Spermine NONOate (BioDeep_00000183916)
human metabolite blood metabolite
代谢物信息卡片
{[(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amino]-oxo-$l^{5}-azanylidene}(hydroxy)amine
化学式: C10H26N6O2 (262.2117136)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: NCCCNCCCCN(CCCN)[N+]([O-])=NO
InChI: InChI=1S/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,17H,1-12H2
描述信息
同义名列表
11 个代谢物同义名
{[(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amino]-oxo-$l^{5}-azanylidene}(hydroxy)amine; [(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amino-oxo-$l^{5}-azanylidene](hydroxy)amine; N-(4-(1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino)butyl)-1,3-propanediamine; Spermine nitric oxide complex; Spermine-nitric oxide; Spermine nonoic acid; Spermine-nonoate; Spermine NONOate; SPER-no; NOC-22; NOC 22
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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American journal of physiology. Renal physiology.
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Endocrinology.
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Metabolism: clinical and experimental.
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10.1016/j.metabol.2012.06.011. [PMID: 22889511] - Leone F Mattioli, Naomi B Holloway, James H Thomas, John G Wood. Fructose, but not dextrose, induces leukocyte adherence to the mesenteric venule of the rat by oxidative stress.
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The Journal of physiology.
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Journal of bacteriology.
2004 Aug; 186(16):5332-41. doi:
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Nitric oxide : biology and chemistry.
2003 Dec; 9(4):201-10. doi:
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IUBMB life.
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10.1096/fj.02-0668fje. [PMID: 12586741] - Hao Zhang, Kalpana Bhargava, Agnes Keszler, Jimmy Feix, Neil Hogg, Joy Joseph, B Kalyanaraman. Transmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications.
The Journal of biological chemistry.
2003 Mar; 278(11):8969-78. doi:
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Fish & shellfish immunology.
2003 Mar; 14(3):207-22. doi:
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Kidney international.
2002 Jun; 61(6):2218-27. doi:
10.1046/j.1523-1755.2002.00360.x. [PMID: 12028463] - Rui Mesquita, Bruno Piçarra, Carlota Saldanha, J Martins e Silva. Nitric oxide effects on human erythrocytes structural and functional properties--an in vitro study.
Clinical hemorheology and microcirculation.
2002; 27(2):137-47. doi:
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Blood.
2001 Feb; 97(4):1009-15. doi:
10.1182/blood.v97.4.1009. [PMID: 11159530] - R Mesquita, I Pires, C Saldanha, J Martins-Silva. Effects of acetylcholine and spermineNONOate on erythrocyte hemorheologic and oxygen carrying properties.
Clinical hemorheology and microcirculation.
2001; 25(3-4):153-63. doi:
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Chemical research in toxicology.
2000 Dec; 13(12):1265-74. doi:
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American journal of physiology. Renal physiology.
2000 Oct; 279(4):F728-35. doi:
10.1152/ajprenal.2000.279.4.f728. [PMID: 10997923] - M Belén Herrero, S Chatterjee, L Lefièvre, E de Lamirande, C Gagnon. Nitric oxide interacts with the cAMP pathway to modulate capacitation of human spermatozoa.
Free radical biology & medicine.
2000 Sep; 29(6):522-36. doi:
10.1016/s0891-5849(00)00339-7. [PMID: 11025196] - B Hinz, H Schröder. The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells.
Pharmaceutical research.
1999 May; 16(5):633-6. doi:
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Nitric oxide : biology and chemistry.
1999; 3(2):132-41. doi:
10.1006/niox.1999.0216. [PMID: 10369183] - B Hinz, H Schröder. Vitamin C attenuates nitrate tolerance independently of its antioxidant effect.
FEBS letters.
1998 May; 428(1-2):97-9. doi:
10.1016/s0014-5793(98)00506-7. [PMID: 9645484] - J Pfeilschifter, A Huwiler. Nitric oxide stimulates stress-activated protein kinases in glomerular endothelial and mesangial cells.
FEBS letters.
1996 Oct; 396(1):67-70. doi:
10.1016/0014-5793(96)01070-8. [PMID: 8906868] - I Y Haddad, S Zhu, J Crow, E Barefield, T Gadilhe, S Matalon. Inhibition of alveolar type II cell ATP and surfactant synthesis by nitric oxide.
The American journal of physiology.
1996 Jun; 270(6 Pt 1):L898-906. doi:
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10.1161/01.hyp.27.3.679. [PMID: 8613224] - A Zini, E De Lamirande, C Gagnon. Low levels of nitric oxide promote human sperm capacitation in vitro.
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1995 Sep; 16(5):424-31. doi:
NULL. [PMID: 8575982] - N Hogg, A Struck, S P Goss, N Santanam, J Joseph, S Parthasarathy, B Kalyanaraman. Inhibition of macrophage-dependent low density lipoprotein oxidation by nitric-oxide donors.
Journal of lipid research.
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Journal of the American Society of Nephrology : JASN.
1995 Jul; 6(1):89-94. doi:
10.1681/asn.v6189. [PMID: 7579075] - S P Goss, N Hogg, B Kalyanaraman. The antioxidant effect of spermine NONOate in human low-density lipoprotein.
Chemical research in toxicology.
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