Taurolidine (BioDeep_00000184165)
human metabolite blood metabolite
代谢物信息卡片
4-[(1,1-dioxo-1lambda6,2,4-thiadiazinan-4-yl)methyl]-1lambda6,2,4-thiadiazinane-1,1-dione
化学式: C7H16N4O4S2 (284.0613)
中文名称: 牛磺罗定, 牛磺酸
谱图信息:
最多检出来源 Homo sapiens(COVID-19)(blood) 25.86%
分子结构信息
SMILES: C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2
InChI: InChI=1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
描述信息
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05C - Irrigating solutions > B05CA - Antiinfectives
D000890 - Anti-Infective Agents
D000970 - Antineoplastic Agents
C254 - Anti-Infective Agent
同义名列表
9 个代谢物同义名
4-[(1,1-dioxo-1lambda6,2,4-thiadiazinan-4-yl)methyl]-1lambda6,2,4-thiadiazinane-1,1-dione; 4,4-Methylenebis-(tetrahydro-1,2,4-thiadiazine- 1,1-dioxide); Bis- (1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)methane; Bis(1,1-dioxo-perhydro-1,2,4-thiadiazinyl-4)methane; Taurolidine; Tauroline; Tauroflex; Taurolin; Taurolidine
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135173
- PubChem: 29566
- HMDB: HMDB0258744
- DrugBank: DB12473
- ChEMBL: CHEMBL2105420
- Wikipedia: Taurolidine
- chemspider: 27486
- CAS: 19388-87-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yan Sun, Guanghui Wan, Liping Liang. Taurolidine lock solution for catheter-related bloodstream infections in pediatric patients: A meta-analysis.
PloS one.
2020; 15(4):e0231110. doi:
10.1371/journal.pone.0231110. [PMID: 32255798] - Feifei Li, Jianni Qi, Chengyong Qin, Zhaoqing Fu, Wanhua Ren. Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer.
Oncology reports.
2018 Dec; 40(6):3743-3751. doi:
10.3892/or.2018.6711. [PMID: 30272302] - Thibaut Girardot, Céline Monard, Thomas Rimmelé. Dialysis catheters in the ICU: selection, insertion and maintenance.
Current opinion in critical care.
2018 12; 24(6):469-475. doi:
10.1097/mcc.0000000000000543. [PMID: 30299308] - Laura Labriola, Michel Jadoul. Taurolidine-based lock solutions for hemodialysis catheters: the enthusiasm should be tempered.
Kidney international.
2018 04; 93(4):1015-1016. doi:
10.1016/j.kint.2018.01.018. [PMID: 29571437] - Wolfgang Winnicki, Harald Herkner, Matthias Lorenz, Ammon Handisurya, Željko Kikić, Bernhard Bielesz, Benjamin Schairer, Thomas Reiter, Farsad Eskandary, Gere Sunder-Plassmann, Guerkan Sengoelge. Taurolidine-based catheter lock regimen significantly reduces overall costs, infection, and dysfunction rates of tunneled hemodialysis catheters.
Kidney international.
2018 03; 93(3):753-760. doi:
10.1016/j.kint.2017.06.026. [PMID: 28890326] - René Fahrner, Anika Möller, Adrian T Press, Andreas Kortgen, Michael Kiehntopf, Falk Rauchfuss, Utz Settmacher, Alexander S Mosig. Short-term treatment with taurolidine is associated with liver injury.
BMC pharmacology & toxicology.
2017 08; 18(1):61. doi:
10.1186/s40360-017-0168-z. [PMID: 28800748] - Abdullah Hamad, Sabah Khalifa, Hisham Bouanane, Hoda Tolba, Aisha Abdulla, Fadwa Alali. Applying a Successful New Protocol for Storing a Tissue Plasminogen Activator for Locking Dysfunctional Permcath: A Single-Center Study.
Blood purification.
2017; 44(3):234-235. doi:
10.1159/000478968. [PMID: 28877519] - Rafał Zwiech, Maria Adelt, Sławomir Chrul. A Taurolidine-Citrate-Heparin Lock Solution Effectively Eradicates Pathogens From the Catheter Biofilm in Hemodialysis Patients.
American journal of therapeutics.
2016 Mar; 23(2):e363-8. doi:
10.1097/mjt.0b013e31828d4610. [PMID: 23665885] - Hanns Möhler, Rolf W Pfirrmann, Karl Frei. Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review).
International journal of oncology.
2014 Oct; 45(4):1329-36. doi:
10.3892/ijo.2014.2566. [PMID: 25175943] - Néstor Fontseré, Celia Cardozo, Javier Donate, Alex Soriano, Mercedes Muros, Mercedes Pons, Josep Mensa, Josep M Campistol, Juan F Navarro-González, Francisco Maduell. Tunneled catheters with taurolidine-citrate-heparin lock solution significantly improve the inflammatory profile of hemodialysis patients.
