Sulfamethoxypyridazine (BioDeep_00000184037)

   

human metabolite blood metabolite


代谢物信息卡片


4-amino-N-(6-methoxypyridazin-3-yl)benzene-1-sulfonamide

化学式: C11H12N4O3S (280.0630082)
中文名称: 磺胺甲氧哒嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=NN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01ED - Long-acting sulfonamides
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides

同义名列表

40 个代谢物同义名

4-amino-N-(6-methoxypyridazin-3-yl)benzene-1-sulfonamide; 4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulphonamide; 4-amino-N-(6-Methoxypyridazin-3-yl)benzenesulphonamide; 4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide; 3-(4-Aminobenzenesulphonamido)-6-methoxypyridazine; 3-(4-Aminobenzenesulfonamido)-6-methoxypyridazine; 3-p-Aminobenzenesulphonamido-6-methoxypyridazine; 3-(p-Aminobenzenesulphamido)-6-methoxypyridazine; 3-(p-Aminobenzenesulfamido)-6-methoxypyridazine; 3-p-Aminobenzenesulfonamido-6-methoxypyridazine; N(1)-(6-Methoxy-3-pyridazinyl)sulphanilamide; N(1)-(6-Methoxy-3-pyridazinyl)sulfanilamide; 6-Methoxy-3-pyridazinylsulphanilamide; 6-Methoxy-3-sulphanilamidopyridazine; 6-Sulphanilamido-3-methoxypyridazine; 6-Methoxy-3-pyridazinylsulfanilamide; 3-Sulphanilamido-6-methoxypyridazine; 3-Sulphanilamide-6-methoxypyridazine; 3-Methoxy-6-sulphanylamidopyridazine; 3-Methoxy-6-sulfanylamidopyridazine; 6-Sulfanilamido-3-methoxypyridazine; 3-Sulfanilamide-6-methoxypyridazine; 3-Sulfanilamido-6-methoxypyridazine; 6-Methoxy-3-sulfanilamidopyridazine; 3-Sulpha-6-methoxypyridazine; 3-Sulfa-6-methoxypyridazine; Sulphamethoxypyridazinum; Sulphamethoxipyridazine; Sulphamethoxypyridazine; Sulfamethoxypyridazinum; Sulphametoxipiridazina; Sulfamethoxipyridazine; Solfametossipiridazina; sulfamethoxypyridazine; Sulphametoxipiridazine; Sulfametoxipiridazina; Sulfametoxipiridazine; Sulfapyridazine; Lederkyn; longin



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ruyi Xu, Chen Yang, Lin Huang, Wenchao Lv, Weijuan Yang, Yongning Wu, FengFu Fu. Broad-Specificity Aptamer of Sulfonamides: Isolation and Its Application in Simultaneous Detection of Multiple Sulfonamides in Fish Sample. Journal of agricultural and food chemistry. 2022 Sep; 70(37):11804-11812. doi: 10.1021/acs.jafc.2c03423. [PMID: 36070569]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ariane C C de Melo, Jaime M S V P Santana, Kelen J R C Nunes, Bernardo L Rodrigues, Nathalia Castilho, Philipe Gabriel, Adolfo H Moraes, Mayra de A Marques, Guilherme A P de Oliveira, Ívina P de Souza, Hernán Terenzi, Elene C Pereira-Maia. New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents. Molecules (Basel, Switzerland). 2019 Jun; 24(11):. doi: 10.3390/molecules24112154. [PMID: 31181667]
  • Nareman D H Khaleel, Waleed M M Mahmoud, Ghada M Hadad, Randa A Abdel-Salam, Klaus Kümmerer. Photolysis of sulfamethoxypyridazine in various aqueous media: aerobic biodegradation and identification of photoproducts by LC-UV-MS/MS. Journal of hazardous materials. 2013 Jan; 244-245(?):654-61. doi: 10.1016/j.jhazmat.2012.10.059. [PMID: 23183348]
  • Yoshiteru Noutoshi, Mika Ikeda, Tamio Saito, Hiroyuki Osada, Ken Shirasu. Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana. Frontiers in plant science. 2012; 3(?):245. doi: 10.3389/fpls.2012.00245. [PMID: 23118736]
