Temafloxacin (BioDeep_00000184198)
human metabolite blood metabolite
代谢物信息卡片
1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)quinoline-3-carboxylic acid, hydrochloride
化学式: C21H18F3N3O3 (417.13001940000004)
中文名称: 替马沙星
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC1CN(CCN1)C1=C(F)C=C2C(=O)C(=CN(C2=C1)C1=C(F)C=C(F)C=C1)C(O)=O
InChI: InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
6 个代谢物同义名
1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)quinoline-3-carboxylic acid, hydrochloride; 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate; Temafloxacin hydrochloride; temafloxacin; Omniflox
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:77796
- PubChem: 60021
- HMDB: HMDB0258796
- DrugBank: DB01405
- ChEMBL: CHEMBL277100
- Wikipedia: Temafloxacin
- chemspider: 54143
- CAS: 108319-06-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kelly A Sprandel, Keith A Rodvold. Safety and tolerability of fluoroquinolones.
Clinical cornerstone.
2003; Suppl 3(?):S29-36. doi:
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Journal of the American Academy of Dermatology.
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Archives of toxicology.
2002 Jan; 75(11-12):725-33. doi:
10.1007/s00204-001-0293-7. [PMID: 11876506] - C Förster, M Rücker, M Shakibaei, I Baumann-Wilschke, J Vormann, R Stahlmann. Effects of fluoroquinolones and magnesium deficiency in murine limb bud cultures.
Archives of toxicology.
1998 Jun; 72(7):411-9. doi:
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American journal of hematology.
1994 Aug; 46(4):363-6. doi:
10.1002/ajh.2830460420. [PMID: 8037192] - A S Mghir, A C Cremieux, R Jambou, M Muffat-Joly, J J Pocidalo, C Carbon. Dextranase enhances antibiotic efficacy in experimental viridans streptococcal endocarditis.
Antimicrobial agents and chemotherapy.
1994 May; 38(5):953-8. doi:
10.1128/aac.38.5.953. [PMID: 8067775] - T Uematsu, K Kondo, S Yano, T Yamaguchi, K Umemura, M Nakashima. Measurement of temafloxacin in human scalp hair as an index of drug exposure.
Journal of pharmaceutical sciences.
1994 Jan; 83(1):42-5. doi:
10.1002/jps.2600830111. [PMID: 8138908] - H Hummler, W F Richter, A G Hendrickx. Developmental toxicity of fleroxacin and comparative pharmacokinetics of four fluoroquinolones in the cynomolgus macaque (Macaca fascicularis).
Toxicology and applied pharmacology.
1993 Sep; 122(1):34-45. doi:
10.1006/taap.1993.1169. [PMID: 8397453] - R L Deamer, J G Prichard, N Koenker, R E James, D Heming. Temafloxacin-induced hemolytic anemia and renal failure.
Clinical pharmacy.
1993 May; 12(5):380-2. doi:
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The Journal of pharmacology and experimental therapeutics.
1992 Sep; 262(3):1203-8. doi:
NULL. [PMID: 1326627] - J W Gu, W Fang, N X Chin, H C Neu. In vitro activity of CP-74,667. A new fluoroquinolone compared with other quinolones.
Diagnostic microbiology and infectious disease.
1992 Sep; 15(7):613-20. doi:
10.1016/0732-8893(90)90039-x. [PMID: 1330421] - F Jehl, L Bresler, C Koechlin, M Merle-Melet, J P Didelot, J Hazebroucq. Pharmacokinetics and biliary elimination of temafloxacin in pigs.
The Journal of antimicrobial chemotherapy.
1992 Aug; 30(2):189-96. doi:
10.1093/jac/30.2.189. [PMID: 1328135] - H Thadepalli, M Hajji, V K Perumal, S K Chuah, S Gollapudi. Evaluation of temafloxacin in a rat model of intra-abdominal abscess.
The Journal of antimicrobial chemotherapy.
