Taspine (BioDeep_00000184155)
human metabolite blood metabolite
代谢物信息卡片
5-[2-(dimethylamino)ethyl]-7,14-dimethoxy-2,9-dioxatetracyclo[6.6.2.0⁴,¹⁶.0¹¹,¹⁵]hexadeca-1(15),4(16),5,7,11,13-hexaene-3,10-dione
化学式: C20H19NO6 (369.12123140000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCC1=CC(=C2C3=C1C(=O)OC4=C(C=CC(=C34)C(=O)O2)OC)OC
InChI: InChI=1S/C20H19NO6/c1-21(2)8-7-10-9-13(25-4)18-16-14(10)20(23)27-17-12(24-3)6-5-11(15(16)17)19(22)26-18/h5-6,9H,7-8H2,1-4H3
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anahí Canedo-Téxon, Feliza Ramón-Farias, Juan Luis Monribot-Villanueva, Emanuel Villafán, Alexandro Alonso-Sánchez, Claudia Anahí Pérez-Torres, Guillermo Ángeles, José Antonio Guerrero-Analco, Enrique Ibarra-Laclette. Novel findings to the biosynthetic pathway of magnoflorine and taspine through transcriptomic and metabolomic analysis of Croton draco (Euphorbiaceae).
BMC plant biology.
2019 Dec; 19(1):560. doi:
10.1186/s12870-019-2195-y. [PMID: 31852435] - Kátia Wolff Cordeiro, Josyelen Lousada Felipe, Kauê Franco Malange, Pâmela Rafaela do Prado, Patrícia de Oliveira Figueiredo, Fernanda Rodrigues Garcez, Karine de Cássia Freitas, Walmir Silva Garcez, Mônica Cristina Toffoli-Kadri. Anti-inflammatory and antinociceptive activities of Croton urucurana Baillon bark.
Journal of ethnopharmacology.
2016 May; 183(?):128-135. doi:
10.1016/j.jep.2016.02.051. [PMID: 26944237] - Silvia Castelli, Prafulla Katkar, Oscar Vassallo, Mattia Falconi, Stig Linder, Alessandro Desideri. A natural anticancer agent thaspine targets human topoisomerase IB.
Anti-cancer agents in medicinal chemistry.
2013 Feb; 13(2):356-63. doi:
10.2174/1871520611313020021. [PMID: 22931416] - Monica Montopoli, Riccardo Bertin, Zheng Chen, Jenny Bolcato, Laura Caparrotta, Guglielmina Froldi. Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines.
Journal of ethnopharmacology.
2012 Dec; 144(3):747-53. doi:
10.1016/j.jep.2012.10.032. [PMID: 23123266] - Yanmin Zhang, Qiao Jiang, Nan Wang, Bingling Dai, Yinnan Chen, Langchong He. Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells.
Phytotherapy research : PTR.
2011 Mar; 25(3):357-64. doi:
10.1002/ptr.3268. [PMID: 20683843] - Meng Sun, Jing Ren, Hui Du, Yanmin Zhang, Jie Zhang, Sicen Wang, Langchong He. A combined A431 cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening compounds from total alkaloid of Radix Caulophylli acting on the human EGFR.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Oct; 878(28):2712-8. doi:
10.1016/j.jchromb.2010.08.010. [PMID: 20829129] - Walid Fayad, Mårten Fryknäs, Slavica Brnjic, Maria Hägg Olofsson, Rolf Larsson, Stig Linder. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.
PloS one.
2009 Oct; 4(10):e7238. doi:
10.1371/journal.pone.0007238. [PMID: 19798419] - Wen Lu, Lang Chong He, Chang He Wang, Yan Hua Li, San Qi Zhang. The use of solid lipid nanoparticles to target a lipophilic molecule to the liver after intravenous administration to mice.
International journal of biological macromolecules.
2008 Oct; 43(3):320-4. doi:
10.1016/j.ijbiomac.2008.06.006. [PMID: 18619484] - Yanmin Zhang, Langchong He, Liang Meng, Wenjuan Luo, Xuemei Xu. Suppression of tumor-induced angiogenesis by taspine isolated from Radix et Rhizoma Leonticis and its mechanism of action in vitro.
Cancer letters.
2008 Apr; 262(1):103-13. doi:
10.1016/j.canlet.2007.11.035. [PMID: 18180095] - Yanmin Zhang, Langchong He, Liang Meng, Wenjuan Luo. Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation.
Vascular pharmacology.
2008 Feb; 48(2-3):129-37. doi:
10.1016/j.vph.2008.01.008. [PMID: 18304881] - Wen Lu, Lang Chong He, Xian-Ming Zeng. HPLC method for the pharmacokinetics and tissue distribution of taspine solution and taspine liposome after intravenous administrations to mice.
Journal of pharmaceutical and biomedical analysis.
2008 Jan; 46(1):170-6. doi:
10.1016/j.jpba.2007.08.009. [PMID: 17889477] - Yan-Min Zhang, Lang-Chong He, Hong-Ying Wang. [Inhibitory effect of taspine on mouse S180 sarcoma and its mechanism].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2007 May; 32(10):953-6. doi:
". [PMID: 17655156] - Judith M Rollinger, Daniela Schuster, Elisabeth Baier, Ernst P Ellmerer, Thierry Langer, Hermann Stuppner. Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.
Journal of natural products.
2006 Sep; 69(9):1341-6. doi:
10.1021/np060268p. [PMID: 16989531] - L F Villegas, A Marçalo, J Martin, I D Fernández, H Maldonado, A J Vaisberg, G B Hammond. (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids.
Journal of natural products.
2001 Oct; 64(10):1357-9. doi:
10.1021/np0102859. [PMID: 11678668] - A J Vaisberg, M Milla, M C Planas, J L Cordova, E R de Agusti, R Ferreyra, M C Mustiga, L Carlin, G B Hammond. Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri.
Planta medica.
1989 Apr; 55(2):140-3. doi:
10.1055/s-2006-961907. [PMID: 2748730] - G P Perdue, R N Blomster, D A Blake, N R Farnsworth. South American plants II: taspine isolation and anti-inflammatory activity.
Journal of pharmaceutical sciences.
1979 Jan; 68(1):124-6. doi:
10.1002/jps.2600680145. [PMID: 758452]