  • Lucio Vera-Cabrera, Alejandra Daw-Garza, Salvador Said-Fernández, Hector Gerardo Lozano-Garza, Noemi Waksman de Torres, Norma Cavazos Rocha, Jorge Ocampo-Candiani, Sung-Hak Choi, Oliverio Welsh. Therapeutic effect of a novel oxazolidinone, DA-7867, in BALB/c mice infected with Nocardia brasiliensis. PLoS neglected tropical diseases. 2008 Sep; 2(9):e289. doi: 10.1371/journal.pntd.0000289. [PMID: 18820738]
  • K Futagawa-Saito, S Hiratsuka, M Kamibeppu, T Hirosawa, K Oyabu, T Fukuyasu. Salmonella in healthy pigs: prevalence, serotype diversity and antimicrobial resistance observed during 1998-1999 and 2004-2005 in Japan. Epidemiology and infection. 2008 Aug; 136(8):1118-23. doi: 10.1017/s0950268807009570. [PMID: 17961277]
  • I García, M C Ortiz, L Sarabia, J M Aldama. Validation of an analytical method to determine sulfamides in kidney by HPLC-DAD and PARAFAC2 with first-order derivative chromatograms. Analytica chimica acta. 2007 Mar; 587(2):222-34. doi: 10.1016/j.aca.2007.01.054. [PMID: 17386777]
  • Titus A M Msagati, Mathew Muzi Nindi. Multiresidue determination of sulfonamides in a variety of biological matrices by supported liquid membrane with high pressure liquid chromatography-electrospray mass spectrometry detection. Talanta. 2004 Sep; 64(1):87-100. doi: 10.1016/j.talanta.2004.02.038. [PMID: 18969572]
  • Inmaculada García, Luis Sarabia, M Cruz Ortiz, J Manuel Aldama. Robustness of the extraction step when parallel factor analysis (PARAFAC) is used to quantify sulfonamides in kidney by high performance liquid chromatography-diode array detection (HPLC-DAD). The Analyst. 2004 Aug; 129(8):766-71. doi: 10.1039/b404320k. [PMID: 15284923]
  • U Rademacher, W Jakob, I Bockhardt. Cryptosporidium infection in beech martens (Martes foina). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 1999 Sep; 30(3):421-2. doi: NULL. [PMID: 10572868]
  • S K Garg, R P Uppal. Bioavailability of sulfamethoxypyridazine following intramuscular or subcutaneous administration in goats. Veterinary research. 1997; 28(1):101-4. doi: NULL. [PMID: 9172837]
  • S K Garg, R P Uppal, J E Rivière. Serum disappearance and urinary excretion of sulfamethoxypyridazine in goats. Revue d'elevage et de medecine veterinaire des pays tropicaux. 1994; 47(2):215-8. doi: NULL. [PMID: 7863073]
  • E H Abdennebi, A Bousfiha, M Ben Goumi, M Oukessou. [Pharmacokinetics and plasma protein binding of sulfamethoxypyridazine in camels (Camelus dromedarius)]. Revue d'elevage et de medecine veterinaire des pays tropicaux. 1994; 47(1):97-102. doi: NULL. [PMID: 7991901]
  • S Mützell. Computed tomography of the brain, hepatotoxic drugs and high alcohol consumption in male alcoholic patients and a random sample from the general male population. Upsala journal of medical sciences. 1992; 97(2):183-94. doi: 10.3109/03009739209179295. [PMID: 1361697]
  • D G Harle, B A Baldo, J V Wells. Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole. Molecular immunology. 1988 Dec; 25(12):1347-54. doi: 10.1016/0161-5890(88)90050-8. [PMID: 3237218]
  • H Bräunlich. Postnatal development and inducibility of renal tubular transport processes in rats. The International journal of pediatric nephrology. 1985 Jul; 6(3):177-82. doi: NULL. [PMID: 3840464]
  • S X He, W B Zhang, S L Zhao, T H Huang, B X Huang. [Identifiability of nonlinear compartmental models for plasma protein binding of sulfa drugs]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1983 Dec; 4(4):265-9. doi: NULL. [PMID: 6230873]