1992 Jun; 29(6):687-92. doi:
10.1093/jac/29.6.687. [PMID: 1324241] - D R Baldwin, R Wise, J M Andrews, J P Ashby, D Honeybourne. The distribution of temafloxacin in bronchial epithelial lining fluid, alveolar macrophages and bronchial mucosa.
The European respiratory journal.
1992 Apr; 5(4):471-6. doi:
NULL. [PMID: 1314193] - G E Stein, E Philip. Comparison of three-day temafloxacin with seven-day ciprofloxacin treatment of urinary tract infections in women.
The Journal of family practice.
1992 Feb; 34(2):180-4. doi:
NULL. [PMID: 1310715] - G R Granneman, P Carpentier, P J Morrison, A G Pernet. Pharmacokinetics of temafloxacin in humans after multiple oral doses.
Antimicrobial agents and chemotherapy.
1992 Feb; 36(2):378-86. doi:
10.1128/aac.36.2.378. [PMID: 1318680] - G R Granneman, U Stephan, B Birner, F Sörgel, D Mukherjee. Effect of antacid medication on the pharmacokinetics of temafloxacin.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):83-9. doi:
10.2165/00003088-199200221-00014. [PMID: 1319875] - G Mahr, F Sörgel, G R Granneman, M Kinzig, P Muth, K Patterson, U Fuhr, P Nickel, U Stephan. Effects of temafloxacin and ciprofloxacin on the pharmacokinetics of caffeine.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):90-7. doi:
10.2165/00003088-199200221-00015. [PMID: 1319876] - G R Granneman, G Mahr, C Locke, P Nickel, W Kirch, W Fabian, M Kinzig, K G Naber, F Sörgel. Pharmacokinetics of temafloxacin in patients with liver impairment.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):24-32. doi:
10.2165/00003088-199200221-00006. [PMID: 1319868] - F Sörgel, G Mahr, G R Granneman, U Stephan, P Nickel, P Muth. Effects of 2 quinolone antibacterials, temafloxacin and enoxacin, on theophylline pharmacokinetics.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):65-74. doi:
10.2165/00003088-199200221-00012. [PMID: 1319873] - F Sörgel, G R Granneman, G Mahr, P Kujath, W Fabian, P Nickel. Hepatobiliary elimination of temafloxacin.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):33-42. doi:
10.2165/00003088-199200221-00007. [PMID: 1319869] - F Sörgel. Penetration of temafloxacin into body tissues and fluids.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):57-63. doi:
10.2165/00003088-199200221-00010. [PMID: 1319872] - G R Granneman. Pharmacokinetics of temafloxacin after multiple oral administration.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):14-23. doi:
10.2165/00003088-199200221-00005. [PMID: 1319867] - T J Lubowski, C H Nightingale, K Sweeney, R Quintiliani. The relative bioavailability of temafloxacin administered through a nasogastric tube with and without enteral feeding.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):43-7. doi:
10.2165/00003088-199200221-00008. [PMID: 1319870] - F Sörgel, G R Granneman, U Stephan, C Locke. Effect of cimetidine on the pharmacokinetics of temafloxacin.
Clinical pharmacokinetics.
1992; 22 Suppl 1(?):75-82. doi:
10.2165/00003088-199200221-00013. [PMID: 1319874] - P C Fuchs. In vitro activity of temafloxacin against gram-positive cocci including methicillin-resistant Staphylococcus aureus.
The American journal of medicine.
1991 Dec; 91(6A):15S-18S. doi:
10.1016/0002-9343(91)90303-f. [PMID: 1662886] - F Sorgel, K G Naber, M Kinzig, G Mahr, P Muth. Comparative pharmacokinetics of ciprofloxacin and temafloxacin in humans: a review.
The American journal of medicine.
1991 Dec; 91(6A):51S-66S. doi:
10.1016/0002-9343(91)90312-l. [PMID: 1662896] - J Segreti. In vitro activity of temafloxacin against pathogens causing sexually transmitted diseases.
