Teriflunomide (BioDeep_00000184224)
human metabolite blood metabolite
代谢物信息卡片
化学式: C12H9F3N2O2 (270.0616)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(O)=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F
InChI: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xiaoyue Ji, Junhong Chen, Chaoying You, Jing Sun, Xiulong Xu. Leflunomide alleviates obesity via activation of the TAK1-AMPK pathway and induction of lipophagy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 11; 37(11):e23227. doi:
10.1096/fj.202301162r. [PMID: 37792678] - Heba Abd-El-Azim, Haidy Abbas, Nesrine S El Sayed, Ahmed M Fayez, Mariam Zewail. Non-invasive management of rheumatoid arthritis using hollow microneedles as a tool for transdermal delivery of teriflunomide loaded solid lipid nanoparticles.
International journal of pharmaceutics.
2023 Aug; 644(?):123334. doi:
10.1016/j.ijpharm.2023.123334. [PMID: 37604364] - Chungen Li, Yue Zhou, Jing Xu, Xia Zhou, Zongkai Huang, Ting Zeng, Xiaowei Yang, Lei Tao, Kun Gou, Xi Zhong, Qiang Chen, Youfu Luo, Yinglan Zhao. A novel series of teriflunomide derivatives as orally active inhibitors of human dihydroorotate dehydrogenase for the treatment of colorectal carcinoma.
European journal of medicinal chemistry.
2022 Aug; 238(?):114489. doi:
10.1016/j.ejmech.2022.114489. [PMID: 35640328] - Mariam Zewail, Nehal M El-Deeb, Mohamed R Mousa, Haidy Abbas. Hyaluronic acid coated teriflunomide (A771726) loaded lipid carriers for the oral management of rheumatoid arthritis.
International journal of pharmaceutics.
2022 Jul; 623(?):121939. doi:
10.1016/j.ijpharm.2022.121939. [PMID: 35724825] - Chungen Li, Xiaowei Yang, Yuan Luo, Huan Liu, Xi Zhong, Xia Zhou, Ting Zeng, Lei Tao, Yue Zhou, Kun Gou, Xinyu Yang, Xiaocong Liu, Qiang Chen, Yinglan Zhao, Youfu Luo. Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment.
Journal of medicinal chemistry.
2021 12; 64(24):18175-18192. doi:
10.1021/acs.jmedchem.1c01711. [PMID: 34905371] - Yao Li, Li Yi, Sipeng Cheng, Yongshan Wang, Jiongjiong Wang, Jing Sun, Quan Zhang, Xiulong Xu. Inhibition of canine distemper virus replication by blocking pyrimidine nucleotide synthesis with A77 1726, the active metabolite of the anti-inflammatory drug leflunomide.
The Journal of general virology.
2021 03; 102(3):. doi:
10.1099/jgv.0.001534. [PMID: 33416466] - Dnyandev Gadhave, Nishant Rasal, Rahul Sonawane, Mahendran Sekar, Chandrakant Kokare. Nose-to-brain delivery of teriflunomide-loaded lipid-based carbopol-gellan gum nanogel for glioma: Pharmacological and in vitro cytotoxicity studies.
International journal of biological macromolecules.
2021 Jan; 167(?):906-920. doi:
10.1016/j.ijbiomac.2020.11.047. [PMID: 33186648] - Dnyandev G Gadhave, Chandrakant R Kokare. Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies.
Drug development and industrial pharmacy.
2019 May; 45(5):839-851. doi:
10.1080/03639045.2019.1576724. [PMID: 30702966] - Guang Fu Dong, Xiao Zhang, De Ning He, Ling Li, Guang Feng Zhang. Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus.
Journal of immunology research.
2015; 2015(?):832916. doi:
10.1155/2015/832916. [PMID: 26090500]
