine model of early systemic inflammation.
Critical care medicine.
2005 Oct; 33(10):2323-31. doi:
10.1097/01.ccm.0000182794.42733.71. [PMID: 16215388] - Mihai Gheorghiade, John R Teerlink, Alexandre Mebazaa. Pharmacology of new agents for acute heart failure syndromes.
The American journal of cardiology.
2005 Sep; 96(6A):68G-73G. doi:
10.1016/j.amjcard.2005.07.023. [PMID: 16181825] - Nir Uriel, Guillermo Torre-Amione, Olga Milo, Edo Kaluski, Loïc Perchenet, Alex Blatt, Isaac Kobrin, Arkadi Turnovski, Shoshana Kaplan, Maurizio Rainisio, Aline Frey, Zvi Vered, Gad Cotter. Echocardiographic ejection fraction in patients with acute heart failure: correlations with hemodynamic, clinical, and neurohormonal measures and short-term outcome.
European journal of heart failure.
2005 Aug; 7(5):815-9. doi:
10.1016/j.ejheart.2004.10.013. [PMID: 16087136] - John R Teerlink, John J V McMurray, Robert C Bourge, John G F Cleland, Gadi Cotter, Guillaume Jondeau, Henry Krum, Marco Metra, Christopher M O'Connor, John D Parker, Guillermo Torre-Amione, Dirk J Van Veldhuisen, Aline Frey, Maurizio Rainisio, Isaac Kobrin. Tezosentan in patients with acute heart failure: design of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Study (VERITAS).
American heart journal.
2005 Jul; 150(1):46-53. doi:
10.1016/j.ahj.2005.04.035. [PMID: 16084150] - Vladimir Kuklin, Mikhail Kirov, Mikhail Sovershaev, Thomas Andreasen, Ole C Ingebretsen, Kirsti Ytrehus, Lars Bjertnaes. Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C.
Critical care (London, England).
2005 Jun; 9(3):R211-7. doi:
10.1186/cc3497. [PMID: 15987392] - Robert A Cox, Perenlei Enkhabaatar, Ann S Burke, Jiro Katahira, Katahiro Shimoda, Abhijit Chandra, Lillian D Traber, David N Herndon, Hal K Hawkins, Daniel L Traber. Effects of a dual endothelin-1 receptor antagonist on airway obstruction and acute lung injury in sheep following smoke inhalation and burn injury.
Clinical science (London, England : 1979).
2005 Mar; 108(3):265-72. doi:
10.1042/cs20040191. [PMID: 15554871] - Daphne Merkus, Birgit Houweling, Anton H van den Meiracker, Frans Boomsma, Dirk J Duncker. Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction.
American journal of physiology. Heart and circulatory physiology.
2005 Feb; 288(2):H871-80. doi:
10.1152/ajpheart.00429.2004. [PMID: 15458948] - Vladimir Kuklin, Mikhail Sovershaev, Thomas Andreasen, Vegard Skogen, Kirsti Ytrehus, Lars Bjertnaes. Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture.
Critical care (London, England).
2005; 9(6):R677-86. doi:
10.1186/cc3882. [PMID: 16280068] - W Urbanowicz, P Sogni, R Moreau, K A Tazi, E Barriere, O Poirel, A Martin, M C Guimont, D Cazals-Hatem, D Lebrec. Tezosentan, an endothelin receptor antagonist, limits liver injury in endotoxin challenged cirrhotic rats.
Gut.
2004 Dec; 53(12):1844-9. doi:
10.1136/gut.2003.036517. [PMID: 15542526] - Gad Cotter, Edo Kaluski, Karl Stangl, Richard Pacher, Christoph Richter, Olga Milo-Cotter, Loïc Perchenet, Isaac Kobrin, Shoshana Kaplan, Maurizio Rainisio, Aline Frey, Eric Neuhart, Zvi Vered, Jasper Dingemanse, Guillermo Torre-Amione. The hemodynamic and neurohormonal effects of low doses of tezosentan (an endothelin A/B receptor antagonist) in patients with acute heart failure.
European journal of heart failure.
2004 Aug; 6(5):601-9. doi:
10.1016/j.ejheart.2004.05.004. [PMID: 15302008] - Vladimir N Kuklin, Mikhail Y Kirov, Oleg V Evgenov, Mikhail A Sovershaev, Jonas Sjöberg, Svetlana S Kirova, Lars J Bjertnaes. Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep.
Critical care medicine.
2004 Mar; 32(3):766-73. doi:
10.1097/01.ccm.0000114575.08269.f6. [PMID: 15090960] - Jasper Dingemanse, Paul L M van Giersbergen. Influence of mild liver impairment on the pharmacokinetics of tezosentan, a drug excreted unchanged into bile.
British journal of clinical pharmacology.
2004 Mar; 57(3):344-8. doi:
10.1046/j.1365-2125.2003.01987.x. [PMID: 14998431] - B O Al-Jiffry, E A Shaffer, C M Woods, M Menadue, F Young, J Oliver, A C Thomas, J Toouli, G T P Saccone. Endogenous endothelin increases gallbladder tone and leads to acute cholecystitis in the Australian possum.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2004 Feb; 16(1):125-33. doi:
10.1046/j.1365-2982.2003.00459.x. [PMID: 14764212] - Cristiane F Freitas, Renato Faro, Desanka Dragosavac, Martine Clozel, Gilberto De Nucci, Edson Antunes. Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs.
Journal of cardiovascular pharmacology.
2004 Jan; 43(1):106-12. doi:
10.1097/00005344-200401000-00016. [PMID: 14668575] - O Picker, L A Schwarte, H J Roth, J Greve, T W L Scheeren. Comparison of the role of endothelin, vasopressin and angiotensin in arterial pressure regulation during sevoflurane anaesthesia in dogs.