  • E A Rudzit, N V Ostapchuk, V I Bobrov. [Characteristics of the distribution of long-acting sulfanilamides in purulent pyelonephritis in rats]. Antibiotiki. 1983 Nov; 28(11):837-41. doi: . [PMID: 6651273]
  • D L Parsons. The effect of protein concentration on the binding of sulfamethoxypyridazine by human and bovine serum albumin. Archives internationales de pharmacodynamie et de therapie. 1980 Apr; 244(2):180-7. doi: NULL. [PMID: 7406580]
  • S Soback, U Lamminsivu. The effect of protein-binding on the excretion of three sulphonamide preparations in the milk of dairy cows, examined by chemical and microbiological methods. Nordisk veterinaermedicin. 1979 Jul; 31(7-8):309-15. doi: NULL. [PMID: 386251]
  • M Stopp, R Hartwich, H Bräunlich. Enhancement of p-aminohippurate accumulation in renal cortical slices after repeated administrations of various organic anionic drugs to rats of different ages. Experientia. 1978 Nov; 34(11):1493-4. doi: 10.1007/bf01932372. [PMID: 720483]
  • H Miese, W E Müller, U Wollert. The influence of increasing albumin concentrations on the determination of the binding of sulfamethoxy-pyridazine to human and bovine serum albumin. Archives internationales de pharmacodynamie et de therapie. 1978 Nov; 236(1):18-26. doi: NULL. [PMID: 570826]
  • M E Bravo, F Monckeberg, J Urbina. The effect of sulphamethoxypyridazine on liver and plasma levels of vitamin A in rats. British journal of pharmacology. 1977 Jun; 60(2):181-3. doi: 10.1111/j.1476-5381.1977.tb07739.x. [PMID: 880429]
  • M Yndestad, B Underdal. Residues of sulfadimidine/sulfanilamide and sulfamethoxypyridazine in sheep tissue. Acta veterinaria Scandinavica. 1977; 18(1):15-22. doi: 10.1186/bf03548461. [PMID: 848402]
  • D Videau. [Experimental pyelonephritis in rats: value in the comparison of antibiotics (author's transl)]. Annales de microbiologie. 1976 Oct; 127B(3):337-50. doi: NULL. [PMID: 798516]
  • H Bräunlich, F K Splinter. [Renal excretion of long term sulfonamides under fluid administration and modification of the urinary pH value]. Acta biologica et medica Germanica. 1976; 35(6):793-8. doi: NULL. [PMID: 10708]
  • M Stopp, C Weise, S Mewes, H Bräunlich. Different inhibitory effects of 2,4-dinitrophenol, iodoacetate, and probenecid on renal excretion of p-aminohippurate, cyclopenthiazide, and sulfamethoxypyridazine in rats. Acta biologica et medica Germanica. 1976; 35(6):787-92. doi: NULL. [PMID: 983625]
  • S R Pattyn, M T Rollier, R Rollier, G Verdoolaeghe-Van Loo. [Sensitivity to dapsone, sulfamethoxypyridazine and ethionamide of mycobacterium leprae taken from patients treated by the drugs]. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association. 1975 Oct; 43(4):356-63. doi: . [PMID: 776843]
  • Aung-Than-Batu, R Htun Nyun, N Hlaing, F Tin, T U, T Myint, K K Kyi. Chloroquine-resistant malaria in Burma. The Journal of tropical medicine and hygiene. 1975 Aug; 78(8):186-9. doi: . [PMID: 128638]
  • H Koslowski, K Menzel, W Braun. [In-vitro studies on the effect of drugs on albumin-bilirubin binding]. Kinderarztliche Praxis. 1975 Feb; 43(2):67-72. doi: NULL. [PMID: 1243824]
  • M Stopp, H Bräunlich. Characterisation of renal tubular transport processes in rats. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression. 1975; 16(6):373-8. doi: NULL. [PMID: 1232809]
  • R Storch, H Brünlich. [Stimulation of renal excretion of p-aminohippuric acid by repeated administration of drugs in young and adult rats]. Acta biologica et medica Germanica. 1975; 34(9):1529-39. doi: . [PMID: 1221741]
