Bosentan (BioDeep_00000018421)
human metabolite blood metabolite
代谢物信息卡片
化学式: C27H29N5O6S (551.1838454000001)
中文名称: 波生坦
谱图信息:
最多检出来源 Homo sapiens(blood) 60%
分子结构信息
SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC
InChI: InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
描述信息
Bosentan is a dual endothelin receptor antagonist important in the treatment of pulmonary artery hypertension (PAH). It is licensed in the United States, the European Union and other countries by Actelion Pharmaceuticals for the management of PAH under the trade name Tracleer®. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
C - Cardiovascular system > C02 - Antihypertensives > C02K - Other antihypertensives > C02KX - Antihypertensives for pulmonary arterial hypertension
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D065128 - Endothelin Receptor Antagonists
C28313 - Endothelin Receptor Antagonist
Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.
同义名列表
12 个代谢物同义名
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2-bipyrimidin)-4-yl) benzenesulphornamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2-bipyrimidin)-4-yl) benzenesulfornamide; p-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulphonamide; p-Tert-butyl-N-(6-(2-hydroxyethoxy)-5-(O-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide; 4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2-bipyrimidin-4-yl)benzenesulfonamide; Bosentan monohydrate; Bosentan anhydrous; Bosentan hydrate; Bosentanum; Bosentan; Tracleer
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:51450
- PubChem: 104865
- HMDB: HMDB0014699
- DrugBank: DB00559
- ChEMBL: CHEMBL957
- Wikipedia: Bosentan
- MeSH: Bosentan
- chemspider: 94651
- CAS: 1174918-31-0
- CAS: 147536-97-8
- CAS: 174227-18-0
- PMhub: MS000007860
- medchemexpress: HY-A0013
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Duygu Yilmaz Usta, Burcu Timur, Zeynep Safak Teksin. Formulation development, optimization by Box-Behnken design, characterization, in vitro, ex-vivo, and in vivo evaluation of bosentan-loaded self-nanoemulsifying drug delivery system: A novel alternative dosage form for pulmonary arterial hypertension treatment.
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Experimental lung research.
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Archivum immunologiae et therapiae experimentalis.
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The Journal of pharmacology and experimental therapeutics.
2015 Feb; 352(2):281-90. doi:
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Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese.
2015 Jan; 56(1):36-43. doi:
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International heart journal.
2015; 56 Suppl(?):S26-30. doi:
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Spinal cord.
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Life sciences.
2014 Nov; 118(2):410-3. doi:
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Life sciences.
2014 Nov; 118(2):420-3. doi:
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International journal of clinical pharmacology and therapeutics.
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Therapeutic drug monitoring.
2014 Oct; 36(5):576-83. doi:
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Clinical research in cardiology : official journal of the German Cardiac Society.
2014 Sep; 103(9):701-10. doi:
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Pharmacology, biochemistry, and behavior.
2014 Sep; 124(?):27-35. doi:
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Experimental dermatology.
2014 Sep; 23(9):664-9. doi:
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Inflammation.
2014 Aug; 37(4):1280-8. doi:
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Journal of pharmaceutical and biomedical analysis.
2014 Aug; 97(?):33-8. doi:
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The Journal of pharmacology and experimental therapeutics.
2014 Jul; 350(1):130-43. doi:
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Journal of pharmaceutical and biomedical analysis.
2014 Jul; 95(?):207-12. doi:
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The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2014 May; 33(5):521-7. doi:
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Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.
2014 Apr; 33(4):213-22. doi:
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Journal of veterinary pharmacology and therapeutics.
2014 Apr; 37(2):192-5. doi:
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Advances in chronic kidney disease.
2014 Mar; 21(2):121-33. doi:
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Atherosclerosis.
2014 Mar; 233(1):32-8. doi:
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Spinal cord.
2014 Mar; 52(3):181-5. doi:
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Journal of pharmaceutical and biomedical analysis.
2014 Feb; 89(?):227-32. doi:
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Rheumatology international.
2014 Feb; 34(2):221-5. doi:
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Biological & pharmaceutical bulletin.
2014; 37(3):461-5. doi:
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British journal of clinical pharmacology.
2014 Jan; 77(1):141-8. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2014 Jan; 137(1):189-211. doi:
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Physiological research.
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European journal of obstetrics, gynecology, and reproductive biology.
2013 Oct; 170(2):458-63. doi:
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International journal of cardiology.
2013 Sep; 168(2):1017-22. doi:
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QJM : monthly journal of the Association of Physicians.
2013 Sep; 106(9):839-48. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2013 Aug; 62(2):394-5. doi:
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Bosnian journal of basic medical sciences.
2013 Aug; 13(3):175-9. doi:
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International journal of cardiology.
2013 Jul; 167(1):220-4. doi:
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BMC cardiovascular disorders.
2013 May; 13(?):36. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
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British journal of pharmacology.
2013 May; 169(1):21-33. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2013 Apr; 110(14):5654-8. doi:
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Pediatric pulmonology.
2013 Jan; 48(1):27-34. doi:
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The European respiratory journal.
2013 Jan; 41(1):96-103. doi:
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PloS one.
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2012 Dec; 52(12):1784-805. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
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Journal of pharmaceutical and biomedical analysis.
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Life sciences.
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