The American journal of medicine.
1991 Dec; 91(6A):24S-26S. doi:
10.1016/0002-9343(91)90305-h. [PMID: 1662891] - R Wise. Comparative penetration of selected fluoroquinolones into respiratory tract fluids and tissues.
The American journal of medicine.
1991 Dec; 91(6A):67S-70S. doi:
10.1016/0002-9343(91)90313-m. [PMID: 1662897] - R W Krasula, A G Pernet. Comparison of organ-specific toxicity of temafloxacin in animals and humans.
The American journal of medicine.
1991 Dec; 91(6A):38S-41S. doi:
10.1016/0002-9343(91)90309-l. [PMID: 1662894] - A G Pernet. Temafloxacin: a safe antibiotic for the elderly, patients with comorbidities, and other special populations.
The American journal of medicine.
1991 Dec; 91(6A):162S-165S. doi:
10.1016/0002-9343(91)90331-q. [PMID: 1662888] - F Ruff, M C Santais, E Callens, J P Chauvin, J Hazebroucq. Effect of temafloxacin on the pharmacokinetics of theophylline.
The American journal of medicine.
1991 Dec; 91(6A):76S-80S. doi:
10.1016/0002-9343(91)90315-o. [PMID: 1662899] - G R Granneman, D R Guay. The influence of age on the pharmacokinetics of temafloxacin.
The American journal of medicine.
1991 Dec; 91(6A):71S-75S. doi:
10.1016/0002-9343(91)90314-n. [PMID: 1662898] - A Iravani. Treatment of uncomplicated urinary tract infections with temafloxacin.
The American journal of medicine.
1991 Dec; 91(6A):124S-128S. doi:
10.1016/0002-9343(91)90324-q. [PMID: 1662882] - C E Cox, S J Childs. Treatment of chronic bacterial prostatitis with temafloxacin.
The American journal of medicine.
1991 Dec; 91(6A):134S-139S. doi:
10.1016/0002-9343(91)90326-s. [PMID: 1662884] - M N Dudley. A review of the pharmacokinetic profile of temafloxacin.
The Journal of antimicrobial chemotherapy.
1991 Dec; 28 Suppl C(?):55-64. doi:
10.1093/jac/28.suppl_c.55. [PMID: 1664830] - R Wise, D R Baldwin, J M Andrews, D Honeybourne. Comparative pharmacokinetic disposition of fluoroquinolones in the lung.
The Journal of antimicrobial chemotherapy.
1991 Dec; 28 Suppl C(?):65-71. doi:
10.1093/jac/28.suppl_c.65. [PMID: 1664831] - E Vallée, E Azoulay-Dupuis, J J Pocidalo, E Bergogne-Bérézin. Pharmacokinetics of four fluoroquinolones in an animal model of infected lung.
The Journal of antimicrobial chemotherapy.
1991 Dec; 28 Suppl C(?):39-44. doi:
10.1093/jac/28.suppl_c.39. [PMID: 1664828] - L A Mandell, T Lawrence, C Rotstein, E A Gorzynski, T R Beam, D Amsterdam. The in-vitro activity of temafloxacin, against gram-positive bacteria.
The Journal of antimicrobial chemotherapy.
1991 Dec; 28 Suppl C(?):15-24. doi:
10.1093/jac/28.suppl_c.15. [PMID: 1664826] - K G Naber, J B Boerema, W Bischoff, H Blenk, J Focht, P Carpentier, J Sylvester. An assessment of temafloxacin in the treatment of chronic bacterial prostatitis.
The Journal of antimicrobial chemotherapy.
1991 Dec; 28 Suppl C(?):87-96. doi:
10.1093/jac/28.suppl_c.87. [PMID: 1664834] - G R Granneman, R Braeckman, J Kraut, S Shupien, J C Craft. Temafloxacin pharmacokinetics in subjects with normal and impaired renal function.
Antimicrobial agents and chemotherapy.
