Talniflumate (BioDeep_00000184127)
human metabolite blood metabolite
代谢物信息卡片
化学式: C21H13F3N2O4 (414.08273740000004)
中文名称: 他尼氟酯
谱图信息:
最多检出来源 Homo sapiens(blood) 83.33%
分子结构信息
SMILES: C1=CC=C2C(=C1)C(OC2=O)OC(=O)C3=C(N=CC=C3)NC4=CC=CC(=C4)C(F)(F)F
InChI: InChI=1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26)
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:91991
- PubChem: 48229
- HMDB: HMDB0258700
- DrugBank: DB09295
- ChEMBL: CHEMBL1081506
- chemspider: 43868
- CAS: 66898-62-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yun Kim, Sung- Yim, Bo-Hyung Kim, SeungHwan Lee. Pharmacokinetic comparison of two formulations of talniflumate 370 mg tablets in healthy Korean volunteers
.
International journal of clinical pharmacology and therapeutics.
2017 Jan; 55(1):102-108. doi:
10.5414/cp202707
. [PMID: 27879193] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068
. [PMID: 22961681] - Eunyoung Kim, Wonku Kang. Contribution of pH to systemic exposure of niflumic acid following oral administration of talniflumate.
European journal of clinical pharmacology.
2011 Apr; 67(4):425-428. doi:
10.1007/s00228-010-0980-5
. [PMID: 21327911] - Wonku Kang, Kibum Kim. Determination of talniflumate and niflumic acid in human plasma by liquid chromatography-tandem mass spectrometry.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2009 Apr; 25(4):571-4. doi:
10.2116/analsci.25.571
. [PMID: 19359802] - Eun Ji Park, Dong Hee Na, Young-Hee Shin, Kang Choon Lee. Liquid chromatography-mass spectrometric method for the sensitive determination of niflumic acid in human plasma and its application to pharmacokinetic study of talniflumate tablet.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Dec; 876(2):159-62. doi:
10.1016/j.jchromb.2008.10.010
. [PMID: 19010744] - Wonku Kang, Kibum Kim, Eun-Young Kim, Kwang-il Kwon, Jun Seok Bang, Young-Ran Yoon. Effect of food on systemic exposure to niflumic acid following postprandial administration of talniflumate.
European journal of clinical pharmacology.
2008 Oct; 64(10):1027-30. doi:
10.1007/s00228-008-0524-4
. [PMID: 18607579] - H W Lee, K J Won, S H Cho, Y H Ha, W S Park, H T Yim, M Baek, J H Rew, S H Yoon, S V Yim, J H Chung, K T Lee. Quantitation of niflumic acid in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection and its application to a bioequivalence study of talniflumate tablets.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jul; 821(2):215-20. doi:
10.1016/j.jchromb.2005.05.008
. [PMID: 15921965] - Dong-Jin Jang, Jeong-Sook Park, Hye-Ran Ko, Jun-Pil Jee, Jin-Ki Kim, Sung Tae Kim, Chong-Kook Kim. Simultaneous determination of niflumic acid and its prodrug, talniflumate in human plasma by high performance liquid chromatography.
Biomedical chromatography : BMC.
2005 Jan; 19(1):32-5. doi:
10.1002/bmc.412
. [PMID: 15470687] - G Houin, D Tremblay, F Bree, A Dufour, P Ledudal, J P Tillement. The pharmacokinetics and availability of niflumic acid in humans.
International journal of clinical pharmacology, therapy, and toxicology.
1983 Mar; 21(3):130-4. doi:
NULL
. [PMID: 6852999]