Dydrogesterone (BioDeep_00000018426)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(1R,2S,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-6,8-dien-5-one
化学式: C21H28O2 (312.2089188)
中文名称: 地屈孕酮
谱图信息:
最多检出来源 Homo sapiens(urine) 40.74%
分子结构信息
SMILES: CC(=O)C1CCC2C1(CCC3C2C=CC4=CC(=O)CCC34C)C
InChI: InChI=1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/m0/s1
描述信息
Dydrogesterone is only found in individuals that have used or taken this drug. It is a synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation. [PubChem]Dydrogesterone works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DB - Pregnadien derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
同义名列表
22 个代谢物同义名
(1R,2S,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-6,8-dien-5-one; 6-Dehydro-9 beta-10 alpha-progesterone; 6 Dehydro 9 beta 10 alpha progesterone; Solvay brand OF dydrogesterone; 6-Dehydro-retro-progesterone; Retro-6-dehydroprogesterone; delta(6)-Retroprogesterone; Δ(6)-retroprogesterone; 10alpha-Isopregnenone; 10a-Isopregnenone; 10Α-isopregnenone; Dehydrogesterone; Dydrogesteronum; Dydrogesterone; Didrogesterone; Hydrogesterone; Didrogesterona; Isopregnenone; Hydrogestrone; MLS002695106; Duphaston; Gynorest
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:31527
- PubChem: 3181
- PubChem: 9051
- HMDB: HMDB0014522
- DrugBank: DB00378
- ChEMBL: CHEMBL1200853
- Wikipedia: Dydrogesterone
- MeSH: Dydrogesterone
- chemspider: 8699
- CAS: 152-62-5
- PMhub: MS000007891
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoqian Di, Yanzhi Hao, Zibo Duan, Yucong Ma, Ying Cao, Zhanwang Tan, Cuimiao Song, Xiaohua Lin. Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.
Reproductive sciences (Thousand Oaks, Calif.).
2023 Jun; ?(?):. doi:
10.1007/s43032-023-01273-1. [PMID: 37280474] - Yu-Xia Jiang, Wen-Jun Shi, Li-Xin Hu, Dong-Dong Ma, Hui Zhang, Choon Nam Ong, Guang-Guo Ying. Dydrogesterone disrupts lipid metabolism in zebrafish brain: A study based on metabolomics and Fourier transform infrared spectroscopy.
Environmental pollution (Barking, Essex : 1987).
2023 Jan; 317(?):120811. doi:
10.1016/j.envpol.2022.120811. [PMID: 36470458] - Tanja K Eggersmann, Albert Wolthuis, Peter H van Amsterdam, Georg Griesinger. Lack of analytical interference of dydrogesterone in progesterone immunoassays.
Clinical chemistry and laboratory medicine.
2022 Jun; 60(7):1039-1045. doi:
10.1515/cclm-2022-0174. [PMID: 35535412] - Kay Neumann, Antonia Masuch, Reinhard Vonthein, Marion Depenbusch, Askan Schultze-Mosgau, Tanja K Eggersmann, Georg Griesinger. Dydrogesterone and 20α-dihydrodydrogesterone plasma levels on day of embryo transfer and clinical outcome in an anovulatory programmed frozen-thawed embryo transfer cycle: a prospective cohort study.
Human reproduction (Oxford, England).
2022 05; 37(6):1183-1193. doi:
10.1093/humrep/deac045. [PMID: 35323905] - Chao Peng, Yan Huang, Yingfang Zhou. Dydrogesterone in the treatment of endometriosis: evidence mapping and meta-analysis.
Archives of gynecology and obstetrics.
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PloS one.
2019; 14(7):e0220450. doi:
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The journal of obstetrics and gynaecology research.
2019 Jan; 45(1):168-175. doi:
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European journal of obstetrics, gynecology, and reproductive biology.
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2017 Oct; 217(?):77-82. doi:
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2013 Feb; 16(1):54-61. doi:
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