  • D Kurata, G R Wilkinson. Erythrocyte uptake and plasma binding of diphenylhydantoin. Clinical pharmacology and therapeutics. 1974 Aug; 16(2):355-62. doi: 10.1002/cpt1974162355. [PMID: 4851901]
  • E Owada, K Takahashi, R Hori, T Arita. Transformation and excretion of drugs in biological systems. X. Renal excretion mechanisms of sulfonamides in rabbits. Chemical & pharmaceutical bulletin. 1974 Mar; 22(3):594-600. doi: 10.1248/cpb.22.594. [PMID: 4424157]
  • E A Jackson, D C McLeod. Pharmacokinetics and dosing of antimicrobial agents in renal impairment, Part II. American journal of hospital pharmacy. 1974 Feb; 31(2):137-48. doi: NULL. [PMID: 4815846]
  • G Asbjornsen. The effect of different serum concentrations of antimicrobial drugs on the Lactobacillus leichmannii vitamin B12 assay. Acta medica Scandinavica. 1973 Dec; 194(6):567-70. doi: NULL. [PMID: 4204166]
  • A H Anton. Drug-protein binding. IV. Modulation of binding. Increasing activity of sulfonamides with displacing agents: a review. Annals of the New York Academy of Sciences. 1973 Nov; 226(?):273-92. doi: 10.1111/j.1749-6632.1973.tb20490.x. [PMID: 4588442]
  • A H Anton, R E Rodriguez. Drug-induced change in the distribution of sulfonamides in the mother rat and its fetus. Science (New York, N.Y.). 1973 Jun; 180(4089):974-6. doi: 10.1126/science.180.4089.974. [PMID: 4706687]
  • G Bernhardt, H Bräunlich, C Dietze, W Lungershausen, R Schade. [Acceleration of renal excretion of p-aminohippuric acid in rats of various ages through repeated administration of foreign substances]. Acta biologica et medica Germanica. 1973; 31(3):423-34. doi: NULL. [PMID: 4775349]
  • J Kampmann, J M Hansen, K Siersboek-Nielsen, H Laursen. Effect of some drugs on penicillin half-life in blood. Clinical pharmacology and therapeutics. 1972 Jul; 13(4):516-9. doi: 10.1002/cpt1972134516. [PMID: 5042368]
  • G B Mendoza, W H Gerwig, K L Stackhouse, G W Easley. Prophylactic use of antibacterial drugs following cystoscopy: a double-blind controlled study of demeclocycline hydrochloride and sulfamethoxypyridazine. The Journal of urology. 1971 Nov; 106(5):682-4. doi: 10.1016/s0022-5347(17)61373-9. [PMID: 5000522]
  • V Parsons, A Porter, F Dische. Cardiomyopathy and renal failure occurring in the puerperium. The Journal of obstetrics and gynaecology of the British Commonwealth. 1971 Jun; 78(6):564-9. doi: 10.1111/j.1471-0528.1971.tb00317.x. [PMID: 5559274]
  • C L Heifetz, J A Chodubski, M O DeCarlo, M W Fisher. Disc-agar diffusion microbiological assay procedure for determining serum and urine levels of sulfacytine and other sulfonamides. Applied microbiology. 1971 May; 21(5):893-8. doi: 10.1128/am.21.5.893-898.1971. [PMID: 4930038]
  • K F Funk. [Tubular reabsorption of sulfanilamides in rats]. Acta biologica et medica Germanica. 1971; 26(6):1259-60. doi: NULL. [PMID: 5153316]
  • K F Funk. [Effect of protein binding on the pharmacokinetics of sulfanilamides in rats]. Acta biologica et medica Germanica. 1971; 27(3):611-7. doi: NULL. [PMID: 5147704]
  • P K Lunde, A Rane, S J Yaffe, L Lund, F Sjöqvist. Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution. Clinical pharmacology and therapeutics. 1970 Nov; 11(6):846-55. doi: 10.1002/cpt1970116846. [PMID: 4394754]
