Sulfameter (BioDeep_00000184036)

   

human metabolite blood metabolite


代谢物信息卡片


4-amino-N-(5-methoxypyrimidin-2-yl)benzene-1-sulfonamide

化学式: C11H12N4O3S (280.0630082)
中文名称: 磺胺-5-甲氧嘧啶, 磺胺对甲氧嘧啶
谱图信息: 最多检出来源 Homo sapiens(blood) 87.5%

分子结构信息

SMILES: COC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01ED - Long-acting sulfonamides
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007917 - Leprostatic Agents
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides

同义名列表

41 个代谢物同义名

4-amino-N-(5-methoxypyrimidin-2-yl)benzene-1-sulfonamide; 4-amino-N-(5-Methoxypyrimidin-2-yl)benzenesulphonamide; 4-Amino-N-(5-methoxy-2-pyrimidinyl)benzenesulphonamide; 4-Amino-N-(5-methoxy-2-pyrimidinyl)benzenesulfonamide; 2-(4-Aminobenzenesulphonamido)-5-methoxypyrimidine; 2-(4-Aminobenzenesulfonamido)-5-methoxypyrimidine; N(1)-(5-Methoxy-2-pyrimidinyl)sulphanilamide; N(1)-(5-Methoxy-2-pyrimidinyl)sulfanilamide; 5-Methoxy-2-sulphanilamidopyrimidine; 2-Sulphanilamido-5-methoxypyrimidine; 2-Sulfanilamido-5-methoxypyrimidine; 5-Methoxy-2-sulfanilamidopyrimidine; 2-Sulphanilamido-5-methoxypyrimidin; 2-Sulfanilamido-5-methoxypyrimidin; Sulpha-5-methoxypyrimidine; Sulfa-5-methoxypyrimidine; Sulphamethoxypyrimidine; Sulfamethoxypyrimidine; 5-Methoxysulphadiazine; 5-Methoxysulfadiazine; Sulphamethoxidiazine; Sulphamethoxydiazine; Sulphametoxydiazinum; Sulfamethoxydiazine; Solfametossidiazina; Sulfametoxydiazinum; Sulphametoxidiazina; Sulphametoxydiazine; Sulfamethoxidiazine; Sulfametoxydiazine; Sulfametoxidiazina; Sulfamethoxydine; Sulfametoxidine; Sulphamethoxine; Sulfametorinum; Sulfamethoxine; Sulphameter; Sulfametin; sulfameter; Sulla; kiron



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ruyi Xu, Chen Yang, Lin Huang, Wenchao Lv, Weijuan Yang, Yongning Wu, FengFu Fu. Broad-Specificity Aptamer of Sulfonamides: Isolation and Its Application in Simultaneous Detection of Multiple Sulfonamides in Fish Sample. Journal of agricultural and food chemistry. 2022 Sep; 70(37):11804-11812. doi: 10.1021/acs.jafc.2c03423. [PMID: 36070569]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tancong Liao, Yuai Zhang, Xiaojian Huang, Zheng Jiang, Xun Tuo. Multi-spectroscopic and molecular docking studies of human serum albumin interactions with sulfametoxydiazine and sulfamonomethoxine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Feb; 246(?):119000. doi: 10.1016/j.saa.2020.119000. [PMID: 33032113]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yoshiteru Noutoshi, Mika Ikeda, Tamio Saito, Hiroyuki Osada, Ken Shirasu. Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana. Frontiers in plant science. 2012; 3(?):245. doi: 10.3389/fpls.2012.00245. [PMID: 23118736]
  • Anja Joachim, Hans-Christian Mundt. Efficacy of sulfonamides and Baycox(®) against Isospora suis in experimental infections of suckling piglets. Parasitology research. 2011 Dec; 109(6):1653-9. doi: 10.1007/s00436-011-2438-9. [PMID: 21556685]
  • Yan-Wen Li, Xiao-Lian Wu, Ce-Hui Mo, Yi-Ping Tai, Xian-Pei Huang, Lei Xiang. Investigation of sulfonamide, tetracycline, and quinolone antibiotics in vegetable farmland soil in the Pearl River Delta area, southern China. Journal of agricultural and food chemistry. 2011 Jul; 59(13):7268-76. doi: 10.1021/jf1047578. [PMID: 21623636]
  • Hanwen Sun, Peiyun Chen, Liqing Li, Peng Cheng. A novel chemiluminescence quenching method for determination of sulfonamides in pharmaceutical and biological fluid based on luminol-Ag(III) complex reaction in alkaline solution. Drug testing and analysis. 2011 May; 3(5):300-5. doi: 10.1002/dta.249. [PMID: 21287695]
  • Yi-Ping Tai, Xiao-Dong Luo, Ce-Hui Mo, Yan-Wen Li, Xiao-Lian Wu, Xing-Yue Liu. [Occurrence of quinolone and sulfonamide antibiotics in swine and cattle manures from large-scale feeding operations of Guangdong Province]. Huan jing ke xue= Huanjing kexue. 2011 Apr; 32(4):1188-93. doi: NULL. [PMID: 21717768]
  • Xiliang Wang, Kui Li, Deshi Shi, Ning Xiong, Xiue Jin, Jundong Yi, Dingren Bi. Development of an immunochromatographic lateral-flow test strip for rapid detection of sulfonamides in eggs and chicken muscles. Journal of agricultural and food chemistry. 2007 Mar; 55(6):2072-8. doi: 10.1021/jf062523h. [PMID: 17316015]
  • I U Asuzu, S N Shetty, O Obidoa. The interaction of aflatoxin B1 with vitamin K, phenylbutazone, and sulfamethoxine in rats. Biochemical medicine and metabolic biology. 1988 Apr; 39(2):158-67. doi: 10.1016/0885-4505(88)90072-2. [PMID: 3132187]
  • M Bohdanecká, O Schück. The influence of furosemide on intrarenal distribution of 2-sulphanilamido-5-methoxypyrimidine in rats with normal and reduced renal parenchyma. Czechoslovak medicine. 1986; 9(3):157-61. doi: NULL. [PMID: 3095075]
  • M Bohdanecká, O Schück. [The effect of diuretics on the intrarenal distribution of sulphamethoxydine in rats]. Casopis lekaru ceskych. 1983 Feb; 122(5):149-52. doi: NULL. [PMID: 6831496]
  • H S Kaumeier. [The influence of food on the bioavailability of drugs on the example of sulfamethoxydiazine (author's transl)]. Arzneimittel-Forschung. 1980; 30(10):1794-800. doi: ". [PMID: 7192117]
  • S Kaumeier. The effect of the composition of food on the absorption of sulfameter. International journal of clinical pharmacology and biopharmacy. 1979 Jun; 17(6):260-3. doi: NULL. [PMID: 468450]
  • Z Sallingova, A Nicak, V Grossmann. [Binding of sulfamethoxydine on blood proteins in relation to age. Comparison of binding to human serum proteins with binding to rat serum proteins]. Ceskoslovenska fysiologie. 1976; 25(4):333-42. doi: NULL. [PMID: 987862]
  • A Toivanen, A Kasan, H Sundquist, P Toivanen. Effect of trimethoprim on the occurrence of drug-resistant coliform bacteria in the faecal flora. Chemotherapy. 1976; 22(2):97-103. doi: 10.1159/000221918. [PMID: 1253636]
  • W H CHEW, K KAPLAN, L WEINSTEIN. STUDIES OF SULFAMETHOXYDIAZINE. I. ABSORPTION AND EXCRETION. Clinical pharmacology and therapeutics. 1965 May; 6(?):307-15. doi: 10.1002/cpt196563307. [PMID: 14296028]