Antimicrobial agents and chemotherapy.
2014 Jul; 58(7):4180-4. doi:
10.1128/aac.02421-14. [PMID: 24820084] - Kevin Marley, Stuart C Helfand, Jennifer Simpson, John E Mata, William G Tracewell, Lisa Brownlee, Shay Bracha, Bernard Séguin. Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma.
Journal of experimental & clinical cancer research : CR.
2013 Oct; 32(?):74. doi:
10.1186/1756-9966-32-74. [PMID: 24422857] - Matthias J E Arlt, Denise K Walters, Ingo J Banke, Patrick Steinmann, Gabor J Puskas, Josefine Bertz, Katharina M Rentsch, Felix Ehrensperger, Walter Born, Bruno Fuchs. The antineoplastic antibiotic taurolidine promotes lung and liver metastasis in two syngeneic osteosarcoma mouse models and exhibits severe liver toxicity.
International journal of cancer.
2012 Sep; 131(5):E804-12. doi:
10.1002/ijc.27378. [PMID: 22120774] - Sigrun Eick, Sabrina Radakovic, Wolfgang Pfister, Sandor Nietzsche, Anton Sculean. Efficacy of taurolidine against periodontopathic species--an in vitro study.
Clinical oral investigations.
2012 Jun; 16(3):735-44. doi:
10.1007/s00784-011-0567-2. [PMID: 21607568] - Laurie R Solomon, John S Cheesbrough, Ramya Bhargava, Nicos Mitsides, Michael Heap, Gerwyn Green, Peter Diggle. Observational study of need for thrombolytic therapy and incidence of bacteremia using taurolidine-citrate-heparin, taurolidine-citrate and heparin catheter locks in patients treated with hemodialysis.
Seminars in dialysis.
2012 Mar; 25(2):233-8. doi:
10.1111/j.1525-139x.2011.00951.x. [PMID: 21916999] - Bernard Branger, Pascal Reboul, Camélia Prelipcean, Maria Eugenia Noguera, Sylvain Cariou, Céline Granolleras, Frédérique Vecina, Bachir Zabadani, Samir Boubenider, Philippe Rousseau, Gérard Deshodt, Pierre Ramperez, Bernard Hory, Eric Picard, Pascal Branchereau, Pascale Fabbro-Peray, Jacques Fourcade. [Tunnelled internal jugular vein catheters with taurolidine lock: an acceptable challenge to arterio-venous fistula in 70 years old haemodialyzed patients: a prospective pilot study].
Nephrologie & therapeutique.
2011 Jul; 7(4):237-41. doi:
10.1016/j.nephro.2011.04.001. [PMID: 21601549] - Li Tang, Lie-Jun Mei, Xiao-Jun Yang, Chao-Qun Huang, Yun-Feng Zhou, Yutaka Yonemura, Yan Li. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study.
Journal of translational medicine.
2011 May; 9(?):53. doi:
10.1186/1479-5876-9-53. [PMID: 21548973] - Vassilis Filiopoulos, Dimitrios Hadjiyannakos, Ioannis Koutis, Sofia Trompouki, Theodora Micha, Dimitrios Lazarou, Dimosthenis Vlassopoulos. Approaches to prolong the use of uncuffed hemodialysis catheters: results of a randomized trial.
American journal of nephrology.
2011; 33(3):260-8. doi:
10.1159/000324685. [PMID: 21372561] - M Gallieni, G Chiarelli, L Olivi, M Cozzolino, D Cusi. Unsuccessful application of taurolidine in the treatment of fungal peritonitis in peritoneal dialysis.
Clinical nephrology.
2011 Jan; 75(1):70-3. doi:
NULL. [PMID: 21176753] - Kishore K Doddakula, Peter M Neary, Jiang H Wang, Shastri Sookhai, Aongus O'Donnell, Tom Aherne, David J Bouchier-Hayes, Henry P Redmond. The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine.
Surgery.
2010 Sep; 148(3):567-72. doi:
10.1016/j.surg.2010.01.006. [PMID: 20223497] - Russell W Chesney, Xiaobin Han, Andrea B Patters. Taurine and the renal system.
Journal of biomedical science.