  • K F Funk, W Oelssner. [Mechanism of hydrolysis of N4-substituted sulfanilamides in vivo]. Die Pharmazie. 1970 Sep; 25(9):557-60. doi: NULL. [PMID: 4098821]
  • K F Funk, W Oelssner, F P Meyer. [Resorption and elimination of N4-substituted sulfanilamides in rats]. Die Pharmazie. 1970 Sep; 25(9):554-6. doi: NULL. [PMID: 5486684]
  • E Reimerdes, J H Thumim. [Behavior of sulfanilamides in the body]. Arzneimittel-Forschung. 1970 Sep; 20(9):1171-9. doi: NULL. [PMID: 4922318]
  • J Tuomisto, P Männistö. Sulphonamide concentrations in urine during forced diuresis. Annales medicinae experimentalis et biologiae Fenniae. 1970; 48(3):195-9. doi: NULL. [PMID: 5472147]
  • J Tuomisto, N E Saris. Effective plasma and urine concentration of some sulfonamides and sulfonamide combinations. Annales medicinae experimentalis et biologiae Fenniae. 1970; 48(1):38-48. doi: NULL. [PMID: 5419724]
  • K F Funk. [Pharmacokinetic model studies on the rat. The single-chamber model of the organism]. Acta biologica et medica Germanica. 1970; 25(1):151-60. doi: NULL. [PMID: 5489670]
  • J Monnier, R Bourse, N Moatti, C Suc. [Comparative theoretical activity of antibiotics on the main gram-negative bacilli]. Pathologie-biologie. 1969 Oct; 17(19):817-24. doi: NULL. [PMID: 4985138]
  • B Tóth, B Kelentey, K Czinder, T Vályi-Nagy. [Distribution of sulfonamide-N4-glycosides in single organs of rabbit]. Arzneimittel-Forschung. 1969 Sep; 19(9):1524-7. doi: NULL. [PMID: 5394527]
  • L Denis, P Nowé, J P Michielsen. [Sulfamethoxypyrazine in urologic practice. Clinical and pharmacological study]. Acta urologica Belgica. 1969; 37(4):407-12. doi: NULL. [PMID: 5399920]
  • J Krieglstein, J W Franz, E Jähnchen. [Increase in albumin binding of promazine, depending on other drugs]. Naunyn-Schmiedebergs Archiv fur Pharmakologie. 1969; 264(3):261. doi: 10.1007/bf02431457. [PMID: 4242407]
  • P F Cooper, G C Wood. Protein-binding of small molecules: new gel filtration method. The Journal of pharmacy and pharmacology. 1968 Dec; 20(?):Suppl:150S+. doi: 10.1111/j.2042-7158.1968.tb09877.x. [PMID: 4388150]
  • A H Anton. The effect of disease, drugs, and dilution on the binding of sulfonamides in human plasma. Clinical pharmacology and therapeutics. 1968 Sep; 9(5):561-7. doi: 10.1002/cpt196895561. [PMID: 5676798]
  • M Timar, I Khédrikh, L Enesku, M Teodoresku, I Nitselea. [Placental stimulating metabolic funcrions of the reticulo-endothelial system]. Farmakologiia i toksikologiia. 1968 Mar; 31(2):213-5. doi: NULL. [PMID: 5674680]
  • H Harmening. [Experience with an ultra-long acting sulfonamide in practice]. Der Landarzt. 1968 Feb; 44(5):234-7. doi: NULL. [PMID: 5716605]
  • T A White, D A Evans. The actylation of sulamethazine and sulfamethoxypyridazine by human subjects. Clinical pharmacology and therapeutics. 1968 Jan; 9(1):80-8. doi: 10.1002/cpt19689180. [PMID: 5638098]
  • H M Solomon, J J Schrogie, D Williams. The displacement of phenylbutazone-14C and warfarin-14C from human albumin by various drugs and fatty acids. Biochemical pharmacology. 1968 Jan; 17(1):143-51. doi: 10.1016/0006-2952(68)90166-4. [PMID: 5638549]
  • S T Madsen. Antibacterial effect of urine after single oral doses of sulfonamide. Chemotherapia. 1968 ; 13(1):16-22. doi: 10.1159/000220526. [PMID: 5656312]
  • M F Vicchi. Special aspects in the diagnosis and treatment of urinary tract infections in pregnancy and the puerperium. American journal of obstetrics and gynecology. 1967 Dec; 99(7):994-9. doi: 10.1016/0002-9378(67)90257-8. [PMID: 4964587]
