Methyl hippurate (BioDeep_00000018408)

 

Secondary id: BioDeep_00000181245

human metabolite Endogenous


代谢物信息卡片


methyl 2-(phenylformamido)acetate

化学式: C10H11NO3 (193.0738896)
中文名称: N-苯甲酰基甘氨酸甲酯
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: COC(=O)CNC(=O)C1=CC=CC=C1
InChI: InChI=1S/C10H11NO3/c1-14-9(12)7-11-10(13)8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,11,13)

描述信息

Methylhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine. Methylhippuric acid is a metabolite of xylene which is an aromatic hydrocarbon widely used as a solvant. The amount of methylhippuric acid can be measured in urine of workers exposed to xylene (PMID 8689499).
Methylhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:

同义名列表

19 个代谢物同义名

methyl 2-(phenylformamido)acetate; methyl (phenylformamido)acetate; N-Benzoyl-glycine methyl ester; N-Benzoylglycine methyl ester; Methyl (benzoylamino)acetate; Benzoylglycine methyl ester; Hippuric acid methyl ester; Methyl benzoylaminoacetate; Methyl N-benzoylglycinate; Hippic acid methyl ester; Methyl benzoylglycinate; Hippurate methyl ester; Methyl hippuric acid; Hippate methyl ester; Methylhippuric acid; Methylhippic acid; METHYL HIPPURATE; Methylhippate; methyl 2-benzamidoacetate



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fu-Kuei Chang, I-Fang Mao, Mei-Lien Chen, Shu-Fang Cheng. Urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to ethylbenzene. The Annals of occupational hygiene. 2011 Jun; 55(5):519-25. doi: 10.1093/annhyg/mer010. [PMID: 21430133]
  • Jin Hee Kim, Jae Yong Moon, Eun-Young Park, Kwan-Hee Lee, Yun-Chul Hong. Changes in oxidative stress biomarker and gene expression levels in workers exposed to volatile organic compounds. Industrial health. 2011; 49(1):8-14. doi: 10.2486/indhealth.ms1112. [PMID: 20823639]
  • Hae-Kwan Cheong, Mina Ha, Jong Seong Lee, Hojang Kwon, Eun-Hee Ha, Yun-Chul Hong, Yeyong Choi, Woo-Chul Jeong, Jongil Hur, Seung-Min Lee, Eun-Jung Kim, Hosub Im. Hebei spirit oil spill exposure and subjective symptoms in residents participating in clean-up activities. Environmental health and toxicology. 2011; 26(?):e2011007. doi: 10.5620/eht.2011.26.e2011007. [PMID: 22125768]
  • Yun-Chul Hong, Eun-Young Park, Min-Seon Park, Jeong Ah Ko, Se-Young Oh, Ho Kim, Kwan-Hee Lee, Jong-Han Leem, Eun-Hee Ha. Community level exposure to chemicals and oxidative stress in adult population. Toxicology letters. 2009 Jan; 184(2):139-44. doi: 10.1016/j.toxlet.2008.11.001. [PMID: 19049859]
  • I F Mao, F K Chang, M L Chen. Delayed and competitively inhibited excretion of urinary hippuric acid in field workers coexposed to toluene, ethyl benzene, and xylene. Archives of environmental contamination and toxicology. 2007 Nov; 53(4):678-83. doi: 10.1007/s00244-006-0084-5. [PMID: 17571200]
  • Fu-Kuei Chang, Mei-Lien Chen, Shu-Fang Cheng, Tung-Sheng Shih, I-Fang Mao. Evaluation of dermal absorption and protective effectiveness of respirators for xylene in spray painters. International archives of occupational and environmental health. 2007 Nov; 81(2):145-50. doi: 10.1007/s00420-007-0197-9. [PMID: 17492305]
  • F K Chang, M L Chen, S F Cheng, T S Shih, I F Mao. Field protection effectiveness of chemical protective suits and gloves evaluated by biomonitoring. Occupational and environmental medicine. 2007 Nov; 64(11):759-62. doi: 10.1136/oem.2006.029199. [PMID: 17522137]