2010 Aug; 17 Suppl 1(?):S4. doi:
10.1186/1423-0127-17-s1-s4. [PMID: 20804616] - Laurie R Solomon, John S Cheesbrough, Leonard Ebah, Tamer Al-Sayed, Michael Heap, Nick Millband, Dee Waterhouse, Sandip Mitra, Alan Curry, Rema Saxena, Rammohan Bhat, Michael Schulz, Peter Diggle. A randomized double-blind controlled trial of taurolidine-citrate catheter locks for the prevention of bacteremia in patients treated with hemodialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2010 Jun; 55(6):1060-8. doi:
10.1053/j.ajkd.2009.11.025. [PMID: 20207458] - Caroline Taylor, John Cahill, Martin Gerrish, Jane Little. A new haemodialysis catheter-locking agent reduces infections in haemodialysis patients.
Journal of renal care.
2008 Sep; 34(3):116-20. doi:
10.1111/j.1755-6686.2008.00027.x. [PMID: 18786077] - Helge Frieling, Kai-Steffen Lauer, Matthias Gründling, Taras Usichenko, Konrad Meissner, Theoni Kanellopoulou, Christian Lehmann, Michael Wendt, Dragan Pavlovic. Peritoneal instillation of taurolidine or polihexanide modulates intestinal microcirculation in experimental endotoxemia.
International journal of colorectal disease.
2007 Jul; 22(7):807-17. doi:
10.1007/s00384-006-0239-x. [PMID: 17119983] - J Marcinkiewicz, P Głuszko, E Kontny, B Kwaśny-Krochin, M Bobek, W Wierzchowski, M Ciszek, W Maśliński. Is Taurolidine a candidate for treatment of rheumatoid arthritis?.
Clinical and experimental rheumatology.
2007 Mar; 25(2):211-8. doi:
NULL. [PMID: 17543144] - Ruediger Stendel, Louis Scheurer, Kathrin Schlatterer, Urs Stalder, Rolf W Pfirrmann, Ingo Fiss, Hanns Möhler, Laurent Bigler. Pharmacokinetics of taurolidine following repeated intravenous infusions measured by HPLC-ESI-MS/MS of the derivatives taurultame and taurinamide in glioblastoma patients.
Clinical pharmacokinetics.
2007; 46(6):513-24. doi:
10.2165/00003088-200746060-00005. [PMID: 17518510] - Chris Braumann, Benedikt Stuhldreier, Eva Bobrich, Charalambos Menenakos, Stephan Rogalla, Christoph A Jacobi. High doses of taurolidine inhibit advanced intraperitoneal tumor growth in rats.
The Journal of surgical research.
2005 Nov; 129(1):129-35. doi:
10.1016/j.jss.2005.03.012. [PMID: 15916768] - Christoph A Jacobi, Charalambos Menenakos, Chris Braumann. Taurolidine--a new drug with anti-tumor and anti-angiogenic effects.
Anti-cancer drugs.
2005 Oct; 16(9):917-21. doi:
10.1097/01.cad.0000176502.40810.b0. [PMID: 16162968] - Maik Kilian, Jan Ilga Gregor, Ina Heukamp, Chris Braumann, Hans Guski, Ingolf Schimke, Martin Karl Walz, Christoph Andreas Jacobi, Frank Axel Wenger. Impact of taurolidin and octreotide on liver metastasis and lipid peroxidation after laparoscopy in chemical induced ductal pancreatic cancer.
Investigational new drugs.
2005 Mar; 23(2):157-64. doi:
10.1007/s10637-005-5861-x. [PMID: 15744592] - Michael Allon. Dialysis catheter-related bacteremia: treatment and prophylaxis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2004 Nov; 44(5):779-91. doi:
10.1016/s0272-6386(04)01078-9. [PMID: 15492943] - M Kilian, I Mautsch, C Braumann, I Schimke, H Guski, C A Jacobi, F A Wenger. Effects of taurolidine and octreotide on tumor growth and lipid peroxidation after staging-laparoscopy in ductal pancreatic cancer.
Prostaglandins, leukotrienes, and essential fatty acids.
2003 Oct; 69(4):261-7. doi:
10.1016/s0952-3278(03)00108-x. [PMID: 12907136] - Sanjay Manocha, Daniel Feinstein, Aseem Kumar, Anand Kumar. Novel therapies for sepsis: antiendotoxin therapies.
Expert opinion on investigational drugs.
2002 Dec; 11(12):1795-812. doi:
10.1517/13543784.11.12.1795. [PMID: 12457439] - A Bauhofer, B Stinner, F Kohlert, B Reckzeh, W Lorenz, I Celik. Granulocyte colony-stimulating factor but not peritoneal lavage increases survival rate after experimental abdominal contamination and infection.
The British journal of surgery.
2002 Nov; 89(11):1457-64. doi:
10.1046/j.1365-2168.2002.02227.x. [PMID: 12390392] - Chirag B Shah, Marc W Mittelman, J W Costerton, Stephen Parenteau, Michael Pelak, Richard Arsenault, Leonard A Mermel. Antimicrobial activity of a novel catheter lock solution.