British journal of anaesthesia.
2004 Jan; 92(1):102-8. doi:
10.1093/bja/aeh025. [PMID: 14665561] - John M Tovar, John G Gums. Tezosentan in the treatment of acute heart failure.
The Annals of pharmacotherapy.
2003 Dec; 37(12):1877-83. doi:
10.1345/aph.1d080. [PMID: 14632537] - Fjølnir F Gudmundsson, Asgaut Viste, Ole L Myking, Ketil Grong, Leif Bostad, Knut Svanes. Effects of the endothelin-1 receptor antagonist tezosentan on renal blood flow and diuresis during prolonged increased intra-abdominal pressure.
The Journal of surgical research.
2003 Nov; 115(1):33-40. doi:
10.1016/s0022-4804(03)00249-x. [PMID: 14572770] - Paul L M van Giersbergen, Peter Wipfli, Jasper Dingemanse. Determination of tezosentan, a parenteral endothelin receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Jul; 792(2):369-73. doi:
10.1016/s1570-0232(03)00271-x. [PMID: 12860045] - P L M van Giersbergen, J Dingemanse. Effect of severe renal impairment on the pharmacokinetics and tolerability of the parenteral endothelin antagonist tezosentan.
International journal of clinical pharmacology and therapeutics.
2003 Jun; 41(6):261-6. doi:
10.5414/cpp41261. [PMID: 12816178] - A Treiber, P L M Van Giersbergen, J Dingemanse. In vivo and in vitro disposition profile of tezosentan, an intravenous dual endothelin receptor antagonist, in humans.
Xenobiotica; the fate of foreign compounds in biological systems.
2003 Apr; 33(4):399-414. doi:
10.1080/0049825021000061624. [PMID: 12745875] - Reza Tabrizchi, Carol Ann Ford. Haemodynamic effects of endothelin receptor antagonist, tezosentan, in tumour necrosis factor-alpha treated anaesthetized rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2003 Feb; 367(2):156-67. doi:
10.1007/s00210-002-0663-6. [PMID: 12595957] - Paul L M van Giersbergen, Frédéric Bodin, Jasper Dingemanse. Cyclosporin increases the exposure to tezosentan, an intravenous dual endothelin receptor antagonist.
European journal of clinical pharmacology.
2002 Jul; 58(4):243-5. doi:
10.1007/s00228-002-0459-0. [PMID: 12136369] - Jasper Dingemanse, Martine Clozel, Paul L M van Giersbergen. Entry-into-humans study with tezosentan, an intravenous dual endothelin receptor antagonist.
Journal of cardiovascular pharmacology.
2002 Jun; 39(6):795-802. doi:
10.1097/00005344-200206000-00004. [PMID: 12021573] - Jasper Dingemanse, Martine Clozel, Paul L M van Giersbergen. Pharmacokinetics and pharmacodynamics of tezosentan, an intravenous dual endothelin receptor antagonist, following chronic infusion in healthy subjects.
British journal of clinical pharmacology.
2002 Apr; 53(4):355-62. doi:
10.1046/j.1365-2125.2002.01158.x. [PMID: 11966665] - Anthony Chin, Jayant Radhakrishnan, Linda Fornell, Eunice John. Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxic shock.
Journal of pediatric surgery.
2002 Mar; 37(3):482-7. doi:
10.1053/jpsu.2002.30871. [PMID: 11877672] - O Picker, A W Schindler, T W Scheeren. Endogenous endothelin and vasopressin support blood pressure during epidural anesthesia in conscious dogs.
Anesthesia and analgesia.
2001 Dec; 93(6):1580-6, table of contents. doi:
10.1097/00000539-200112000-00054. [PMID: 11726449] - A Chin, J Radhakrishnan, L Fornell, E John. Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets.
Journal of pediatric surgery.
2001 Dec; 36(12):1824-8. doi:
10.1053/jpsu.2001.28852. [PMID: 11733915] - C Qiu, S S Ding, P Hess, J P Clozel, M Clozel. Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure.
Journal of cardiovascular pharmacology.
2001 Aug; 38(2):317-24. doi:
10.1097/00005344-200108000-00017. [PMID: 11483881] - G Torre-Amione, J B Young, J Durand, B Bozkurt, D L Mann, I Kobrin, C M Pratt. Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure.
Circulation.
2001 Feb; 103(7):973-80. doi:
10.1161/01.cir.103.7.973. [PMID: 11181472] - S M Wilhelm, N T Stowe, A V Robinson, J A Schulak. The use of the endothelin receptor antagonist, tezosentan, before or after renal ischemia protects renal function.
Transplantation.
2001 Jan; 71(2):211-6. doi:
10.1097/00007890-200101270-00007. [PMID: 11213061] - S M Duchman, V Thohan, D Kalra, G Torre-Amione. Endothelin-1: a new target of therapeutic intervention for the treatment of heart failure.
Current opinion in cardiology.
2000 May; 15(3):136-40. doi:
10.1097/00001573-200005000-00003. [PMID: 10952418] - J D Tune, K N Richmond, M W Gorman, R A Olsson, E O Feigl. Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise.
American journal of physiology. Heart and circulatory physiology.
2000 Jan; 278(1):H74-84. doi:
10.1152/ajpheart.2000.278.1.h74. [PMID: 10644586] - M Clozel, H Ramuz, J P Clozel, V Breu, P Hess, B M Löffler, P Coassolo, S Roux. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use.
The Journal of pharmacology and experimental therapeutics.
1999 Aug; 290(2):840-6. doi:
NULL. [PMID: 10411600]