  • A Rossolini, C Panero, P Puglisi, C Pindinelli. [Serum sulfonamide curve in children treated with a new sulfonamide-pyrazole compound in rectal administration]. Minerva pediatrica. 1967 Oct; 19(40):1822-7. doi: NULL. [PMID: 5606443]
  • L M Polukhina, E N Padeĭskaia, G N Pershin. [Concentration of the prolonged action of sulfanilamides--sulfamethoxypyrazine (kelfizin) and sulfapyridazine in the blood and organs of albino mice]. Farmakologiia i toksikologiia. 1967 Jul; 30(4):470-3. doi: . [PMID: 5598904]
  • H Macdonald, V A Place, H Falk, M A Darken. Effect of food on absorption of sulfonamides in man. Chemotherapy. 1967; 12(5):282-5. doi: 10.1159/000220510. [PMID: 6081878]
  • O V Olesen. Determination of phenobarbital and phenytoin in serum by ultraviolet spectrophotometry. Scandinavian journal of clinical and laboratory investigation. 1967; 20(1):63-9. doi: 10.3109/00365516709076922. [PMID: 4383495]
  • H Macdonald, V A Place, H Falk, M A Darken. Sulfasymazine: absorption, excretion and metabolism in man. Chemotherapy. 1967; 12(6):360-8. doi: 10.1159/000220519. [PMID: 5590105]
  • P J Little. The incidence of urinary infection in 5000 pregnant women. Lancet (London, England). 1966 Oct; 2(7470):925-8. doi: 10.1016/s0140-6736(66)90534-4. [PMID: 4162367]
  • J Clausen. Binding of sulfonamides to serum proteins: physicochemical and immunochemical studies. The Journal of pharmacology and experimental therapeutics. 1966 Jul; 153(1):167-75. doi: NULL. [PMID: 5921355]
  • C M Kunin. Clinical pharmacology of the new penicillins. II. Effect of drugs which interfere with binding to serum proteins. Clinical pharmacology and therapeutics. 1966 Mar; 7(2):180-8. doi: 10.1002/cpt196672180. [PMID: 4956691]
  • P M Keen. The displacement of three anionic drugs from binding to bovine serum albumin by various anionic compounds. British journal of pharmacology and chemotherapy. 1966 Mar; 26(3):704-12. doi: 10.1111/j.1476-5381.1966.tb01850.x. [PMID: 4959940]
  • B Josephson, P Furst. Sulfonamides competing with bilirubin for conjugation to albumin. Scandinavian journal of clinical and laboratory investigation. 1966; 18(1):51-63. doi: 10.3109/00365516609065606. [PMID: 5918673]
  • S T Madsen. A comparative study of the excretion of sulfonamide-metabolites in cases of renal failure and hepatitis. Chemotherapy. 1966; 11(1):1-9. doi: 10.1159/000220433. [PMID: 5957159]
  • H B Falk, R G Kelly. An automated method for the determination of sulfonamides in plasma. Clinical chemistry. 1965 Dec; 11(12):1045-50. doi: 10.1093/clinchem/11.12.1045. [PMID: 5898037]
  • W H Linkenheimer, S J Stolzenberg. Pharmacologic characteristics of 4 sulfonamides in sheep. American journal of veterinary research. 1965 Sep; 26(114):1095-102. doi: NULL. [PMID: 5885724]
  • W H Linkenheimer, S J Stolzenberg. Pharmacologic characteristics of 4 sulfonamides in swine. American journal of veterinary research. 1965 Sep; 26(114):1086-94. doi: NULL. [PMID: 5885723]
  • A H ANTON, J J BOYLE. ALTERATION OF THE ACETYLATION OF SULFONAMIDES BY PROTEIN BINDING, SULFINPYRAZONE, AND SURAMIN. Canadian journal of physiology and pharmacology. 1964 Nov; 42(?):809-17. doi: 10.1139/y64-091. [PMID: 14324214]
