Oxyphenonium (BioDeep_00000018392)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C21H34NO3+ (348.2538554)
中文名称: 美索菌素
谱图信息:
最多检出来源 Homo sapiens(blood) 98.46%
分子结构信息
SMILES: CC[N+](C)(CC)CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
InChI: InChI=1S/C21H34NO3/c1-4-22(3,5-2)16-17-25-20(23)21(24,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6,8-9,12-13,19,24H,4-5,7,10-11,14-17H2,1-3H3/q+1
描述信息
A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. [PubChem]
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AB - Synthetic anticholinergics, quaternary ammonium compounds
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
同义名列表
26 个代谢物同义名
{2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]ethyl}diethylmethylazanium; 2-((Cyclohexylhydroxyphenylacetyl)oxy)-N,N-diethyl-N-methylethanaminium; Oxyphenonium bromide, (+-)-isomer; Oxyphenonium bromide, (-)-isomer; Oxyphenonium bromide, (+)-isomer; Oxyphenonium iodide, (S)-isomer; Oxyphenonium iodide, (R)-isomer; Oxyphenonium, (+-)-isomer; Oxyphenonium, (S)-isomer; Oxyphenonium, (R)-isomer; Hydroxymethylgramicidin; Chloride, oxyphenonium; Bromide, oxyphenonium; Oxyphenonium chloride; Iodide, oxyphenonium; Oxyphenonium bromide; Oxyphenonium iodide; oxyphenonium; Oxiphenonum; Methocidin; Oxyphenon; Spastrex; Methacin; Metacin; Atrenyl; DCF
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:94329
- PubChem: 5749
- HMDB: HMDB0014364
- DrugBank: DB00219
- ChEMBL: CHEMBL1201286
- Wikipedia: Oxyphenonium bromide
- MeSH: Oxyphenonium
- chemspider: 5547
- CAS: 14214-84-7
- CAS: 1407-05-2
- PMhub: MS000007628
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- G I Nezhinskaya, A L Vladykin, N S Sapronov. Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist.
Bulletin of experimental biology and medicine.
2008 Jan; 145(1):55-7. doi:
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Life sciences.
2007 May; 80(24-25):2342-6. doi:
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Autonomic & autacoid pharmacology.
2007 Apr; 27(2):99-104. doi:
10.1111/j.1474-8673.2007.00395.x
. [PMID: 17391279] - J Smisterová, K Ensing, R A de Zeeuw. Effect of purification followed by solubilization of receptor material on quantitative receptor assays for anticholinergic drugs.
Journal of pharmaceutical and biomedical analysis.
1996 Aug; 14(11):1425-33. doi:
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Magnetic resonance in medicine.
1991 Feb; 17(2):509-15. doi:
10.1002/mrm.1910170221
. [PMID: 1905776] - K G Feitsma, B F Drenth, R A De Zeeuw, R Oosting, D K Meijer. Unequal disposition of enantiomers of the organic cation oxyphenonium in the rat isolated perfused liver.
The Journal of pharmacy and pharmacology.
1989 Jan; 41(1):27-31. doi:
10.1111/j.2042-7158.1989.tb06323.x
. [PMID: 2565960] - K Ensing, F Kluivingh, T K Gerding, R A De Zeeuw. Development of a sensitive radioreceptor assay for oxyphenonium in plasma and urine.
The Journal of pharmacy and pharmacology.
1984 Apr; 36(4):235-9. doi:
10.1111/j.2042-7158.1984.tb04356.x
. [PMID: 6144769] - K Ensing, R A de Zeeuw. Radioreceptor assay for oxyphenonium.
European journal of respiratory diseases. Supplement.
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NULL
. [PMID: 6428927] - L E van Bork, J H Jonkman, J E Greving, N G Orie, R Peset, K de Vries, R A de Zeeuw. Relationship between plasma concentration and the pulmonary and cardiac effects of three anticholinergics.
European journal of respiratory diseases. Supplement.
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NULL
. [PMID: 6145613] - G H Koëter, H Meurs, J H Jonkman, J Greving, J Leferink, H J Sluiter, R A de Zeeuw, K de Vries. Protective effect of oral oxyphenonium bromide, terbutaline and theophylline against the bronchial obstructive effects of inhaled histamine, acetylcholine and propranolol.
European journal of clinical pharmacology.
1984; 26(4):435-41. doi:
10.1007/bf00542137
. [PMID: 6329769] - E Harvey, M Loberg, J Ryan, S Sikorski, W Faith, M Cooper. Hepatic clearance mechanism of Tc-99m-HIDA and its effect on quantitation of hepatobiliary function: Concise communication.
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Archives of internal medicine.
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. [PMID: 416763] - J E Greving, J H Jonkman, F Fiks, R A de Zeeuw, L E van Bork, N G Orie. Determination of oxyphenonium bromide in plasma and urine by means of ion-pair extraction, derivatization and gas chromatography-electron-capture detection.
Journal of chromatography.
1977 Nov; 142(?):611-9. doi:
10.1016/s0021-9673(01)92072-2
. [PMID: 410817] - S A Kenawy, A M El Masry, S F Saad, M T Khayyal, M T Abdel Aziz. Comparative study on the effect of neostigmine, trimetaphan an oxyphenonium on some aspects of 5-hydroxytryptamine metabolism in rats.
The Journal of pharmacy and pharmacology.
1975 Nov; 27(11):871-3. doi:
10.1111/j.2042-7158.1975.tb10235.x
. [PMID: 1501] - J Czarnecki. [Studies on the 24 hour urinary excretion of 5-hydroxyindoleacetic acid in patients with stomach or duodenal ulcer before, during and after treatment with Spasmophen in relation to the "basal HC1 excretion" and the clinical condition of patients].
Polskie Archiwum Medycyny Wewnetrznej.
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Acta pharmacologica et toxicologica.
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10.1111/j.1600-0773.1965.tb03580.x
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