Antimicrobial agents and chemotherapy.
2002 Jun; 46(6):1674-9. doi:
10.1128/aac.46.6.1674-1679.2002. [PMID: 12019075] - Bridget M Egan, David J Bouchier-Hayes, Claire Condron, Cathal J Kelly, Hazem Abdih. Taurolidine attenuates the hemodynamic and respiratory changes associated with endotoxemia.
Shock (Augusta, Ga.).
2002 Apr; 17(4):308-11. doi:
10.1097/00024382-200204000-00012. [PMID: 11954832] - K Sodemann, H D Polaschegg, B Feldmer. Two years' experience with Dialock and CLS (a new antimicrobial lock solution).
Blood purification.
2001; 19(2):251-4. doi:
10.1159/000046950. [PMID: 11150819] - C Rosman, G J Westerveld, K Kooi, R P Bleichrodt. Local treatment of generalised peritonitis in rats; effects on bacteria, endotoxin and mortality.
The European journal of surgery = Acta chirurgica.
1999 Nov; 165(11):1072-9. doi:
10.1080/110241599750007928. [PMID: 10595613] - D Konukoglu, H Iynem, E Ziylan. Antioxidant status in experimental peritonitis: effects of alpha tocopherol and taurolin.
Pharmacological research.
1999 Mar; 39(3):247-51. doi:
10.1006/phrs.1998.0439. [PMID: 10094852] - C Rosman, G J Westerveld, W van Oeveren, K Kooi, R P Bleichrodt. Effect of intraperitoneal antimicrobials on the concentration of bacteria, endotoxin, and tumor necrosis factor in abdominal fluid and plasma in rats.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.
1996; 28(5):351-60. doi:
10.1159/000129476. [PMID: 8880124] - H P Redmond, A L Leahy, J A Carey, A Darzi, B Maxwell, F B Keane, W A Tanner. Beneficial effects of taurolidine in experimental pancreatitis.
The Journal of surgical research.
1994 Mar; 56(3):256-60. doi:
10.1006/jsre.1994.1040. [PMID: 7511718] - W H Traub, B Leonhard, D Bauer. Taurolidine: in vitro activity against multiple-antibiotic-resistant, nosocomially significant clinical isolates of Staphylococcus aureus, Enterococcus faecium, and diverse Enterobacteriaceae.
Chemotherapy.
1993 Sep; 39(5):322-30. doi:
10.1159/000239144. [PMID: 8370323] - J I Blenkharn. In-vitro antibacterial activity of noxythiolin and taurolidine.
The Journal of pharmacy and pharmacology.
1990 Aug; 42(8):589-90. doi:
10.1111/j.2042-7158.1990.tb07066.x. [PMID: 1981591] - J I Blenkharn. Sustained anti-adherence activity of taurolidine (Taurolin) and noxythiolin (Noxyflex S) solutions.
The Journal of pharmacy and pharmacology.
1988 Jul; 40(7):509-11. doi:
10.1111/j.2042-7158.1988.tb05288.x. [PMID: 2904994] - S P Gorman, D F McCafferty, A D Woolfson, D S Jones. A comparative study of the microbial antiadherence capacities of three antimicrobial agents.
Journal of clinical pharmacy and therapeutics.
1987 Dec; 12(6):393-9. doi:
10.1111/j.1365-2710.1987.tb00552.x. [PMID: 3326886] - S P Gorman, D F McCafferty, A D Woolfson, D S Jones. Reduced adherence of micro-organisms to human mucosal epithelial cells following treatment with Taurolin, a novel antimicrobial agent.
The Journal of applied bacteriology.
1987 Apr; 62(4):315-20. doi:
10.1111/j.1365-2672.1987.tb04926.x. [PMID: 3298185] - G Görtz, R Häring, M Henckel, H Meinhold. [Thyroid function after peritoneal lavage with polivinylpyrrolidone-iodine solution in diffuse peritonitis].
Zentralblatt fur Chirurgie.
1984; 109(5):319-30. doi:
NULL. [PMID: 6720126] - C Steinbach-Lebbin, A J Ganz, A Chang, P G Waser. [Pharmacokinetics of Taurolin].
Arzneimittel-Forschung.
1982; 32(12):1542-6. doi:
NULL. [PMID: 6891594] - B I Knight, G G Skellern, M K Browne, R W Pfirrmann. Peritoneal absorption of the antibacterial and antiendotoxin taurolin in peritonitis.
British journal of clinical pharmacology.
1981 Nov; 12(5):695-9. doi:
10.1111/j.1365-2125.1981.tb01292.x. [PMID: 7332737]
