N-(2-Hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl)acetamide (BioDeep_00000183946)
human metabolite blood metabolite
代谢物信息卡片
化学式: C8H9F3N4O4 (282.0576)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C(=N1)[N+](=O)[O-])CC(=O)NCC(C(F)(F)F)O
InChI: InChI=1S/C8H9F3N4O4/c9-8(10,11)5(16)3-13-6(17)4-14-2-1-12-7(14)15(18)19/h1-2,5,16H,3-4H2,(H,13,17)
描述信息
同义名列表
4 个代谢物同义名
2-(2-Nitro-1H-imidazol-1-yl)-N-(3,3,3-trifluoro-2-hydroxypropyl)ethanimidate; 2-(2-nitro-1H-imidazol-1-yl)-N-(3,3,3-trifluoro-2-hydroxypropyl)acetamide; N-(2-Hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl)acetamide; 2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoro-2-hydroxypropyl)acetamide
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- C P Lee, G S Payne, A Oregioni, R Ruddle, S Tan, F I Raynaud, D Eaton, M J Campbell, K Cross, G Halbert, M Tracy, J McNamara, B Seddon, M O Leach, P Workman, I Judson. A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.
British journal of cancer.
2009 Dec; 101(11):1860-8. doi:
10.1038/sj.bjc.6605425. [PMID: 19935799] - Beatrice M Seddon, Geoffrey S Payne, Laura Simmons, Ruth Ruddle, Rachel Grimshaw, Siew Tan, Alison Turner, Florence Raynaud, Gavin Halbert, Martin O Leach, Ian Judson, Paul Workman. A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2003 Nov; 9(14):5101-12. doi:
NULL. [PMID: 14613987] - Beatrice M Seddon, Ross J Maxwell, Davina J Honess, Rachel Grimshaw, Florence Raynaud, Gillian M Tozer, Paul Workman. Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2002 Jul; 8(7):2323-35. doi:
NULL. [PMID: 12114437] - P M McSheehy, S P Robinson, A S Ojugo, E O Aboagye, M B Cannell, M O Leach, I R Judson, J R Griffiths. Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.
Cancer research.
1998 Mar; 58(6):1185-94. doi:
NULL. [PMID: 9515804] - E O Aboagye, A D Lewis, M A Graham, M Tracy, A B Kelson, K J Ryan, P Workman. The pharmacokinetics, bioavailability and biodistribution in mice of a rationally designed 2-nitroimidazole hypoxia probe SR-4554.
Anti-cancer drug design.
1996 Apr; 11(3):231-42. doi:
NULL. [PMID: 8663910] - E O Aboagye, M A Graham, A D Lewis, P Workman, A B Kelson, M Tracy. Development and validation of a solid-phase extraction and high-performance liquid chromatographic assay for a novel fluorinated 2-nitroimidazole hypoxia probe (SR-4554) in Balb/c mouse plasma.
Journal of chromatography. B, Biomedical applications.
1995 Oct; 672(1):125-32. doi:
10.1016/0378-4347(95)00204-v. [PMID: 8590924] - E O Aboagye, A D Lewis, A Johnson, P Workman, M Tracy, I M Huxham. The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semiquantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy loss spectroscopic analysis.
British journal of cancer.
1995 Aug; 72(2):312-8. doi:
10.1038/bjc.1995.330. [PMID: 7640211]