  • B TOTH, B KELENTEY, K CZINDER, T VALYI-NAGY. [ISOLATION OF BETA-N4-GLUCOSIDASE FROM RABBIT PLASMA AND EXAMINATION OF ITS PROPERTIES WITH SULFONAMIDE-BETA-N4-GLUCOSIDES]. Biochemical pharmacology. 1964 Jun; 13(?):881-91. doi: 10.1016/0006-2952(64)90032-2. [PMID: 14186837]
  • Y MITSUI, K KONISHI, T KINOUCHI, T MIKI. TRACHOMA: ITS TREATMENT WITH A LONG-ACTING SULFONAMIDE ADMINISTERED ORALLY. The American journal of tropical medicine and hygiene. 1964 May; 13(?):488-91. doi: 10.4269/ajtmh.1964.13.488. [PMID: 14159989]
  • B TOTH, B KELENTEY, K CZINDER. [IN VIVO HYDROLYSIS OF SULFONAMIDE-N4-GLYCOSIDES AND THEIR LINKAGE TO PROTEINS]. Kiserletes orvostudomany. 1964 Apr; 16(?):126-31. doi: NULL. [PMID: 14155556]
  • C M SMYTHE. MANAGEMENT ACUTE PYELONEPHRITIS. Modern treatment. 1964 Jan; 1(?):63-77. doi: NULL. [PMID: 14161717]
  • E GENAZZANI, G PAGNINI. BINDING CAPABILITY OF VARIOUS SULFONAMIDES TO SERUMS OF DIFFERENT ANIMAL SPECIES. American journal of veterinary research. 1963 Nov; 24(?):1212-6. doi: NULL. [PMID: 14081457]
  • D GALUBA, T ZALEWSKI. [CLINICAL PICTURE OF ACUTE NON-INFLAMMATORY RENAL FAILURE IN CHILDREN]. Pediatria polska. 1963 Sep; 38(?):811-7. doi: NULL. [PMID: 14091561]
  • Z PLACKOVA, J WAGNER, I M HAIS. [COMPARISON OF THE FATE OF VARIOUS PYRIDAZINE SULFONAMIDES IN THE ANIMAL BODY]. Ceskoslovenska farmacie. 1963 Jun; 12(?):239-42. doi: NULL. [PMID: 14076174]
  • G SALVI, A C PLANCHER. [Renal clearance and blood protein binding of sulfamethoxypyridazine and N-4-acetylsulfamethoxypyridazine]. Arzneimittel-Forschung. 1963 Apr; 13(?):343-4. doi: NULL. [PMID: 13991222]
  • N HASUMURA, K NAKAMURA. [On the ratio of the binding of various long-acting sulfa drugs to plasma proteins]. Sogo igaku. Medicine. 1962 Dec; 19(?):911-3. doi: NULL. [PMID: 13960929]
  • J SARMIENTO, G MONTES. [Inhibition of the accumulation of phenol red by sulfamethoxypyridazine in renal tissue slices]. Revista de la Facultad de Medicina, Universidad Nacional de Colombia. 1962 Oct; 30(?):73-6. doi: NULL. [PMID: 13986559]
  • S D'AGOSTINO, R MADDALUNO, P GIOVAGNOLI. [Behavior of the urinary reducing power after administration of isoniazid, penicillin, cycloserine and sulfamethoxypyridazine]. Clinique (Paris, France). 1962 Jul; 23(?):48-56. doi: NULL. [PMID: 13882935]
  • A HOLMGARD, B JOSEPHSON, H BUCHT, P A ORSTEN. A new sulfonamide combination designed for treatment of kidney and urinary tract infections: its blood concentration and renal excretion. Current therapeutic research, clinical and experimental. 1961 Sep; 3(?):397-404. doi: NULL. [PMID: 13715486]
  • M GRECO, G COLALONGO. [Action of a sulfonamide (3-sulfanilamido-6-methoxypyridazine) on the serum level of properdin]. Bollettino della Societa italiana di biologia sperimentale. 1961 Apr; 37(?):296-8. doi: NULL. [PMID: 13708145]
  • W E CLAPPER, L E PLANK. Blood and urine concentrations of sulfamethoxypyridazine in hospital patients. Antibiotics & chemotherapy (Northfield, Ill.). 1958 Sep; 8(9):461-5. doi: NULL. [PMID: 24544951]
  • C V PRYLES, M FINLAND. N1 acetyl sulfamethoxypyridazine: concentrations in blood and urine during oral administration and comparisons with sulfamethoxypyridazine. The American journal of the medical sciences. 1958 May; 235(5):555-61. doi: NULL. [PMID: 13533417]
  • M FINLAND, W F JONES, M ZIAI, G R CHERRICK. Sulfamethoxypyridazine: concentrations in blood and urine during oral administration of various dosages. The American journal of the medical sciences. 1957 Nov; 234(5):505-16 passim. doi: NULL. [PMID: 13487563]