1991 Nov; 35(11):2345-51. doi:
10.1128/aac.35.11.2345. [PMID: 1666497] - G R Granneman, L L Varga. High-performance liquid chromatographic procedures for the determination of temafloxacin in biological matrices.
Journal of chromatography.
1991 Jul; 568(1):197-206. doi:
10.1016/0378-4347(91)80353-e. [PMID: 1663118] - C Perronne, A Gikas, C Truffot-Pernot, J Grosset, J L Vilde, J J Pocidalo. Activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine compared with that of clarithromycin against multiplication of Mycobacterium avium complex within human macrophages.
Antimicrobial agents and chemotherapy.
1991 Jul; 35(7):1356-9. doi:
10.1128/aac.35.7.1356. [PMID: 1656860] - J M Brogard, J F Westphal, C Koechlin, F Jehl, M Dorner, J F Blickle, H Monteil. [Experimental study on the hepatobiliary kinetics and excretion of temafloxacin. Evidence for production of active metabolites by the rabbit liver].
Pathologie-biologie.
1991 May; 39(5):524-9. doi:
NULL. [PMID: 1881688] - D J Back, J Tjia, C Martin, E Millar, T Mant, P Morrison, M Orme. The lack of interaction between temafloxacin and combined oral contraceptive steroids.
Contraception.
1991 Apr; 43(4):317-23. doi:
10.1016/0010-7824(91)90070-v. [PMID: 1906791] - G R Granneman, P Carpentier, P J Morrison, A G Pernet. Pharmacokinetics of temafloxacin in humans after single oral doses.
Antimicrobial agents and chemotherapy.
1991 Mar; 35(3):436-41. doi:
10.1128/aac.35.3.436. [PMID: 2039194] - M A Cooper, J M Andrews, J P Ashby, R S Matthews, R Wise. In-vitro activity of sparfloxacin, a new quinolone antimicrobial agent.
The Journal of antimicrobial chemotherapy.
1990 Nov; 26(5):667-76. doi:
10.1093/jac/26.5.667. [PMID: 2079449] - A F Tarantal, S B Lehrer, B L Lasley, A G Hendrickx. Developmental toxicity of temafloxacin hydrochloride in the long-tailed macaque (Macaca fascicularis).
Teratology.
1990 Sep; 42(3):233-42. doi:
10.1002/tera.1420420307. [PMID: 2274889] - B I Davies, F P Maesen, H L Gubbelmans, H M Cremers. Temafloxacin in acute purulent exacerbations of chronic bronchitis.
The Journal of antimicrobial chemotherapy.
1990 Aug; 26(2):237-46. doi:
10.1093/jac/26.2.237. [PMID: 2120178] - D R Baldwin, L Wilkinson, J M Andrews, J P Ashby, R Wise, D Honeybourne. Concentrations of temafloxacin in serum and bronchial mucosa.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
1990 Jun; 9(6):432-4. doi:
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Drugs under experimental and clinical research.
1990; 16(8):407-16. doi:
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Antimicrobial agents and chemotherapy.
1989 Sep; 33(9):1531-4. doi:
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The Journal of antimicrobial chemotherapy.
1989 Sep; 24(3):415-24. doi:
10.1093/jac/24.3.415. [PMID: 2808194] - C Koechlin, F Jehl, L Linger, H Monteil. High-performance liquid chromatography for the determination of three new fluoroquinolones, fleroxacin, temafloxacin and A-64730, in biological fluids.
Journal of chromatography.
1989 Jul; 491(2):379-87. doi:
10.1016/s0378-4347(00)82855-8. [PMID: 2509509] - D J Hardy, R N Swanson, D M Hensey, N R Ramer, R R Bower, C W Hanson, D T Chu, P B Fernandes. Comparative antibacterial activities of temafloxacin hydrochloride (A-62254) and two reference fluoroquinolones.
Antimicrobial agents and chemotherapy.
1987 Nov; 31(11):1768-74. doi:
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